JP2019502684A5 - - Google Patents
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- JP2019502684A5 JP2019502684A5 JP2018531122A JP2018531122A JP2019502684A5 JP 2019502684 A5 JP2019502684 A5 JP 2019502684A5 JP 2018531122 A JP2018531122 A JP 2018531122A JP 2018531122 A JP2018531122 A JP 2018531122A JP 2019502684 A5 JP2019502684 A5 JP 2019502684A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- amino acid
- terminal lysine
- acid residue
- conjugated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108060003951 Immunoglobulin Proteins 0.000 claims description 165
- 102000018358 immunoglobulin Human genes 0.000 claims description 165
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- 239000004472 Lysine Substances 0.000 claims description 118
- 235000018977 lysine Nutrition 0.000 claims description 118
- 125000000539 amino acid group Chemical group 0.000 claims description 114
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 110
- 210000004899 c-terminal region Anatomy 0.000 claims description 109
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- 239000000126 substance Substances 0.000 claims description 43
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 26
- 235000004554 glutamine Nutrition 0.000 claims description 26
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- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 20
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 20
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 20
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 20
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 20
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 20
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 20
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 20
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 20
- 239000004473 Threonine Substances 0.000 claims description 20
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 20
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 20
- 229960003767 alanine Drugs 0.000 claims description 20
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- 235000018417 cysteine Nutrition 0.000 claims description 20
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 20
- 229960002885 histidine Drugs 0.000 claims description 20
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- 229960001153 serine Drugs 0.000 claims description 20
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
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- 239000003814 drug Substances 0.000 claims description 14
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims description 14
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021176196A JP2022023181A (ja) | 2015-12-18 | 2021-10-28 | Ｃ末端リジンで結合体化された免疫グロブリン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562269138P | 2015-12-18 | 2015-12-18 | |
| US62/269,138 | 2015-12-18 | ||
| PCT/US2016/067165 WO2017106643A1 (en) | 2015-12-18 | 2016-12-16 | C-terminal lysine conjugated immunoglobulins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021176196A Division JP2022023181A (ja) | 2015-12-18 | 2021-10-28 | Ｃ末端リジンで結合体化された免疫グロブリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502684A JP2019502684A (ja) | 2019-01-31 |
| JP2019502684A5 true JP2019502684A5 (enExample) | 2020-01-30 |
| JP6970090B2 JP6970090B2 (ja) | 2021-11-24 |
Family
ID=57960810
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531122A Active JP6970090B2 (ja) | 2015-12-18 | 2016-12-16 | Ｃ末端リジンで結合体化された免疫グロブリン |
| JP2021176196A Pending JP2022023181A (ja) | 2015-12-18 | 2021-10-28 | Ｃ末端リジンで結合体化された免疫グロブリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021176196A Pending JP2022023181A (ja) | 2015-12-18 | 2021-10-28 | Ｃ末端リジンで結合体化された免疫グロブリン |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11135304B2 (enExample) |
| EP (2) | EP4032902A1 (enExample) |
| JP (2) | JP6970090B2 (enExample) |
| KR (1) | KR102728631B1 (enExample) |
| CN (1) | CN108602878B (enExample) |
| AU (1) | AU2016369524B2 (enExample) |
| BR (1) | BR112018012388A2 (enExample) |
| CL (1) | CL2018001565A1 (enExample) |
| CO (1) | CO2018005876A2 (enExample) |
| ES (1) | ES2910699T3 (enExample) |
| IL (1) | IL259754B (enExample) |
| MA (1) | MA44074A (enExample) |
| MX (1) | MX2018007451A (enExample) |
| MY (1) | MY192987A (enExample) |
| NZ (1) | NZ742916A (enExample) |
| PE (1) | PE20181624A1 (enExample) |
| PH (1) | PH12018501272A1 (enExample) |
| RU (1) | RU2747581C2 (enExample) |
| SG (1) | SG11201804856VA (enExample) |
| UA (1) | UA124622C2 (enExample) |
| WO (1) | WO2017106643A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017025179A1 (en) * | 2015-08-07 | 2017-02-16 | Merck Patent Gmbh | A transglutamine tag for efficient site-specific bioconjugation |
| EP4032902A1 (en) * | 2015-12-18 | 2022-07-27 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
| SI3464336T1 (sl) | 2016-06-01 | 2022-06-30 | Athira Pharma, Inc. | Spojine |
| SG11201810470XA (en) * | 2016-06-10 | 2018-12-28 | Eisai R&D Man Co Ltd | Lysine conjugated immunoglobulins |
| EP3272864A1 (en) * | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| CA3061467A1 (en) | 2017-04-28 | 2019-10-24 | Ajinomoto Co., Inc. | Compound having affinity substance to soluble protein, cleavable portionand reactive group, or salt thereof |
| WO2019035681A2 (ko) | 2017-08-17 | 2019-02-21 | 주식회사 엘지화학 | 전고체 전지용 전극 및 그 제조방법 |
| AU2018337671B2 (en) | 2017-09-19 | 2021-03-04 | Paul Scherrer Institut | Transglutaminase conjugation method and linker |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| WO2020028832A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| EP3829594A4 (en) * | 2018-08-02 | 2022-05-11 | Dyne Therapeutics, Inc. | MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| EP3830259A4 (en) | 2018-08-02 | 2022-05-04 | Dyne Therapeutics, Inc. | MUSCLE TARGETED COMPLEXES AND THEIR USES IN THE TREATMENT OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY |
| US11487713B1 (en) * | 2018-12-11 | 2022-11-01 | United Services Automobile Association (Usaa) | Distributed ledger regulatory auditing system and method |
| WO2021090062A1 (en) | 2019-11-07 | 2021-05-14 | Eisai R&D Management Co., Ltd. | Anti-mesothelin eribulin antibody-drug conjugates and methods of use |
| WO2021154477A1 (en) | 2020-01-31 | 2021-08-05 | Dyne Therapeutics, Inc. | Anti-transferrin receptor (tfr) antibody and uses thereof |
| EP4161966A1 (en) | 2020-06-05 | 2023-04-12 | Eisai R&D Management Co., Ltd. | Anti-bcma antibody-drug conjugates and methods of use |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| JP7789396B2 (ja) | 2020-10-25 | 2025-12-22 | アラリス バイオテック アーゲー | 抗体－リンカーコンジュゲートを生成するための手段および方法 |
| WO2022176134A1 (ja) * | 2021-02-18 | 2022-08-25 | 日本電信電話株式会社 | 分類装置、分類方法、および、分類プログラム |
| WO2023283623A1 (en) | 2021-07-09 | 2023-01-12 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating dystrophinopathies |
| IL316143A (en) | 2022-04-15 | 2024-12-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of myotonic dystrophy |
| US20240056486A1 (en) * | 2022-08-10 | 2024-02-15 | Microsoft Technology Licensing, Llc | Resource policy adjustment based on data characterization |
| IL322523A (en) | 2023-02-28 | 2025-10-01 | Eisai R&D Man Co Ltd | Anti-PSMA antibodies, conjugates and methods of use |
| WO2024185164A1 (ja) * | 2023-03-03 | 2024-09-12 | エヌ・ティ・ティ・コミュニケーションズ株式会社 | 情報処理装置、情報処理方法および情報処理プログラム |
| US12430657B2 (en) * | 2024-01-24 | 2025-09-30 | ComplyAuto IP LLC | Dynamic automated content compliance verification |
| WO2025198987A1 (en) * | 2024-03-21 | 2025-09-25 | Merck Sharp & Dohme Llc | Polypeptides for bioconjugation |
| WO2025199464A1 (en) | 2024-03-22 | 2025-09-25 | Eisai R&D Management Co., Ltd. | Anti-trop2 antibody-drug conjugates and methods of use |
| CN120779021A (zh) * | 2024-04-08 | 2025-10-14 | 菲鹏生物股份有限公司 | 抗体缀合物及其用途 |
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| WO2026044149A2 (en) | 2024-08-21 | 2026-02-26 | Eisai R&D Management Co., Ltd. | Synthesis of drug-linker combinations for antibody-drug conjugates |
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| EP2033662B1 (en) | 2004-01-21 | 2012-10-17 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| AT503902B1 (de) * | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
| US8426179B2 (en) * | 2007-08-30 | 2013-04-23 | Northwestern University | Synthetic peptide and peptide conjugates and related tissue coupling methods via transglutaminase enzyme |
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