US20230284667A1 - Vitamin formulation - Google Patents
Vitamin formulation Download PDFInfo
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- US20230284667A1 US20230284667A1 US18/199,700 US202318199700A US2023284667A1 US 20230284667 A1 US20230284667 A1 US 20230284667A1 US 202318199700 A US202318199700 A US 202318199700A US 2023284667 A1 US2023284667 A1 US 2023284667A1
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- vitamin
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- 235000019634 flavors Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 150000002840 non-reducing disaccharides Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Images
Classifications
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/155—Vitamins A or D
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/26—Food, ingredients or supplements targeted to meet non-medical requirements, e.g. environmental, religious
- A23V2200/264—All vegan ingredients, i.e. all animal product free
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/60—Sugars, e.g. mono-, di-, tri-, tetra-saccharides
- A23V2250/636—Trehalose
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/70—Vitamins
- A23V2250/702—Vitamin A
Definitions
- the present patent application relates to solid particles comprising a high amount of at least one fat-soluble vitamin, which are more stable when compressed into tablets. Furthermore, the particles can be free of any animal derived ingredient and therefore suitable for vegetarians.
- Compressed tablets are a very useful way for administering fat-soluble vitamins. They are easy to be consumed, easy to store and good to handle.
- the tablet contains usually less of the fat-soluble vitamin in the compressed tablet than in the formulation, which was compressed. Usually the content of the fat-soluble vitamins is getting less during the storage of the compressed tablets.
- Gelatine which is often used to formulate fat-soluble vitamins, is usually sourced from an animal source and therefore not suitable for vegetarians.
- FIGS. 1 - 3 are each graphs of the data in Tables 5-7, respectively, below showing vitamin A rentention (IU/g) versus days of storage.
- SP solid particles
- the present invention relates to solid particles (SP’) consisting of
- non-reducing sugars are non-reducing disaccharides; more preferably sucrose and/or trehalose, most preferred is trehalose.
- Sucrose is a disaccharide combination of the monosaccharides glucose and fructose with the formula C 12 H 22 O 11 . It is commercially available from many suppliers.
- Sucrose is often extracted and refined from either cane or beet sugar for human
- Trehalose also known as mycose or tremalose
- mycose or tremalose is a natural alpha-linked disaccharide formed by an ⁇ , ⁇ -1,1-glucoside bond between two ⁇ -glucose units.
- trehalose is derived from corn starch.
- biological pathways for trehalose biosynthesis There are known biological pathways for trehalose biosynthesis.
- Trehalose is available commercially from various suppliers.
- the amount of non-reducing sugar in the solid particles is from 5 - 55 weight-% (wt- %), based on the total weight of the solid particles.
- wt- % weight-%
- solid particles which are solid particles (SP) or (SP′) comprising 5 - 55 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
- the present invention relates to solid particles (SP2), which are solid particles (SP) or (SP’) comprising 10 - 50 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
- solid particles which are solid particles (SP) or (SP’) comprising 15 - 45 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
- the solid particles according to the present invention comprise at least one fat-soluble vitamin.
- Fat-soluble vitamins are vitamin A, D, E, and K (as well as derivatives thereof).
- vitamin A and/or its derivatives are used.
- the present invention relates to solid particles (SP4), which are solid particles (SP), (SP’), (SP1) or (SP2), wherein the fat-soluble vitamin is vitamin A and/or a derivative of vitamin A (especially vitamin A acetate or vitamin A palmitate).
- the solid particles according to the present invention comprise usually comprise 20 - 75 wt-%, based on the total weight of the solid particles, of at least one fat soluble vitamin, preferably, 25 - 70 wt-%, based on the total weight of the solid particles.
- the present invention relates to solid particles (SP5), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3) or (SP4), wherein the solid particles comprise 20 - 75 wt-%, based on the total weight of the solid particles, of the fat-soluble vitamin(s).
- the present invention relates to solid particles (SP6), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4) or (SP5), wherein the solid particles comprise 25- 70 wt-%, based on the total weight of the solid particles, of the fat-soluble vitamin(s).
- the solid particles according to the present invention comprise at least one emulsifier. Any commonly known and used emulsifier can be used. A single emulsifier as well as a mixture of emulsifiers can be used.
- More preferred emulsifiers are modified (food) starches, polysaccharide gums and plant proteins.
- the starches can be modified physically and chemically.
- Pregelatinized starches are examples of physically modified starches.
- Acidic modified, oxidized, crosslinked, starch esters, starch ethers and cationic starches are examples of chemically modified starches.
- the amount of the emulsifier(s) in the solid particles is usually from 20 - 70 wt-%, based on the total weight of the solid particles; preferably 25 - 65 wt-%, based on the total weight of the solid particles.
- solid particles which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is chosen from the group consisting of modified (food) starches, ascorbyl palmitate, pectin, alginate, carrageenan, furcellaran, dextrin derivatives, celluloses and cellulose derivatives (e.g.
- solid particles which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is not derived from an animal source.
- solid particles which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is chosen from the group consisting of modified (food) starches, polysaccharide gums and plant proteins.
- solid particles which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′) or (SP7′′), wherein the amount of the emulsifier(s) in the solid particles is 20 - 70 wt-%, based on the total weight of the solid particles.
- solid particles which are solid particles SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′) or (SP7′′), wherein the amount of the emulsifier(s) in the solid particles is 25 - 65 wt-%, based on the total weight of the solid particles.
- the solid particles can comprise further ingredients (auxiliary agents).
- auxiliary agents are for example antioxidants (such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)), butylated hydroxytoluene (BHT), ascorbyl palmitate, butylated hydroxyanisole (BHA), propyl gallate, tert. butyl hydroxyquinoline, ethoxyquin and/or ascorbic acid esters of a fatty acid); stabilisers (such as gel-forming agents as xanthan gum, gellan gum); humectants (such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances; fillers and buffers.
- antioxidants such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)
- BHT butylated hydroxytoluene
- BHA butylated hydroxyanisole
- PHA propyl gallate
- humectants such as g
- auxiliary agents can be useful for the solid particles, for their production, for the final product (for what the solid particles used) and/or for the production of the final product.
- These compounds can optionally be used in an amount of up to 15 wt-%, based on the solid particles.
- solid particles which are solid particles (SP), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8) or (SP9), comprising up to 15 wt-%, based on the solid particles, of at least one auxiliary agents.
- the present invention relates to solid particles (SP11), which are solid particles (SP10), wherein the auxiliary agent (or auxiliary agents) is chosen from the group consisting of antioxidants (such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)), butylated hydroxytoluene (BHT), ascorbyl palmitate, butylated hydroxyanisole (BHA), propyl gallate, tert.
- antioxidants such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)
- BHT butylated hydroxytoluene
- BHA butylated hydroxyanisole
- propyl gallate tert.
- butyl hydroxyquinoline, ethoxyquin and/or ascorbic acid esters of a fatty acid stabilisers (such as gel-forming agents as xanthan gum, gellan gum); humectants (such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances; fillers and buffers.
- the solid particles according to the present invention are coated with a powder, which is used in the powder catch process.
- a powder can be for example corn starch.
- the amount of the powder (especially of corn starch) can be up to 15 wt-%, based on the total weight of the powder coated particles. Usually the content of the powder coating is kept as low as possible, so that another coating layer can be created.
- This layer can be of any known and used coating material.
- a suitable size of the solid particles of the present invention is between 50 -1000 ⁇ m (preferably 100 - 800 ⁇ m); the size is defined by the diameter of the longest dimension of the particle and measured by commonly known method (like laser diffraction)
- All particle sizes of the solid particles according to the present invention are determined by laser diffraction technique using a “Mastersizer 3000” of Malvern Instruments Ltd., UK. Further information on this particle size characterization method can e.g. be found in “Basic principles of particle size analytics”, Dr. Alan Rawle, Malvern Instruments Limited, Enigma Business Part, Grovewood Road, Malvern, Worcestershire, WR14 1XZ, UK and the “Manual of Malvern particle size analyzer”. Particular reference is made to the user manual number MAN 0096, Issue 1.0, November 1994.
- particle sizes referring to the coarse particles of the solid particles according to the present invention are Dv90 values (volume diameter, 90% of the population resides below this point, and 10% resides above this point) determined by laser diffraction.
- the particle size can be determined in the dry form, i.e. as powder or in suspension.
- the particle size of the solid particles according to the present invention is determined as powder.
- the distribution of the particle size of the solid particles is also no essential feature of the present invention.
- the shape of the solid particles is also not an essential feature of the present invention.
- the shape can be sphere-like or any other form (also mixtures of shapes). Usually and preferably, the particles are sphere-like.
- the particles can be produced by any commonly known process, which are used to produce such particles (spray drying, spray chilling, etc.).
- the solid particles according to the present invention are mainly used for producing compressed tablet.
- the present invention relates to the use of at least one solid particle (SP), (SP′), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8), (SP9), (SP10) and/or (SP11) in the production of compressed tablets.
- SP solid particle
- the pressure, which is used to producing tablets, is at least 5 kN
- the pressure which is used to producing tablets, is usually between 5 and 40 kN, preferably between 10 - 40 kN, more preferably between 5 - 40 kN.
- the present invention relates to the process (P) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of at least 5 kN.
- SP solid particle
- the present invention relates to the process (P′) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of between 5 and 40kN,
- SP solid particle
- the present invention relates to the process (P′′) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of between 10 - 40 kN.
- SP solid particle
- the present invention relates to the process (P′′′) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of between 15 - 40 kN.
- SP solid particle
- the present invention relates to the process (P1), which is process (P), (P′), (P′′) or (P′′′), wherein at least one further ingredient is added.
- the tablet can be a dietary supplement or a pharmaceutical product. This depends what is added to the compressed tablets additionally.
- the present invention also relates to compressed tablets comprising at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7′′), (SP8), (SP9), (SP10) and/or (SP11).
- SP solid particle
- the invention is illustrated by the following Example. All temperatures are given in °C and all parts and percentages are related to the weight.
- the moisture of the emulsion determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of corn starch using a rotating spray nozzle.
- the obtained particles were sieved off (150 to 600 ⁇ m) from the excess of corn starch and dried at room temperature using a stream off air.
- the moisture of the emulsion determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of corn starch using a rotating spray nozzle.
- the obtained particles were sieved off (150 to 600 ⁇ m) from the excess of corn starch and dried at room temperature using a stream off air.
- the moisture of the emulsion determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of corn starch using a rotating spray nozzle.
- the obtained particles were sieved off (150 to 600 ⁇ m) from the excess of corn starch and dried at room temperature using a stream off air.
- the moisture of the emulsion determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of cornstarch using a rotating spray nozzle.
- the obtained particles were sieved off (150 to 600 ⁇ m) from the excess of corn starch and dried at room temperature using a stream off air.
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Abstract
Solid particles comprising at least one fat-soluble vitamin are provided and exhibit better stability when compressed into tablets.
Description
- This application is a continuation of U.S. Application Serial No. 15/775,425 filed on May 11, 2018 (now U.S. Pat. No. XX,XXX,XXX), which in turn is the U.S. national phase of International Application No. PCT/EP2016/080421 filed 9 Dec. 2016, which designated the U.S. and claims priority to EP Patent Application No. 15199204.7 filed 10 Dec. 2015, the entire contents of each of which are hereby incorporated by reference.
- The present patent application relates to solid particles comprising a high amount of at least one fat-soluble vitamin, which are more stable when compressed into tablets. Furthermore, the particles can be free of any animal derived ingredient and therefore suitable for vegetarians.
- Compressed tablets are a very useful way for administering fat-soluble vitamins. They are easy to be consumed, easy to store and good to handle.
- When compressed tablets are produced, harsh conditions are to be applied. It is clear that a certain pressure has to be used to compress any formulation into a tablet. Therefore, there is usually an issue, that the ingredients, which are part of the formulation, which is used to be compressed, are squeezed out and therefore are not part of the tablet anymore. In other words, the tablet contains usually less of the fat-soluble vitamin in the compressed tablet than in the formulation, which was compressed. Usually the content of the fat-soluble vitamins is getting less during the storage of the compressed tablets.
- Gelatine, which is often used to formulate fat-soluble vitamins, is usually sourced from an animal source and therefore not suitable for vegetarians.
- Due to the importance of compressed tablets, comprising fat-soluble vitamins, there is always a need for improved compressible formulations.
- Surprisingly it was found that such an improvement was achieved by adding one or more non-reducing sugar to the solid formulation, which is used to produce compressed tablets.
-
FIGS. 1-3 are each graphs of the data in Tables 5-7, respectively, below showing vitamin A rentention (IU/g) versus days of storage. - The embodiments disclosed herein relate to solid particles (SP) comprising:
- (i) at least 20 weight-% (wt-%), based on the total weight of the solid particles, of least one fat soluble vitamin,
- (ii) at least one emulsifier, and
- (iii) at least one non-reducing sugar.
- These solid particles show better storage stability (of the fat-soluble vitamin) when compressed into tablets.
- It also possible to produce solid particles with only these three kind of ingredients.
- Therefore, the present invention relates to solid particles (SP’) consisting of
- (i) at least 20 weight-% (wt-%), based on the total weight of the solid particles, of least one fat soluble vitamin,
- (ii) at least one emulsifier, and
- (iii) at least one non-reducing sugar.
- Preferred non-reducing sugars are non-reducing disaccharides; more preferably sucrose and/or trehalose, most preferred is trehalose.
- Sucrose is a disaccharide combination of the monosaccharides glucose and fructose with the formula C12H22O11. It is commercially available from many suppliers.
- Sucrose is often extracted and refined from either cane or beet sugar for human
- Trehalose, also known as mycose or tremalose, is a natural alpha-linked disaccharide formed by an α,α-1,1-glucoside bond between two α-glucose units. There is an industrial process where trehalose is derived from corn starch. There are known biological pathways for trehalose biosynthesis.
- Trehalose is available commercially from various suppliers.
- The amount of non-reducing sugar in the solid particles is from 5 - 55 weight-% (wt- %), based on the total weight of the solid particles. Preferably 10 - 50 wt-%, based on the total weight of the solid particles; more preferably 15 - 45 wt-%, based on the total weight of the solid particles.
- Therefore the present invention relates to solid particles (SP1), which are solid particles (SP) or (SP′) comprising 5 - 55 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
- Therefore the present invention relates to solid particles (SP2), which are solid particles (SP) or (SP’) comprising 10 - 50 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
- Therefore the present invention relates to solid particles (SP3), which are solid particles (SP) or (SP’) comprising 15 - 45 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
- The solid particles according to the present invention comprise at least one fat-soluble vitamin.
- Fat-soluble vitamins are vitamin A, D, E, and K (as well as derivatives thereof). In a preferred embodiment of the present invention, vitamin A and/or its derivatives (such as vitamin A acetate and vitamin A palmitate) are used.
- Therefore, the present invention relates to solid particles (SP4), which are solid particles (SP), (SP’), (SP1) or (SP2), wherein the fat-soluble vitamin is vitamin A and/or a derivative of vitamin A (especially vitamin A acetate or vitamin A palmitate).
- The solid particles according to the present invention comprise usually comprise 20 - 75 wt-%, based on the total weight of the solid particles, of at least one fat soluble vitamin, preferably, 25 - 70 wt-%, based on the total weight of the solid particles.
- Therefore, the present invention relates to solid particles (SP5), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3) or (SP4), wherein the solid particles comprise 20 - 75 wt-%, based on the total weight of the solid particles, of the fat-soluble vitamin(s).
- Therefore, the present invention relates to solid particles (SP6), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4) or (SP5), wherein the solid particles comprise 25- 70 wt-%, based on the total weight of the solid particles, of the fat-soluble vitamin(s).
- Furthermore, the solid particles according to the present invention comprise at least one emulsifier. Any commonly known and used emulsifier can be used. A single emulsifier as well as a mixture of emulsifiers can be used.
- Suitable emulsifiers are modified (food) starches, ascorbyl palmitate, pectin, alginate, carrageenan, furcellaran, dextrin derivatives, celluloses and cellulose derivatives (e.g. cellulose acetate, methyl cellulose, hydroxypropyl methyl cellulose), lignosulfonate, polysaccharide gums (such as gum acacia (= gum arabic), modified gum acacia, TIC gum, flaxseed gum, ghatti gum, tamarind gum and arabinogalactan), gelatine (bovine, fish, pork, poultry), plant proteins (such as are for example peas, soybeans, castor beans, cotton, potatoes, sweet potatoes, manioc, rapeseed, sunflowers, sesame, linseed, safflower, lentils, nuts, wheat, rice, maize, barley, rye, oats, lupin and sorghum), animal proteins including milk or whey proteins, lecithin, polyglycerol ester of fatty acids, monoglycerides of fatty acids, diglycerides of fatty acids, sorbitan ester, and sugar ester (as well as derivatives thereof).
- Preferred are emulsifiers, which are not derived from an animal source.
- More preferred emulsifiers are modified (food) starches, polysaccharide gums and plant proteins.
- The starches can be modified physically and chemically. Pregelatinized starches are examples of physically modified starches. Acidic modified, oxidized, crosslinked, starch esters, starch ethers and cationic starches are examples of chemically modified starches.
- The amount of the emulsifier(s) in the solid particles is usually from 20 - 70 wt-%, based on the total weight of the solid particles; preferably 25 - 65 wt-%, based on the total weight of the solid particles.
- Therefore the present invention relates to solid particles (SP7), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is chosen from the group consisting of modified (food) starches, ascorbyl palmitate, pectin, alginate, carrageenan, furcellaran, dextrin derivatives, celluloses and cellulose derivatives (e.g. cellulose acetate, methyl cellulose, hydroxypropyl methyl cellulose), lignosulfonate, polysaccharide gums (such as gum acacia (= gum arabic), modified gum acacia, TIC gum, flaxseed gum, ghatti gum, tamarind gum and arabinogalactan), gelatine (bovine, fish, pork, poultry), plant proteins (such as are for example peas, soybeans, castor beans, cotton, potatoes, sweet potatoes, manioc, rapeseed, sunflowers, sesame, linseed, safflower, lentils, nuts, wheat, rice, maize, barley, rye, oats, lupin and sorghum), animal proteins including milk or whey proteins, lecithin, polyglycerol ester of fatty acids, monoglycerides of fatty acids, diglycerides of fatty acids, sorbitan ester, and sugar ester (as well as derivatives thereof).
- Therefore the present invention relates to solid particles (SP7′), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is not derived from an animal source.
- Therefore the present invention relates to solid particles (SP7″), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is chosen from the group consisting of modified (food) starches, polysaccharide gums and plant proteins.
- Therefore the present invention relates to solid particles (SP8), which are solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′) or (SP7″), wherein the amount of the emulsifier(s) in the solid particles is 20 - 70 wt-%, based on the total weight of the solid particles.
- Therefore the present invention relates to solid particles (SP9), which are solid particles SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′) or (SP7″), wherein the amount of the emulsifier(s) in the solid particles is 25 - 65 wt-%, based on the total weight of the solid particles.
- Furthermore, the solid particles can comprise further ingredients (auxiliary agents). Such auxiliary agents are for example antioxidants (such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)), butylated hydroxytoluene (BHT), ascorbyl palmitate, butylated hydroxyanisole (BHA), propyl gallate, tert. butyl hydroxyquinoline, ethoxyquin and/or ascorbic acid esters of a fatty acid); stabilisers (such as gel-forming agents as xanthan gum, gellan gum); humectants (such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances; fillers and buffers.
- These auxiliary agents can be useful for the solid particles, for their production, for the final product (for what the solid particles used) and/or for the production of the final product.
- These compounds can optionally be used in an amount of up to 15 wt-%, based on the solid particles.
- Therefore the present invention relates to solid particles (SP10), which are solid particles (SP), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8) or (SP9), comprising up to 15 wt-%, based on the solid particles, of at least one auxiliary agents.
- Therefore the present invention relates to solid particles (SP11), which are solid particles (SP10), wherein the auxiliary agent (or auxiliary agents) is chosen from the group consisting of antioxidants (such as ascorbic acid or salts thereof, tocopherol (synthetic or natural)), butylated hydroxytoluene (BHT), ascorbyl palmitate, butylated hydroxyanisole (BHA), propyl gallate, tert. butyl hydroxyquinoline, ethoxyquin and/or ascorbic acid esters of a fatty acid); stabilisers (such as gel-forming agents as xanthan gum, gellan gum); humectants (such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances; fillers and buffers.
- Depending on the way of the production of the solid particles according to the present invention it also possible that they are coated with a powder, which is used in the powder catch process. Such a powder can be for example corn starch.
- The amount of the powder (especially of corn starch) can be up to 15 wt-%, based on the total weight of the powder coated particles. Usually the content of the powder coating is kept as low as possible, so that another coating layer can be created.
- Furthermore, it is also possible to coat the solid particles with a coating layer. This layer can be of any known and used coating material.
- A suitable size of the solid particles of the present invention is between 50 -1000 µm (preferably 100 - 800 µm); the size is defined by the diameter of the longest dimension of the particle and measured by commonly known method (like laser diffraction)
- All particle sizes of the solid particles according to the present invention are determined by laser diffraction technique using a “Mastersizer 3000” of Malvern Instruments Ltd., UK. Further information on this particle size characterization method can e.g. be found in “Basic principles of particle size analytics”, Dr. Alan Rawle, Malvern Instruments Limited, Enigma Business Part, Grovewood Road, Malvern, Worcestershire, WR14 1XZ, UK and the “Manual of Malvern particle size analyzer”. Particular reference is made to the user manual number MAN 0096, Issue 1.0, November 1994. If nothing else is stated all particle sizes referring to the coarse particles of the solid particles according to the present invention are Dv90 values (volume diameter, 90% of the population resides below this point, and 10% resides above this point) determined by laser diffraction. The particle size can be determined in the dry form, i.e. as powder or in suspension. Preferably, the particle size of the solid particles according to the present invention is determined as powder.
- The distribution of the particle size of the solid particles is also no essential feature of the present invention.
- The shape of the solid particles is also not an essential feature of the present invention. The shape can be sphere-like or any other form (also mixtures of shapes). Usually and preferably, the particles are sphere-like.
- The particles can be produced by any commonly known process, which are used to produce such particles (spray drying, spray chilling, etc.).
- The process of coating such small particles is well known. It is usually done by fluidized bed spray granulation, film coating or wet granulation.
- The solid particles according to the present invention are mainly used for producing compressed tablet.
- Therefore the present invention relates to the use of at least one solid particle (SP), (SP′), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11) in the production of compressed tablets.
- The pressure, which is used to producing tablets, is at least 5 kN
- The pressure, which is used to producing tablets, is usually between 5 and 40 kN, preferably between 10 - 40 kN, more preferably between 5 - 40 kN.
- Therefore the present invention relates to the process (P) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of at least 5 kN.
- Therefore the present invention relates to the process (P′) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of between 5 and 40kN,
- Therefore the present invention relates to the process (P″) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of between 10 - 40 kN.
- Therefore the present invention relates to the process (P‴) of producing compressed tables wherein at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11) are compressed with at pressure of between 15 - 40 kN.
- It is also possible to add any further ingredients (such as fillers, dyestuffs, antioxidants, flavours, etc.) to the solid particles according to the present invention before compressing the particles into the tablet.
- Therefore the present invention relates to the process (P1), which is process (P), (P′), (P″) or (P‴), wherein at least one further ingredient is added.
- The tablet can be a dietary supplement or a pharmaceutical product. This depends what is added to the compressed tablets additionally.
- Furthermore the present invention also relates to compressed tablets comprising at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11).
- The invention is illustrated by the following Example. All temperatures are given in °C and all parts and percentages are related to the weight.
- 370.6 g of deionized water were heated up to 60° C. - 65° C. in a vessel. 316.75 g of food modified starch and 121.2 g of trehalose were added and the mixture was brought into solution while stirring at 60-65° C. The obtained solution was cooled to50- 55° C. and degassed for 1 hour. Thereupon, 190.82 g of an oil mixture (180.78 g vitamin A acetate, 5.02 g BHT and 5.02 g dl-alpha-tocopherol) were added to the matrix system and emulsified. The temperature of the process was always kept below 65° C. After emulsification the inner phase of the emulsion had an average particle size of about 272 nm (Dv(0.1 )=100 nm, Dv(0.5)=272 nm, Dv(0.9)=559 nm), measurement realized by laser diffraction (Malvern 3000). After emulsification the moisture of the emulsion, determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of corn starch using a rotating spray nozzle. The obtained particles were sieved off (150 to 600 µm) from the excess of corn starch and dried at room temperature using a stream off air. The final product particle size after drying was in average 246 µm (Dv(0.1)= 198 µm, Dv(0.5) =246 µm, Dv(0.9) = 303 µm) measured by laser diffraction (Malvern 3000).
- Solid particles with the composition as listed in table 1 have been obtained.
-
TABLE 1 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00 dl-alpha-Tocopherol 0.75 BHT 0.75 Food modified starch 47.31 Trehalose 18.19 Corn Starch 4.00 Water 2.00 Total 100.00 - 381 g of deionized water were heated up to 60° C. - 65° C. in a vessel. 316.75 g of food modified starch and 122.2 g of trehalose were added and the mixture was brought into solution while stirring at 60-65° C. The obtained solution was cooled to 50-55° C. and degassed for 1 hour. Thereupon, 190.78 g of vitamin A acetate were added to the matrix system and emulsified. The temperature of the process was always kept below 65° C. After emulsification the inner phase of the emulsion had an average particle size of about 333 nm (Dv(0.1 )=175 nm, Dv(0.5)=333 nm, Dv(0.9)=558 nm), measurement realized by laser diffraction (Malvern 3000). After emulsification the moisture of the emulsion, determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of corn starch using a rotating spray nozzle. The obtained particles were sieved off (150 to 600 µm) from the excess of corn starch and dried at room temperature using a stream off air. The final product particle size after drying was in average 180 µm (Dv(0.1) =180 µm, Dv(0.5) =240 µm, Dv(0.9) = 321 µm) measured by laser diffraction (Malvern 3000).
- Solid particles with the composition as listed in table 21 have been obtained.
-
TABLE 2 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00 Food modified starch 48.31 Trehalose 18.19 Corn Starch 4.00 Water 2.00 Total 100.00 - 370.6 g of deionized water were heated up to 60° C. - 65° C. in a vessel. 317.4 g of food modified starch and 122.1 g of sucrose were added and the mixture was brought into solution while stirring at 60-65° C. The obtained solution was cooled to 50-55° C. and degassed for 1 hour. Thereupon, 197.3 g of an oil mixture (186.9 g vitamin A acetate, 10.4 g BHT) were added to the matrix system and emulsified. The temperature of the process was always kept below 65° C. After emulsification the inner phase of the emulsion had an average particle size of about 276 nm (Dv(0.1)=112 nm, Dv(0.5)=276 nm, Dv(0.9)=516 nm), measurement realized by laser diffraction (Malvern 3000). After emulsification the moisture of the emulsion, determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of corn starch using a rotating spray nozzle. The obtained particles were sieved off (150 to 600 µm) from the excess of corn starch and dried at room temperature using a stream off air. The final product particle size after drying was in average 272 µm (Dv(0.1) =197 µm, Dv(0.5) =272 µm, Dv(0.9) = 377 µm) measured by laser diffraction (Malvern 3000).
- Solid particles with the composition as listed in Table 3 have been obtained
-
TABLE 3 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00 BHT 1.50 Food modified starch 45.86 Sucrose 17.64 Corn Starch 5.00 Water 3.00 Total 100.00 - 381 g of deionized water were heated up to 60° C. - 65° C. in a vessel. 143.78 g of food modified starch and 287.56 g of trehalose were added and the mixture was brought into solution while stirring at 60-65° C. The obtained solution was cooled to 50-55° C. and degassed for 1 hour. Thereupon, 187.68 g of an oil mixture (177.80 g vitamin A acetate, 4.94 g BHT and 4.94 g dl-alpha-tocopherol) were added to the matrix system and emulsified. The temperature of the process was always kept below 65° C. After emulsification the inner phase of the emulsion had an average particle size of about 493 nm (Dv(0.1)=215 nm, Dv(0.5)=493 nm, Dv(0.9)=987 nm), measurement realized by laser diffraction (Malvern 3000). After emulsification the moisture of the emulsion, determined by a halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checked and adapted if necessary. Afterwards 150 g of the emulsion were sprayed into a spray pan containing 1500 g of cornstarch using a rotating spray nozzle. The obtained particles were sieved off (150 to 600 µm) from the excess of corn starch and dried at room temperature using a stream off air. The final product particle size after drying was in average 234 µm (Dv(0.1) =189 µm, Dv(0.5) =234 µm, Dv(0.9) = 293 µm) measured by laser diffraction (Malvern 3000).
- Solid particles with the composition as listed in Table 4 have been obtained.
-
TABLE 4 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00 dl-alpha-Tocopherol 0.75 BHT 0.75 Gum acacia 21.83 Trehalose 43.67 Corn Starch 4.00 Water 2.00 Total 100.00 - 110.3 g of powder consisting of 27 g of vitamin A acetate particles (as obtained in Example 1), 33.24 g microcrystalline cellulose, 49.86 g calcium phosphate and 0.2 g of magnesium stearate was mixed during 10 min. This end preparation was then compressed with a pressure of 35 KN. The tablets (common disk-shaped; 0.2 g) were stored at room temperature in a closed brown-glass bottle and the vitamin A acetate content determined after 1, 7 and 35 days of storage.
- For the purpose to show the superior property of the particles according to the present invention, comparative examples were also carried, wherein instead of trehalose or sucrose other sugars, which are no non-reducing sugars, have been used. These comparative solid particles were prepare as described in Example 1.
- The impact of the use of trehalose is far better than other types of plasticizer. This can be seen on the
FIGS. 1, 2, and 3 . (in tables 5 - 7, the solid particles are listed. The concentration of the ingredients is the same as in Example 1). -
TABLE 5 Compressed tablets as on FIG. 1 Graph Composition of the solid particles 1 Vitamin A acetate Food modified starch Maltodextrin12 BHT/ toco 2 Vitamin A acetate Food modified starch trehalose BHT/ toco 3 Vitamin A acetate Food modified starch sucrose BHT/toco -
TABLE 6 Compressed tablets as on FIG. 2 Graph Composition of the solid particles 1 Vitamin A acetate Food modified starches Maltodextrin 20-23 BHT/ toco 2 Vitamin A acetate Food modified starches Maltodextrin 12BHT/ toco 3 Vitamin A acetate Food modified starch trehalose BHT/toco -
TABLE 7 Compressed tablets as on FIG. 3 Graph Composition of the solid particles 1 Vitamin A acetate Gum acacia Maltodextrin 20-23 BHT/ toco 2 Vitamin A acetate Gum acacia Maltodextrin 12 BHT/ toco 3 Vitamin A acetate Gum acacia trehalose BHT/toco
Claims (21)
1. Solid particles comprising:
at least 20 wt-%, based on the total weight of the solid particles, of least one fat soluble vitamin,
at least one emulsifier, and
at least one non-reducing sugar.
2. The solid particles according to claim 1 , wherein the at least one non-reducing sugar is present in an amount of 5-55 wt.%, based on the total weight of the solid particles, of at least one non-reducing sugar.
3. The solid particles according to claim 1 , wherein the at least one reducing sugar comprises trehalose.
4. The solid particles according to claim 2 , wherein the at least one non-reducing sugar is present in an amount of 10 - 50 wt.%, based on the total weight of the solid particles.
5. The solid particles according to claim 1 , wherein the fat soluble vitamin is vitamin A and/or derivatives thereof.
6. The solid particles according to claim 5 , wherein the fat soluble vitamin is selected from the group consisting of vitamin A acetate and vitamin A palmitate.
7. The solid particles according to claim 1 , wherein the at least one fat-soluble vitamin is present in an amount of 20 - 75 wt.%, based on the total weight of the solid particles.
8. The solid particles according to 7 , wherein the at least one fat-soluble vitamin is present in an amount of 20 - 70 wt.%, based on the total weight of the solid particles.
9. The solid particles according to claim 1 , wherein the at least one emulsifier is present in an amount of 20 - 70 wt.%, based on the total weight of the solid particles.
10. The solid particles according to claim 1 , wherein the at least emulsifier is selected from the group consisting of modified food starch and gum acacia.
11. The solid particles according to claim 1 , wherein the solid particles have a size (Dv90) between 50-1000 µm.
12. The solid particles according to claim 1 , wherein the solid particles have a size (Dv90) between 100-800 µm.
13. A compressed tablet comprising the solid particles according to claim 1 .
14. The compressed tablet according to claim 13 , wherein the solid particles comprise:
(i) at least 20 wt.%, based on the total weight of the solid particles, of least one fat soluble vitamin selected from the group consisting of vitamin A, vitamin A acetate and vitamin A palmitate,
(ii) 20 - 70 wt.%, based on the total weight of the solid particles, of at least one emulsifier selected from the group consisting of modified food starch and gum acacia, and
(iii) 5 - 55 wt.%, based on the total weight of the solid particles, of trehalose as a non-reducing sugar.
15. The compressed tablet according to claim 14 , wherein the trehalose is present in an amount of 10 - 50 wt.%, based on the total weight of the solid particles.
16. The compressed tablet according to claim 14 , wherein the at least one fat-soluble vitamin is present in an amount of 20 - 75 wt.%, based on the total weight of the solid particles.
17. The compressed tablet according to claim 14 , wherein the at least one fat-soluble vitamin is present in an amount of 25 - 70 wt.%, based on the total weight of the solid particles.
18. The compressed tablet according to claim 14 , wherein the solid particles have a size (Dv90) between 50-1000 µm.
19. The compressed table according to claim 14 , wherein the solid particles have a size (Dv90) between 100-800 µm.
20. A method of forming a compressed tablet comprising subjecting the solid particles according to claim 1 to a pressure of at least 5 kN to thereby form the compressed tablet comprised of the solid particles.
21. The method according to claim 20 , wherein the compression pressure is between 5 and 40 kN.
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BR112019023437A2 (en) * | 2017-05-19 | 2020-06-16 | Dsm Ip Assets B.V. | SOLID PARTICLES |
US20210100730A1 (en) * | 2018-04-27 | 2021-04-08 | Dsm Ip Assets B.V. | Powderous formulation |
CN112105268A (en) * | 2018-04-27 | 2020-12-18 | 帝斯曼知识产权资产管理有限公司 | Powder composition comprising a carotenoid and/or a derivative thereof, a D-glucose oligomer and a modified polysaccharide, and food, feed or personal care formulation comprising such a composition |
WO2021069752A1 (en) * | 2019-10-11 | 2021-04-15 | Dsm Ip Assets B.V. | New feed additives of fat-soluble vitamins |
WO2022078924A1 (en) * | 2020-10-12 | 2022-04-21 | Dsm Ip Assets B.V. | New feed additives of fat-soluble vitamins |
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US5938990A (en) * | 1994-07-01 | 1999-08-17 | Roche Vitamins Inc. | Encapsulation of oleophilic substances and compositions produced thereby |
ES2192064T3 (en) * | 1998-08-25 | 2003-09-16 | Basf Health & Nutrition As | GELATINOUS FISH COMPOSITION TO USE AS INGREDIENT IN TABLETS. |
EP1066761B1 (en) * | 1999-07-06 | 2004-09-29 | DSM IP Assets B.V. | Compositions containing fat-soluble substances in a carbohydrate matrix |
CN1101151C (en) * | 2000-05-01 | 2003-02-12 | 湖南金健米业股份有限公司 | Method for producing antistaling instant rice-flour noodles |
US20060252761A1 (en) * | 2001-03-29 | 2006-11-09 | Michael Davis | Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine |
CN100365988C (en) | 2004-01-09 | 2008-01-30 | 华为技术有限公司 | Session connection resource management optimizing method |
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DE102004046026A1 (en) | 2004-09-21 | 2006-03-23 | Basf Ag | Process for the preparation of dry powders of one or more carotenoids |
CN101115404B (en) * | 2005-02-02 | 2013-06-05 | 帝斯曼知识产权资产管理有限公司 | Powder compositions |
DE102005030952A1 (en) * | 2005-06-30 | 2007-01-18 | Basf Ag | Process for the preparation of an aqueous suspension and a pulverulent preparation of one or more carotenoids |
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WO2007042153A1 (en) * | 2005-10-11 | 2007-04-19 | Bayer Consumer Care Ag | Mixture of iron and copper salts masking mettalic taste |
WO2007045488A1 (en) * | 2005-10-21 | 2007-04-26 | Dsm Ip Assets B.V. | Novel formulations of fat-soluble active ingredients with high bioavailability |
WO2007090614A1 (en) * | 2006-02-06 | 2007-08-16 | Dsm Ip Assetts B.V. | Compositions of active ingredients |
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US20080102131A1 (en) * | 2006-10-31 | 2008-05-01 | Kaneka Corporation | Particulate composition comprising bioactive substance and method of producing the same |
ES2727933T3 (en) * | 2007-03-15 | 2019-10-21 | Dsm Ip Assets Bv | Carotenoid compositions containing modified acacia gum |
KR20100047869A (en) * | 2007-07-19 | 2010-05-10 | 디에스엠 아이피 어셋츠 비.브이. | Tablettable formulations of lipophilic health ingredients |
US20110052707A1 (en) * | 2008-02-12 | 2011-03-03 | Neil Robert Buck | Combination of vitamin d and 25-hydroxyvitamin d 3 |
AU2010233097B2 (en) * | 2009-04-10 | 2016-04-07 | Abraxis Bioscience, Llc | Nanoparticle formulations and uses thereof |
CA2768236C (en) * | 2009-07-16 | 2018-05-22 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
CN102319263B (en) * | 2011-08-17 | 2013-04-17 | 江门市新会区光华生物科技有限公司 | Film coated tablets containing a plurality of vitamins and mineral matters, and its preparation process |
CA2851566C (en) * | 2011-10-14 | 2020-01-14 | Dsm Ip Assets B.V. | Novel coating system |
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EP3386320A1 (en) | 2018-10-17 |
BR112018011476B1 (en) | 2022-04-12 |
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KR20180091007A (en) | 2018-08-14 |
JP2019502658A (en) | 2019-01-31 |
WO2017097974A1 (en) | 2017-06-15 |
US11696594B2 (en) | 2023-07-11 |
BR112018011476A2 (en) | 2018-12-04 |
US20180343909A1 (en) | 2018-12-06 |
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