JP2021038228A5 - - Google Patents
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- JP2021038228A5 JP2021038228A5 JP2020180340A JP2020180340A JP2021038228A5 JP 2021038228 A5 JP2021038228 A5 JP 2021038228A5 JP 2020180340 A JP2020180340 A JP 2020180340A JP 2020180340 A JP2020180340 A JP 2020180340A JP 2021038228 A5 JP2021038228 A5 JP 2021038228A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- oxo
- methyl
- difluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- -1 azepine-7-yl Chemical group 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 5
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 206010011878 Deafness Diseases 0.000 claims 3
- 229940125373 Gamma-Secretase Inhibitor Drugs 0.000 claims 3
- 210000003030 auditory receptor cell Anatomy 0.000 claims 3
- 239000003540 gamma secretase inhibitor Substances 0.000 claims 3
- 231100000888 hearing loss Toxicity 0.000 claims 3
- 230000010370 hearing loss Effects 0.000 claims 3
- 208000016354 hearing loss disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 231100000199 ototoxic Toxicity 0.000 claims 3
- 230000002970 ototoxic effect Effects 0.000 claims 3
- PKXWXXPNHIWQHW-RCBQFDQVSA-N (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide Chemical compound C1CN(C)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](O)C(C)C)C2=CC=CC=C21 PKXWXXPNHIWQHW-RCBQFDQVSA-N 0.000 claims 2
- IZAOBRWCUGOKNH-OAHLLOKOSA-N 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid Chemical compound C=1C=C(Cl)C=CC=1S(=O)(=O)N([C@H](C)C=1C(=CC(F)=CC=1)CCCC(O)=O)C1=CC(F)=CC=C1F IZAOBRWCUGOKNH-OAHLLOKOSA-N 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- KJSSPOWBVHTGDG-UHFFFAOYSA-N 2-(2,2,3,3,3-pentafluoropropyl)propanediamide Chemical compound NC(=O)C(C(N)=O)CC(F)(F)C(F)(F)F KJSSPOWBVHTGDG-UHFFFAOYSA-N 0.000 claims 1
- XCGJIFAKUZNNOR-UHFFFAOYSA-N 3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid Chemical compound C1CC(CCC(=O)O)CCC1(S(=O)(=O)C=1C=CC(Cl)=CC=1)C1=CC(F)=CC=C1F XCGJIFAKUZNNOR-UHFFFAOYSA-N 0.000 claims 1
- XEAOPVUAMONVLA-QGZVFWFLSA-N Avagacestat Chemical compound C=1C=C(Cl)C=CC=1S(=O)(=O)N([C@H](CCC(F)(F)F)C(=O)N)CC(C(=C1)F)=CC=C1C=1N=CON=1 XEAOPVUAMONVLA-QGZVFWFLSA-N 0.000 claims 1
- DWJXYEABWRJFSP-XOBRGWDASA-N DAPT Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)OC(C)(C)C)C=1C=CC=CC=1)C(=O)CC1=CC(F)=CC(F)=C1 DWJXYEABWRJFSP-XOBRGWDASA-N 0.000 claims 1
- NGBKFLTYGSREKK-PMACEKPBSA-N Z-Val-Phe-H Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C=O)C(=O)OCC1=CC=CC=C1 NGBKFLTYGSREKK-PMACEKPBSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- 108010007877 calpain inhibitor III Proteins 0.000 claims 1
- 230000006727 cell loss Effects 0.000 claims 1
- JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 claims 1
- 125000004212 difluorophenyl group Chemical group 0.000 claims 1
- 238000011977 dual antiplatelet therapy Methods 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950001900 semagacestat Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- SJMDMGHPMLKLHQ-UHFFFAOYSA-N tert-butyl 2-aminoacetate Chemical compound CC(C)(C)OC(=O)CN SJMDMGHPMLKLHQ-UHFFFAOYSA-N 0.000 claims 1
- MURCDOXDAHPNRQ-PJRHAEEISA-N tert-butyl n-[(2s,3r,5s)-6-[[(2s)-1-[[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate Chemical compound C([C@@H]([C@H](O)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)CC=1C=CC=CC=1)NC(=O)OC(C)(C)C)C1=CC=CC=C1 MURCDOXDAHPNRQ-PJRHAEEISA-N 0.000 claims 1
- 229920000428 triblock copolymer Polymers 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022069599A JP2022109965A (ja) | 2012-09-07 | 2022-04-20 | 聴覚喪失治療 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698475P | 2012-09-07 | 2012-09-07 | |
| US61/698,475 | 2012-09-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019091552A Division JP2019172679A (ja) | 2012-09-07 | 2019-05-14 | 聴覚喪失治療 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022069599A Division JP2022109965A (ja) | 2012-09-07 | 2022-04-20 | 聴覚喪失治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021038228A JP2021038228A (ja) | 2021-03-11 |
| JP2021038228A5 true JP2021038228A5 (https=) | 2021-07-26 |
Family
ID=50237627
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531223A Withdrawn JP2015527398A (ja) | 2012-09-07 | 2013-09-06 | 聴覚喪失治療 |
| JP2019091552A Withdrawn JP2019172679A (ja) | 2012-09-07 | 2019-05-14 | 聴覚喪失治療 |
| JP2020180340A Withdrawn JP2021038228A (ja) | 2012-09-07 | 2020-10-28 | 聴覚喪失治療 |
| JP2022069599A Pending JP2022109965A (ja) | 2012-09-07 | 2022-04-20 | 聴覚喪失治療 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531223A Withdrawn JP2015527398A (ja) | 2012-09-07 | 2013-09-06 | 聴覚喪失治療 |
| JP2019091552A Withdrawn JP2019172679A (ja) | 2012-09-07 | 2019-05-14 | 聴覚喪失治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022069599A Pending JP2022109965A (ja) | 2012-09-07 | 2022-04-20 | 聴覚喪失治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20150209367A1 (https=) |
| EP (2) | EP3970725B1 (https=) |
| JP (4) | JP2015527398A (https=) |
| AU (1) | AU2013312358B2 (https=) |
| CA (1) | CA2883896C (https=) |
| HK (1) | HK1211875A1 (https=) |
| WO (1) | WO2014039781A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008076556A2 (en) | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| US20150209367A1 (en) * | 2012-09-07 | 2015-07-30 | Massachusetts Eye & Ear Infirmary | Treating Hearing Loss |
| JO3491B1 (ar) * | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| WO2017075136A1 (en) * | 2015-10-27 | 2017-05-04 | Purdue Research Foundation | Polymer-based therapeutics for inductive browning of fat |
| ES2751082T3 (es) * | 2015-10-30 | 2020-03-30 | Pipeline Therapeutics Inc | Compuestos de dibenzo azepina y su uso en el tratamiento de enfermedades y trastornos óticos |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| EP3407901B1 (en) | 2016-01-29 | 2021-07-21 | Massachusetts Eye & Ear Infirmary | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
| AU2017290256A1 (en) | 2016-06-29 | 2019-01-17 | Otonomy, Inc. | Triglyceride otic formulations and uses thereof |
| US10576125B2 (en) | 2016-10-31 | 2020-03-03 | Hough Ear Institute | Methods for enhancing synaptogenesis and neuritogenesis |
| WO2018111926A2 (en) * | 2016-12-16 | 2018-06-21 | Inception 3, Inc. | Methods of treating cochlear synaptopathy |
| CA3114113A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions and methods related to otic therapeutic agents |
| US20220175776A1 (en) | 2019-04-08 | 2022-06-09 | Frequency Therapeutics, Inc. | Combination of chir99021 and valproic acid for treating hearing loss |
| TWI781536B (zh) | 2021-02-26 | 2022-10-21 | 國立臺灣科技大學 | 藥物釋放組合物、其製造方法及其用途 |
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-
2013
- 2013-09-06 US US14/426,629 patent/US20150209367A1/en not_active Abandoned
- 2013-09-06 HK HK16100053.6A patent/HK1211875A1/xx unknown
- 2013-09-06 EP EP21190313.3A patent/EP3970725B1/en active Active
- 2013-09-06 AU AU2013312358A patent/AU2013312358B2/en active Active
- 2013-09-06 EP EP13836099.5A patent/EP2892506B1/en active Active
- 2013-09-06 JP JP2015531223A patent/JP2015527398A/ja not_active Withdrawn
- 2013-09-06 WO PCT/US2013/058446 patent/WO2014039781A1/en not_active Ceased
- 2013-09-06 CA CA2883896A patent/CA2883896C/en active Active
-
2018
- 2018-06-13 US US16/007,586 patent/US10898492B2/en active Active
-
2019
- 2019-05-14 JP JP2019091552A patent/JP2019172679A/ja not_active Withdrawn
-
2020
- 2020-10-28 JP JP2020180340A patent/JP2021038228A/ja not_active Withdrawn
- 2020-12-10 US US17/118,111 patent/US12161647B2/en active Active
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2022
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