JP2019501670A5 - - Google Patents

Download PDF

Info

Publication number
JP2019501670A5
JP2019501670A5 JP2018555309A JP2018555309A JP2019501670A5 JP 2019501670 A5 JP2019501670 A5 JP 2019501670A5 JP 2018555309 A JP2018555309 A JP 2018555309A JP 2018555309 A JP2018555309 A JP 2018555309A JP 2019501670 A5 JP2019501670 A5 JP 2019501670A5
Authority
JP
Japan
Prior art keywords
virus
ligand
inhibitor
promoter
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018555309A
Other languages
English (en)
Japanese (ja)
Other versions
JP6959258B2 (ja
JP2019501670A (ja
Filing date
Publication date
Priority claimed from GBGB1600382.4A external-priority patent/GB201600382D0/en
Priority claimed from GBGB1600380.8A external-priority patent/GB201600380D0/en
Priority claimed from GBGB1600381.6A external-priority patent/GB201600381D0/en
Application filed filed Critical
Priority claimed from PCT/GB2017/050036 external-priority patent/WO2017118864A1/en
Publication of JP2019501670A publication Critical patent/JP2019501670A/ja
Publication of JP2019501670A5 publication Critical patent/JP2019501670A5/ja
Priority to JP2021163811A priority Critical patent/JP7295192B2/ja
Publication of JP6959258B2 publication Critical patent/JP6959258B2/ja
Application granted granted Critical
Priority to JP2023094818A priority patent/JP2023113885A/ja
Priority to JP2025128636A priority patent/JP2025163138A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018555309A 2016-01-08 2017-01-09 改変された腫瘍溶解性ウイルス Active JP6959258B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021163811A JP7295192B2 (ja) 2016-01-08 2021-10-05 改変された腫瘍溶解性ウイルス
JP2023094818A JP2023113885A (ja) 2016-01-08 2023-06-08 改変された腫瘍溶解性ウイルス
JP2025128636A JP2025163138A (ja) 2016-01-08 2025-07-31 改変された腫瘍溶解性ウイルス

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1600382.4 2016-01-08
GBGB1600381.6A GB201600381D0 (en) 2016-01-08 2016-01-08 Virus strain
GBGB1600380.8A GB201600380D0 (en) 2016-01-08 2016-01-08 Modified virus
GB1600380.8 2016-01-08
GB1600381.6 2016-01-08
GBGB1600382.4A GB201600382D0 (en) 2016-01-08 2016-01-08 Engineered virus
PCT/GB2017/050036 WO2017118864A1 (en) 2016-01-08 2017-01-09 Modified oncolytic viurs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021163811A Division JP7295192B2 (ja) 2016-01-08 2021-10-05 改変された腫瘍溶解性ウイルス

Publications (3)

Publication Number Publication Date
JP2019501670A JP2019501670A (ja) 2019-01-24
JP2019501670A5 true JP2019501670A5 (OSRAM) 2020-01-30
JP6959258B2 JP6959258B2 (ja) 2021-11-02

Family

ID=57796748

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2018555309A Active JP6959258B2 (ja) 2016-01-08 2017-01-09 改変された腫瘍溶解性ウイルス
JP2018555311A Active JP7038664B2 (ja) 2016-01-08 2017-01-09 操作された腫瘍溶解性ウイルス
JP2018555310A Active JP7038065B2 (ja) 2016-01-08 2017-01-09 腫瘍溶解性ウイルス株
JP2021163811A Active JP7295192B2 (ja) 2016-01-08 2021-10-05 改変された腫瘍溶解性ウイルス
JP2022034569A Pending JP2022078225A (ja) 2016-01-08 2022-03-07 操作された腫瘍溶解性ウイルス
JP2023094818A Pending JP2023113885A (ja) 2016-01-08 2023-06-08 改変された腫瘍溶解性ウイルス
JP2024119344A Pending JP2024153748A (ja) 2016-01-08 2024-07-25 操作された腫瘍溶解性ウイルス
JP2025128636A Pending JP2025163138A (ja) 2016-01-08 2025-07-31 改変された腫瘍溶解性ウイルス

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2018555311A Active JP7038664B2 (ja) 2016-01-08 2017-01-09 操作された腫瘍溶解性ウイルス
JP2018555310A Active JP7038065B2 (ja) 2016-01-08 2017-01-09 腫瘍溶解性ウイルス株
JP2021163811A Active JP7295192B2 (ja) 2016-01-08 2021-10-05 改変された腫瘍溶解性ウイルス
JP2022034569A Pending JP2022078225A (ja) 2016-01-08 2022-03-07 操作された腫瘍溶解性ウイルス
JP2023094818A Pending JP2023113885A (ja) 2016-01-08 2023-06-08 改変された腫瘍溶解性ウイルス
JP2024119344A Pending JP2024153748A (ja) 2016-01-08 2024-07-25 操作された腫瘍溶解性ウイルス
JP2025128636A Pending JP2025163138A (ja) 2016-01-08 2025-07-31 改変された腫瘍溶解性ウイルス

Country Status (13)

Country Link
US (13) US10626377B2 (OSRAM)
EP (8) EP3778881A1 (OSRAM)
JP (8) JP6959258B2 (OSRAM)
KR (2) KR20250026348A (OSRAM)
CN (3) CN109153977B (OSRAM)
AU (2) AU2017205216B2 (OSRAM)
CA (3) CA3010987A1 (OSRAM)
DK (4) DK3400291T4 (OSRAM)
ES (4) ES2831080T5 (OSRAM)
IL (2) IL260480B (OSRAM)
MX (1) MX2018008413A (OSRAM)
SG (2) SG11201805835WA (OSRAM)
WO (4) WO2017118865A1 (OSRAM)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2695101A (en) * 2000-01-21 2001-07-31 Biovex Ltd Virus strains
TWI531652B (zh) 2005-12-02 2016-05-01 美國紐約大學西奈山醫學院 表現非原生表面蛋白質之嵌合病毒及其用途
WO2008153832A2 (en) 2007-05-31 2008-12-18 Krishnan Ramu Switched reluctance machines with minimum stator core
NZ711946A (en) 2013-03-14 2020-05-29 Icahn School Med Mount Sinai Newcastle disease viruses and uses thereof
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
NZ739503A (en) 2015-07-16 2023-06-30 Bioxcel Therapeutics Inc A novel approach for treatment of cancer using immunomodulation
CA3010987A1 (en) 2016-01-08 2017-07-13 Replimune Limited Oncolytic herpes simplex virus type 1 strain
BR112018015390A2 (pt) 2016-01-27 2018-12-18 Oncorus, Inc. vetores virais oncolíticos e usos dos mesmos
RS65430B1 (sr) 2016-03-16 2024-05-31 Amal Therapeutics Sa Kombinacija modulatora imunološke kontrolne tačke i kompleksa koji sadrži peptid koji prodire u ćeliju, teret i tlr peptidni agonist za primenu u medicini
EP3380621A4 (en) * 2016-04-22 2019-05-08 Immvira Co., Limited CONSTRUCTION OF THE VECTOR OF OBLIGATES ONCOLYTIC HERPES SIMPLEX VIRUSES (OHSV) AND CANCER THERAPY CONSTRUCTIONS
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
US10888594B2 (en) 2016-05-30 2021-01-12 National University Corporation Tottori University Genetically engineered vaccinia viruses
US20190336552A1 (en) 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
WO2018006005A1 (en) 2016-06-30 2018-01-04 Oncorus, Inc. Pseudotyped oncolytic viral delivery of therapeutic polypeptides
KR102879364B1 (ko) 2016-09-21 2025-11-04 아말 테라퓨틱스 에스에이 암 치료를 위한, 세포 투과 펩타이드, 멀티 에피토프 및 tlr 펩타이드 작용제를 포함하는 융합체
CN108261426B (zh) * 2017-01-04 2019-04-05 杭州康万达医药科技有限公司 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用
GB201700350D0 (en) * 2017-01-09 2017-02-22 Replimune Ltd Altered virus
KR20190139225A (ko) 2017-04-28 2019-12-17 머크 샤프 앤드 돔 코포레이션 암 치료제용 생물마커
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
WO2019023483A1 (en) 2017-07-26 2019-01-31 Oncorus, Inc. ONCOLYTIC VIRAL VECTORS AND USES THEREOF
TN2020000015A1 (en) 2017-08-03 2021-10-04 Amgen Inc Interleukin-21 muteins and methods of treatment
EP4403175A3 (en) 2017-09-08 2024-10-02 Amgen Inc. Inhibitors of kras g12c and methods of using the same
CN109554353B (zh) * 2017-09-26 2021-08-06 杭州康万达医药科技有限公司 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
EP3708657A4 (en) * 2017-11-08 2021-08-25 Kagoshima University ONCOLYTIC VIRUS (ONCOLYTIC IMMUNOTHERAPY) THAT IS CAPABLE OF TREATING METASTATIC CANCER ALSO WITH ENSURED SAFETY, WITH EXPRESSION CONTROL SYSTEM THAT BUILDS AN OPTIMAL EXPRESSION LEVEL
BR112020009363A2 (pt) * 2017-11-13 2020-10-27 Bioxcel Therapeutics, Inc. métodos e composições para tratar câncer por modificação de múltiplos braços do sistema imunológico
US11865081B2 (en) 2017-12-29 2024-01-09 Virogin Biotech Canada Ltd. Oncolytic viral delivery of therapeutic polypeptides
SG11202005605SA (en) 2018-01-12 2020-07-29 Amgen Inc Anti-pd-1 antibodies and methods of treatment
WO2019147982A1 (en) * 2018-01-26 2019-08-01 Celldex Therapeutics, Inc. Methods of treating cancer with dendritic cell mobilizing agents
GB201804473D0 (en) * 2018-03-21 2018-05-02 Valo Therapeutics Oy Modified oncolytic adenoviruses
CN108635380A (zh) * 2018-04-13 2018-10-12 北京唯源立康生物科技有限公司 重组溶瘤病毒组合物及其在制备用于治疗肿瘤的药物中的应用
JP2021527694A (ja) * 2018-06-21 2021-10-14 レプリミュン リミテッド 腫瘍溶解性ウイルスを用いた処置
AU2019292580A1 (en) * 2018-06-29 2021-02-04 Krystal Biotech, Inc. Compositions and methods for antibody delivery
CN109161561A (zh) * 2018-08-09 2019-01-08 湖北科技学院 一种选择性杀灭前列腺癌细胞的新型溶瘤病毒及其构建方法
WO2020037215A1 (en) 2018-08-17 2020-02-20 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease
WO2020052551A1 (en) * 2018-09-10 2020-03-19 Genesail Biotech (Shanghai) Co. Ltd. A modified oncolytic virus, composition and use thereof
US11638730B2 (en) * 2018-09-26 2023-05-02 Astellas Pharma Inc. Cancer therapy by combination use of oncolytic vaccinia virus and immune checkpoint inhibitor, and pharmaceutical composition and combination medicine for use in the cancer therapy
AR117547A1 (es) 2018-12-27 2021-08-11 Amgen Inc Formulaciones de virus liofilizadas
CN111606999B (zh) * 2019-02-26 2022-09-06 南京惟亚德生物医药有限公司 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用
AU2020232264A1 (en) * 2019-03-05 2021-08-26 Amgen Inc. Use of oncolytic viruses for the treatment of cancer
TW202102543A (zh) 2019-03-29 2021-01-16 美商安進公司 溶瘤病毒在癌症新輔助療法中之用途
CN110054678B (zh) * 2019-05-16 2023-04-18 中国医学科学院血液病医院(血液学研究所) 一种膜结合型mFLT3LG蛋白及其应用
CN110218707B (zh) * 2019-05-29 2021-10-22 上海市公共卫生临床中心 一种新型溶瘤病毒及其制备方法和应用
WO2021024897A1 (ja) * 2019-08-05 2021-02-11 国立大学法人東海国立大学機構 悪性腫瘍を治療するための併用薬、悪性腫瘍を治療するための医薬組成物、および、悪性腫瘍治療用医薬組成物
AU2020378088A1 (en) * 2019-11-06 2022-05-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Replication-enhanced oncolytic adenoviruses
CN110982795B (zh) * 2020-03-05 2020-06-16 北京唯源立康生物科技有限公司 一种单纯疱疹病毒及其用途
CN110982794B (zh) * 2020-03-05 2020-06-16 北京唯源立康生物科技有限公司 一种修饰的单纯疱疹病毒
EP4112724A4 (en) * 2020-03-05 2023-08-23 Beijing Wellgene Biotech Co., Ltd. HERPES SIMPLEX VIRUS AND ITS USE
JPWO2021193081A1 (OSRAM) * 2020-03-23 2021-09-30
EP4172323A1 (en) 2020-06-29 2023-05-03 Flagship Pioneering Innovations V, Inc. Viruses engineered to promote thanotransmission and their use in treating cancer
US11839659B2 (en) 2020-07-02 2023-12-12 Northwestern University Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein
CN112941039A (zh) * 2021-02-01 2021-06-11 南京大学 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用
DE102022104146A1 (de) 2021-03-19 2022-09-22 Yamada Manufacturing Co., Ltd. Lenkvorrichtung
AU2022255538A1 (en) * 2021-04-08 2023-09-28 Immvira Biopharmaceuticals Co., Limited Genetically modified oncolytic herpes simplex virus delivering chemokine and tumor associated/specific antigen
WO2022245808A1 (en) * 2021-05-18 2022-11-24 The Penn State Research Foundation Oncolytic virus based cancer therapy
CN113583979B (zh) * 2021-08-03 2022-11-22 杭州荣谷生物科技有限公司 一种重组溶瘤痘苗病毒、制备方法及其用途
EP4464441A4 (en) 2022-01-11 2025-12-03 Mitsubishi Materials Corp CUTTING TOOL WITH A SURFACE COATING
WO2024055022A2 (en) * 2022-09-08 2024-03-14 Virogin Biotech Canada Ltd Oncolytic virus expressing an immune cell engager for tumor targeting
WO2025248110A1 (en) * 2024-05-31 2025-12-04 Replimune Limited An oncolytic herpes simplex virus (hsv) and an anti-pd-1 antibody for use in treating braf mutant melanoma

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU594014B2 (en) 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
CA1282721C (en) 1984-06-04 1991-04-09 Bernard Roizman Herpes simplex virus as a vector
US5288641A (en) 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
DE3584341D1 (de) 1984-08-24 1991-11-14 Upjohn Co Rekombinante dna-verbindungen und expression von polypeptiden wie tpa.
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5698531A (en) 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5328688A (en) 1990-09-10 1994-07-12 Arch Development Corporation Recombinant herpes simplex viruses vaccines and methods
US6770274B1 (en) 1990-09-14 2004-08-03 The General Hospital Corporation Viral mutant HSV mediated destruction of neoplastic cells
US6040169A (en) 1991-01-31 2000-03-21 Medical Research Council Herpes simplex virus-1 deletion variants and vaccines thereof
JP3974167B2 (ja) 1992-03-31 2007-09-12 アーチ デベロプメント コーポレイション 遺伝子,腫瘍及びウイルス感染の治療,並びにプログラムされた細胞死(アポプトーシス)を予防するための方法及び組成物
US6699468B1 (en) 1994-06-23 2004-03-02 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
CA2234060A1 (en) 1995-10-06 1997-04-10 Arch Development Corporation Methods and compositions for viral enhancement of cell killing
US5824318A (en) 1996-07-24 1998-10-20 American Cyanamid Company Avirulent herpetic viruses useful as tumoricidal agents and vaccines
GB9700411D0 (en) 1997-01-10 1997-02-26 Univ London Eukaryotic gene expression cassette and uses thereof
US6379674B1 (en) 1997-08-12 2002-04-30 Georgetown University Use of herpes vectors for tumor therapy
US7300774B1 (en) 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
US6428968B1 (en) 1999-03-15 2002-08-06 The Trustees Of The University Of Pennsylvania Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject
CA2388807C (en) 1999-11-12 2013-08-06 Matthew C. Coffey Viruses for the treatment of cellular proliferative disorders
AU2695101A (en) 2000-01-21 2001-07-31 Biovex Ltd Virus strains
EP1381280B1 (en) 2001-03-27 2011-05-11 Catherex, Inc. Viral vectors and their use in therapeutic methods
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
WO2006002394A2 (en) 2004-06-24 2006-01-05 New York University Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
EP1819735A1 (en) 2004-11-04 2007-08-22 Pfizer Products Inc. Ctla-4 antibody and aromatase inhibitor or combination treatment for breast cancer
US9866961B2 (en) 2004-12-01 2018-01-09 Todd Beauchamp Multi-channel loudspeaker enclosure with laterally projecting wings and method for orienting and driving multiple loudspeakers
KR100996801B1 (ko) 2005-03-08 2010-11-25 파마시아 앤드 업존 캄파니 엘엘씨 항-MAdCAM 항체 조성물
PT2650020T (pt) 2005-05-06 2016-12-12 Providence Health & Services - Oregon Proteína de fusão de imunoglobulina ox-40 trimérica e métodos do campo de utilização
EP1909849B1 (en) 2005-06-23 2013-08-07 The University Of Houston Use of mutant herpes simplex virus-2 for cancer therapy
GB0522476D0 (en) 2005-11-03 2005-12-14 Biovex Ltd Oncolytic herpes virus vectors
AU2007241023B2 (en) 2006-03-30 2013-11-28 University Of California Methods and compositions for localized secretion of anti-CTLA-4 antibodies
US8313896B2 (en) * 2008-04-04 2012-11-20 The General Hospital Corporation Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer
EP2307033A4 (en) 2008-05-29 2012-06-13 Gen Hospital Corp USE OF ONCOLYTIC HERPESVIRUS FOR THE KILLING OF CANCER STEM CELLS
BRPI0920679A2 (pt) 2008-10-08 2022-05-17 Intrexon Corp Células construídas expressando múltiplos imunomoduladores e usos das mesmas
US20100297072A1 (en) 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
CA2781300A1 (en) 2009-11-20 2011-05-26 Infinity Pharmaceuticals, Inc. Methods and compositions for treating hedgehog-associated cancers
WO2011119925A2 (en) * 2010-03-25 2011-09-29 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthetic herpes simplex viruses for treatment of cancers
WO2011118866A1 (ko) 2010-03-26 2011-09-29 연세대학교 산학협력단 네트워크를 통한 심사요청 방법
CN103221544A (zh) * 2010-09-24 2013-07-24 昂克斯治疗有限公司 编码单克隆抗-ctla-4抗体的溶瘤腺病毒载体
HRP20182194T1 (hr) * 2011-09-08 2019-02-22 New York University Onkolitički herpes simpleks virus i njegova terapeutska uporaba
FI20115914L (fi) 2011-09-16 2013-03-17 Oncos Therapeutics Ltd Muunnettu onkolyyttinen virus
DK2806883T3 (da) * 2012-01-25 2019-07-22 Dnatrix Inc Biomarkører og kombinationsterapier under anvendelse af onkolytisk virus og immunomodulation
US20150190505A1 (en) 2012-07-30 2015-07-09 Alex Wah Hin Yeung Live and in-vivo tumor specific cancer vaccine system developed by co-administration of either at least two or all three of the following components such as tumor cells, an oncolytic virus vector with transgenic expression of gm-csf and an immune checkpoint modulator
ES2871910T3 (es) 2012-08-30 2021-11-02 Amgen Inc Un método para tratar el melanoma usando un virus de herpes simple y un inhibidor de puntos de control inmunitario
WO2014066532A1 (en) 2012-10-23 2014-05-01 Bristol-Myers Squibb Company Combination of anti-kir and anti-ctla-4 antibodies to treat cancer
HK1211235A1 (en) 2013-02-22 2016-05-20 霍夫曼-拉罗奇有限公司 Methods of treating cancer and preventing drug resistance
NZ711946A (en) 2013-03-14 2020-05-29 Icahn School Med Mount Sinai Newcastle disease viruses and uses thereof
EA039404B1 (ru) 2013-09-03 2022-01-24 Медиммун Лимитед Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием
EP3831398A1 (en) 2013-10-25 2021-06-09 PsiOxus Therapeutics Limited Oncolytic adenoviruses armed with heterologous genes
JP6588024B2 (ja) 2013-10-28 2019-10-09 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 腫瘍溶解性hsvベクター
CA2931322A1 (en) 2013-11-22 2015-05-28 Dnatrix, Inc. Adenovirus expressing immune cell stimulatory receptor agonist(s)
WO2015128313A1 (en) 2014-02-25 2015-09-03 Deutsches Krebsforschungszentrum Rna viruses for immunovirotherapy
MA39818A (fr) * 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
EP3169340B1 (en) 2014-07-16 2020-09-02 Institut Gustave Roussy Combination of oncolytic virus with immune checkpoint modulators
EP3552615B8 (en) 2014-07-16 2022-03-02 Transgene Oncolytic virus for expression of immune checkpoint modulators
US20160040186A1 (en) 2014-08-07 2016-02-11 Xiaoyun Liu Dna construct and method for transgene expression
GB201419579D0 (en) 2014-11-03 2014-12-17 Iomet Pharma Ltd Pharmaceutical compound
CA2974529C (en) 2015-01-23 2023-08-15 Dreamwell, Ltd. Automated mattress manufacturing process and apparatus
CA3010987A1 (en) * 2016-01-08 2017-07-13 Replimune Limited Oncolytic herpes simplex virus type 1 strain
EP3380621A4 (en) 2016-04-22 2019-05-08 Immvira Co., Limited CONSTRUCTION OF THE VECTOR OF OBLIGATES ONCOLYTIC HERPES SIMPLEX VIRUSES (OHSV) AND CANCER THERAPY CONSTRUCTIONS
GB201700350D0 (en) 2017-01-09 2017-02-22 Replimune Ltd Altered virus
US12029647B2 (en) * 2017-03-07 2024-07-09 4C Medical Technologies, Inc. Systems, methods and devices for prosthetic heart valve with single valve leaflet
JP2021527694A (ja) 2018-06-21 2021-10-14 レプリミュン リミテッド 腫瘍溶解性ウイルスを用いた処置
AU2019410148A1 (en) 2018-12-21 2021-08-12 Ottawa Hospital Research Institute Modified orthopoxvirus vectors

Similar Documents

Publication Publication Date Title
JP2019501670A5 (OSRAM)
JP2019501671A5 (OSRAM)
JP2019500909A5 (OSRAM)
JP7295192B2 (ja) 改変された腫瘍溶解性ウイルス
JP2020503871A5 (OSRAM)
US20240358781A1 (en) Altered virus
Guo et al. Oncolytic immunotherapy: conceptual evolution, current strategies, and future perspectives
JP2024095709A5 (OSRAM)
US20210252135A1 (en) Treatment using oncolytic virus
Dong et al. Combination therapy with oncolytic viruses and immune checkpoint inhibitors in head and neck squamous cell carcinomas: an approach of complementary advantages
Meng et al. Advances in the study of antitumour immunotherapy for Newcastle disease virus
US12331079B2 (en) Oncolytic virus platform to treat cancers with myxoma virus
CN107073099A (zh) 用于治疗癌症的联合方法
Wang et al. Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy?
JPWO2019243847A5 (OSRAM)
Zinovieva et al. Oncolytic Vesicular Stomatitis Virus: Optimisation Strategies for Anti-Cancer Therapies
AU2019333181B2 (en) Chimeric oncolytic herpesvirus that stimulate an antitumor immune response
Lasek et al. Interleukin 12: Antitumor activity and immunotherapeutic potential in oncology
US20220088183A1 (en) Chimeric oncolytic herpesvirus that stimulates an antitumor immune response
WO2024120489A1 (en) Use of dr-18 and oncolytic vaccinia virus in preparation of anti-tumor drug
Sriuranpong et al. EMPOWER-lung 1: A randomized, open-label, multi-national, phase III trial of cemiplimab, a human PD-1 monoclonal antibody, versus chemotherapy in first-line treatment of advanced non-small cell lung cancer (NSCLC) with PD-L1≥ 50%
Hendriks et al. Phase I safety and pharmacokinetics of ADU-1604, an anti-CTLA-4 antibody, in adults with metastatic melanoma
Brown Tumor/Virus-Induced Cytokine Production