CA2883896C - Treating hearing loss - Google Patents

Treating hearing loss Download PDF

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Publication number
CA2883896C
CA2883896C CA2883896A CA2883896A CA2883896C CA 2883896 C CA2883896 C CA 2883896C CA 2883896 A CA2883896 A CA 2883896A CA 2883896 A CA2883896 A CA 2883896A CA 2883896 C CA2883896 C CA 2883896C
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CA
Canada
Prior art keywords
composition
cells
use according
hair
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2883896A
Other languages
English (en)
French (fr)
Other versions
CA2883896A1 (en
Inventor
Albert Edge
Hideyuki Okano
Masato Fujioka
Kunio MIZUTARI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Eye and Ear
Original Assignee
Massachusetts Eye and Ear Infirmary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye and Ear Infirmary filed Critical Massachusetts Eye and Ear Infirmary
Publication of CA2883896A1 publication Critical patent/CA2883896A1/en
Application granted granted Critical
Publication of CA2883896C publication Critical patent/CA2883896C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2883896A 2012-09-07 2013-09-06 Treating hearing loss Active CA2883896C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261698475P 2012-09-07 2012-09-07
US61/698,475 2012-09-07
PCT/US2013/058446 WO2014039781A1 (en) 2012-09-07 2013-09-06 Treating hearing loss

Publications (2)

Publication Number Publication Date
CA2883896A1 CA2883896A1 (en) 2014-03-13
CA2883896C true CA2883896C (en) 2023-03-07

Family

ID=50237627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2883896A Active CA2883896C (en) 2012-09-07 2013-09-06 Treating hearing loss

Country Status (7)

Country Link
US (3) US20150209367A1 (https=)
EP (2) EP3970725B1 (https=)
JP (4) JP2015527398A (https=)
AU (1) AU2013312358B2 (https=)
CA (1) CA2883896C (https=)
HK (1) HK1211875A1 (https=)
WO (1) WO2014039781A1 (https=)

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US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
EP3407901B1 (en) 2016-01-29 2021-07-21 Massachusetts Eye & Ear Infirmary Expansion and differentiation of inner ear supporting cells and methods of use thereof
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WO2018111926A2 (en) * 2016-12-16 2018-06-21 Inception 3, Inc. Methods of treating cochlear synaptopathy
CA3114113A1 (en) 2018-10-02 2020-04-09 Frequency Therapeutics, Inc. Pharmaceutical compositions and methods related to otic therapeutic agents
US20220175776A1 (en) 2019-04-08 2022-06-09 Frequency Therapeutics, Inc. Combination of chir99021 and valproic acid for treating hearing loss
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Also Published As

Publication number Publication date
EP2892506A1 (en) 2015-07-15
US20210299138A1 (en) 2021-09-30
US20180369253A1 (en) 2018-12-27
CA2883896A1 (en) 2014-03-13
EP2892506B1 (en) 2021-11-03
EP3970725B1 (en) 2025-08-20
US12161647B2 (en) 2024-12-10
US10898492B2 (en) 2021-01-26
WO2014039781A1 (en) 2014-03-13
EP3970725A1 (en) 2022-03-23
JP2019172679A (ja) 2019-10-10
JP2021038228A (ja) 2021-03-11
EP2892506A4 (en) 2016-04-20
JP2022109965A (ja) 2022-07-28
AU2013312358A1 (en) 2015-03-19
AU2013312358B2 (en) 2018-08-09
JP2015527398A (ja) 2015-09-17
US20150209367A1 (en) 2015-07-30
HK1211875A1 (en) 2016-06-03

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