CN108934169A - 用于抑制因子d的组合物和方法 - Google Patents

用于抑制因子d的组合物和方法 Download PDF

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Publication number
CN108934169A
CN108934169A CN201780018764.5A CN201780018764A CN108934169A CN 108934169 A CN108934169 A CN 108934169A CN 201780018764 A CN201780018764 A CN 201780018764A CN 108934169 A CN108934169 A CN 108934169A
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aptamer
factor
complement factor
complement
cases
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English (en)
Chinese (zh)
Inventor
卡尔·埃里克森
克里斯多夫·P·鲁斯科尼
凯文·G·麦克卢尔
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Vitriza Medical Co
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Vitriza Medical Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN201780018764.5A 2016-01-20 2017-01-20 用于抑制因子d的组合物和方法 Pending CN108934169A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662281092P 2016-01-20 2016-01-20
US62/281,092 2016-01-20
US201662297095P 2016-02-18 2016-02-18
US62/297,095 2016-02-18
PCT/US2017/014458 WO2017127761A1 (en) 2016-01-20 2017-01-20 Compositions and methods for inhibiting factor d

Publications (1)

Publication Number Publication Date
CN108934169A true CN108934169A (zh) 2018-12-04

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Family Applications (1)

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CN201780018764.5A Pending CN108934169A (zh) 2016-01-20 2017-01-20 用于抑制因子d的组合物和方法

Country Status (8)

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US (4) US10174325B2 (enExample)
EP (1) EP3405577B8 (enExample)
JP (3) JP2019506159A (enExample)
CN (1) CN108934169A (enExample)
AU (3) AU2017210042B2 (enExample)
CA (1) CA3011819A1 (enExample)
GB (1) GB2553252B (enExample)
WO (1) WO2017127761A1 (enExample)

Cited By (1)

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CN114686481A (zh) * 2020-12-31 2022-07-01 北京键凯科技股份有限公司 一种抑制cfd表达的干扰rna及其制备方法和应用

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WO2020069024A1 (en) 2018-09-25 2020-04-02 Achillion Pharmaceuticals, Inc. Morphic forms of complement factor d inhibitors
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WO2021081395A1 (en) * 2019-10-23 2021-04-29 Gemini Therapeutics Inc. Methods for treating patients having cfh mutations with recombinant cfh proteins
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Publication number Priority date Publication date Assignee Title
CN114686481A (zh) * 2020-12-31 2022-07-01 北京键凯科技股份有限公司 一种抑制cfd表达的干扰rna及其制备方法和应用
CN114686481B (zh) * 2020-12-31 2023-08-15 北京键凯科技股份有限公司 一种抑制cfd表达的干扰rna及其制备方法和应用

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GB2553252A8 (en) 2018-03-14
EP3405577A1 (en) 2018-11-28
JP2024029136A (ja) 2024-03-05
EP3405577B1 (en) 2022-12-14
GB2553252B (en) 2019-07-31
US20200392502A1 (en) 2020-12-17
EP3405577B8 (en) 2023-02-15
GB2553252A (en) 2018-02-28
US20250197868A1 (en) 2025-06-19
US10174325B2 (en) 2019-01-08
AU2017210042A1 (en) 2018-07-26
CA3011819A1 (en) 2017-07-27
GB201718801D0 (en) 2017-12-27
US20180051287A1 (en) 2018-02-22
US11274307B2 (en) 2022-03-15
JP2022078283A (ja) 2022-05-24
JP2019506159A (ja) 2019-03-07
AU2021202392A1 (en) 2021-05-20
AU2023202548A1 (en) 2023-06-01
US20190161755A1 (en) 2019-05-30
AU2021202392B2 (en) 2023-02-02
AU2017210042B2 (en) 2021-01-21
HK1251610A1 (zh) 2019-02-01
EP3405577A4 (en) 2019-09-11
WO2017127761A1 (en) 2017-07-27

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