JP2019502659A5 - - Google Patents
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- Publication number
- JP2019502659A5 JP2019502659A5 JP2018525567A JP2018525567A JP2019502659A5 JP 2019502659 A5 JP2019502659 A5 JP 2019502659A5 JP 2018525567 A JP2018525567 A JP 2018525567A JP 2018525567 A JP2018525567 A JP 2018525567A JP 2019502659 A5 JP2019502659 A5 JP 2019502659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- independently
- heterocycloalkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 241000606125 Bacteroides Species 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- -1 substituted Chemical class 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 241000606790 Haemophilus Species 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000588807 Bordetella Species 0.000 claims 2
- 241000186216 Corynebacterium Species 0.000 claims 2
- 241000588914 Enterobacter Species 0.000 claims 2
- 241000186359 Mycobacterium Species 0.000 claims 2
- 241000606860 Pasteurella Species 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 1
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 241000588624 Acinetobacter calcoaceticus Species 0.000 claims 1
- 241001148231 Acinetobacter haemolyticus Species 0.000 claims 1
- 241000606124 Bacteroides fragilis Species 0.000 claims 1
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 1
- 241000589969 Borreliella burgdorferi Species 0.000 claims 1
- 241000589513 Burkholderia cepacia Species 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241000589877 Campylobacter coli Species 0.000 claims 1
- 241000589875 Campylobacter jejuni Species 0.000 claims 1
- 241000588919 Citrobacter freundii Species 0.000 claims 1
- 241001478240 Coccus Species 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000589602 Francisella tularensis Species 0.000 claims 1
- 241000207201 Gardnerella vaginalis Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 241001454354 Kingella Species 0.000 claims 1
- 241000588749 Klebsiella oxytoca Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589242 Legionella pneumophila Species 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- 241000588771 Morganella <proteobacterium> Species 0.000 claims 1
- 241000186367 Mycobacterium avium Species 0.000 claims 1
- 241000186364 Mycobacterium intracellulare Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000606210 Parabacteroides distasonis Species 0.000 claims 1
- 241000588770 Proteus mirabilis Species 0.000 claims 1
- 241000588778 Providencia stuartii Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 241000589540 Pseudomonas fluorescens Species 0.000 claims 1
- 241000589776 Pseudomonas putida Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 claims 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 241000607762 Shigella flexneri Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000191984 Staphylococcus haemolyticus Species 0.000 claims 1
- 241000192087 Staphylococcus hominis Species 0.000 claims 1
- 241000191980 Staphylococcus intermedius Species 0.000 claims 1
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims 1
- 241000122973 Stenotrophomonas maltophilia Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims 1
- 241000607481 Yersinia intermedia Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 230000037006 agalactosis Effects 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 210000003555 cloaca Anatomy 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000001848 dysentery Diseases 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229940118764 francisella tularensis Drugs 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2015095166 | 2015-11-20 | ||
| CNPCT/CN2015/095166 | 2015-11-20 | ||
| CN2016105042 | 2016-11-08 | ||
| CNPCT/CN2016/105042 | 2016-11-08 | ||
| PCT/CN2016/106598 WO2017084630A1 (en) | 2015-11-20 | 2016-11-21 | Macrocyclic broad spectrum antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502659A JP2019502659A (ja) | 2019-01-31 |
| JP2019502659A5 true JP2019502659A5 (cg-RX-API-DMAC7.html) | 2019-12-26 |
| JP6868323B2 JP6868323B2 (ja) | 2021-05-12 |
Family
ID=58717386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525567A Active JP6868323B2 (ja) | 2015-11-20 | 2016-11-21 | 大環状広域抗生物質 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20180327367A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3377473B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6868323B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180111776A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108884058B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016357927B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018010255A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3005674A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL259426B (cg-RX-API-DMAC7.html) |
| MX (1) | MX386742B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2766543C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI725075B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017084630A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| EP3145944B1 (en) | 2014-05-20 | 2021-05-05 | RQX Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| RU2761476C2 (ru) * | 2015-11-20 | 2021-12-08 | АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. | Макроциклические антибиотики широкого спектра действия |
| ES2946600T3 (es) * | 2016-10-21 | 2023-07-21 | Xellia Pharmaceuticals Aps | Formulaciones líquidas de daptomicina |
| KR102671585B1 (ko) * | 2017-02-15 | 2024-06-04 | 알큐엑스 파마슈티컬스, 인크. | 거대환형 광범위 항생제 |
| HRP20231497T8 (hr) * | 2019-05-28 | 2024-08-02 | F. Hoffmann-La Roche Ag | Makrociklični antibiotici širokog spektra |
| CN112707809B (zh) * | 2020-12-30 | 2023-08-29 | 丽珠集团新北江制药股份有限公司 | 一种制备噁唑啉杀虫剂氟雷拉纳中间体的方法 |
| CN115819247A (zh) * | 2022-12-22 | 2023-03-21 | 浙江卓浩生物科技有限公司 | 一种乙二胺及其连续制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011112441A1 (en) * | 2010-03-09 | 2011-09-15 | Merck Sharp & Dohme Corp. | Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials |
| TWI642684B (zh) * | 2011-05-27 | 2018-12-01 | Ｒｑｘ製藥股份有限公司 | 廣效性抗生素 |
| CN104284664A (zh) * | 2012-03-14 | 2015-01-14 | 斯克里普斯研究所 | 广谱抗生素Arylomycin类似物 |
| CN103788176A (zh) * | 2012-10-31 | 2014-05-14 | 上海来益生物药物研究开发中心有限责任公司 | 一种arylomycin类化合物及其制备方法和应用 |
| BR112015011697A2 (pt) * | 2012-11-21 | 2017-07-11 | Rqx Pharmaceuticals Inc | antibióticos macrocíclicos de amplo espectro |
| EP3145944B1 (en) * | 2014-05-20 | 2021-05-05 | RQX Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
-
2016
- 2016-11-18 TW TW105137804A patent/TWI725075B/zh not_active IP Right Cessation
- 2016-11-21 BR BR112018010255A patent/BR112018010255A2/pt not_active Application Discontinuation
- 2016-11-21 WO PCT/CN2016/106598 patent/WO2017084630A1/en not_active Ceased
- 2016-11-21 JP JP2018525567A patent/JP6868323B2/ja active Active
- 2016-11-21 KR KR1020187017083A patent/KR20180111776A/ko not_active Ceased
- 2016-11-21 CA CA3005674A patent/CA3005674A1/en not_active Abandoned
- 2016-11-21 CN CN201680079604.7A patent/CN108884058B/zh active Active
- 2016-11-21 US US15/777,499 patent/US20180327367A1/en not_active Abandoned
- 2016-11-21 EP EP16840309.5A patent/EP3377473B1/en active Active
- 2016-11-21 MX MX2018006190A patent/MX386742B/es unknown
- 2016-11-21 AU AU2016357927A patent/AU2016357927B2/en not_active Ceased
- 2016-11-21 RU RU2018122505A patent/RU2766543C2/ru active
-
2018
- 2018-05-16 IL IL259426A patent/IL259426B/en unknown
-
2022
- 2022-12-08 US US18/063,173 patent/US20230133817A1/en not_active Abandoned