PH12018501272A1 - C-terminal lysine conjugated immunoglobulins - Google Patents

C-terminal lysine conjugated immunoglobulins

Info

Publication number
PH12018501272A1
PH12018501272A1 PH12018501272A PH12018501272A PH12018501272A1 PH 12018501272 A1 PH12018501272 A1 PH 12018501272A1 PH 12018501272 A PH12018501272 A PH 12018501272A PH 12018501272 A PH12018501272 A PH 12018501272A PH 12018501272 A1 PH12018501272 A1 PH 12018501272A1
Authority
PH
Philippines
Prior art keywords
terminal lysine
conjugated immunoglobulins
lysine conjugated
immunoglobulins
terminal
Prior art date
Application number
PH12018501272A
Other languages
English (en)
Inventor
Jared Spidel
Earl Albone
Original Assignee
Eisai R And D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R And D Man Co Ltd filed Critical Eisai R And D Man Co Ltd
Publication of PH12018501272A1 publication Critical patent/PH12018501272A1/en

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    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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