JP2019502658A - ビタミン製剤 - Google Patents
ビタミン製剤 Download PDFInfo
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- JP2019502658A JP2019502658A JP2018525440A JP2018525440A JP2019502658A JP 2019502658 A JP2019502658 A JP 2019502658A JP 2018525440 A JP2018525440 A JP 2018525440A JP 2018525440 A JP2018525440 A JP 2018525440A JP 2019502658 A JP2019502658 A JP 2019502658A
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Images
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Abstract
Description
(i)固体粒子の総重量を基準にして少なくとも20重量%(wt%)の、少なくとも1種の脂溶性ビタミン、
(ii)少なくとも1種の乳化剤、および
(iii)少なくとも1種の非還元糖
を含む固体粒子(SP)に関する。
(i)固体粒子の総重量を基準にして少なくとも20重量%(wt%)の、少なくとも1種の脂溶性ビタミンと、
(ii)少なくとも1種の乳化剤、および
(iii)少なくとも1種の非還元糖
からなる固体粒子(SP’)に関する。
[実施例1:食用加工デンプンおよびトレハロース]
370.6gの脱イオン水を、容器内で最高60℃〜65℃に加熱した。316.75gの食用加工デンプンと121.2gのトレハロースを添加し、混合物を、60〜65℃で撹拌しながら、溶液とした。得られた溶液を、50〜55℃に冷却し、1時間脱気した。その後すぐ、この基質系に、190.82gの油混合物(180.78gビタミンA酢酸エステル、5.02g BHT、および5.02g dl−α−トコフェロール)を添加し、乳化させた。このプロセスの温度は、常に65℃未満に維持した。乳化後、エマルジョンの内相は、約272nm(Dv(0.1)=100nm、Dv(0.5)=272nm、Dv(0.9)=559nm)の平均粒径(レーザー回折(Malvern 3000)によって実現される測定値)を有していた。乳化後、ハロゲン水分計(Mettler Toledo社、HR73−P型)によって決定されるエマルジョンの水分を確認し、必要であれば適合させた。その後、150gのエマルジョンを、回転式スプレーノズルを使用して、1500gのコーンスターチを含有するスプレー皿に噴射した。得られた粒子を、過剰のコーンスターチからふるい分けし(150から600μm)、空気流を使用して、室温で乾燥させた。乾燥後の最終産物の粒径は、平均で246μm(Dv(0.1)=198μm、Dv(0.5)=246μm、Dv(0.9)=303μm)(レーザー回折(Malvern 3000)によって測定)であった。
381gの脱イオン水を、容器内で最高60℃〜65℃に加熱した。316.75gの食用加工デンプンと122.2gのトレハロースを添加し、混合物を、60〜65℃で撹拌しながら、溶液とした。得られた溶液を、50〜55℃に冷却し、1時間脱気した。その後すぐ、この基質系に、190.78gのビタミンA酢酸エステルを添加し、乳化させた。このプロセスの温度は、常に65℃未満に維持した。乳化後、エマルジョンの内相は、約333nm(Dv(0.1)=175nm、Dv(0.5)=333nm、Dv(0.9)=558nm)の平均粒径(レーザー回折(Malvern 3000)によって実現される測定値)を有していた。乳化後、ハロゲン水分計(Mettler Toledo社、HR73−P型)によって決定されるエマルジョンの水分を確認し、必要であれば適合させた。その後、150gのエマルジョンを、回転式スプレーノズルを使用して、1500gのコーンスターチを含有するスプレー皿に噴射した。得られた粒子を、過剰のコーンスターチからふるい分けし(150から600μm)、空気流を使用して、室温で乾燥させた。乾燥後の最終産物の粒径は、平均で180μm(Dv(0.1)=180μm、Dv(0.5)=240μm、Dv(0.9)=321μm)(レーザー回折(Malvern 3000)によって測定)であった。
370.6gの脱イオン水を、容器内で最高60℃〜65℃に加熱した。317.4gの食用加工デンプンと122.1gのスクロースを添加し、混合物を、60〜65℃で撹拌しながら、溶液とした。得られた溶液を、50〜55℃に冷却し、1時間脱気した。その後すぐ、この基質系に、197.3gの油混合物(186.9gビタミンA酢酸エステル、10.4g BHT)を添加し、乳化させた。このプロセスの温度は、常に65℃未満に維持した。乳化後、エマルジョンの内相は、約276nm(Dv(0.1)=112nm、Dv(0.5)=276nm、Dv(0.9)=516nm)の平均粒径(レーザー回折(Malvern 3000)によって実現される測定値)を有していた。乳化後、ハロゲン水分計(Mettler Toledo社、HR73−P型)によって決定されるエマルジョンの水分を確認し、必要であれば適合させた。その後、150gのエマルジョンを、回転式スプレーノズルを使用して、1500gのコーンスターチを含有するスプレー皿に噴射した。得られた粒子を、過剰のコーンスターチからふるい分けし(150から600μm)、空気流を使用して、室温で乾燥させた。乾燥後の最終産物の粒径は、平均で272μm(Dv(0.1)=197μm、Dv(0.5)=272μm、Dv(0.9)=377μm)(レーザー回折(Malvern 3000)によって測定)であった。
381gの脱イオン水を、容器内で最高60℃〜65℃に加熱した。143.78gの食用加工デンプンと287.56gのトレハロースを添加し、混合物を、60〜65℃で撹拌しながら、溶液とした。得られた溶液を、50〜55℃に冷却し、1時間脱気した。その後すぐ、この基質系に、187.68gの油混合物(177.80gビタミンA酢酸エステル、4.94g BHT、および4.94g dl−α−トコフェロール)を添加し、乳化させた。このプロセスの温度は、常に65℃未満に維持した。乳化後、エマルジョンの内相は、約493nm(Dv(0.1)=215nm、Dv(0.5)=493nm、Dv(0.9)=987nm)の平均粒径(レーザー回折(Malvern 3000)によって実現される測定値)を有していた。乳化後、ハロゲン水分計(Mettler Toledo社、HR73−P型)によって決定されるエマルジョンの水分を確認し、必要であれば適合させた。その後、150gのエマルジョンを、回転式スプレーノズルを使用して、1500gのコーンスターチを含有するスプレー皿に噴射した。得られた粒子を、過剰のコーンスターチからふるい分けし(150から600μm)、空気流を使用して、室温で乾燥させた。乾燥後の最終産物の粒径は、平均で234μm(Dv(0.1)=189μm、Dv(0.5)=234μm、Dv(0.9)=293μm)(レーザー回折(Malvern 3000)によって測定)であった。
27gのビタミンA酢酸エステル粒子(実施例1で得られたもの)、33.24g微結晶セルロース、49.86gリン酸カルシウム、および0.2gのステアリン酸マグネシウムからなる100gの粉末を、10分間混合した。次いで、この最終調製物を、35KNの圧力で圧縮した。この錠剤(一般的な円盤型;0.2g)を、閉じた褐色ガラス瓶に入れて室温で保管し、保管の1、7、および35日後に、ビタミンA酢酸エステル含有量を決定した。
Claims (10)
- 固体粒子であって、
(i)前記固体粒子の総重量を基準にして少なくとも20wt%の、少なくとも1種の脂溶性ビタミン、
(ii)少なくとも1種の乳化剤、および
(iii)少なくとも1種の非還元糖
を含む固体粒子。 - 前記固体粒子の総重量を基準にして5〜55重量%(wt%)の少なくとも1種の非還元糖(好ましくはトレハロース)を含む、請求項1に記載の固体粒子。
- 前記固体粒子の総重量を基準にして10〜50重量%(wt%)の少なくとも1種の非還元糖を含む、請求項1に記載の固体粒子。
- 前記脂溶性ビタミンが、ビタミンAおよびその誘導体(ビタミンA酢酸エステルまたはビタミンAパルミチン酸エステルなど)の群から選択される、請求項1〜3のいずれか一項に記載の固体粒子。
- 前記固体粒子の総重量を基準にして20〜75wt%の少なくとも1種の脂溶性ビタミンを含む、請求項1〜4のいずれか一項に記載の固体粒子。
- 前記固体粒子の総重量を基準にして25〜70wt%の少なくとも1種の脂溶性ビタミンを含む、請求項1〜5のいずれか一項に記載の固体粒子。
- 前記固体粒子の総重量を基準にして20〜70wt%の少なくとも1種の乳化剤を含む、請求項1〜6のいずれか一項に記載の固体粒子。
- 前記少なくとも1種の乳化剤が、加工された(食品用)デンプン、パルミチン酸アスコルビル、ペクチン、アルギン酸塩、カラギーナン、ファーセレラン、デキストリン誘導体、セルロースおよびセルロース誘導体(例えば、酢酸セルロース、メチルセルロース、ヒドロキシプロピルメチルセルロース)、リグニンスルホン酸塩、多糖ガム(アカシアガム(=アラビアゴム)、修飾されたアカシアガム、TICガム、アマニガム、ガティガム、タマリンドガム、およびアラビノガラクタンなど)、ゼラチン(ウシ、魚、豚肉、家禽)、植物タンパク質(例えば、エンドウマメ、ダイズ、トウゴマ、綿、ジャガイモ、サツマイモ、マニオク、ナタネ、ヒマワリ、ゴマ、アマニ、ベニバナ、レンズマメ、堅果、コムギ、米、トウモロコシ、オオムギ、ライムギ、オートムギ、ルピナス、およびモロコシなど)、乳または乳清タンパク質を含めた動物タンパク質、レシチン、脂肪酸のポリグリセロールエステル、脂肪酸のモノグリセリド、脂肪酸のジグリセリド、ソルビタンエステル、および糖エステル(ならびにこれらの誘導体)からなる群から選択される、請求項1〜7のいずれか一項に記載の固体粒子。
- 圧縮錠剤の製造における、請求項1〜8のいずれか一項に記載の固体粒子の使用。
- 請求項1〜8のいずれか一項に記載の少なくとも1種の固体粒子を含む圧縮錠剤。
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JP7315287B2 (ja) * | 2018-04-27 | 2023-07-26 | ディーエスエム アイピー アセッツ ビー.ブイ. | 粉末状製剤 |
CN112105268A (zh) * | 2018-04-27 | 2020-12-18 | 帝斯曼知识产权资产管理有限公司 | 包含类胡萝卜素和/或其衍生物、d-葡萄糖低聚物和改性多糖的粉末组合物以及包含该组合物的食物、饲料或个人护理制剂 |
US20240108032A1 (en) * | 2019-10-11 | 2024-04-04 | Dsm Ip Assets B.V. | New feed additives of fat-soluble vitamins |
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JP6930537B2 (ja) | 2021-09-01 |
EP3386320A1 (en) | 2018-10-17 |
KR20180091007A (ko) | 2018-08-14 |
US11696594B2 (en) | 2023-07-11 |
CN108366605A (zh) | 2018-08-03 |
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