JP2019501973A5 - - Google Patents
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- Publication number
- JP2019501973A5 JP2019501973A5 JP2018555314A JP2018555314A JP2019501973A5 JP 2019501973 A5 JP2019501973 A5 JP 2019501973A5 JP 2018555314 A JP2018555314 A JP 2018555314A JP 2018555314 A JP2018555314 A JP 2018555314A JP 2019501973 A5 JP2019501973 A5 JP 2019501973A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- cancer
- cell
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 210000001744 T-lymphocyte Anatomy 0.000 claims 13
- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 claims 11
- 231100000617 superantigen Toxicity 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000000091 immunopotentiator Effects 0.000 claims 5
- 230000004913 activation Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 101710160107 Outer membrane protein A Proteins 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 229960003852 atezolizumab Drugs 0.000 claims 2
- 230000005754 cellular signaling Effects 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 231100000655 enterotoxin Toxicity 0.000 claims 2
- 230000001900 immune effect Effects 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276955P | 2016-01-10 | 2016-01-10 | |
| US62/276,955 | 2016-01-10 | ||
| PCT/IB2017/000511 WO2017122098A2 (en) | 2016-01-10 | 2017-01-10 | Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501973A JP2019501973A (ja) | 2019-01-24 |
| JP2019501973A5 true JP2019501973A5 (cg-RX-API-DMAC7.html) | 2020-02-20 |
| JP7161938B2 JP7161938B2 (ja) | 2022-10-27 |
Family
ID=58737690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555314A Active JP7161938B2 (ja) | 2016-01-10 | 2017-01-10 | スーパー抗原媒介性癌免疫療法の能力を増強するための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10314910B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3411409B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7161938B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20180100412A (cg-RX-API-DMAC7.html) |
| CN (2) | CN117679499A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017206656B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3010678A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201891601A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL260423B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2018008383A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017122098A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201804565B (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017206656B2 (en) * | 2016-01-10 | 2024-02-01 | Neotx Therapeutics Ltd. | Immunopotentiator enhanced superantigen mediated cancer immunotherapy |
| JP7536295B2 (ja) * | 2018-05-16 | 2024-08-20 | デューク ユニバーシティ | 免疫毒素とチェックポイント阻害剤との組み合わせを用いるネオアジュバントがん処置 |
| CN108840923B (zh) * | 2018-06-22 | 2021-08-03 | 上海交通大学医学院附属仁济医院 | 一种靶向pd-l1的多肽及其应用 |
| KR20220009428A (ko) * | 2019-05-15 | 2022-01-24 | 네오티엑스 테라퓨틱스 엘티디. | 암 치료 |
| US20230085724A1 (en) * | 2020-03-05 | 2023-03-23 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
| CN116490521A (zh) * | 2020-07-20 | 2023-07-25 | 尼奥克斯医疗有限公司 | 用于治疗癌症的方法和组合物中的超抗原偶联物 |
| WO2022037323A1 (zh) * | 2020-08-19 | 2022-02-24 | 上海易慕峰生物科技有限公司 | 人源化抗体、嵌合抗原受体、核酸、载体、细胞及应用 |
| IL307842A (en) * | 2021-04-22 | 2023-12-01 | Neotx Therapeutics Ltd | Methods and compositions for treating glioblastoma |
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| CN116284448B (zh) * | 2023-02-14 | 2024-06-21 | 浙江大学 | 一种超抗原参与的三功能t细胞衔接器及其应用 |
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| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
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| US5389514A (en) | 1992-08-28 | 1995-02-14 | Fox Chase Cancer Center | Method for specifically altering the nucleotide sequence of RNA |
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| SE9402430L (sv) | 1994-07-11 | 1996-01-12 | Pharmacia Ab | Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten |
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| HRP20201928T1 (hr) * | 2014-11-20 | 2021-02-05 | F. Hoffmann - La Roche Ag | Kombinirana terapija bispecifičnom antigen vezujućom molekulom koja aktivira t-stanice, za cd3 i folatni receptor 1 (folr1), i antagonistom vezivanja osi pd-1 |
| AU2017206656B2 (en) * | 2016-01-10 | 2024-02-01 | Neotx Therapeutics Ltd. | Immunopotentiator enhanced superantigen mediated cancer immunotherapy |
-
2017
- 2017-01-10 AU AU2017206656A patent/AU2017206656B2/en active Active
- 2017-01-10 CN CN202311526574.8A patent/CN117679499A/zh active Pending
- 2017-01-10 CA CA3010678A patent/CA3010678A1/en active Pending
- 2017-01-10 JP JP2018555314A patent/JP7161938B2/ja active Active
- 2017-01-10 MX MX2018008383A patent/MX2018008383A/es unknown
- 2017-01-10 EP EP17724437.3A patent/EP3411409B1/en active Active
- 2017-01-10 EA EA201891601A patent/EA201891601A1/ru unknown
- 2017-01-10 WO PCT/IB2017/000511 patent/WO2017122098A2/en not_active Ceased
- 2017-01-10 CN CN201780016492.5A patent/CN109195988B/zh active Active
- 2017-01-10 US US15/402,888 patent/US10314910B2/en active Active
- 2017-01-10 KR KR1020187022673A patent/KR20180100412A/ko not_active Ceased
- 2017-01-10 KR KR1020257014967A patent/KR20250071286A/ko active Pending
-
2018
- 2018-07-04 IL IL260423A patent/IL260423B2/en unknown
- 2018-07-09 ZA ZA2018/04565A patent/ZA201804565B/en unknown
-
2019
- 2019-05-14 US US16/411,276 patent/US11202829B2/en active Active
- 2019-12-11 US US16/710,432 patent/US11607452B2/en active Active
-
2023
- 2023-02-09 US US18/166,938 patent/US20240100156A1/en active Pending
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