|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
USD309535S
(en)
|
1987-03-30 |
1990-07-31 |
Chromcraft Furniture Corp. |
Chair
|
|
USD360535S
(en)
|
1994-02-14 |
1995-07-25 |
Staffan Sjoberg |
Combined beach chair and beach mattress
|
|
US6635632B1
(en)
|
1996-12-23 |
2003-10-21 |
Athena Neurosciences, Inc. |
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
|
|
HUP0001232A3
(en)
|
1996-12-23 |
2001-02-28 |
Elan Pharmaceuticals Inc San F |
Cycloalkyl, lactam, lactone derivatives and their thio analogues inhibiting betha-amyloid peptide release and/or its synthesis and pharmaceutical compositions containing the compounds
|
|
US6683048B1
(en)
|
1997-04-10 |
2004-01-27 |
Mcgill University |
Compounds and methods for stimulating gene expression and cellular differentiation
|
|
WO1999065897A1
(en)
|
1998-06-19 |
1999-12-23 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
WO2000059939A1
(en)
|
1999-04-05 |
2000-10-12 |
Adherex Technologies Inc. |
COMPOUNDS AND METHODS FOR STIMULATING β-CATENIN MEDIATED GENE EXPRESSION AND DIFFERENTIATION
|
|
JP2003516974A
(ja)
|
1999-12-17 |
2003-05-20 |
カイロン コーポレイション |
グリコーゲンシンターゼキナーゼ３のピラジンベースインヒビター
|
|
JP2003520266A
(ja)
|
2000-01-24 |
2003-07-02 |
メルク シャープ エンド ドーム リミテッド |
γ−セクレターゼ阻害薬
|
|
GB0005251D0
(en)
|
2000-03-03 |
2000-04-26 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
WO2001070677A1
(en)
|
2000-03-20 |
2001-09-27 |
Merck Sharp & Dohme Limited |
Sulphonamido-substituted bridged bicycloalkyl derivatives
|
|
GB0008710D0
(en)
|
2000-04-07 |
2000-05-31 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
USD447031S1
(en)
|
2000-04-20 |
2001-08-28 |
Wang Keaun Oh |
Hand carry air tacker
|
|
CN1441841B
(zh)
|
2000-07-11 |
2013-03-20 |
桑得医药品公司 |
对内耳的细胞再生和分化的刺激
|
|
WO2002059285A1
(en)
|
2000-10-27 |
2002-08-01 |
Fred Hutchinson Cancer Research Center |
Methods for immortalizing cells
|
|
CA2427206C
(en)
|
2000-11-02 |
2011-06-28 |
Merck Sharp & Dohme Limited |
Sulfamides as gamma-secretase inhibitors
|
|
UA74849C2
(en)
|
2000-11-17 |
2006-02-15 |
Lilly Co Eli |
Lactam
|
|
US7468365B2
(en)
|
2000-11-17 |
2008-12-23 |
Eli Lilly And Company |
Lactam compound
|
|
US6483732B2
(en)
|
2000-12-13 |
2002-11-19 |
Koninklijke Philips Electronics N.V. |
Relational content addressable memory
|
|
GB0119152D0
(en)
|
2001-08-06 |
2001-09-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7206639B2
(en)
|
2002-03-15 |
2007-04-17 |
Sarcos Investments Lc |
Cochlear drug delivery system and method
|
|
EP1503998B1
(en)
|
2002-05-01 |
2009-07-01 |
MERCK SHARP & DOHME LTD. |
Heteroaryl substituted spirocyclic sufamides for inhibition of gamma secretase
|
|
GB0209991D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0209995D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0209997D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0223038D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
GB0223039D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
GB0225475D0
(en)
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0225474D0
(en)
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7456190B2
(en)
|
2003-03-13 |
2008-11-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as protein kinase inhibitors
|
|
KR20060002908A
(ko)
|
2003-03-31 |
2006-01-09 |
와이어쓰 |
베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체
|
|
WO2005010524A1
(en)
|
2003-06-04 |
2005-02-03 |
Curis, Inc. |
Stem cell-based methods for identifying and characterizing agents
|
|
GB0318447D0
(en)
|
2003-08-05 |
2003-09-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2537099A1
(en)
|
2003-08-28 |
2005-03-10 |
Choongwae Pharma Corporation |
Modulation of .beta.-catenin/tcf activated transcription
|
|
US7514459B2
(en)
|
2003-09-24 |
2009-04-07 |
Merck Sharp & Dohme Ltd. |
Gamma-secretase inhibitors
|
|
GB0326039D0
(en)
|
2003-11-07 |
2003-12-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US8673634B2
(en)
|
2003-11-13 |
2014-03-18 |
Massachusetts Eye & Ear Infirmary |
Method for the treatment of hearing loss
|
|
US20050256036A1
(en)
|
2004-01-27 |
2005-11-17 |
Boyle Bryan J |
Gastrointestinal proliferative factor and uses thereof
|
|
WO2005072793A1
(en)
|
2004-01-29 |
2005-08-11 |
The Charles Stark Draper Laboratory, Inc. |
Implantable drug delivery apparatus
|
|
SI1720909T1
(sl)
|
2004-02-23 |
2012-01-31 |
Lilly Co Eli |
Anti-abeta protitelo
|
|
JP2006117536A
(ja)
*
|
2004-10-19 |
2006-05-11 |
Kyoto Univ |
内耳の有毛細胞を誘導するための医薬
|
|
US9265933B2
(en)
|
2005-09-08 |
2016-02-23 |
Massachusetts Eye And Ear Infirmary |
Cochlear implants containing biological cells and uses thereof
|
|
US20090306045A1
(en)
|
2005-12-22 |
2009-12-10 |
Ira Mellman |
Inhibition of Glycogen Synthase Kinase and Methods of Treating Autoimmune or Immune Inflammatory Disease
|
|
CA2644136A1
(en)
|
2006-02-27 |
2007-09-07 |
The Johns Hopkins University |
Cancer treatment with gamma-secretase inhibitors
|
|
WO2007121272A2
(en)
*
|
2006-04-11 |
2007-10-25 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions involving nucleotide repeat disorders
|
|
US8175269B2
(en)
|
2006-07-05 |
2012-05-08 |
Oracle International Corporation |
System and method for enterprise security including symmetric key protection
|
|
WO2008076556A2
(en)
|
2006-11-15 |
2008-06-26 |
Massachusetts Eye & Ear Infirmary |
Generation of inner ear cells
|
|
WO2008071605A2
(en)
|
2006-12-15 |
2008-06-19 |
F. Hoffmann-La Roche Ag |
Methods of treating inflammatory diseases
|
|
JP5385904B2
(ja)
|
2007-08-14 |
2014-01-08 |
イーライ リリー アンド カンパニー |
γ−セクレターゼ阻害剤
|
|
WO2009047163A1
(en)
|
2007-10-10 |
2009-04-16 |
F. Hoffmann-La Roche Ag |
Methods of treating inflammatory diseases
|
|
MA33076B1
(fr)
|
2008-01-11 |
2012-03-01 |
Hoffmann La Roche |
Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer
|
|
US8188131B2
(en)
|
2008-02-07 |
2012-05-29 |
Massachusetts Eye & Ear Infirmary |
Compounds that enhance Atoh1 expression
|
|
GB2459910B
(en)
|
2008-04-21 |
2010-03-31 |
Otonomy Inc |
Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders
|
|
EP2278999B1
(en)
|
2008-04-21 |
2025-01-29 |
Dompé farmaceutici S.p.A. |
Auris formulations for treating otic diseases and conditions
|
|
US8030297B2
(en)
|
2008-05-14 |
2011-10-04 |
Otonomy, Inc. |
Controlled release corticosteroid compositions and methods for the treatment of OTIC disorders
|
|
US8648119B2
(en)
*
|
2008-05-23 |
2014-02-11 |
Otonomy, Inc. |
Controlled release immunomodulator compositions and methods for the treatment of otic disorders
|
|
US8496957B2
(en)
|
2008-07-21 |
2013-07-30 |
Otonomy, Inc |
Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
|
|
AU2009316264B2
(en)
|
2008-11-24 |
2016-09-15 |
Massachusetts Eye & Ear Infirmary |
Pathways to generate hair cells
|
|
WO2010068564A1
(en)
|
2008-12-11 |
2010-06-17 |
Merck Sharp & Dohme Corp. |
Method for treating alzheimer's disease and related conditions
|
|
WO2010090954A1
(en)
|
2009-02-06 |
2010-08-12 |
Merck Sharp & Dohme Corp. |
Novel trifluoromethylsulfonamide gamma secretase inhibitor
|
|
SI2493876T1
(sl)
|
2009-10-28 |
2014-04-30 |
Pfizer Inc. |
Derivati imidazola kot inhibitorji kazein-kinaze
|
|
CA134865S
(en)
|
2010-02-11 |
2010-11-10 |
Hankook Tire Co Ltd |
Automobile tire
|
|
WO2012005805A1
(en)
|
2010-05-07 |
2012-01-12 |
Glaxosmithkline Llc |
Azaindazoles
|
|
US8895528B2
(en)
|
2010-05-26 |
2014-11-25 |
Curna, Inc. |
Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
|
|
WO2012018499A2
(en)
|
2010-08-05 |
2012-02-09 |
Acetylon Pharmaceuticals |
Specific regulation of cytokine levels by hdac6 inhibitors
|
|
RU2456356C1
(ru)
|
2011-04-29 |
2012-07-20 |
Борис Сергеевич Кустов |
Коллоидный раствор наносеребра и способ его получения
|
|
US20150209367A1
(en)
*
|
2012-09-07 |
2015-07-30 |
Massachusetts Eye & Ear Infirmary |
Treating Hearing Loss
|
|
US20150209406A1
(en)
|
2012-09-07 |
2015-07-30 |
Massachusetts Eye And Ear Infirmary |
Methods and compositions for regenerating hair cells and/or supporting cells
|
|
PL2970890T3
(pl)
|
2013-03-14 |
2020-11-16 |
The Brigham And Women's Hospital, Inc. |
Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych
|
|
US9572815B2
(en)
|
2013-03-15 |
2017-02-21 |
St. Jude Children's Research Hospital |
Methods and compositions of p27KIP1 transcriptional modulators
|
|
US10603295B2
(en)
|
2014-04-28 |
2020-03-31 |
Massachusetts Eye And Ear Infirmary |
Sensorineural hair cell differentiation
|
|
WO2016022776A2
(en)
|
2014-08-06 |
2016-02-11 |
Massachusetts Eye And Ear Infirmary |
Increasing atoh1 life to drive sensorineural hair cell differentiantion
|
|
JO3491B1
(ar)
|
2015-07-07 |
2020-07-05 |
Audion Therapeutics |
مركبات مثبطة لإشارات مسار notch
|
|
US11185536B2
(en)
|
2015-12-04 |
2021-11-30 |
Massachusetts Eye And Ear Infirmary |
Treatment of hearing loss by inhibition of casein kinase 1
|
|
US11021687B2
(en)
|
2016-01-08 |
2021-06-01 |
The Brigham And Women's Hospital, Inc. |
Production of differentiated enteroendocrine cells and insulin producing cells
|
|
EP3407901B1
(en)
|
2016-01-29 |
2021-07-21 |
Massachusetts Eye & Ear Infirmary |
Expansion and differentiation of inner ear supporting cells and methods of use thereof
|
|
WO2018111926A2
(en)
|
2016-12-16 |
2018-06-21 |
Inception 3, Inc. |
Methods of treating cochlear synaptopathy
|
|
US20220008433A1
(en)
|
2018-11-30 |
2022-01-13 |
Massachusetts Eye And Ear Infirmary |
Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells
|