JP2019026634A - Composition for hair and external composition for skin - Google Patents

Abstract

To provide a composition that contains natural product-derived active ingredient with excellent biological safety, and particularly has hair-growing effect, anti-aging effect and whitening effect.SOLUTION: A composition for hair contains extract from carrot of Araliaceae Panax which contains high-concentration saponin, and a composition for hair contains extract from carrot of Araliaceae Panax which contains high-concentration saponin and extract from Camellia sinensis of genus Camellia, family Theaceae. An external composition for skin contains extract from carrot of Araliaceae Panax which contains high-concentration saponin, extract from Camellia sinensis of genus Camellia, family Theaceae, and extract from a plant that belongs to genus Callicarpa.SELECTED DRAWING: None

Description

  The present invention relates to a composition containing a novel active ingredient having excellent biological safety derived from a natural product, and in particular, having a hair restoration effect, an anti-aging effect and a whitening effect.

  In recent years, due to various factors such as aging, stress or ultraviolet rays, the scalp has been damaged, and not only men but also women have problems with hair. Corresponding to this, various hair cosmetics are available. Proposed. Conventionally, studies on male pattern alopecia (major alopecia) and female pattern alopecia (male pattern alopecia in women) have been conducted as hair problems, and male hormones are involved in these alopecia As a result, various anti-androgenic hormones and female hormone-like agents have been proposed as agents for improving hair troubles.

  Furthermore, recent research has shown that not only the number of hairs is reduced, but also the hair growth period is shortened in the hair growth cycle (hair cycle), thereby reducing the hair diameter (thickness), thereby reducing the hair thinning. It has also become clear that the condition and the “decrease in elasticity” of hair occur. Hair grows according to a periodic hair cycle (hair cycle) consisting of a resting phase, a growth phase, and a regression phase, and the cycle is adjusted by various factors. Therefore, hair can be grown thick and long by promoting the production of factors that shift from the resting phase to the growing phase and factors that are involved in maintaining the growing phase. As a result, hair loss, prevention / improvement of thinning hair, and further reduction of hair gloss and stiffness can be improved.

  In order to prevent the aging and unhealth of the scalp as described above and keep it in a youthful state, various hair-growth / hair-restoring agents and hair loss inhibitors are also based on the research on scalp damage and hair loss mechanisms described above. An agent (referred to as a hair restorer or the like) has been proposed. For example, minoxidil and adenosine are known as active ingredients that exhibit hair-growth / hair-growth effects, and hair-growth agents containing these ingredients have been proposed. However, active ingredients blended in conventional hair restorers and the like may cause side effects such as irritation of the scalp, and there is a need for sufficiently effective and safe hair-growth ingredients and hair loss-inhibiting ingredients.

JP 2016-523957

  As a result of earnest examination of the above-mentioned problems of the prior art, the present inventors have found that a carrot extract containing a high concentration of saponin suppresses the growth of highly active male hormone (DHT) -dependent SC-3 cells. I found. Moreover, it discovered newly providing the composition for hair which has the effect of making a hair-growth effect and a hair cycle healthy by using together the carrot extract and the tea extract containing methylated catechin. In addition, Patent Document 1 discloses a composition for skin protection containing epigallocatechin and ginseng-side gins derived from ginseng, but it has a tea extract containing carrot extract and methylated catechin. It has not been known that an object has a hair-growth effect, and further has an effect of adjusting the environment in the hair papilla cells and making the hair cycle healthy.

The present invention is a carrot extract of Araliaceae genus Panax, which contains a high concentration of saponin.
The present invention is a hair composition containing a carrot extract containing a high concentration of saponin as an active ingredient.
The present invention is a hair composition comprising a carrot extract containing a high concentration of saponin, and an extract of Camellia sinensis, a plant of the genus Camellia (Theaceae).
The present invention includes a carrot extract of Araliaceae (Panax) containing a high concentration of saponin, and an extract of Camellia sinensis, a plant of the genus Camellia (Theaceae), An external composition for skin comprising an extract of a plant belonging to the genus Callicarpa.

  The present invention is a carrot extract containing a high concentration of saponin, and can provide a hair composition having an excellent hair-growth effect due to the androgen receptor binding inhibitory effect exhibited by this extract. Furthermore, by using a carrot extract and a tea extract having methylated catechins in combination, a hair composition that exhibits a hair-growth effect, and further improves the environment in the hair papilla cells and makes the hair cycle healthy. Can be provided.

  In addition, the present invention uses a carrot extract containing a high concentration of saponin, a tea extract having methylated catechins, and a plant extract of the genus Callicarpa to achieve an anti-aging effect and a whitening effect. An excellent external composition for skin can be provided.

  Examples of plants belonging to the genus Tochibanin ginseng used in the present invention include Panax ginseng C.A. Meyer, Panax japonicus, Sancynin ginseng (Ginseng, Panax pseudoginseng) and the like.

  There is no particular limitation on the extract part of the genus Arsiaceae, and appropriate parts such as whole grass, leaves, flowers, stamens, pistils, stems, roots, seeds (fruits) and fruits can be used. From the content of, use of roots and fruits is preferable. Red ginseng and white ginseng obtained by processing the roots of plants belonging to the genus Tochibaninjin are also usable.

  The “cha” used in the present invention is “Camellia sinensis” which is a plant of the genus Camellia (Theaceae). Any kind of tea can be used, for example, Yutaka Midori, Okumidori, Samidori, Sayaka Kaori, Kanaya Midori, Asatsuyu, Samidori, Kokou, Benifukuki, Tadanishi, etc. .

  The material of the tea used in the present invention may be any of the whole grass, leaves, flower parts, stems, seeds, fruits, roots, etc., but the use of whole grasses or leaves is preferred. When using leaves, oolong tea leaves or black tea leaves may be used.

  Examples of plants belonging to the genus Murasakikikib used in the present invention include, for example, Murasakikikibu (Callicarpa japonica), Omurasakikibu (Callicarpa japonica var. Luxurians), Komurasaki (Callicarpa dichotoma), Horumirisakiki (Callicarpa formosana), Yabumurasaki (Callicarpa llis) Is mentioned.

  The extract is prepared by washing the plant to be extracted beforehand with water if necessary to remove foreign substances, and then leaving it as it is or drying, and further chopping or pulverizing it if necessary, followed by a dipping method or countercurrent flow. It can carry out by making it contact with an extraction solvent in accordance with conventional methods, such as an extraction method and a steam distillation method. In the present invention, a supercritical extraction method may be employed.

  The extraction solvent used for the extract treatment includes water; lower alcohols such as methanol, ethanol and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin; ethyl acetate and butyl acetate. And esters such as methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene and chloroform. A mixture of two or more types is used. In the present invention, it is preferable to use solvents having different polarities (such as water and ethanol) from the viewpoint that saponin can be obtained at a high concentration.

  In preparing the extract, the pH of the extract is not particularly limited, but it is generally preferably in the range of pH 3-9. The pH is adjusted by blending an alkaline adjusting agent such as sodium hydroxide, sodium carbonate or potassium hydroxide, or an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid or sulfuric acid into the extraction solvent. be able to.

  Extraction conditions such as extraction temperature and time vary depending on the type and pH of the solvent used, the size of the plant material, and the like. For example, methanol or ethanol, or a mixed solvent of water and lower alcohol or polyhydric alcohol is used as the extraction solvent. In the case of the immersion method, the extraction temperature is in the range of 0 to 80 ° C. In the case of cold temperature extraction at 4 ° C., the extraction time is preferably in the range of 1 day to 7 days, and in the middle temperature extraction around 40 ° C., it is preferably in the range of 1 hour to 3 days. In the case of high-temperature extraction at 80 ° C., the range is preferably 1 to 24 hours. In the case of the immersion method, the bath ratio is a weight ratio, and the solvent is generally in the range of 1 to 200 times, preferably 1 to 100 times the amount of the plant material.

  Among the extracts prepared as described above, the carrot extract may be subjected to an operation called aging in order to increase the saponin concentration. For example, the extract is aged by allowing it to stand at 20 to 25 ° C. or room temperature for 5 to 10 days. In addition, the saponin concentration may be increased by using an enzymatic decomposition method or a fermentation method.

  The extract prepared as described above is further combined with one or more of activated carbon treatment, ion exchange resin treatment, synthetic adsorbent, silica gel, and recrystallization treatment to obtain a high-concentration saponin. It may be prepared into an extract containing. Activated carbon is not only plant materials such as pine trees, bamboo, coconut shells, walnut shells, etc., but also carbonaceous, petroleum, etc. as raw materials, and high temperature carbonization using gas such as water vapor, carbon dioxide, air etc. as those raw materials Any of activated carbon obtained by applying a physical method such as a chemical method or a chemical method such as zinc chloride and then heating and heating to a porous chemical method may be used. Examples of the synthetic adsorbent include nonionic resins such as styrene / divinylbenzene copolymer and methacrylic acid ester polymer.

  When the extract according to the present invention is incorporated into a hair composition or a composition for external use on skin (including cosmetics, quasi-drugs, and external medicines), for example, if it is a skin external preparation for hair growth and hair restoration, Specifically, it is 0.00001 to 5.0 wt% (solid content wt%, hereinafter the same), preferably 0.001 to 3.0 wt%. In addition, in the case of a skin external preparation for hair washing such as shampoo, it is generally 0.00001 to 5.0% by weight (solid content% by weight, hereinafter the same), preferably 0.0001 to 1.0% by weight. %. In the case of a rinse or a conditioner, it is generally 0.00001 to 5.0 wt% (solid content wt%, hereinafter the same), and preferably 0.001 to 1.0 wt%. In the case of skin care basic cosmetics, it is generally in the range of 0.002 to 1.0% by weight, preferably 0.02 to 0.2% by weight. In the case of makeup cosmetics, it is generally 0.002 to 1. 0.0% by weight, preferably 0.02 to 0.2% by weight.

  When the extract according to the present invention is blended in a skin external preparation for hair, other active ingredients (hair matrix cell activator, anti-androgen hormone agent, blood circulation promoter, sebum secretion inhibitor, Anti-inflammatory agents, hair protection agents, hair cycle growth maintenance agents, etc.) may be combined to provide a synergistic hair growth / hair restoration effect, hair quality improvement effect and scalp inflammation prevention: Improvement effects can also be expected.

  For example, ingredients that can be expected to have a synergistic effect on hair growth / hair growth effect and scalp inflammation prevention / improvement include minoxidil, cyproterone acetate, pentadecanoic acid glyceride, 6-aminobenzylpurine (cytopurine), adenosine, trans-3, 4'-dimethyl 3-hydroxyflavanone (t-flavanone), assembly extract, hinokitiol, photosensitizer, pantothenic acid and derivatives thereof, vitamin E and derivatives thereof, nicotinic acid derivatives (such as nicotinamide), carpronium chloride, female hormones (Ethynylestradiol, estrone, etc.), salicylic acid, dipotassium glycyrrhizinate, hinokitiol, benzalkonium chloride, isopropylmethylphenol, l-menthol, pyridoxine hydrochloride (vitamin B6), thioxolone, camphor, le Russin, perilla leaf extract, tea extract, extract of Japanese cypress rafji root, bis-type alkaloids obtained from cypress red pheasant, licorice extract, assembly extract, maimai flower extract, chamomile extract, royal jelly fermented product, fermented lotus seed, ginkgo biloba Extract, pardalco bark extract, gentian extract, ginseng extract, soy milk fermented liquor, black soybean hydrolysate extract, hamcho extract, bamboo shoot extract, kudzu root extract, beetroot extract, clove extract, collagen, amino acids, vitamins, etc. Any one or more of them may be blended.

  In particular, cytokines (TGF-β1) involved in “dipotassium glycyrrhizinate, licorice extract, Pardarco bark extract or gentian extract” that suppress inflammation of the scalp, hair growth (transduction inducing factor from hair growth phase to regression phase), etc. "Perilla leaf extract", which suppresses the synthesis of the skin, "Isopropylmethylphenol", which suppresses inflammation of the scalp and has a bactericidal effect, "Tamazaki Rafuji root extract or bis-type alkaloid obtained from it", blood "Ginseng extract" having a flow promoting effect and sebum secretion inhibiting effect, "Sembly extract" having a blood circulation promoting effect, "Soy milk fermented liquid" having an effect of inhibiting sebum oxidation, "Achesh extract" to restore the barrier function of the scalp, "Bamboo shoot extract or kudzu root extract" that promotes the transition to the hair growth stage, Is preferably used in combination with at least one or more of inhibiting hair "Mitsuishikonbu extract" and suppresses drying of the scalp "collagen".

  Moreover, in addition to the above-mentioned components, hair cosmetics (including quasi-drugs) containing the extract according to the present invention usually include components used in hair compositions such as oily components, surfactants ( Synthetic, natural products), moisturizers, thickeners, antiseptics / bactericides, powder components, UV absorbers, antioxidants, chelating agents, ph adjusters, dyes, fragrances, etc., as needed can do. Moreover, as long as the effectiveness and characteristics of the active ingredient according to the present invention are not impaired, it may be combined with other physiologically active ingredients.

  Here, as the oil component, for example, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, palm oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, Macadamia nut oil, carrot oil, ginseng oil, bergamot oil, plant-derived oils such as squalane; animal-derived oils such as mink oil, turtle oil; waxes such as beeswax, carnauba wax, rice wax, lanolin; Hydrocarbons such as paraffin, petrolatum, paraffin wax, squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol and stearyl alcohol; myristin Isopropyl acid, palmitic acid Isopropyl, butyl oleate, 2-ethylhexyl glycerides, synthetic esters and synthetic triglycerides such as higher fatty acid octyldodecyl (octyl stearate dodecyl and the like), and the like.

  Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene Nonionic surfactants such as oxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, Anions such as polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates Surfactant; quaternary ammonium salt, primary to tertiary fatty amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N, Cationic surfactants such as N-dialkylmorphonium salts and polyethylene polyamine fatty acid amide salts; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-alkylene Amphoteric surfactants such as ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.

  Examples of emulsifiers or emulsifiers include stevia derivatives such as enzyme-treated stevia, saponins or derivatives thereof, casein or salts thereof (sodium, etc.), sugar-protein complexes, sucrose or esters thereof, lactose, soybean-derived water-soluble Polysaccharides, soy-derived protein and polysaccharide complex, lanolin or derivatives thereof, cholesterol, stevia derivatives (stevia enzyme-treated products, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins and their Derivatives, lecithin and derivatives thereof (hydrogenated lecithin, etc.), lactic acid bacteria fermented rice, lactic acid bacteria fermented rice, lactic acid bacteria fermented cereals (wheat, legumes, millet, etc.) and the like can also be blended.

  Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and sugars such as trehalose, mucopolysaccharides (for example, hyaluron). Acid and derivatives thereof, chondroitin and derivatives thereof, heparin and derivatives thereof, elastin and derivatives thereof, collagen hydrolyzate, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, silane root (white and white) Examples include extracts, various amino acids, and derivatives thereof.

  Examples of the thickener include brown algae such as alginic acid, agar, carrageenan and fucoidan, green algae or red algae-derived components; silane root (white) extract; pectin, locust bean gum, aloe polysaccharides, alkaligenes-producing polysaccharides, etc. Polysaccharides; gums such as xanthan gum, tragacanth gum and guar gum; cellulose derivatives such as carboxymethylcellulose and hydroxyethylcellulose; synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer and acrylic acid / methacrylic acid copolymer; hyaluronic acid And its derivatives; polyglutamic acid and its derivatives.

  Examples of the antiseptic / bactericidal agent include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzaza chloride Plant-derived ethanol such as ruconium, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodenyl urea), propanediol, 1,2-pentanediol, various essential oils, dry bark, radish fermented liquor, sugarcane Alternatively, there is 1,3-butylene glycol.

  Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, and cellulose. System powder, cereal (rice, wheat, corn, millet, etc.) powder, legume (soybean, red bean, etc.) powder, and the like.

  Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .

  Examples of the antioxidant include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives (for example, vitamin E nicotinate, vitamin E linoleate, etc.).

  Examples of chelating agents include trisodium ethylenediaminehydroxyethyl triacetate, edetic acid or salts thereof, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate, tetrasodium hydroxyethanediphosphonate, and the like.

  Examples of the pH adjuster include citric acid or a salt thereof, lactic acid or a salt thereof, glycolic acid, succinic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, sodium hydroxide, potassium hydroxide and the like.

  Examples of the physiologically active component include placenta extract, Sakuhakuhi extract, Yukinoshita extract, perilla extract, rice bran extract or hydrolyzate thereof, white coconut extract or hydrolyzate thereof, fermented white coconut, peony Extract or hydrolyzate thereof, lotus seed extract or hydrolyzate thereof, party extract or hydrolyzate thereof, pearl barley hydrolysate, barley seed fermented product, sake lees extract or ceramide contained therein, fermented sake lees Pandanus amaryllifolius Roxb. Extract, Arcangelicia flava Merrilli extract, rice leaf extract or hydrolyzate thereof, eggplant (bergamot, long eggplant, Kamo eggplant, rice Eggplant etc.) extract or hydrolyzate thereof, apricot fruit extract, seaweed extract such as catamen giraffe, jellyfish water, rice extract or added Hydrolyzate, rice fermentation extract, germinated rice extract or hydrolyzate thereof, germinated rice fermented product, damask rose flower extract, linoleic acid and its derivatives or extracts (eg liposomal linoleic acid, etc.), animal or Collagen derived from fish and derivatives thereof, elastin and derivatives thereof, glycyrrhetinic acid and derivatives thereof, t-cycloamino acid derivatives, vitamin A and derivatives thereof, allantoin, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, carrot extract , Red ginseng extract, loofah extract, anaosa extract, peach extract, peach extract, kiwi extract, sunflower seed or bud extract, Zizyphus joazeiro extract, daisy extract or fermentation , Hibiscus flower extract or fermented product, Hagoromogusa extract, cheri Moya extract, mango extract, mangosteen extract, funori extract, oolong tea extract, purple orchid extract, yam peel or seed coat extract or hydrolysate, safflower flower extract, Casablanca extract, sweet potato extract Alternatively, there are fermented products thereof, guava leaf extract, dokudami extract, evening birch extract, aloe extract, fig flower extract, apple extract and the like.

  Next, the present invention will be described more specifically with reference to production examples, formulation examples, and test examples, but the present invention is not limited thereto. In the following, all parts are parts by weight, and all percentages are% by weight.

Production Example 1 Preparation of carrot extract 500 g of purified water and 500 g of ethanol were added to 100 g of dried ginseng and immersed at 4 ° C. for 12 hours. This was filtered and further allowed to stand at room temperature for 1 week. The extract solution after standing was filtered to obtain 680 g of a brown transparent carrot extract solution (solid content concentration: 2.78%).

Production Example 2 Preparation of carrot extract Carrot extract solution (713 g) was obtained in the same manner as in Production Example 1, except that 100 g of dried tochiban carrot was used instead of ginseng (solid content concentration 2.26%).

Production Example 3 Preparation of carrot extract Carrot extract solution (675 g) was obtained in the same manner as in Production Example 1, except that 100 g of dried citrus carrot was used instead of ginseng (solid content concentration: 2.47%).

Production Example 4 Preparation of carrot extract 691 g of carrot extract solution was obtained in the same manner as in Production Example 1 except that 100 g of dried red ginseng was used (solid content concentration: 2.83%).

Comparative Production Example 1 Preparation of carrot extract 420 g of purified water and 180 g of 1,3-butylene glycol were added to 100 g of dried ginseng and extracted at 40 ° C. for 24 hours. This was filtered to obtain 452 g of a brown transparent carrot extract solution (solid content concentration 3.26%).

Test Example 1 Saponin concentration measurement test [Test method]
To 0.2 g of the carrot extract solution obtained in Production Examples 1 to 4 and Test Example 1, 2.0 mL of acetic anhydride was added, heated in a water bath for 2 minutes, and then filtered. To 1.0 mL of the obtained filtrate, 0.5 mL of sulfuric acid was gently added, and it was confirmed whether the contact interface between both solutions was reddish brown.
Next, the state of the test tube in which the interface was observed to be red was photographed with a digital camera, and the intensity of redness was quantified by image analysis. First, the obtained image file was imported into image analysis software (CS analyzer, manufactured by ATTO), converted into a grayscale image with only R (redness) of RGB elements, and further reversed in black and white. Only the portion of the interface that was red in the original image was selected, and the whiteness intensity (redness intensity of the original image) was analyzed. The obtained numerical value was compared with the carrot extract of Comparative Production Example 1, and the relative value of the analysis values of Production Examples 1 to 4 was shown with the analysis value of Comparative Production Example 1 as 1.0.

The measurement results of Test Example 1 are shown below.
[Table 1]

  As shown in Table 1, it was confirmed that the extracts according to Production Examples 1 to 4 of the present invention contained saponin in a higher concentration than the extract of Comparative Production Example 1.

Test Example 2 Evaluation test of highly active male hormone (DHT) receptor binding inhibitory effect SC-3 cells showing DHT-dependent proliferation were seeded in a 96-well microplate, and after 24 hours, both DHT and sample solution were added to each well. Was added. Here, as the sample solutions, those prepared by using the extracts of Production Examples 1 to 4 and the extracts of Comparative Production Examples 1 and 2 as solutions, respectively, with final concentrations of 1.0% and 2.0% were used. After addition of both DHT and sample solution, SC-3 cells were further cultured for 3 days, and cell proliferation was measured using the MTT reduction method. In addition, the control group which does not add a sample solution was set, and cell proliferation was measured by the MTT reduction method. The measurement results are shown as relative values when the value of the control group is 100.

The results of Test Example 2 of the present invention are shown in Table 2.
[Table 2]

  As shown in Table 2, it was confirmed that the extracts according to Production Examples 1 to 4 of the present invention have a markedly superior SC-3 cell proliferation inhibitory effect as compared with the extract of Comparative Production Example 1. It was. Therefore, the composition for hair which exhibits the hair growth effect based on an androgen receptor binding inhibitory effect can be provided by mix | blending the extract which concerns on this invention.

  In addition to the carrot extract, the tea extract may be used in combination with the hair composition according to the present invention. In particular, Benifuuki extract contains methylated catechins and has an effect of suppressing intracellular oxidative damage and an anti-inflammatory effect (see the application publication “JP-A-2015-134737” by the present applicant), and therefore combined with a carrot extract. By blending with the hair composition, the environment inside the dermal papilla cells is adjusted and the effect of making the hair cycle healthy is exhibited.

  Further, in the present invention, in addition to the carrot extract having an antioxidative effect, benifuki extract having an anti-inflammatory effect, and murasakixib fruit extract having a melanin synthesis inhibitory effect and a melanin degradation promoting effect are used as active ingredients, An external skin composition (skin care cosmetic) having an excellent anti-aging effect and whitening effect due to these effects can also be provided.

Formulation Example 1 Hair restorer [ingredient] part 1,3-butylene glycol 10.0
Ethanol 20.0
Dipotassium glycyrrhizinate 0.1
Panax ginseng extract 0.3
Japanese cypress rafuji extract 0.01
Extract of Production Example 1 5.0
Fragrance Appropriate amount Purified water An amount that makes the total amount 100 parts.

Formulation Example 2 Hair restorer In the ingredients of Formulation Example 1, a hair restorer was obtained in the same manner as Formulation Example 1 except that Extract 5.0 of Production Example 2 was used instead of Extract 5.0 of Production Example 1.

Formulation Example 3 Hair restorer In the ingredients of Formulation Example 1, a hair restorer was obtained in the same manner as Formulation Example 1 except that Extract 5.0 of Production Example 3 was used instead of Extract 5.0 of Production Example 1.

Formulation Example 4 Hair restorer In the components of Formulation Example 1, a hair restorer was obtained in the same manner as Formulation Example 1 except that Extract 5.0 of Production Example 4 was used instead of Extract 5.0 of Production Example 1.

Formulation Example 5 Hair restorer In the ingredients of Formulation Example 1, a hair restorer was obtained in the same manner as Formulation Example 1 except that assembly extract 0.3 was used instead of Panax ginseng extract 0.3.

Formulation Example 6 Hair growth material A hair growth material was obtained in the same manner as in Formulation Example 1 except that, in the components of Formulation Example 1, instead of Tamazaki Rafuji Extract 0.01, assembly extract 0.3 was used.

Formulation Example 7 Hair restorer [ingredient] part 1,3-butylene glycol 10.0
Ethanol 20.0
Dipotassium glycyrrhizinate 0.1
Panax ginseng extract 0.3
Japanese cypress rafuji extract 0.01
Extract of Production Example 1 3.0
Benifuuki tea leaf extract 2.0
Fragrance Appropriate amount Purified water An amount that makes the total amount 100 parts.

Formulation Example 8 Hair restorer [ingredient] part l-menthol 0.8
Adenosine 1.0
Extract of Production Example 1 2.0
Assembly extract 0.3
1,3-butylene glycol 10.0
Phenoxyethanol 0.2
Ethanol 20.0
Purified water in an amount of 100 parts The above ingredients were sufficiently stirred and mixed to obtain a hair growth material.

Formulation Example 9 Hair growth material A hair growth material was obtained in the same manner as in Formulation Example 8 except that minoxidil was used in place of adenosine in the ingredients of Formulation Example 8.

Formulation Example 10 Hair growth material A hair growth material was obtained in the same manner as in Formulation Example 8 except that 6-benzylaminopurine was used instead of adenosine in the ingredients of Formulation Example 8.

Formulation Example 11 Hair restorer [ingredient] Part Potassium glycyrrhizinate
l-Menthol 0.1
Extract of Production Example 1 1.0
Soy lecithin 0.2
1,3-butylene glycol 10.0
Ethanol 20.0
Bamboo shoot extract 3.0
Brown algae extract 3.0
Hamcho Extract 3.0
Gentian extract 3.0
Amamo extract 3.0
Perilla leaf extract 3.0
Amount of purified water totaling 100 parts

Formulation Example 12. Hair cream [ingredient] part liquid paraffin 15.0
Vaseline 15.0
Sara honey bee 2.0
Extract of Production Example 1 3.0
Benifuuki tea leaf extract 2.0
Brown algae extract 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Glycerin 5.0
1,3-butylene glycol 2.0
Polyoxyethylene hydrogenated castor oil 3.0
Chelating agent 0.1
Preservative 0.1
Fragrance 0.1
Dye 0.01
Amount of purified water totaling 100 parts

Formulation Example 13 Hair shampoo [ingredient] part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) sodium alkyl ether sulfate 20.0
Lauryldimethylaminoacetic acid betaine 10.0
Palm oil fatty acid diethanolamide 4.0
Methylparaben 0.1
Citric acid 0.1
Extract of Production Example 1 3.0
Collagen 5.0
Amamo extract 5.0
Hamcho Extract 5.0
Paudalco Bark Extract 5.0
Perilla leaf extract 5.0
1,3-butylene glycol 2.0
Amount of purified water totaling 100 parts

Formulation Example 14. Hair Shampoo A hair shampoo was obtained in the same manner as in Formulation Example 13 except that the extract 3.0 of Production Example 2 was used in place of the extract 3.0 of Production Example 1 among the ingredients of Formulation Example 13.

Example 15. Hair Rinse [Component] Part Polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
Extract of Production Example 1 3.0
Benifuuki tea leaf extract 2.0
1,3-butylene glycol 5.0
Amount of purified water totaling 100 parts

Example 16 Hair rinse Hair rinse was obtained in the same manner as in Formulation Example 15 except that, in the ingredients of Formulation Example 15, Extract 3.0 of Production Example 2 was used instead of Extract 3.0 of Production Example 1.

Formulation Example 17. Hair rinse A hair rinse was obtained in the same manner as in Formulation Example 15 except that the extract 3.0 in Production Example 3 was used instead of the extract 3.0 in Production Example 1 among the ingredients in Formulation Example 15.

Formulation Example 18. Hair rinse Hair rinse was obtained in the same manner as in Formulation Example 15 except that, in the ingredients of Formulation Example 15, Extract 3.0 of Production Example 4 was used instead of Extract 3.0 of Production Example 1.

Formulation Example 19. Lotion [Ingredients] part Jojoba oil 1.0
Polyoxyethylene (5.5) cetyl alcohol 5.0
Butylparaben 0.1
Extract of Production Example 1 5.0
Benifuuki tea leaf extract 2.0
Murasakixikibu fruit extract 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Potassium hydroxide appropriate amount Purified water Amount that makes 100 parts in total

Formulation Example 20. Latex [Ingredients] part Liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Lotus essential oil 0.025
Polyoxyethylene (20) sorbitan monostearate 1.0
Lipophilic glyceryl stearate 1.0
Hydrogenated soybean lecithin 1.5
Extract of Production Example 1 3.0
L-ascorbic acid-2-glucoside 2.0
Benifuuki tea leaf extract 2.0
Murasakixikibu fruit extract 2.0
Potassium hydroxide 0.5
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethylcellulose 0.3
Sodium hyaluronate 0.01
Water-soluble collagen 0.1
Perfume Appropriate amount Purified water Total amount to 100 parts

Formulation Example 21. Emulsion An emulsion was obtained in the same manner as in Formulation Example 20, except that 2.0 parts of tranexamic acid was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide contained in Formulation Example 20. It was.

Formulation Example 22. Emulsion An emulsion was obtained in the same manner as in Formulation Example 20, except that 3.0 parts of arbutin was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide contained in Formulation Example 20. .

Formulation Example 23. Emulsion In the same manner as in Formulation Example 20, except that 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide contained in Formulation Example 20 were used, the emulsion was prepared. Obtained.

Formulation Example 24. Lotion [Ingredient] part Extract of Production Example 2 10.0
Benifuuki tea leaf extract 2.0
Murasakixikibu fruit extract 2.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Guar gum 0.1
Perfume Appropriate amount Potassium hydroxide Appropriate amount Pure water

Example 25. Liquid foundation [ingredient] part Stearic acid 2.4
Propylene glycol monostearate 2.0
Cetostearyl alcohol 0.2
Liquid lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
Extract of Production Example 3 5.0
Benifuuki tea leaf extract 2.0
Murasakixikibu fruit extract 2.0
Sodium carboxymethylcellulose 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Titanium oxide 8.0
Talc 4.0
Color pigment Appropriate amount Purified water Amount that makes 100 parts

Formulation Example 17. Body shampoo [ingredient] part N-lauroylmethylalanine sodium 25.0
Palm oil fatty acid potassium liquid (40%) 26.0
Palm oil fatty acid diethanolamide 3.0
Methylparaben 0.1
Extract of Production Example 1 5.0
Benifuuki tea leaf extract 2.0
Murasakixikibu fruit extract 2.0
1,3-butylene glycol 2.0
Amount of purified water totaling 100 parts

Claims (4)

  An extract of carrot of the genus Araceae, which contains a high concentration of saponin.   A hair composition comprising the carrot extract according to claim 1.   A composition for hair comprising an extract of a carrot belonging to the genus Araceae, which contains a high concentration of saponin, and an extract of a tea belonging to the camellia family, Camellia.   An external composition for skin comprising an extract of a carrot belonging to the genus Araceae, which contains a high concentration of saponin, an extract of a tea belonging to the genus Camellia, and an extract of a plant belonging to the genus Murasakikib.