CN108884058B - 大环广谱抗生素 - Google Patents

大环广谱抗生素 Download PDF

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CN108884058B
CN108884058B CN201680079604.7A CN201680079604A CN108884058B CN 108884058 B CN108884058 B CN 108884058B CN 201680079604 A CN201680079604 A CN 201680079604A CN 108884058 B CN108884058 B CN 108884058B
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CN108884058A (zh
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陈永胜
彼得·安德鲁·史密斯
塔克·柯伦·罗伯茨
罗伯特·I·希古奇
普拉苏纳·帕拉塞利
迈克尔·F·T·凯勒
雅各布·布拉德利·施瓦兹
詹姆斯·约翰·克劳福德
强·Q·李
艾米丽·J·哈南
胡慧勇
郁志勇
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Genentech Inc
RQx Pharmaceuticals Inc
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Genentech Inc
RQx Pharmaceuticals Inc
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/425—Thiazoles
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    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
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  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201680079604.7A 2015-11-20 2016-11-21 大环广谱抗生素 Active CN108884058B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2015095166 2015-11-20
CNPCT/CN2015/095166 2015-11-20
CN2016105042 2016-11-08
CNPCT/CN2016/105042 2016-11-08
PCT/CN2016/106598 WO2017084630A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP3145944B1 (en) 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
RU2761476C2 (ru) * 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
ES2946600T3 (es) * 2016-10-21 2023-07-21 Xellia Pharmaceuticals Aps Formulaciones líquidas de daptomicina
KR102671585B1 (ko) * 2017-02-15 2024-06-04 알큐엑스 파마슈티컬스, 인크. 거대환형 광범위 항생제
HRP20231497T8 (hr) * 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra
CN112707809B (zh) * 2020-12-30 2023-08-29 丽珠集团新北江制药股份有限公司 一种制备噁唑啉杀虫剂氟雷拉纳中间体的方法
CN115819247A (zh) * 2022-12-22 2023-03-21 浙江卓浩生物科技有限公司 一种乙二胺及其连续制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104284664A (zh) * 2012-03-14 2015-01-14 斯克里普斯研究所 广谱抗生素Arylomycin类似物
CN104903302A (zh) * 2012-11-21 2015-09-09 阿奇克斯制药公司 大环广谱抗生素

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011112441A1 (en) * 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
CN103788176A (zh) * 2012-10-31 2014-05-14 上海来益生物药物研究开发中心有限责任公司 一种arylomycin类化合物及其制备方法和应用
EP3145944B1 (en) * 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104284664A (zh) * 2012-03-14 2015-01-14 斯克里普斯研究所 广谱抗生素Arylomycin类似物
CN104903302A (zh) * 2012-11-21 2015-09-09 阿奇克斯制药公司 大环广谱抗生素

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Efforts toward broadening the spectrum of arylomycin antibiotic activity;Jian Liu et al.;《Bioorganic & Medicinal Chemistry Letters》;20130814;第23卷;5654-5659 *
氰基在药物分子设计中的应用;王江等;《有机化学》;20121231;第32卷;1643-1652 *

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