JP2019503386A5 - - Google Patents
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- Publication number
- JP2019503386A5 JP2019503386A5 JP2018539087A JP2018539087A JP2019503386A5 JP 2019503386 A5 JP2019503386 A5 JP 2019503386A5 JP 2018539087 A JP2018539087 A JP 2018539087A JP 2018539087 A JP2018539087 A JP 2018539087A JP 2019503386 A5 JP2019503386 A5 JP 2019503386A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- inhibitor
- entinostat
- administered
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662288121P | 2016-01-28 | 2016-01-28 | |
| US62/288,121 | 2016-01-28 | ||
| PCT/US2017/015389 WO2017132536A1 (en) | 2016-01-28 | 2017-01-27 | Use of histone deacetylase inhibitors for enhancing immunotherapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019503386A JP2019503386A (ja) | 2019-02-07 |
| JP2019503386A5 true JP2019503386A5 (https=) | 2020-03-05 |
Family
ID=58010402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018539087A Pending JP2019503386A (ja) | 2016-01-28 | 2017-01-27 | 免疫療法を増強するためのヒストンデアセチラーゼ阻害剤の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10813919B2 (https=) |
| EP (1) | EP3407913A1 (https=) |
| JP (1) | JP2019503386A (https=) |
| KR (1) | KR20180104122A (https=) |
| CN (1) | CN108883179A (https=) |
| AU (1) | AU2017211383A1 (https=) |
| BR (1) | BR112018015291A2 (https=) |
| CA (1) | CA3013047A1 (https=) |
| IL (1) | IL260765A (https=) |
| MX (1) | MX2018009247A (https=) |
| RU (1) | RU2018130831A (https=) |
| WO (1) | WO2017132536A1 (https=) |
| ZA (1) | ZA201805066B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016317915B2 (en) | 2015-09-01 | 2021-02-18 | Agenus Inc. | Anti-PD-1 antibodies and methods of use thereof |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| CN110300599B (zh) | 2016-12-07 | 2024-07-02 | 艾吉纳斯公司 | 抗体和其使用方法 |
| US12016900B2 (en) | 2017-06-04 | 2024-06-25 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent |
| WO2018225063A1 (en) * | 2017-06-04 | 2018-12-13 | Rappaport Family Institute For Research In The Medical Sciences | Method of predicting personalized response to cancer treatment with immune checkpoint inhibitors and kits therefor |
| US12070489B2 (en) | 2018-12-12 | 2024-08-27 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with a cancer therapy in combination with another therapeutic agent |
| IL264068B2 (en) * | 2018-01-05 | 2023-07-01 | Great Novel Therapeutics Biotech & Medicals Corp | Aggregate and pharmaceutical preparation containing an hdac inhibitor and an nsaid aggregate together with an immune checkpoint inhibitor for use in a method for removing immunosuppression in the microenvironment of a tumor or stimulating an immune system against cancer cells |
| CN111836636A (zh) * | 2018-01-12 | 2020-10-27 | 维拉克塔治疗公司 | 用于细胞免疫疗法的表观遗传修饰剂 |
| KR20210028339A (ko) * | 2019-09-04 | 2021-03-12 | 크리스탈지노믹스(주) | Hdac 저해제와 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 약학 조성물 |
| CN112569360A (zh) * | 2019-09-30 | 2021-03-30 | 中国医学科学院药物研究所 | 一种基于阻断pd-1/pd-l1的抗肿瘤药物组合物及其应用 |
| WO2023017525A1 (en) | 2021-08-11 | 2023-02-16 | OncoHost Ltd. | Predicting patient response |
| EP4705341A1 (en) * | 2023-05-05 | 2026-03-11 | Euro-Celtique S.A. | Combinations for treating cancer |
| WO2024238811A2 (en) * | 2023-05-18 | 2024-11-21 | Avstera Therapeutics Corp. | Composition comprising hdac inhibitor and immune checkpoint inhibitor and methods for using the same |
| US12553903B2 (en) | 2023-06-01 | 2026-02-17 | Cg Pharmaceuticals, Inc | Ivaltinostat combination therapy for treating pancreatic cancer |
| WO2025155922A1 (en) * | 2024-01-19 | 2025-07-24 | The Trustees Of Indiana University | Hdac3 inhibitors to treat arrhythmogenic cardiomyopathy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101523391B1 (ko) | 2006-12-27 | 2015-05-27 | 에모리 유니버시티 | 감염 및 종양 치료를 위한 조성물 및 방법 |
| US9987258B2 (en) | 2014-04-06 | 2018-06-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Histone deacetylase as a modulator of PDL1 expression and activity |
| ES2986548T3 (es) * | 2015-03-20 | 2024-11-11 | Syndax Pharmaceuticals Inc | Combinación de inhibidor de HDAC y anticuerpo anti-PD-1 para el tratamiento del cáncer, en donde la combinación no comprende 5-azacitidina |
| US20180250320A1 (en) | 2015-08-26 | 2018-09-06 | The Johns Hopkins University | Compositions and methods for treating solid tumors |
| BR112018003238A2 (en) * | 2015-09-02 | 2018-09-25 | Syndax Pharmaceuticals, Inc. | patient selection for combination therapy |
-
2017
- 2017-01-27 US US16/072,659 patent/US10813919B2/en active Active
- 2017-01-27 JP JP2018539087A patent/JP2019503386A/ja active Pending
- 2017-01-27 BR BR112018015291A patent/BR112018015291A2/pt not_active IP Right Cessation
- 2017-01-27 MX MX2018009247A patent/MX2018009247A/es unknown
- 2017-01-27 KR KR1020187024674A patent/KR20180104122A/ko not_active Withdrawn
- 2017-01-27 AU AU2017211383A patent/AU2017211383A1/en not_active Abandoned
- 2017-01-27 CA CA3013047A patent/CA3013047A1/en not_active Abandoned
- 2017-01-27 WO PCT/US2017/015389 patent/WO2017132536A1/en not_active Ceased
- 2017-01-27 EP EP17704370.0A patent/EP3407913A1/en not_active Withdrawn
- 2017-01-27 RU RU2018130831A patent/RU2018130831A/ru not_active Application Discontinuation
- 2017-01-27 CN CN201780020460.2A patent/CN108883179A/zh active Pending
-
2018
- 2018-07-24 IL IL260765A patent/IL260765A/en unknown
- 2018-07-27 ZA ZA2018/05066A patent/ZA201805066B/en unknown
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