JP2019502691A5 - - Google Patents
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- Publication number
- JP2019502691A5 JP2019502691A5 JP2018531378A JP2018531378A JP2019502691A5 JP 2019502691 A5 JP2019502691 A5 JP 2019502691A5 JP 2018531378 A JP2018531378 A JP 2018531378A JP 2018531378 A JP2018531378 A JP 2018531378A JP 2019502691 A5 JP2019502691 A5 JP 2019502691A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- quinoline
- difluoromethoxy
- trans
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268630P | 2015-12-17 | 2015-12-17 | |
| US62/268,630 | 2015-12-17 | ||
| PCT/IB2016/057676 WO2017103851A1 (en) | 2015-12-17 | 2016-12-15 | Quinoline-3-carboxamides as h-pgds inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019502691A JP2019502691A (ja) | 2019-01-31 |
| JP2019502691A5 true JP2019502691A5 (https=) | 2020-02-06 |
Family
ID=57589094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531378A Pending JP2019502691A (ja) | 2015-12-17 | 2016-12-15 | Ｈ−ｐｇｄｓ阻害剤としてのキノリン−３−カルボキサミド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210238162A1 (https=) |
| EP (1) | EP3390384B1 (https=) |
| JP (1) | JP2019502691A (https=) |
| KR (1) | KR20180095580A (https=) |
| CN (1) | CN108430992A (https=) |
| AR (1) | AR107044A1 (https=) |
| AU (1) | AU2016370779B2 (https=) |
| BR (1) | BR112018012469B1 (https=) |
| CA (1) | CA3008358A1 (https=) |
| RU (1) | RU2018126105A (https=) |
| TW (1) | TW201733988A (https=) |
| UY (1) | UY37028A (https=) |
| WO (1) | WO2017103851A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3317269B1 (en) | 2015-07-02 | 2022-09-21 | F. Hoffmann-La Roche AG | Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| WO2018073193A1 (en) | 2016-10-17 | 2018-04-26 | F. Hoffmann-La Roche Ag | Bicyclic pyridone lactams and methods of use thereof |
| SI3538512T1 (sl) | 2016-11-11 | 2021-09-30 | Bayer Animal Health Gmbh | Novi antihelmintični kinolin-3-karboksamidni derivati |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| WO2018195123A1 (en) | 2017-04-18 | 2018-10-25 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| TW201908311A (zh) | 2017-06-13 | 2019-03-01 | 英商葛蘭素史克智慧財產發展有限公司 | 化合物 |
| KR20200036909A (ko) | 2017-08-04 | 2020-04-07 | 바이엘 애니멀 헬스 게엠베하 | 연충에 의한 감염을 치료하기 위한 퀴놀린 유도체 |
| DK3676297T3 (da) | 2017-09-01 | 2023-08-14 | Denali Therapeutics Inc | Forbindelser, sammensætninger og fremgangsmåder |
| JP2021506811A (ja) * | 2017-12-13 | 2021-02-22 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｈ−ｐｇｄｓの阻害剤として作用する縮合ピリジン |
| WO2019115768A1 (en) | 2017-12-15 | 2019-06-20 | Bayer Animal Health Gmbh | Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives |
| US10968201B2 (en) | 2018-04-17 | 2021-04-06 | Tempest Therapeutics, Inc. | Bicyclic carboxamides and methods of use thereof |
| WO2019204537A1 (en) * | 2018-04-20 | 2019-10-24 | Genentech, Inc. | N-[4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol e-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs) |
| US11572357B2 (en) | 2018-05-09 | 2023-02-07 | Bayer Animal Health Gmbh | Quinoline derivatives |
| US20220177456A1 (en) * | 2019-03-06 | 2022-06-09 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| AU2021253168A1 (en) | 2020-04-09 | 2022-11-03 | Elanco Animal Health Gmbh | Substituted condensed azines as anthelmintic compounds |
| CN111549000B (zh) * | 2020-06-18 | 2022-07-29 | 中国医学科学院整形外科医院 | 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用 |
| CN115667259B (zh) | 2020-06-19 | 2025-06-17 | 佐藤制药株式会社 | 抑制h-pgds的稠环化合物 |
| KR20230067637A (ko) * | 2020-09-11 | 2023-05-16 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 근이영양증을 치료하기 위한 조성물 및 방법 |
| US20240262834A1 (en) * | 2021-05-28 | 2024-08-08 | Merck Sharp & Dohme Llc | Synthesis of btk inhibitor and intermediates thereof |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| WO2023113023A1 (ja) | 2021-12-17 | 2023-06-22 | 佐藤製薬株式会社 | Ｈ－ｐｇｄｓを阻害するアザインドール誘導体 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2122261T3 (es) | 1993-03-17 | 1998-12-16 | Minnesota Mining & Mfg | Formulacion de aerosol que contiene un adyuvante de dispersion derivado de un ester, una amida o un mercaptoester. |
| US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| DK1196397T3 (da) * | 1999-06-02 | 2006-01-02 | Nps Pharma Inc | Metabotrope glutamatreceptorantagonister og anvendelse deraf til behandling af sygdomme i centralnervesystemet |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| WO2005094805A1 (ja) * | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
| TW200720255A (en) | 2005-07-13 | 2007-06-01 | Taiho Pharmaceutical Co Ltd | Benzoimidazole compound capable of inhibiting prostaglandin d synthetase |
| JP2007051121A (ja) | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンｄ合成酵素を阻害するピリミジン化合物 |
| DOP2006000210A (es) | 2005-10-04 | 2007-06-15 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| CA2672373C (en) | 2006-12-19 | 2011-08-30 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| NZ579892A (en) | 2007-03-30 | 2012-03-30 | Sanofi Aventis | Pyrimidine hydrazide compounds as prostaglandin D synthase inhibitors |
| GB0706793D0 (en) | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
| EP2231666B1 (en) * | 2007-12-12 | 2015-07-29 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| CA2725481A1 (en) * | 2008-06-18 | 2009-12-23 | Pfizer Limited | Nicotinamide derivatives |
| TW201010997A (en) * | 2008-06-18 | 2010-03-16 | Pfizer Ltd | Nicotinamide derivatives |
| US8536185B2 (en) | 2008-09-22 | 2013-09-17 | Cayman Chemical Company, Incorporated | Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases |
| ES2564454T3 (es) | 2009-03-09 | 2016-03-22 | Taiho Pharmaceutical Co., Ltd. | Compuesto de piperazina que puede inhibir la prostaglandina D sintasa |
| JPWO2011043359A1 (ja) | 2009-10-06 | 2013-03-04 | 協和発酵キリン株式会社 | 芳香族複素環化合物を含有する医薬 |
| NZ599099A (en) | 2009-10-08 | 2013-05-31 | Sanofi Sa | Phenyloxadiazole derivatives as pgds inhibitors |
| WO2011090062A1 (ja) | 2010-01-22 | 2011-07-28 | 大鵬薬品工業株式会社 | Pgds阻害作用を有するピペラジン化合物 |
| US9212209B2 (en) * | 2012-07-13 | 2015-12-15 | Indiana University Research And Technology Corporation | Screening methods for spinal muscular atrophy |
-
2016
- 2016-12-15 CN CN201680074158.0A patent/CN108430992A/zh active Pending
- 2016-12-15 AU AU2016370779A patent/AU2016370779B2/en not_active Expired - Fee Related
- 2016-12-15 AR ARP160103847A patent/AR107044A1/es unknown
- 2016-12-15 CA CA3008358A patent/CA3008358A1/en not_active Abandoned
- 2016-12-15 BR BR112018012469-9A patent/BR112018012469B1/pt not_active IP Right Cessation
- 2016-12-15 WO PCT/IB2016/057676 patent/WO2017103851A1/en not_active Ceased
- 2016-12-15 US US16/062,223 patent/US20210238162A1/en not_active Abandoned
- 2016-12-15 EP EP16815960.6A patent/EP3390384B1/en active Active
- 2016-12-15 JP JP2018531378A patent/JP2019502691A/ja active Pending
- 2016-12-15 UY UY0001037028A patent/UY37028A/es unknown
- 2016-12-15 RU RU2018126105A patent/RU2018126105A/ru not_active Application Discontinuation
- 2016-12-15 TW TW105141512A patent/TW201733988A/zh unknown
- 2016-12-15 KR KR1020187019904A patent/KR20180095580A/ko not_active Withdrawn
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