JP2019131579A5 - - Google Patents
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- Publication number
- JP2019131579A5 JP2019131579A5 JP2019070293A JP2019070293A JP2019131579A5 JP 2019131579 A5 JP2019131579 A5 JP 2019131579A5 JP 2019070293 A JP2019070293 A JP 2019070293A JP 2019070293 A JP2019070293 A JP 2019070293A JP 2019131579 A5 JP2019131579 A5 JP 2019131579A5
- Authority
- JP
- Japan
- Prior art keywords
- crystal
- mixture
- hemisulfate
- following
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 28
- 239000013078 crystal Substances 0.000 claims 22
- 238000000634 powder X-ray diffraction Methods 0.000 claims 9
- QYNUQALWYRSVHF-OLZOCXBDSA-N (6R)-5,10-methylenetetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C1)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-OLZOCXBDSA-N 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 6
- 238000005079 FT-Raman Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13004050.4 | 2013-08-14 | ||
| EP13004050.4A EP2837631A1 (en) | 2013-08-14 | 2013-08-14 | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533926A Division JP6617104B2 (ja) | 2013-08-14 | 2014-08-14 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019131579A JP2019131579A (ja) | 2019-08-08 |
| JP2019131579A5 true JP2019131579A5 (enExample) | 2020-01-09 |
| JP6764501B2 JP6764501B2 (ja) | 2020-09-30 |
Family
ID=48998397
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533926A Active JP6617104B2 (ja) | 2013-08-14 | 2014-08-14 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2018164332A Active JP6735321B2 (ja) | 2013-08-14 | 2018-09-03 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2019070293A Active JP6764501B2 (ja) | 2013-08-14 | 2019-04-02 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2020083208A Active JP7396960B2 (ja) | 2013-08-14 | 2020-05-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2021183793A Active JP7710356B2 (ja) | 2013-08-14 | 2021-11-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533926A Active JP6617104B2 (ja) | 2013-08-14 | 2014-08-14 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2018164332A Active JP6735321B2 (ja) | 2013-08-14 | 2018-09-03 | ５，１０−メチレン−（６ｒ）−テトラヒドロ葉酸のヘミ硫酸塩 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020083208A Active JP7396960B2 (ja) | 2013-08-14 | 2020-05-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
| JP2021183793A Active JP7710356B2 (ja) | 2013-08-14 | 2021-11-11 | ５，１０－メチレン－（６ｒ）－テトラヒドロ葉酸のヘミ硫酸塩 |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US20160185787A1 (enExample) |
| EP (3) | EP2837631A1 (enExample) |
| JP (5) | JP6617104B2 (enExample) |
| KR (2) | KR102410373B1 (enExample) |
| CN (2) | CN108096200A (enExample) |
| AU (2) | AU2014307872B2 (enExample) |
| BR (2) | BR122020002802B1 (enExample) |
| CA (1) | CA2921178C (enExample) |
| CY (2) | CY1119694T1 (enExample) |
| DK (2) | DK3033344T3 (enExample) |
| EA (3) | EA202091271A3 (enExample) |
| ES (2) | ES2871483T3 (enExample) |
| HK (1) | HK1256262A1 (enExample) |
| HR (2) | HRP20171895T1 (enExample) |
| HU (2) | HUE054504T2 (enExample) |
| IL (2) | IL244069B (enExample) |
| LT (2) | LT3033344T (enExample) |
| MX (2) | MX360355B (enExample) |
| NO (1) | NO3033344T3 (enExample) |
| NZ (2) | NZ717825A (enExample) |
| PL (2) | PL3033344T3 (enExample) |
| PT (2) | PT3287460T (enExample) |
| RS (2) | RS56910B1 (enExample) |
| SG (2) | SG11201601016PA (enExample) |
| SI (2) | SI3033344T1 (enExample) |
| WO (1) | WO2015022407A1 (enExample) |
| ZA (1) | ZA201509204B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| US10059710B2 (en) | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
| EP3446703A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | 6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy |
| EP3446704A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| PT3668516T (pt) * | 2017-08-16 | 2021-12-23 | Merck Patent Gmbh | Liofilizados estáveis que compreendem ácido 5,10-metileno-(6r)-tetra-hidrofólico e um ácido dicarboxílico |
| MX2020007009A (es) * | 2018-01-05 | 2020-11-11 | Isofol Medical Ab | Metodos para tratar canceres colorrectales metastasicos y colorrectales. |
| KR20220152385A (ko) * | 2020-03-30 | 2022-11-15 | 수미토모 케미칼 컴퍼니 리미티드 | 적층체 |
| CN119325374A (zh) | 2022-06-08 | 2025-01-17 | 默克专利股份有限公司 | 包含5,10-亚甲基-(6r)-四氢叶酸的稳定的冻干物 |
| WO2023237483A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Concentrated solutions comprising 5,10-methylene-(6r)-tetrahydrofolic acid |
| KR20250022144A (ko) | 2022-06-08 | 2025-02-14 | 메르크 파텐트 게엠베하 | 5,10-메틸렌-(6R)-테트라히드로폴산 및 NACl을 포함하는 안정한 약학적 조성물 |
| CN119343131A (zh) | 2022-06-08 | 2025-01-21 | 默克专利股份有限公司 | 包含5,10-亚甲基-(6r)-四氢叶酸钠的浓缩溶液 |
| WO2023237484A1 (en) | 2022-06-08 | 2023-12-14 | Merck Patent Gmbh | Compositions comprising disodium 5,10-methylene-(6r)-tetrahydrofolate |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2300505A (en) * | 1940-10-31 | 1942-11-03 | Bell Telephone Labor Inc | Selective system |
| CA1215945A (en) | 1983-03-20 | 1986-12-30 | Bengt Gustavsson | Fluid transfer system |
| DE3821875C1 (enExample) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| CH682664A5 (en) * | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
| CH684644A5 (de) | 1992-07-13 | 1994-11-15 | Eprova Ag | 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen. |
| HU226998B1 (en) * | 2000-11-23 | 2010-04-28 | Richter Gedeon Nyrt | Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same |
| CH696628A5 (de) * | 2002-02-26 | 2007-08-31 | Eprova Ag | Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der |
| CH697021A5 (de) | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
| WO2007064968A2 (en) | 2005-12-02 | 2007-06-07 | Adventrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions of 5,10 methylenetetrahydrofolate |
| AU2007336369B2 (en) * | 2006-12-21 | 2013-01-17 | F. Hoffmann-La Roche Ag | Polymorphs of a mGluR5 receptor antagonist |
| JP5294968B2 (ja) | 2009-05-01 | 2013-09-18 | 三星ダイヤモンド工業株式会社 | スクライブヘッド及び該スクライブヘッドを用いたスクライブ装置 |
| CN103998047A (zh) * | 2011-10-19 | 2014-08-20 | 墨卡托医疗系统公司 | 局部调节组织和细胞以提高疗效包括肾去神经支配 |
| EP2837766A1 (de) * | 2013-08-14 | 2015-02-18 | Sika Technology AG | Verfahren zum Ausfüllen einer Fuge mit einem Kleb- und/oder Dichtstoff sowie System zum Ausfüllen einer Fuge mit einem Kleb- und/oder Dichtstoff |
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| JP6971761B2 (ja) * | 2017-10-11 | 2021-11-24 | 株式会社Ｉｈｉプラント | タンクの構築方法 |
-
2013
- 2013-08-14 EP EP13004050.4A patent/EP2837631A1/en not_active Withdrawn
-
2014
- 2014-08-14 CA CA2921178A patent/CA2921178C/en active Active
- 2014-08-14 DK DK14758102.9T patent/DK3033344T3/en active
- 2014-08-14 SG SG11201601016PA patent/SG11201601016PA/en unknown
- 2014-08-14 EA EA202091271A patent/EA202091271A3/ru unknown
- 2014-08-14 DK DK17190279.4T patent/DK3287460T3/da active
- 2014-08-14 RS RS20171337A patent/RS56910B1/sr unknown
- 2014-08-14 HU HUE17190279A patent/HUE054504T2/hu unknown
- 2014-08-14 HR HRP20171895TT patent/HRP20171895T1/hr unknown
- 2014-08-14 PL PL14758102T patent/PL3033344T3/pl unknown
- 2014-08-14 KR KR1020217009189A patent/KR102410373B1/ko active Active
- 2014-08-14 CN CN201810160334.3A patent/CN108096200A/zh active Pending
- 2014-08-14 ES ES17190279T patent/ES2871483T3/es active Active
- 2014-08-14 WO PCT/EP2014/067447 patent/WO2015022407A1/en not_active Ceased
- 2014-08-14 SI SI201430529T patent/SI3033344T1/en unknown
- 2014-08-14 MX MX2016001834A patent/MX360355B/es active IP Right Grant
- 2014-08-14 US US14/912,328 patent/US20160185787A1/en not_active Abandoned
- 2014-08-14 ES ES14758102.9T patent/ES2654474T3/es active Active
- 2014-08-14 NZ NZ71782514A patent/NZ717825A/en unknown
- 2014-08-14 EP EP14758102.9A patent/EP3033344B1/en active Active
- 2014-08-14 SI SI201431825T patent/SI3287460T1/sl unknown
- 2014-08-14 KR KR1020167006595A patent/KR102439605B1/ko active Active
- 2014-08-14 AU AU2014307872A patent/AU2014307872B2/en active Active
- 2014-08-14 RS RS20210630A patent/RS61986B1/sr unknown
- 2014-08-14 HU HUE14758102A patent/HUE037615T2/hu unknown
- 2014-08-14 NO NO14758102A patent/NO3033344T3/no unknown
- 2014-08-14 EP EP17190279.4A patent/EP3287460B1/en active Active
- 2014-08-14 MX MX2018013134A patent/MX382578B/es unknown
- 2014-08-14 BR BR122020002802-5A patent/BR122020002802B1/pt active IP Right Grant
- 2014-08-14 JP JP2016533926A patent/JP6617104B2/ja active Active
- 2014-08-14 PL PL17190279T patent/PL3287460T3/pl unknown
- 2014-08-14 NZ NZ745811A patent/NZ745811A/en unknown
- 2014-08-14 SG SG10201801179VA patent/SG10201801179VA/en unknown
- 2014-08-14 BR BR112016002770-1A patent/BR112016002770B1/pt active IP Right Grant
- 2014-08-14 EA EA201600172A patent/EA032179B1/ru not_active IP Right Cessation
- 2014-08-14 LT LTEP14758102.9T patent/LT3033344T/lt unknown
- 2014-08-14 LT LTEP17190279.4T patent/LT3287460T/lt unknown
- 2014-08-14 PT PT171902794T patent/PT3287460T/pt unknown
- 2014-08-14 CN CN201480044477.8A patent/CN105452250B/zh active Active
- 2014-08-14 PT PT147581029T patent/PT3033344T/pt unknown
- 2014-08-14 EA EA201892729A patent/EA201892729A1/ru unknown
-
2015
- 2015-12-17 ZA ZA2015/09204A patent/ZA201509204B/en unknown
-
2016
- 2016-02-11 IL IL244069A patent/IL244069B/en active IP Right Grant
-
2017
- 2017-12-12 CY CY20171101298T patent/CY1119694T1/el unknown
-
2018
- 2018-09-03 JP JP2018164332A patent/JP6735321B2/ja active Active
- 2018-11-29 HK HK18115320.9A patent/HK1256262A1/zh unknown
- 2018-12-06 US US16/212,056 patent/US20190106431A1/en not_active Abandoned
- 2018-12-13 AU AU2018278943A patent/AU2018278943B2/en active Active
-
2019
- 2019-04-02 JP JP2019070293A patent/JP6764501B2/ja active Active
- 2019-09-08 IL IL269170A patent/IL269170B/en active IP Right Grant
-
2020
- 2020-05-11 JP JP2020083208A patent/JP7396960B2/ja active Active
-
2021
- 2021-04-27 CY CY20211100364T patent/CY1124076T1/el unknown
- 2021-05-12 HR HRP20210743TT patent/HRP20210743T1/hr unknown
- 2021-10-08 US US17/496,939 patent/US12122783B2/en active Active
- 2021-11-11 JP JP2021183793A patent/JP7710356B2/ja active Active
-
2024
- 2024-08-09 US US18/799,606 patent/US20240400574A1/en active Pending
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