AU2013312358B2 - Treating hearing loss - Google Patents

Treating hearing loss Download PDF

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Publication number
AU2013312358B2
AU2013312358B2 AU2013312358A AU2013312358A AU2013312358B2 AU 2013312358 B2 AU2013312358 B2 AU 2013312358B2 AU 2013312358 A AU2013312358 A AU 2013312358A AU 2013312358 A AU2013312358 A AU 2013312358A AU 2013312358 B2 AU2013312358 B2 AU 2013312358B2
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AU
Australia
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khz
pct
rule
substitute sheet
cells
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AU2013312358A
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AU2013312358A1 (en
Inventor
Albert Edge
Masato Fujioka
Kunio MIZUTARI
Hideyuki Okano
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Massachusetts Eye and Ear
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Massachusetts Eye and Ear Infirmary
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2013312358A 2012-09-07 2013-09-06 Treating hearing loss Active AU2013312358B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261698475P 2012-09-07 2012-09-07
US61/698,475 2012-09-07
PCT/US2013/058446 WO2014039781A1 (en) 2012-09-07 2013-09-06 Treating hearing loss

Publications (2)

Publication Number Publication Date
AU2013312358A1 AU2013312358A1 (en) 2015-03-19
AU2013312358B2 true AU2013312358B2 (en) 2018-08-09

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ID=50237627

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013312358A Active AU2013312358B2 (en) 2012-09-07 2013-09-06 Treating hearing loss

Country Status (7)

Country Link
US (3) US20150209367A1 (https=)
EP (2) EP3970725B1 (https=)
JP (4) JP2015527398A (https=)
AU (1) AU2013312358B2 (https=)
CA (1) CA2883896C (https=)
HK (1) HK1211875A1 (https=)
WO (1) WO2014039781A1 (https=)

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US11185536B2 (en) 2015-12-04 2021-11-30 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
EP3407901B1 (en) 2016-01-29 2021-07-21 Massachusetts Eye & Ear Infirmary Expansion and differentiation of inner ear supporting cells and methods of use thereof
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US10576125B2 (en) 2016-10-31 2020-03-03 Hough Ear Institute Methods for enhancing synaptogenesis and neuritogenesis
WO2018111926A2 (en) * 2016-12-16 2018-06-21 Inception 3, Inc. Methods of treating cochlear synaptopathy
CA3114113A1 (en) 2018-10-02 2020-04-09 Frequency Therapeutics, Inc. Pharmaceutical compositions and methods related to otic therapeutic agents
US20220175776A1 (en) 2019-04-08 2022-06-09 Frequency Therapeutics, Inc. Combination of chir99021 and valproic acid for treating hearing loss
TWI781536B (zh) 2021-02-26 2022-10-21 國立臺灣科技大學 藥物釋放組合物、其製造方法及其用途

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Also Published As

Publication number Publication date
EP2892506A1 (en) 2015-07-15
US20210299138A1 (en) 2021-09-30
US20180369253A1 (en) 2018-12-27
CA2883896A1 (en) 2014-03-13
EP2892506B1 (en) 2021-11-03
EP3970725B1 (en) 2025-08-20
US12161647B2 (en) 2024-12-10
US10898492B2 (en) 2021-01-26
CA2883896C (en) 2023-03-07
WO2014039781A1 (en) 2014-03-13
EP3970725A1 (en) 2022-03-23
JP2019172679A (ja) 2019-10-10
JP2021038228A (ja) 2021-03-11
EP2892506A4 (en) 2016-04-20
JP2022109965A (ja) 2022-07-28
AU2013312358A1 (en) 2015-03-19
JP2015527398A (ja) 2015-09-17
US20150209367A1 (en) 2015-07-30
HK1211875A1 (en) 2016-06-03

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