JP2019505585A5 - - Google Patents

Download PDF

Info

Publication number
JP2019505585A5
JP2019505585A5 JP2018554660A JP2018554660A JP2019505585A5 JP 2019505585 A5 JP2019505585 A5 JP 2019505585A5 JP 2018554660 A JP2018554660 A JP 2018554660A JP 2018554660 A JP2018554660 A JP 2018554660A JP 2019505585 A5 JP2019505585 A5 JP 2019505585A5
Authority
JP
Japan
Prior art keywords
formulation
abdnaz
cancer
patient
whole blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018554660A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019505585A (ja
JP6931004B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/012948 external-priority patent/WO2017123593A1/en
Publication of JP2019505585A publication Critical patent/JP2019505585A/ja
Publication of JP2019505585A5 publication Critical patent/JP2019505585A5/ja
Application granted granted Critical
Publication of JP6931004B2 publication Critical patent/JP6931004B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018554660A 2016-01-11 2017-01-11 2−ブロモ−1−(3,3−ジニトロアゼチジン−1−イル)エタノンの静脈内投与のための組成物および方法 Active JP6931004B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662277236P 2016-01-11 2016-01-11
US62/277,236 2016-01-11
PCT/US2017/012948 WO2017123593A1 (en) 2016-01-11 2017-01-11 Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone

Publications (3)

Publication Number Publication Date
JP2019505585A JP2019505585A (ja) 2019-02-28
JP2019505585A5 true JP2019505585A5 (cg-RX-API-DMAC7.html) 2020-02-27
JP6931004B2 JP6931004B2 (ja) 2021-09-01

Family

ID=59311661

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018554660A Active JP6931004B2 (ja) 2016-01-11 2017-01-11 2−ブロモ−1−(3,3−ジニトロアゼチジン−1−イル)エタノンの静脈内投与のための組成物および方法

Country Status (14)

Country Link
US (2) US11576895B2 (cg-RX-API-DMAC7.html)
EP (1) EP3402480B1 (cg-RX-API-DMAC7.html)
JP (1) JP6931004B2 (cg-RX-API-DMAC7.html)
KR (1) KR20190040931A (cg-RX-API-DMAC7.html)
CN (2) CN118236371A (cg-RX-API-DMAC7.html)
AU (1) AU2017207304B2 (cg-RX-API-DMAC7.html)
CA (1) CA3011103A1 (cg-RX-API-DMAC7.html)
DK (1) DK3402480T3 (cg-RX-API-DMAC7.html)
EA (1) EA201891606A1 (cg-RX-API-DMAC7.html)
ES (1) ES2880482T3 (cg-RX-API-DMAC7.html)
MX (1) MX2018008528A (cg-RX-API-DMAC7.html)
PL (1) PL3402480T3 (cg-RX-API-DMAC7.html)
SG (1) SG11201805942UA (cg-RX-API-DMAC7.html)
WO (1) WO2017123593A1 (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
KR20190040931A (ko) 2016-01-11 2019-04-19 에피센트알엑스, 인코포레이티드 2-브로모-1-(3,3-디니트로아제티딘-1-일)에타논의 정맥내 투여를 위한 조성물 및 방법
EP3526195A4 (en) 2016-10-14 2020-05-20 EpicentRx, Inc. SULFOXYALKYLE ORGANONITRO, RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN MEDICINE
IL271777B2 (en) 2017-07-07 2024-09-01 Epicentrx Inc Compositions for parenteral administration of therapeutic agents
US11510901B2 (en) 2018-01-08 2022-11-29 Epicentrx, Inc. Methods and compositions utilizing RRx-001 combination therapy for radioprotection
EP3801678A4 (en) 2018-06-11 2022-04-06 EpicentRx, Inc. MEDICATION INFUSION DEVICES, SYSTEMS AND METHODS
IL293672A (en) 2019-12-11 2022-08-01 Epicentrx Inc Drug infusion devices, systems and methods
MX2023014676A (es) * 2021-06-09 2024-02-06 Epicentrx Inc Composiciones de abdnaz cristalinas y metodos de elaboracion y uso de estas.
WO2023154480A1 (en) * 2022-02-10 2023-08-17 Epicentrx, Inc. Compositions and methods for treatment of nafld and nash and related dyslipidemias
WO2024098009A1 (en) 2022-11-04 2024-05-10 Epicentrx, Inc. Rrx-001 for minimizing post-infarct adverse ventricular remodeling and complications
WO2024124152A1 (en) 2022-12-08 2024-06-13 Epicentrx, Inc. Rrx-001 for the treatment of a hemoglobinopathy
WO2024145484A1 (en) * 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2978453A (en) 1956-12-12 1961-04-04 Aerojet General Co 3, 3, 5, 5-tetranitropiperidine
JPS4830376B1 (cg-RX-API-DMAC7.html) 1970-12-29 1973-09-19
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
JPS5511509A (en) * 1978-07-07 1980-01-26 Toomasu Gorudon Robaato Cancer therapy
US4935450A (en) 1982-09-17 1990-06-19 Therapeutical Systems Corporation Cancer therapy system for effecting oncolysis of malignant neoplasms
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
US4584130A (en) 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
GB8728418D0 (en) 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5693794A (en) 1988-09-30 1997-12-02 The United States Of America As Represented By The Secretary Of The Navy Caged polynitramine compound
JP2659614B2 (ja) 1990-11-13 1997-09-30 株式会社日立製作所 表示制御装置
TW198712B (cg-RX-API-DMAC7.html) 1991-04-17 1993-01-21 Hoffmann La Roche
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
WO1993008842A1 (en) 1991-11-08 1993-05-13 Somatogen, Inc. Hemoglobins as drug delivery agents
DE4226974C2 (de) 1992-08-14 1994-08-11 Fresenius Ag Verfahren und Vorrichtung zur kontinuierlichen Aufbereitung einer Zellsuspension
US5336784A (en) 1993-06-07 1994-08-09 The Regents Of The University Of California Synthesis of 1,3,3-trinitroazetidine
ES2092460T3 (es) 1994-05-27 2001-02-01 Cellegy Pharma Inc Composicion dadora de oxido nitrico para el tratamiento de trastornos anales.
WO1996019198A1 (en) 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol drug formulations
NZ304009A (en) 1995-03-14 1999-02-25 Siemens Ag Ultrasonic atomizer device with a removable precision dosating unit
ES2177771T3 (es) 1995-03-14 2002-12-16 Siemens Ag Dispositivo atomizador ultrasonico con unidad desmontable de dosificacion de precision.
US5580988A (en) 1995-05-15 1996-12-03 The United States Of America As Represented By The Secretary Of The Army Substituted azetidines and processes of using them
AU5798996A (en) 1995-05-15 1996-11-29 Sachs, Michael C. Adnaz, compositions and processes
US5898038A (en) 1996-03-19 1999-04-27 Board Of Regents, The University Of Texas System Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
EP0932598A1 (en) 1996-10-11 1999-08-04 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
AU3129097A (en) 1996-10-15 1998-05-11 Eastman Chemical Company Explosive formulations
US5945446A (en) 1997-02-10 1999-08-31 Laubc Biochemicals, Corporation Process for preparing synthetic soil-extract materials and medicaments based thereon
HUP9701554D0 (en) 1997-09-18 1997-11-28 Human Oltoanyagtermeloe Gyogys Pharmaceutical composition containing plazma proteins
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
GB9720797D0 (en) 1997-09-30 1997-12-03 Rhodes John Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
US6056966A (en) 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
AU750313B2 (en) 1998-07-27 2002-07-18 St. Jude Pharmaceuticals, Inc. Chemically induced intracellular hyperthermia
US6448253B1 (en) 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6391911B1 (en) 1999-02-26 2002-05-21 Robert E. Bases Coadministration of lucanthone and radiation for treatment of cancer
US20020077276A1 (en) 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
US20020156033A1 (en) 2000-03-03 2002-10-24 Bratzler Robert L. Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
HRP20020808A2 (en) 2000-04-10 2004-12-31 Pfizer Prod Inc Benzoamide piperidine containing compounds and related compounds
US6861530B2 (en) 2000-07-07 2005-03-01 Kyowa Hakko Kogyo Co., Ltd. Piperidine derivatives
RU2188026C1 (ru) 2001-01-12 2002-08-27 Ростовский научно-исследовательский онкологический институт Способ лечения рака почки
DE10111049A1 (de) 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut
US20050070872A1 (en) 2001-12-28 2005-03-31 Kenichi Sato Blood bag system and method of inactivating pathogenic microorganisms
EP1336602A1 (en) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003282534A1 (en) 2002-10-07 2004-05-04 Radiorx, Inc. X-nitro compounds, pharmaceutical compositions thereof and uses therof
US6870061B2 (en) 2003-01-10 2005-03-22 Alliant Techsystems Inc. Continuous process and system for production of glycidyl nitrate from glycerin, nitric acid and caustic and conversion of glycidyl nitrate to poly(glycidyl nitrate)
AU2004237574A1 (en) 2003-03-13 2004-11-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
EP1646608B1 (en) 2003-06-25 2011-03-02 JE IL Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
US20040265238A1 (en) 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
WO2005004884A2 (en) 2003-07-09 2005-01-20 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
GB0326047D0 (en) 2003-11-07 2003-12-10 Univ Sheffield Substance
RU2265440C2 (ru) 2004-01-13 2005-12-10 Ростовский научно-исследовательский онкологический институт МЗ РФ Способ предоперационного лечения рака молочной железы
JP2008512490A (ja) 2004-09-08 2008-04-24 チェルシー・セラピューティクス,インコーポレイテッド 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤
US20060264415A1 (en) 2005-04-01 2006-11-23 Methylgene Inc. Inhibitors of histone deacetylase
US8367734B1 (en) 2005-08-11 2013-02-05 Amphastar Pharmaceuticals Inc. Stable epinephrine suspension formulation with high inhalation delivery efficiency
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
BRPI0616755A2 (pt) 2005-09-27 2011-06-28 Novartis Ag compostos de carboxiamina e métodos de uso dos mesmos
FR2891843A1 (fr) 2005-10-06 2007-04-13 Erytech Pharma Soc Par Actions Erythrocytes contenant du 5-fluorouracile
GB0611405D0 (en) 2006-06-09 2006-07-19 Univ Belfast FKBP-L: A novel inhibitor of angiogenesis
CN200946766Y (zh) 2006-06-09 2007-09-12 刘余厚 一种套管式紫外灯
US8122281B2 (en) 2007-04-13 2012-02-21 International Business Machines Corporation System and method for dependent failure-aware allocation of distributed data-processing systems
US9511016B2 (en) 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
CA2721153C (en) 2008-04-10 2018-10-02 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
EP2128133A1 (en) 2008-05-26 2009-12-02 Lek Pharmaceuticals D.D. Ezetimibe process and composition
EP2416790B1 (en) 2009-04-09 2018-05-23 Entegrion, Inc. Spray-dried blood products and methods of making same
EP2416650B1 (en) 2009-04-10 2020-02-26 Abraxis BioScience, LLC Nanoparticle formulations and uses therof
CN101708337B (zh) 2009-08-18 2011-08-10 上海交通大学医学院附属新华医院 一种包载奥沙利铂的人血白蛋白纳米粒的制备方法
RU2411953C1 (ru) 2009-09-02 2011-02-20 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт" Федерального агентства по высокотехнологичной мед. помощи Способ лечения рака молочной железы
US8471041B2 (en) 2010-02-09 2013-06-25 Alliant Techsystems Inc. Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
WO2012078992A1 (en) * 2010-12-09 2012-06-14 Radiorx, Inc. Organonitro compounds for use in treating non-hodgkin's lymphoma and leukemia, and methods relating thereto
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
ES2935573T3 (es) 2011-10-07 2023-03-08 Epicentrx Inc Compuestos de organonitro tioéter y usos médicos de estos
US8530461B2 (en) 2011-12-29 2013-09-10 Boehringer Ingelheim International Gmbh Azetidine derivatives
EP2687225A1 (en) 2012-07-19 2014-01-22 Alfact Innovation HIP/PAP protein and derivatives thereof for use in treating cancer
WO2014039960A1 (en) 2012-09-10 2014-03-13 Celgene Corporation Methods for the treatment of locally advanced breast cancer
CA2917403C (en) 2013-08-27 2018-05-29 Halliburton Energy Services, Inc. Energetic cocrystals for treatment of a subterranean formation
US20140220163A1 (en) 2014-02-04 2014-08-07 Hamzeh Soleimani Babadi Powder mixture composition of natural materials for controlling deficiencies in polypeptide alpha and beta hemoglobin chains
FR3017299B1 (fr) 2014-02-12 2018-05-18 Erytech Pharma Composition pharmaceutique comprenant des erythrocytes encapsulant une enzyme a plp et son cofacteur
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
KR20190040931A (ko) 2016-01-11 2019-04-19 에피센트알엑스, 인코포레이티드 2-브로모-1-(3,3-디니트로아제티딘-1-일)에타논의 정맥내 투여를 위한 조성물 및 방법
EP3526195A4 (en) 2016-10-14 2020-05-20 EpicentRx, Inc. SULFOXYALKYLE ORGANONITRO, RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN MEDICINE
IL271777B2 (en) 2017-07-07 2024-09-01 Epicentrx Inc Compositions for parenteral administration of therapeutic agents
US20200345689A1 (en) 2018-01-08 2020-11-05 Epicentrx, Inc. METHODS AND COMPOSITIONS UTILIZING RRx-001 FOR RADIOPROTECTION
US11510901B2 (en) 2018-01-08 2022-11-29 Epicentrx, Inc. Methods and compositions utilizing RRx-001 combination therapy for radioprotection
EP3801678A4 (en) 2018-06-11 2022-04-06 EpicentRx, Inc. MEDICATION INFUSION DEVICES, SYSTEMS AND METHODS
IL293672A (en) 2019-12-11 2022-08-01 Epicentrx Inc Drug infusion devices, systems and methods
TW202228708A (zh) 2020-09-29 2022-08-01 浩峰生物科技股份有限公司 樟芝酸h與其衍生物用於治療神經系統疾病的用途
CN114621125B (zh) 2020-12-14 2024-07-09 中国科学技术大学 Nlrp3炎症小体抑制剂及其应用
MX2023014676A (es) 2021-06-09 2024-02-06 Epicentrx Inc Composiciones de abdnaz cristalinas y metodos de elaboracion y uso de estas.

Similar Documents

Publication Publication Date Title
JP2019505585A5 (cg-RX-API-DMAC7.html)
Fitzharris et al. VP16-213 as a single agent in advanced testicular tumors
ES2880482T3 (es) Composiciones y métodos para la administración intravenosa de 2-bromo-1-(3,3-dinitroazetidin-1-il)etanona
MD20070267A (en) Gastroresistant pharmaceutical formulation containing rifaximin
UA123889C2 (uk) Кон'югати піролобензодіазепін-антитіло
JP2011529919A5 (cg-RX-API-DMAC7.html)
Peng et al. Development of in situ forming thermosensitive hydrogel for radiotherapy combined with chemotherapy in a mouse model of hepatocellular carcinoma
CN105452258B (zh) 使用双核金(i)化合物用于癌症治疗的方法
UA119537C2 (uk) ЗАСТОСУВАННЯ ЗАМІЩЕНИХ 2,3-ДИГІДРОІМІДАЗО[1,2-c]ХІНАЗОЛІНІВ ДЛЯ ЛІКУВАННЯ ЛІМФОМ
WO2006003488A3 (en) Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof
JP2015511609A5 (cg-RX-API-DMAC7.html)
JP6229865B2 (ja) エピルビシン複合化ブロック共重合体と、抗癌剤とを含むミセル、及び当該ミセルを含む癌又は耐性癌、転移癌の治療に適用可能な医薬組成物
JP2018035162A5 (cg-RX-API-DMAC7.html)
JP2020502131A5 (cg-RX-API-DMAC7.html)
US10881641B2 (en) Methods and use of compounds that bind to RelA of NF-kB
CN112334127A (zh) 生物响应水凝胶基质及使用方法
JP2018517759A5 (cg-RX-API-DMAC7.html)
JP2017534652A5 (cg-RX-API-DMAC7.html)
Carrasco et al. Meroxest improves the prognosis of immunocompetent C57BL/6 mice with allografts of E0771 mouse breast tumor cells
KR101544222B1 (ko) 유두상 신세포암에서의 템시로리무스의 항종양 활성
DK2874625T3 (en) USE OF VEGFR-3 INHIBITORS FOR TREATMENT OF HEPATOCELLULAR CARCINOM
JP2010526839A (ja) ポリメラーゼ阻害剤、及び腫瘍の治療のためのそれらの使用
Wang et al. Targeted nanotherapy platform mediated tumor-infiltrating CD8+ T cell immune function effects for collaborative anti-tumor photothermal immunotherapy for cervical cancer
US20200199681A1 (en) Mda-7 cancer therapies and methods of detecting biomolecules
US20230381349A1 (en) Methods and compositions for imaging and treating cancer