JP2003088323A - Method for extracting active ingredient from solid material with hard surface and edible composition containing the active ingredient - Google Patents

Method for extracting active ingredient from solid material with hard surface and edible composition containing the active ingredient

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Publication number
JP2003088323A
JP2003088323A JP2001280812A JP2001280812A JP2003088323A JP 2003088323 A JP2003088323 A JP 2003088323A JP 2001280812 A JP2001280812 A JP 2001280812A JP 2001280812 A JP2001280812 A JP 2001280812A JP 2003088323 A JP2003088323 A JP 2003088323A
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JP
Japan
Prior art keywords
extract
ginseng
extracting
hot water
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2001280812A
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Japanese (ja)
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JP4306987B2 (en
Inventor
Kazuyoshi Matsunaga
和義 松永
Takafumi Ishihara
隆文 石原
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Bizen Chemical Co Ltd
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Bizen Chemical Co Ltd
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Abstract

PROBLEM TO BE SOLVED: To provide a method for extracting active ingredients from a solid material with hard surface, and to provide an extract including both the inorganic and organic active ingredients in high concentrations. SOLUTION: This extract is a root of Panax notiginseng extract. The method for producing the extract comprises the steps of hot water extraction of root of Panax notiginseng under acidic conditions at high pressures (preferably in the presence of an organic acid), separation of the resultant hot water extract liquid from extraction residues, and extraction of the residues with an organic solvent. This extract thus obtained is soluble to water and includes the organic active ingredient(s) selected from the group consisting of minerals, dencichin, saponins, vitamins, amino acids and γ-amino acids in high concentrations. This method may additionally include the step of pulverizing the root of Panax notiginseng.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【発明の属する技術分野】本発明は、表面硬質の固形物
から有効成分を抽出する方法に関し、より詳細には、サ
ポニン類、ミネラル、ビタミン類、デンシチンなどを高
濃度で含有する田七人参エキスの製造方法、この方法に
よって得られる田七人参エキスおよびその利用に関す
る。
TECHNICAL FIELD The present invention relates to a method for extracting an active ingredient from a solid substance having a hard surface, and more specifically, a field extract of ginseng extract containing saponins, minerals, vitamins, densitin, etc. at a high concentration. And a method for producing the ginseng extract obtained by this method.

【0002】[0002]

【従来技術】田七人参は、三七人参とも呼ばれるウコギ
科人参属の多年生草本である。その塊根は乾燥して生薬
(以下、田七人参という)として用いられる。田七人参
は、中国では明時代の薬用植物書「本草綱目」に登場す
るくらい古くから知られた漢方生薬で、現在でも高血
圧、慢性肝炎、動脈硬化、糖尿病といった生活習慣病や
ガンに効き目があるといわれている。 田七人参の薬効
成分は、サポニン、カリウム、マグネシウム、カルシウ
ム、各種アミノ酸、ビタミン類、デンシチンなどであ
り、とりわけサポニンは、田七人参の乾燥重量あたり7
〜12%含まれ、この値は、高価な朝鮮人参のサポニン
含量0.3〜3%より高く、田七人参の薬効の高さが伺
え、「超高貴薬」の異名がある所以である。なお、本明
細書で用いる「%」は特に指定がなければ重量%を意味
する。
2. Description of the Related Art Ganoderma lucidum is a perennial herb belonging to the genus Ginseng, also called Radix Notoginseng. The tuberous root is dried and used as a crude drug (hereinafter referred to as "Tanachinin ginseng"). Chinese herb medicine is a Chinese herbal medicine that has been known for a long time as it appeared in the medicinal plant book "Honzo Tsuname" in the Ming dynasty in China. It is said that there is. The medicinal properties of Tana ginseng are saponin, potassium, magnesium, calcium, various amino acids, vitamins, densitin, etc. Especially, saponin is 7 per g of Ganjin ginseng dry weight.
-12%, which is higher than the saponin content of expensive ginseng, which is 0.3-3%, and the high medicinal effect of Ganoderma lucidum can be seen, which is why it is synonymous with "super noble drug". Incidentally, “%” used in the present specification means% by weight unless otherwise specified.

【0003】しかし、田七人参と称されるものの外部組
織は非常に硬く、その内容成分を有効に抽出することは
非常に困難なため、その製品は田七人参を単に破砕・粉
砕しただけの微粒子または微粉末の形態のものがほとん
どである。しかしこの微粉末などを使うことによる製剤
化、例えば、打錠化は容易でなく、破損、ひび割れ、表
面荒れなどによる製品欠陥率が高くなる傾向にある。
[0003] However, although the external structure of what is called Tana ginseng is very hard and it is very difficult to effectively extract its content components, the product is simply crushed and crushed Tana ginseng. Mostly in the form of fine particles or fine powder. However, it is not easy to formulate, for example, tablet by using this fine powder, and the product defect rate due to breakage, cracking, surface roughness, etc. tends to increase.

【0004】その一方、希エタノールによる田七人参の
抽出エキスは吸湿性が高く、そして有効成分の抽出率が
悪く、元来田七人参に含まれている有効成分の種類、特
に無機成分を効率的に抽出する方法は採用されていな
い。これは、一般に、無機成分を効率的に抽出しようと
すれば、有効有機成分の抽出率が低下するためである。
On the other hand, the extract of Ganoderma lucidum with dilute ethanol has a high hygroscopicity and the extraction rate of the active ingredient is poor, so that the type of the active ingredient originally contained in Ganoderma radix ginseng, especially the inorganic component, is efficiently used. The method of extracting manually is not adopted. This is because the extraction rate of the effective organic component generally decreases if the inorganic component is efficiently extracted.

【0005】[0005]

【発明が解決しようとする課題】このような背景から、
本発明は、表面が硬い乾燥品である田七人参などから無
機および有機の有効成分の各々を高濃度で含有し、水に
可溶性であり、そして安全性の点で懸念のない田七人参
エキスおよびその製造方法を提供し、さらには健康増進
や疾病予防に有効利用されうる食用組成物を提供するこ
とを目的とする。さらに、本発明の方法は、大豆、高麗
人参および乾姜などの表面が硬質の固形物素材から有用
成分を効率的に抽出するため、およびそれらの抽出エキ
スを提供するために適用可能である。
From such a background,
The present invention contains high-concentration each of inorganic and organic active ingredients such as Tana ginseng which has a hard surface and is a dry product, is soluble in water, and has no concern in terms of safety. And a method for producing the same, and further, to provide an edible composition that can be effectively used for promoting health and preventing diseases. Furthermore, the method of the present invention can be applied to efficiently extract useful components from a solid material having a hard surface such as soybean, ginseng and ginger, and to provide an extract thereof.

【0006】[0006]

【課題を解決するための手段】田七人参は、有機化合物
および無機化合物の有効成分を含んでいる。本明細書で
用いる用語、田七人参の「有機化合物の有効成分」また
は「有機有効成分」とは、サポニン類、デンシチン、ア
ミノ酸類、γ−アミノ酸、ビタミン類などをいい、そし
て本明細書で用いる用語、田七人参の「無機化合物の有
効成分」または「無機有効成分」とは、栄養学的に有用
な微量元素であるカリウム、カルシウム、マグネシウ
ム、亜鉛、鉄、ゲルマニウムなどのミネラルなどをい
う。
[Means for Solving the Problems] Shichijin ginseng contains active ingredients of organic compounds and inorganic compounds. As used herein, the term "active ingredients of organic compounds" or "organic active ingredients" of Tanahedii ginseng refers to saponins, densitins, amino acids, γ-amino acids, vitamins, and the like, and herein. The term used, "an active ingredient of an inorganic compound" or "inorganic active ingredient" of Ganoderma lucidum, refers to minerals such as potassium, calcium, magnesium, zinc, iron and germanium which are nutritionally useful trace elements. .

【0007】この内、田七人参の有機有効成分を抽出す
るためには、一般に、水あるいはエタノールを溶媒とし
て用いる加熱処理法が採られている。例えば、表面の非
常に硬い田七人参に対して、水溶液中で1夜放置後、次
いで50重量%エタノール溶液で5時間、さらに、70
重量%エタノール溶液で5時間加熱処理を行った後、全
ての抽出液を合併し、それを濃縮およびフリーズドライ
をして田七人参エキスが得られる。しかし、この方法で
得られる抽出エキス粉末の量は、出発材料の田七人参重
量に対し約18%に過ぎないことがわかった。そして、
田七人参の乾燥原形(以下、姿という)の表皮は僅かに
軟化している程度で、常圧下での加熱では硬い表皮を十
分に破壊することは出来ないことが明らかとなった。
[0007] Among them, in order to extract the organic active ingredient of Ganoderma lucidum, a heat treatment method using water or ethanol as a solvent is generally adopted. For example, for Ginseng with very hard surface, leave it in an aqueous solution overnight, and then in a 50 wt% ethanol solution for 5 hours, then 70
After heat treatment with a wt% ethanol solution for 5 hours, all the extracts are combined, concentrated and freeze-dried to obtain the Panax notoginseng extract. However, it was found that the amount of the extract powder obtained by this method was only about 18% based on the weight of the starting material Ganoderma lucidum. And
It was clarified that the dry epidermis (hereinafter referred to as "figure") of Tanachi ginseng was slightly softened, and the hard epidermis could not be sufficiently destroyed by heating under normal pressure.

【0008】加熱強度を増すことは熱分解や酸化分解な
どで有機有効成分に化学変化を与えてしまう。それに対
して、加圧処理すると分解や合成などの変化は起きにく
い。従って、本発明者らは、浸透力のある溶液中で加圧
処理を施すことにより、表面構成膜の細胞破壊を起こし
て、物質輸送を容易にすることにより、田七人参の内容
成分の抽出を行うことを考えた。従って、本発明は、田
七人参を有機酸溶液中で加圧処理し、表皮部分の細胞破
壊を行うことによって、まず、ミネラル類を抽出し、次
いで、希釈エタノール溶液で有機有効成分を抽出する二
段階抽出法によって、無機および有機の両有効成分を高
濃度含有し、しかも水溶性である田七人参抽出エキス末
を製造する方法、得られた田七人参エキス、およびこの
田七人参エキスを含む食用組成物を提供する。
Increasing the heating strength causes a chemical change in the organic effective ingredient due to thermal decomposition or oxidative decomposition. On the other hand, when pressure treatment is applied, changes such as decomposition and synthesis are unlikely to occur. Therefore, the present inventors extracted the content components of Tanachi ginseng by applying pressure treatment in a solution having an osmotic force to cause cell destruction of the surface constituting membrane and facilitate mass transport. Thought to do. Therefore, according to the present invention, by treating Shichinin ginseng under pressure in an organic acid solution to destroy cells in the epidermis, first, minerals are extracted, and then, an organic active ingredient is extracted with a diluted ethanol solution. By the two-stage extraction method, a method for producing a water-soluble Tana ginseng extract extract powder containing both inorganic and organic active ingredients in high concentrations, the obtained Tana ginseng extract, and this Tana ginseng extract. An edible composition comprising is provided.

【0009】本発明は、田七人参エキスに関し、この田
七人参エキスは、田七人参を酸性条件および加圧条件下
で熱水抽出する工程、熱水抽出液を抽出残渣から分離す
る工程、および上記抽出残渣を有機溶媒で抽出する工程
を包含する方法によって製造され、水溶性であって、ミ
ネラル、デンシチン、サポニン、ビタミン、アミノ酸お
よびγ−アミノ酸からなる群から選択される有機有効成
分を高濃度で含有する。
[0009] The present invention relates to an extract of Radix Notoginseng. This extract of Radix Notoginseng is subjected to hot water extraction of Radix Notoginseng under acidic conditions and pressure conditions, a step of separating a hot water extract from an extraction residue, And a water-soluble organic active ingredient selected from the group consisting of minerals, densitins, saponins, vitamins, amino acids and γ-amino acids, which is produced by a method including a step of extracting the extraction residue with an organic solvent. Contains at a concentration.

【0010】好ましくは、上記方法は、田七人参を細粒
化または粉末化する工程をさらに包含する。
[0010] Preferably, the above method further comprises the step of granulating or powdering the Ganoderma lucidum.

【0011】好ましくは、上記酸性条件および加圧条件
下で熱水抽出する工程は有機酸の存在下で行なわれる。
Preferably, the step of hot water extraction under the acidic condition and the pressurized condition is carried out in the presence of an organic acid.

【0012】好ましくは、上記有機酸は、クエン酸およ
び酢酸からなる群から選択される。
[0012] Preferably, the organic acid is selected from the group consisting of citric acid and acetic acid.

【0013】好ましくは、上記ミネラルは、カリウム、
カルシウム、マグネシウム、亜鉛、鉄およびゲルマニウ
ムからなる群から選択される。
Preferably, the mineral is potassium,
It is selected from the group consisting of calcium, magnesium, zinc, iron and germanium.

【0014】本発明はまた、田七人参エキスの製造方法
に関し、この方法は、田七人参を酸性条件および加圧条
件下で熱水抽出する工程、熱水抽出液を抽出残渣から分
離する工程、およびこの抽出残渣を有機溶媒で抽出する
工程を包含する。
[0014] The present invention also relates to a method for producing an extract of Panax notoginseng, which comprises a step of extracting hot extract of Panax notoginseng under acidic conditions and pressure conditions, and a step of separating a hot water extract from an extraction residue. , And extracting the extraction residue with an organic solvent.

【0015】本発明の方法は、田七人参を細粒化または
粉末化する工程をさらに包含し得る。
The method of the present invention may further include the step of granulating or powdering Ganoderma lucidum.

【0016】好ましくは、上記酸性条件および加圧条件
下で熱水抽出する工程はpH6以下で行なわれ、上記有
機溶媒で抽出する工程は40〜50%エタノール水溶液
を用いて加温下で行なわれる。
Preferably, the step of hot water extraction under the acidic condition and the pressurized condition is carried out at a pH of 6 or less, and the step of extracting with the organic solvent is carried out under heating with an aqueous 40-50% ethanol solution. .

【0017】本発明はまた、上記の田七人参エキスを含
む食用組成物に関する。
The present invention also relates to an edible composition containing the above extract of Panax notoginseng.

【0018】本発明はまた、表面硬質の固形物から有効
成分を抽出する方法に関し、この方法は、表面硬質の固
形分を酸性条件および加圧条件下で熱水抽出する工程、
熱水抽出液を抽出残渣から分離する工程、およびこの抽
出残渣を有機溶媒で抽出する工程を包含する。
The present invention also relates to a method for extracting an active ingredient from a hard surface solid, which comprises hot water extraction of the hard surface solid under acidic and pressurized conditions,
A step of separating the hot water extract from the extraction residue, and a step of extracting the extraction residue with an organic solvent are included.

【0019】[0019]

【発明の実施の形態】本発明の実施の形態について、以
下詳述する。
BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in detail below.

【0020】代表的には、本発明の抽出エキスの原料と
なる素材は田七人参である。田七人参は、ジンセノシ
ド、ミネラルおよびビタミンを高い濃度で含むものが好
適に用いられ、その産地、収穫時期にかかわらず、姿、
またはそれを破砕・粉砕した細粒子、微粒子および微粉
末のいずれの形態をも本発明の抽出エキスの原料として
用い得る。
[0020] Typically, the raw material for the extract of the present invention is Tanachi ginseng. Ginsenoside, minerals and vitamins containing a high concentration of ginseng are preferably used, and regardless of their origin or harvest time,
Alternatively, any form of fine particles, fine particles and fine powder obtained by crushing / crushing it may be used as a raw material of the extract of the present invention.

【0021】本発明の田七人参エキスの製造方法は、田
七人参を酸性条件および加圧条件下で熱水抽出する工
程、熱水抽出液を抽出残渣から分離する工程、および該
抽出残渣を有機溶媒で抽出する工程を包含する。
The method for producing Ganoderma radix ginseng extract of the present invention comprises a step of hot water extraction of Ganoderma cypress ginseng under acidic conditions and pressure conditions, a step of separating a hot water extract from an extraction residue, and the extraction residue. The step of extracting with an organic solvent is included.

【0022】上記酸性条件は、リン酸、塩酸などの無機
酸を添加することにより達成され得る。好ましくは、上
記酸性条件は、クエン酸、酢酸、乳酸、酒石酸、リンゴ
酸、乳酸、コハク酸、グルコン酸、グルクロン酸、これ
ら有機酸のナトリウムやカリウム塩、およびこれらの混
合物を用いて達成され得る。上記酢酸は、食用酢(合成
酢、リンゴ酢、果実酢、昆布酢、ワインビネガーなどの
醸造酢、およびこれらを任意の割合で混合した混合物を
含む)として添加され得る。より好ましくは、上記酸性
条件は、クエン酸、酢酸を用いて達成され得る。最も好
ましくは、上記酸性条件は、クエン酸を用いて達成され
得る。
The above acidic conditions can be achieved by adding an inorganic acid such as phosphoric acid or hydrochloric acid. Preferably, the acidic conditions may be achieved using citric acid, acetic acid, lactic acid, tartaric acid, malic acid, lactic acid, succinic acid, gluconic acid, glucuronic acid, sodium and potassium salts of these organic acids, and mixtures thereof. . The acetic acid may be added as edible vinegar (including synthetic vinegar, apple vinegar, fruit vinegar, kelp vinegar, brewed vinegar such as wine vinegar, and a mixture of these in any proportion). More preferably, the acidic conditions can be achieved by using citric acid or acetic acid. Most preferably, the acidic conditions can be achieved with citric acid.

【0023】上記無機酸または有機酸は、素材、代表的
には、田七人参を含む水溶液がpH6以下、好ましくは
pH5〜1の範囲になるに十分な量、通常0.1〜20
重量%の範囲、より好ましくは1〜15重量%の範囲、
最も好ましくは5〜9重量%の範囲で添加される。通
常、田七人参に添加される有機酸は、通常、田七人参に
対して2〜15倍容量、好ましくは、田七人参に対して
8〜10倍容量の水に溶解したのちに田七人参に添加さ
れる。
The above-mentioned inorganic acid or organic acid is a material, typically, an amount sufficient to bring an aqueous solution containing Tanchijin ginseng to pH 6 or less, preferably pH 5 to 1, usually 0.1 to 20.
Wt% range, more preferably 1-15 wt% range,
Most preferably, it is added in the range of 5 to 9% by weight. Usually, the organic acid to be added to Tana ginseng is usually dissolved in water in an amount of 2 to 15 times, and preferably 8 to 10 times the amount of Tana ginseng in water. Added to carrot.

【0024】上記田七人参を酸性条件および加圧条件下
で熱水抽出する工程は、代表的には、この田七人参を含
む有機酸含有溶液を、1〜1.3kgf/cm2の加圧
下で加熱することによって行なわれる。好ましくは、こ
の田七人参を含む有機酸含有溶液は、加圧下で加熱する
前に、大気圧下、約100℃の温度で、通常10分〜数
時間の間、好ましくは30分〜2時間の間予備加熱さ
れ、それによって有効成分の抽出効率を向上し得る。
[0024] In the step of hot-water extraction of Tanabata ginseng under acidic conditions and pressure conditions, typically, an organic acid-containing solution containing this Tanabata ginseng is added at 1 to 1.3 kgf / cm 2 . It is carried out by heating under pressure. Preferably, the organic acid-containing solution containing this Ganoderma lucidum is heated under pressure at a temperature of about 100 ° C. under atmospheric pressure for usually 10 minutes to several hours, preferably 30 minutes to 2 hours. It may be pre-heated during this, thereby improving the extraction efficiency of the active ingredient.

【0025】上記熱水抽出液を抽出残渣から分離する工
程は、濾過、遠心分離など当該分野で公知の方法によっ
て実施される。上記抽出残渣を有機溶媒で抽出する工程
は、水で希釈された有機溶剤を用いて行なわれる。この
ような有機溶媒として、アセトン、メタノール、エタノ
ールなどを用い得る。好ましくは、エタノール、および
アセトンが用いられ、より好ましくはエタノールが用い
られる。通常、有機溶剤濃度は20重量%〜80重量%
の範囲の水溶液として用いられ、好ましくは40重量%
〜50重量%の範囲の水溶液として用いられる。この有
機溶媒水溶液を田七人参に対して、通常、2〜10倍容
量の範囲、好ましくは、5〜8倍容量の範囲で添加して
抽出残渣から有効成分を抽出する。
The step of separating the hot water extract from the extraction residue is carried out by a method known in the art such as filtration or centrifugation. The step of extracting the extraction residue with an organic solvent is performed using an organic solvent diluted with water. As such an organic solvent, acetone, methanol, ethanol or the like can be used. Preferably, ethanol and acetone are used, and more preferably ethanol is used. Usually, the organic solvent concentration is 20% to 80% by weight.
Used as an aqueous solution in the range of, preferably 40% by weight
Used as an aqueous solution in the range of ˜50% by weight. This organic solvent aqueous solution is usually added in the range of 2 to 10 times by volume, preferably in the range of 5 to 8 times by volume, to extract the active ingredient from the extraction residue.

【0026】上記熱水抽出液と上記有機溶媒抽出液とは
組み合わされて、フリーズドライ、スプレードライなど
当該分野で公知の方法によって濃縮および乾燥し、田七
人参エキス粉末を得る。
The hot water extract and the organic solvent extract are combined and concentrated and dried by a method known in the art such as freeze-drying or spray-drying to obtain powder of Tanchijin ginseng extract.

【0027】本発明の有機および無機有効成分を高い濃
度で含有する田七人参エキス粉末の効率的製造法の代表
例を以下に示す。
A representative example of an efficient method for producing the powder of Ganoderma lucidum extract containing high concentrations of the organic and inorganic active ingredients of the present invention is shown below.

【0028】適宜に細粒化した田七人参を10重量%ク
エン酸水溶液とともに90〜100℃において、必要に
応じて攪拌しながら1時間加熱する。ついで1.1〜
1.3kgf/cm2に保ちながら、昇圧を開始してか
ら2時間にわたって加圧・加熱した後、濾過などの常法
に従って抽出液と固形分抽出残渣とに分ける。続いて固
形物の抽出残渣は、40重量%〜50重量%のエタノー
ル溶液とともに60〜75℃に保ちながら1時間加熱す
る。エタノール含有抽出液は濾過等の常法に従って抽出
液と固形分残渣とに分ける。このエタノール抽出液を、
上記クエン酸抽出液とを合わせて混合してフリーズドラ
イやスプレードライなどの乾燥処理によって、本発明の
有機および無機有効成分を高濃度で含有する田七人参エ
キス粉末を得る。なお、このとき用いる田七人参は、
姿、細粒、または粉末のいずれでもよい。
[0028] Appropriately pulverized Tanachi ginseng is heated with a 10% by weight aqueous solution of citric acid at 90 to 100 ° C for 1 hour with stirring if necessary. Then 1.1 ~
While keeping the pressure at 1.3 kgf / cm 2 , pressurization and heating are continued for 2 hours after the pressurization is started, and then the extract and the solid content extraction residue are separated according to a conventional method such as filtration. Subsequently, the extraction residue of the solid matter is heated with a 40 wt% to 50 wt% ethanol solution at 60 to 75 ° C. for 1 hour. The ethanol-containing extract is separated into an extract and a solid residue according to a conventional method such as filtration. This ethanol extract,
The above citric acid extract is mixed together and dried by freeze-drying, spray-drying or the like to obtain a powder of Tanchijin ginseng extract containing the organic and inorganic active ingredients of the present invention at a high concentration. In addition, the seven fields of ginseng used at this time are
It may be in the form, fine particles, or powder.

【0029】また、上記の例では、表面硬質の素材とし
て田七人参を用いた例を記載したが、表面硬質の素材と
しては、田七人参に限られず、大豆、高麗人参、乾姜お
よびウコンなどを田七人参にかえて実施してもよく、こ
れら素材に含有されている有効成分を損なうことなく、
有機および無機有効成分を網羅的に抽出してそれぞれの
エキスを得ることができる。なお、本発明で用いられる
表面硬質の固形物はこれらの例に限定されないことはい
うまでもない。
Further, in the above-mentioned example, the example using Tanchi ginseng as the hard surface material is described, but the hard surface material is not limited to Tanchi ginseng, soybean, ginseng, ginger and turmeric. It may be carried out in place of Nana Ginseng, etc., without damaging the active ingredients contained in these materials,
Organic and inorganic active ingredients can be exhaustively extracted to obtain respective extracts. Needless to say, the solid material having a hard surface used in the present invention is not limited to these examples.

【0030】本発明の有機および無機有効成分を高濃度
で含有する田七人参エキス粉末は、他社市販の粉末品と
同程度またはそれ以上の粗サポニンやミネラルを含むこ
とを特徴とする。すなわち、市販粉末品と同製品の本発
明による抽出エキス末の粗サポニン、カルシウム、マグ
ネシウム含有量を比較すると、前者においては順に7.
48%、819ppm、610ppmであり、後者につ
いては順に10.22%、574ppm、627ppm
であった。また、本発明の田七人参エキス粉末は、ジン
セノシドRb1,ジンセノシドRg1、デンシチン、ア
ルギニンおよびカリウムなどの有機有効成分もまた市販
の粉末品と同程度またはそれ以上含み得る。
The Tannin ginseng extract powder of the present invention, which contains a high concentration of organic and inorganic active ingredients, is characterized by containing crude saponins and minerals in the same amount as or more than those of powder products commercially available from other companies. That is, when comparing the contents of crude saponin, calcium, and magnesium in the extract powder of the present invention of the commercial powder product and the same product, in the former case, in order of 7.
48%, 819 ppm, 610 ppm, and the latter in order of 10.22%, 574 ppm, 627 ppm.
Met. In addition, the powdered Tannin ginseng extract of the present invention may also contain organic active ingredients such as ginsenoside Rb1, ginsenoside Rg1, densitine, arginine and potassium in the same amount or more than the commercially available powder products.

【0031】本発明の有機および無機有効成分を高濃度
で含有する田七人参エキス粉末は、水に対して非常によ
く溶けることが大きな特徴である。そのため、液状、ゲ
ル状あるいは固形状の食品組成物として種類を限定せず
に利用できる。例えば、清涼飲料水、ジュース、茶、ゼ
リー、プリン、パン、クッキー、キャラメル、おかきな
どに添加したり、必要に応じて、でんぷん、デキストリ
ン、乳糖などの賦型剤、その他の食用組成物のエキス
剤、色素、香料などとともに粉末、顆粒、錠剤に加工し
たり、ゼラチンなどの被覆剤を用いてカプセルに成形加
工して健康食品や栄養補助食品などとして利用できる。
なお、本発明の食用組成物はこれらの例に限定されない
ことはいうまでもない。
The characteristic feature of the powdery extract of Panax notoginseng of the present invention containing the organic and inorganic active ingredients in high concentration is that it is very well soluble in water. Therefore, the liquid, gel, or solid food composition can be used without limiting the type. For example, added to soft drinks, juice, tea, jelly, pudding, bread, cookies, caramel, oysters, etc., if necessary, starch, dextrin, lactose and other excipients, extract of other edible composition It can be used as a health food, dietary supplement, etc. by processing into powder, granules, tablets with agents, pigments, fragrances, etc., or forming into capsules using a coating agent such as gelatin.
Needless to say, the edible composition of the present invention is not limited to these examples.

【0032】また、有機および無機有効成分を高い濃度
で含有する田七人参エキス粉末の食用組成物に対する使
用量は、当該食用組成物の種類や状態などに依存して、
ほぼ0.1〜100重量%の範囲で添加され得る。
Further, the amount of the Tanchinin ginseng extract powder containing a high concentration of organic and inorganic active ingredients in the edible composition depends on the kind and state of the edible composition.
It may be added in the range of approximately 0.1 to 100% by weight.

【0033】本発明の意義の1つは、 田七人参中の有
効成分が水溶性の性状を持って抽出されるため、他の物
質との配合調整が容易となり、機能性因子としての効果
を高め得ることである。例えば、本田七人参エキス粉末
が、ホスファチジルセリン、EPA,核酸成分などと配
合されることにより、それぞれの持つ生理機能が発揮さ
れるとともに、補足強化さらには相乗効果によって広範
囲の症状に対応できるようになる。
One of the meanings of the present invention is that since the active ingredient in Ganoderma lucidum is extracted with a water-soluble property, it becomes easy to mix and adjust with other substances, and the effect as a functional factor is obtained. It can be raised. For example, when Honda ninjin ginseng extract powder is blended with phosphatidylserine, EPA, nucleic acid component, etc., the physiological functions of each are exerted, and supplementation and further synergistic effects enable treatment of a wide range of symptoms. Become.

【0034】以下、実施例により本発明をさらに具体的
に説明する。
The present invention will be described in more detail below with reference to examples.

【0035】(実施例1〜4)4つの三角フラスコの各
々に、水175mL、田七人参姿30〜35gを添加
し、そして田七人参姿の10、12.5、15および2
2重量%のクエン酸をそれぞれ加えた(実施例1〜
4)。各々の三角フラスコの口を食品包装用ラップフィ
ルムで蓋をするように覆って、オートクレーブ中で1.
1〜1.2kgf/cm2の加圧下で約2時間煮沸し
た。放冷後、溶液部分を遠心分離(3,000rpm、
5分)して田七人参の熱水抽出液を得た。沈殿残渣は元
の田七人参姿が残っている三角フラスコに戻し、残存す
る田七人参姿とともに、50%エタノール溶液200m
Lを用い、三角フラスコに還流冷却器をつけて85℃、
1〜1.5時間加温することによりさらに抽出した。こ
の加熱溶液を放冷後、遠心分離(5,000rpm、1
0分)してエタノール抽出液を分取し、先に分取した抽
出液と併せて減圧下で濃縮し、フリーズドライ処理を行
って粉末にした。これらの粉末についての粉末量の収
率、ミネラル類および粗サポニンの含有量の測定結果を
表1にまとめて示す。なお、ミネラル類は原子吸光法、
そして粗サポニンは重量法により測定した。
(Examples 1 to 4) To each of the four Erlenmeyer flasks, 175 mL of water and 30 to 35 g of ginseng ginseng were added, and ten ginseng ginseng of 10, 12.5, 15 and 2 were added.
2 wt% of citric acid was added respectively (Examples 1 to 1
4). 1. Cover the mouth of each Erlenmeyer flask with a wrapping film for food packaging to cover, and in an autoclave.
It was boiled under a pressure of 1 to 1.2 kgf / cm 2 for about 2 hours. After allowing to cool, the solution portion was centrifuged (3,000 rpm,
5 minutes) to obtain a hot water extract of Panax ginseng. The precipitation residue was returned to the Erlenmeyer flask in which the original figure of Radix Notoginseng remained, and the remaining appearance of Radix Notoginseng with 200m of 50% ethanol solution
L, equipped with a reflux condenser in an Erlenmeyer flask,
Further extraction was carried out by heating for 1 to 1.5 hours. After allowing the heated solution to cool, it is centrifuged (5,000 rpm, 1
(0 min) to separate the ethanol extract, and the extract was combined with the extract previously collected, concentrated under reduced pressure, and freeze-dried to give a powder. Table 1 shows the measurement results of the yield of powder amount, the content of minerals and the content of crude saponin for these powders. For minerals, atomic absorption method,
And the crude saponin was measured by the gravimetric method.

【0036】[0036]

【表1】 表1より種々の濃度のクエン酸水溶液と50%エタノー
ル溶液を用いて、田七人参姿から、直接ミネラルおよび
粗サポニンの無機および有機の有効成分を含む抽出エキ
スが得られることが明らかになった。これは田七人参姿
という極めて硬い固形物素材も、クエン酸存在下で加圧
・加熱することにより、表面組織が軟弱になり、組織内
部から含有成分が溶出されることを示している。そして
エキス粉末収量が少ないときはミネラル類および粗サポ
ニン量が多く(実施例2)、エキス粉末収量が多い時は
ミネラル類および粗サポニン量が少ない(実施例3)と
い傾向が認められたが、田七人参姿に対して添加される
クエン酸の濃度が10重量%〜22重量%の範囲では、
抽出される有効成分に大差はないと判断された。
[Table 1] From Table 1, it was clarified that the extract extracts containing the inorganic and organic active ingredients of minerals and crude saponins can be obtained directly from Ginseng ginseng using various concentrations of citric acid aqueous solution and 50% ethanol solution. . This indicates that even with an extremely hard solid material such as the figure of Ginseng ginseng, the surface tissue becomes soft and the contained components are eluted from the inside of the tissue by pressurizing and heating in the presence of citric acid. When the yield of the extract powder was low, the amounts of minerals and crude saponin were large (Example 2), and when the yield of the extract powder was high, the amounts of minerals and crude saponin were low (Example 3). When the concentration of citric acid added to the figure of Ginseng is 10 wt% to 22 wt%,
It was judged that there was no great difference in the extracted active ingredients.

【0037】なお、田七人参姿9.8gを水100mL
に時々超音波を5分間かけながら11日間浸漬した後、
エタノール50mLを加えて75℃、7時間加熱還流し
た。この抽出液を分取した後、残存固形分を70%エタ
ノール溶液100mLとともに80℃、5時間加熱還流
して固液分離を行って抽出液を集め、先の抽出液と合せ
て濃縮乾固して得られた乾燥品の収率は18%にすぎな
かった。この結果と表1の結果を比較すると、本発明の
クエン酸溶液による加圧抽出と希釈エタノール溶液によ
る加熱抽出を組み合わせた方法は、抽出に要する所要時
間、エキスの収率においてその有効性が明らかである。
It should be noted that 9.8 g of the seven ginseng fields are added to 100 mL of water.
After immersing in ultrasonic waves for 5 minutes for 11 days,
50 mL of ethanol was added and the mixture was heated under reflux at 75 ° C. for 7 hours. After this extract was collected, the residual solid content was heated and refluxed with 100 mL of 70% ethanol solution at 80 ° C. for 5 hours to perform solid-liquid separation to collect the extract, and the extract was combined and concentrated to dryness. The yield of the dried product obtained was only 18%. Comparing this result with the result in Table 1, the effectiveness of the method of the present invention in which the pressure extraction with the citric acid solution and the heat extraction with the diluted ethanol solution are combined is effective in the time required for the extraction and the yield of the extract. Is.

【0038】(実施例5)田七人参姿に対するクエン酸
濃度10重量%におけるミネラル類と粗サポニンの抽出
率の程度を把握するため、田七人参の粉末形態を使用し
て検討した。田七人参粉末そのものと、田七人参粉末を
実施例1と同様の抽出方法行って得た抽出エキス粉末
(実施例5)の成分測定を行い、田七人参粉末自体の測
定値と比較検討した結果を表2に示した。この結果から
カルシウムを除いて、マグネシウム等のミネラル類と粗
サポニンは96〜111%の収率を得て、本発明の有効
性が明らかとなった。
(Example 5) In order to understand the extent of extraction of minerals and crude saponins at a citric acid concentration of 10% by weight with respect to Ganoderma lucidum, a powder form of Ganoderma lucidum was examined. The ingredients of the extract of Tanchijin ginseng itself and the extract powder of Example 7 obtained by performing the same extraction method as in Example 1 on the powder of Tanchijin ginseng were measured and compared with the measured values of the extract of Tannin ginseng powder itself. The results are shown in Table 2. From this result, minerals such as magnesium and crude saponin except for calcium were obtained in a yield of 96 to 111%, demonstrating the effectiveness of the present invention.

【0039】[0039]

【表2】 (実施例6〜9)次に、表面が非常に硬い田七人参姿か
ら成分抽出に有効な酸類と、生成されたエキス末の酸味
度を弱める目的で、クエン酸(実施例3)、リンゴ酸
(実施例6)、黒酢(実施例7)、グルコン酸(実施例
8)、グルクロン酸(実施例9)による検討を実施例3
の条件に従って検討した。その結果を表3に示す。この
うち、リンゴ酸とグルコン酸は田七人参姿からの抽出エ
キスがフリーズドライ法によっては粉末化できるが、ス
プレードライ法では粉末化できないという製剤生産上で
の大きな欠点が認められた。また、グルクロン酸は非常
に高価であるためコストの面で不適切である。クエン酸
と黒酢との比較では抽出末収量が前者の方が高いことか
ら、田七人参の抽出エキスを得るためには、クエン酸が
最適であることがわかった。
[Table 2] (Examples 6 to 9) Next, acids that are effective for extracting components from the appearance of Tanchijin ginseng whose surface is very hard, and citric acid (Example 3) and apple for the purpose of weakening the acidity of the resulting extract powder. Examination with acid (Example 6), black vinegar (Example 7), gluconic acid (Example 8), and glucuronic acid (Example 9) was conducted in Example 3
It examined according to the conditions of. The results are shown in Table 3. Among them, malic acid and gluconic acid were found to be a major defect in the production of a pharmaceutical preparation, in which an extract extracted from the figure of Radix Notoginseng could be pulverized by the freeze-drying method, but could not be pulverized by the spray-drying method. In addition, glucuronic acid is very expensive and is not suitable in terms of cost. From the comparison between citric acid and black vinegar, the yield of the extracted powder was higher in the former, and it was found that citric acid is the most suitable for obtaining the extract of Ganoderma lucidum.

【0040】[0040]

【表3】 (実施例10〜13)次いで、抽出エキス粉末量を増加
する方法を検討した。熱水抽出操作終了後の田七人参姿
を裁断してみると、中心部に白色部分が残っていること
がわかったので、抽出操作を次のように改めた。すなわ
ち、田七人参を姿(実施例10)の形態から、大粒子
(約10〜約15mmφ:実施例11)、中粒子(約5
〜約7mmφ:実施例12)および小粒子(約2〜約3
mmφ:実施例13)に破砕し、粒子状形態に変えて同
様に処理して粉末エキスの抽出率を比較した。
[Table 3] (Examples 10 to 13) Next, a method for increasing the amount of the extract powder was examined. After cutting the hot water extraction operation, we saw the figure of Ginseng ginseng, and it was found that a white part remained in the center, so the extraction operation was amended as follows. That is, from the form of the figure of Ganoderma lucidum (Example 10), large particles (about 10 to about 15 mmφ: Example 11) and medium particles (about 5).
~ About 7 mmφ: Example 12) and small particles (about 2 to about 3).
mmφ: crushed into Example 13), changed to a particulate form and treated in the same manner to compare the extraction ratio of the powder extract.

【0041】4つの三角フラスコの各々に、田七人参
姿、大粒子、中粒子、および小粒子15〜20gと、そ
の1/10重量のクエン酸と水130mlとを入れて、
沸騰水中で1時間加熱処理した後に、食品包装用ラップ
フィルムで各三角フラスコの口を蓋をするように覆っ
て、オートクレーブ中で1.1〜1.2kgf/cm2
の加圧下で約2時間煮沸した。放冷後、それぞれの試料
について、溶液部分を遠心分離(3,000rpm、5
分)して熱水抽出液を得た。沈殿残渣は元の田七人参姿
が残っている三角フラスコに戻し、残存する田七人参姿
とともに50%エタノール溶液200mLを用い、各三
角フラスコに還流冷却器をつけて85℃、1〜1.5時
間加温することによりさらに抽出した。この加熱溶液を
放冷後、それぞれ遠心分離(5,000rpm、10
分)してエタノール抽出溶液を分取し、それぞれ先に分
取した抽出液と併せて減圧下で濃縮し、フリーズドライ
処理を行って粉末化した。他の形態のものも田七人参姿
と同様の操作を行った。
To each of the four Erlenmeyer flasks, the figure of Ginseng ginseng, large particles, medium particles and small particles of 15 to 20 g, citric acid of 1/10 weight thereof and 130 ml of water were put,
After heat treatment for 1 hour in boiling water, the mouth of each Erlenmeyer flask is covered with a wrap film for food packaging so as to cover it, and 1.1 to 1.2 kgf / cm 2 in an autoclave.
It was boiled under pressure for about 2 hours. After allowing to cool, the solution portion of each sample was centrifuged (3,000 rpm, 5
Min) to obtain a hot water extract. The precipitation residue was returned to the Erlenmeyer flask with the original figure of Ginseng, and 200 mL of 50% ethanol solution was used together with the figure of Ginseng remaining, and a reflux condenser was attached to each Erlenmeyer flask at 85 ° C for 1-1. Further extraction was carried out by heating for 5 hours. After allowing this heated solution to cool, it was centrifuged (5,000 rpm, 10
The ethanol extract solution was separated, and the extract solution was combined with each of the extract solutions previously collected, concentrated under reduced pressure, and freeze-dried to give a powder. For other forms, the same operations as for the seven fields of ginseng were performed.

【0042】実施例10〜13の結果を表4に示した。
表4の結果から明らかなように、姿から細粒化すること
により各有効成分の含有量を保持したままで、エキス粉
末量、つまり抽出率を、約2倍に増加させることができ
た。また、理由は不明だが粒状を小さくした方が粗サポ
ニン含有量が低下する傾向が認められた。
The results of Examples 10 to 13 are shown in Table 4.
As is clear from the results in Table 4, the amount of the extract powder, that is, the extraction rate could be increased about twice by keeping the content of each active ingredient by making the particles finer from the shape. Although the reason is unknown, it was confirmed that the crude saponin content tended to decrease as the particle size decreased.

【0043】なお、表4には示していないが、本発明の
素材として田七人参の粉末形態(80メッシュを通過)
を用いたときの抽出エキス末の収率は、75.3%であ
り、その粗サポニン含有率は9.7%であった。
Although not shown in Table 4, the powder form of Ganoderma radix as a raw material of the present invention (passes through 80 mesh)
The yield of the extract powder obtained when was used was 75.3%, and the crude saponin content was 9.7%.

【0044】[0044]

【表4】 なお、高麗人参と大豆のそれぞれの乾燥原形(姿)各2
0gを実施例10と同様に処理して得た、それぞれのエ
キス粉末収率は、30%および27.5%であり、本発
明の方法が、表面硬度が高い固形物素材に広く適用でき
ることが示された。
[Table 4] Each ginseng and soybean dry original form (appearance) 2 each
The extract powder yields obtained by treating 0 g in the same manner as in Example 10 were 30% and 27.5%, respectively, and the method of the present invention can be widely applied to solid materials having high surface hardness. Was shown.

【0045】(実施例14)小粒子状の田七人参(実施
例13と同一品)91kgとクエン酸9kgおよび水5
50lを加圧装置付きタンクに入れた。90〜96℃で
1時間加熱を続けた後、加圧状態にして1.1kgf/
cm2に保ち2時間抽出した。得られた加熱抽出液を、
NA500濾紙を装着した加圧濾過装置で濾過して分取
した。続いてタンク内の抽出残渣に45重量%エタノー
ル溶液700lを加え、65℃、2時間加熱還流を行っ
た後、得られたエタノール抽出液を、NA500濾紙を
装着した加圧濾過装置で濾過して分取した。クエン酸抽
出液とエタノール抽出液の濾液を合併して濃縮した後、
スプレードライ法によってエキス粉末を65.76kg
を得た。本実施例のエキス粉末中の成分分析の結果を表
5に示す。スケールアップによってエキス抽出率は若干
低下する傾向が認められたが、エキス中の有効成分含有
量は実験室レベルと同等であった。ミネラル成分のうち
有機態のものは、カリウム、カルシウム、マグネシウ
ム、鉄、および亜鉛において、それぞれ10.7%、4
7.3%、37.4%、86.5%および89.6%で
あった。
(Example 14) 91 kg of small particulate Ginseng (the same product as in Example 13), 9 kg of citric acid and 5 parts of water
50 l were placed in a tank with pressure device. After continuing heating at 90 to 96 ° C for 1 hour, pressurize to 1.1 kgf /
It was kept at cm 2 and extracted for 2 hours. The resulting heated extract,
It was filtered and collected by a pressure filter equipped with NA500 filter paper. Subsequently, 700 l of a 45% by weight ethanol solution was added to the extraction residue in the tank, the mixture was heated under reflux at 65 ° C. for 2 hours, and the obtained ethanol extract was filtered with a pressure filter equipped with NA500 filter paper. I collected it. After the filtrates of citric acid extract and ethanol extract were combined and concentrated,
65.76 kg of extract powder by spray dry method
Got Table 5 shows the results of component analysis in the extract powder of this example. Although the extract extraction rate tended to decrease slightly due to scale-up, the active ingredient content in the extract was equivalent to the laboratory level. Among the mineral components, organic components are 10.7% and 4 for potassium, calcium, magnesium, iron, and zinc, respectively.
It was 7.3%, 37.4%, 86.5%, and 89.6%.

【0046】なお、有機態亜鉛と無機態亜鉛の測定は以
下のようにして行った。
The organic zinc and the inorganic zinc were measured as follows.

【0047】エキス粉末の0.5gを栓付試験管に取
り、水を加えて完全に溶解して一定容積にする。同容の
エタノールを徐々に加えて良く振り混ぜると沈殿が生じ
るので、そのまま、冷凍庫内に3時間静置する。この試
験管を取り出し遠心分離(3,000rpm、10分)
によって固液分離を行う。上清は濃縮してエタノールを
留去した後、蒸留水に溶かして元の一定容積にして無機
態亜鉛の測定溶液とする。一方の固体は2N-塩酸溶液
に溶かして元の一定容積に合わせて、有機態亜鉛の測定
溶液とする。それぞれの測定溶液につい亜鉛含量を湿式
分解後原子吸光法により測定した。
0.5 g of the extract powder was placed in a test tube with a stopper, and water was added to completely dissolve the solution and bring it to a constant volume. If the same volume of ethanol is gradually added and shaken well, a precipitate will form, so leave it in the freezer for 3 hours. Remove this test tube and centrifuge (3,000 rpm, 10 minutes)
Solid-liquid separation is performed by. After concentrating the supernatant and distilling off ethanol, the supernatant is dissolved in distilled water to make the original constant volume and used as a measurement solution of inorganic zinc. One of the solids is dissolved in a 2N-hydrochloric acid solution and adjusted to the original constant volume to obtain a measurement solution of organic zinc. The zinc content of each measurement solution was measured by the atomic absorption method after wet decomposition.

【0048】また、ジンセノシドRg1の定量結果は
2.5g/100gであった(高速液体クロマトグラフ
ィー(HPLC)による)。デンシチンおよび遊離γ−
アミノ酪酸の定量結果はそれぞれ931.1ppmおよ
び1460ppmであった。また、ゲルマニウム含量は
35ppbであった。その他の微量成分として、100
g当たりの含量を示すと、ビタミン類ではサイアミン塩
酸塩0.18mg、リボフラビン0.35mgであり
(いずれもHPLC法による)、遊離アミノ酸類ではア
ミノ酸自動分析法によって、アルギニン(740m
g)、アスパラギン酸(136mg)、アラニン(29
mg)、プロリン(23mg)、ロイシン、リジン、セ
リン、スレオニン、バリン、フェニルアラニン、チロジ
ン、イソロイシン、グリシン、ヒスチジン、グルタミン
酸が13〜5mg定量された。
The quantitative determination result of ginsenoside Rg1 was 2.5 g / 100 g (according to high performance liquid chromatography (HPLC)). Dencitin and free γ-
The quantitative results of aminobutyric acid were 931.1 ppm and 1460 ppm, respectively. The germanium content was 35 ppb. As other trace ingredients, 100
The content per g is 0.18 mg of thiamine hydrochloride and 0.35 mg of riboflavin for vitamins (all by HPLC method), and free amino acids by arginine (740 m
g), aspartic acid (136 mg), alanine (29
mg), proline (23 mg), leucine, lysine, serine, threonine, valine, phenylalanine, tyrosine, isoleucine, glycine, histidine, and glutamic acid were quantified at 13 to 5 mg.

【0049】[0049]

【表5】 さらに、本発明による抽出エキス粉末中には、グリコー
ゲンが37.45%含有されていることが明らかになっ
た。この値は、田七人参当たりに換算すると25.25
%となり、そしてそれ故、元の田七人参当たりのグリコ
ーゲン含有率4.42%に対し、上記の処理によって、
5.7倍のグリコーゲンが生成されたことを示してい
る。
[Table 5] Further, it was revealed that glycogen was contained in the extract powder of the present invention at 37.45%. This value is 25.25 when converted to per seven ginseng.
%, And therefore the original glycogen content per ginseng of 4.42% was
It shows that 5.7 times as much glycogen was produced.

【0050】(実施例15)フォスファチジルセリン
(PS40)6.0重量%、マルトース6.6重量%、
リン酸カルシウム1.6重量%相当量を混合機によっ
て、予備配合末を作成し、これと本発明の田七人参エ
キス末20.9重量%、でんぷん10重量%および乳糖
ー粉末セルロース45重量%とをよく混合して篩過す
る。これを混合機に投入し、さらにショ糖脂肪酸エステ
ル5重量%、リン酸カルシウム0.9重量%および乳糖
ー粉末セルロース5重量%をいれて混合する。この粉末
を打錠機で打錠後シェラックコーティングしてポリシン
グを行って、錠剤型の食用組成物を試作した。
(Example 15) Phosphatidylserine (PS40) 6.0% by weight, maltose 6.6% by weight,
By calcium phosphate 1.6 wt% amount equivalent mixer to create a pre-compounded Powder, this and Panax ginseng extract powder 20.9% by weight of the present invention, a 10% by weight starch and lactose over powdered cellulose 45 wt% Mix well and sieve. This is put into a mixer, and 5% by weight of sucrose fatty acid ester, 0.9% by weight of calcium phosphate and 5% by weight of lactose-powdered cellulose are added and mixed. This powder was tabletted with a tableting machine, shellac-coated, and polished to produce a tablet-type edible composition.

【0051】(実施例16)本発明の田七人参エキス末
1kgに、2重量%核酸酵母エキスおよび0.5重量%
デキストリンを混合し、15重量%還元麦芽糖水溶液を
噴霧し、噴霧造粒機に供して、造粒化した後、乾燥、篩
過して顆粒状の食用組成物を試作した。
(Example 16) 2 kg by weight of nucleic acid yeast extract and 0.5% by weight were added to 1 kg of powdered ginseng extract of the present invention.
Dextrin was mixed, a 15 wt% reduced maltose aqueous solution was sprayed, and the mixture was subjected to a spray granulator for granulation, followed by drying and sieving to produce a granular edible composition.

【0052】[0052]

【発明の効果】本発明によれば、表面が非常に硬質であ
る田七人参姿を、有機酸の存在下で加圧するという簡便
な操作に続き、希釈エタノール溶液で再抽出することに
より、サポニン類、デンシチン、アミノ酸、γ−アミノ
酸、ビタミン類などの有機成分、およびカリウム、カル
シウム、マグネシウム、亜鉛、鉄などのミネラル成分を
も含有する田七人参エキスを製造できる。そして、抽出
原料の形態としては、姿、細粒、粉末のいずれでも良
く、その上、体内で吸収性の良い水溶性のエキス粉末を
製造できることを特徴とする。また、田七人参中の有効
成分が水溶性の性状を持って抽出できているため、他の
物質との配合調整が容易となり、機能性因子としての効
果を高めた健康食品や栄養補助食品をはじめ各種飲食物
を製造することができる。
EFFECTS OF THE INVENTION According to the present invention, saponin is regenerated by diluting ethanol solution with a simple operation of pressurizing Tachinichinin ginseng, which has a very hard surface, in the presence of an organic acid. It is possible to produce an extract of Panax notoginseng which also contains organic components such as compounds, densitins, amino acids, γ-amino acids and vitamins, and mineral components such as potassium, calcium, magnesium, zinc and iron. Further, the form of the extraction raw material may be any of the form, fine granules and powder, and moreover, it is characterized in that a water-soluble extract powder having good absorbability in the body can be produced. In addition, since the active ingredient in Ganoderma ginseng can be extracted with water-soluble properties, it is easy to adjust the combination with other substances, and health foods and nutritional supplements with enhanced effect as a functional factor can be obtained. First, various foods and drinks can be produced.

Claims (10)

【特許請求の範囲】[Claims] 【請求項1】 田七人参エキスであって、 田七人参を酸性条件および加圧条件下で熱水抽出する工
程、 熱水抽出液を抽出残渣から分離する工程、および該抽出
残渣を有機溶媒で抽出する工程を包含する方法によって
製造され、 水溶性であって、ミネラル、デンシチン、サポニン、ビ
タミン、アミノ酸およびγ−アミノ酸からなる群から選
択される有機有効成分を高濃度で含有する、田七人参エ
キス。
1. An extract of Panax notoginseng, which comprises extracting Panax notoginseng with hot water under acidic conditions and pressure conditions, separating the hot water extract from the extraction residue, and extracting the extraction residue with an organic solvent. Manufactured by a method including a step of extracting with a water-soluble, high-concentration organic active ingredient selected from the group consisting of minerals, densitin, saponin, vitamins, amino acids and γ-amino acids, Carrot extract.
【請求項2】 前記方法が、田七人参を細粒化または粉
末化する工程をさらに包含する、請求項1に記載の田七
人参エキス。
2. The extract of Panax notoginseng according to claim 1, wherein the method further comprises a step of granulating or powdering Panax notoginseng.
【請求項3】 前記酸性条件および加圧条件下で熱水抽
出する工程が有機酸の存在下で行なわれる、請求項1に
記載の田七人参エキス。
3. The Tannin ginseng extract according to claim 1, wherein the step of hot water extraction under the acidic condition and the pressurized condition is performed in the presence of an organic acid.
【請求項4】 前記有機酸が、クエン酸および酢酸から
なる群から選択される、請求項3に記載の田七人参エキ
ス。
4. The Panax notoginseng extract according to claim 3, wherein the organic acid is selected from the group consisting of citric acid and acetic acid.
【請求項5】 前記ミネラルが、カリウム、カルシウ
ム、マグネシウム、亜鉛、鉄およびゲルマニウムからな
る群から選択される、請求項1に記載の田七人参エキ
ス。
5. The Radix Notoginseng extract according to claim 1, wherein the mineral is selected from the group consisting of potassium, calcium, magnesium, zinc, iron and germanium.
【請求項6】 田七人参エキスの製造方法であって、 田七人参を酸性条件および加圧条件下で熱水抽出する工
程、 熱水抽出液を抽出残渣から分離する工程、および該抽出
残渣を有機溶媒で抽出する工程、を包含する方法。
6. A method for producing a Panax notoginseng extract, comprising the steps of extracting Panax ginseng with hot water under acidic and pressurized conditions, separating the hot water extract from the extraction residue, and the extraction residue. Extraction with an organic solvent.
【請求項7】 田七人参を細粒化または粉末化する工程
をさらに包含する、請求項6に記載の方法。
7. The method according to claim 6, further comprising the step of finely granulating or powdering Ginseng ginseng.
【請求項8】 前記酸性条件および加圧条件下で熱水抽
出する工程がpH6以下で行なわれ、前記有機溶媒で抽
出する工程が40〜50%エタノール水溶液を用いて加
温下で行なわれる、請求項6に記載の方法。
8. The step of extracting with hot water under the acidic condition and the pressurized condition is carried out at a pH of 6 or lower, and the step of extracting with the organic solvent is carried out under heating with an aqueous 40-50% ethanol solution. The method of claim 6.
【請求項9】 請求項1に記載の田七人参エキスを含
む、食用組成物。
9. An edible composition comprising the extract of Panax notoginseng according to claim 1.
【請求項10】 表面硬質の固形物から有効成分を抽出
する方法であって、 表面硬質の固形分を酸性条件および加圧条件下で熱水抽
出する工程、 熱水抽出液を抽出残渣から分離する工程、および該抽出
残渣を有機溶媒で抽出する工程、を包含する方法。
10. A method for extracting an active ingredient from a hard surfaced solid, comprising the steps of: extracting hot solids with hot water under acidic and pressurized conditions; separating a hot water extract from an extraction residue. And a step of extracting the extraction residue with an organic solvent.
JP2001280812A 2001-09-14 2001-09-14 Extraction method of active ingredient from solid surface solid and edible composition containing the active ingredient Expired - Fee Related JP4306987B2 (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396543B2 (en) 2001-12-07 2008-07-08 Bizen Chemical Co., Ltd. Process for physicochemically producing glycogen and glycogen obtained thereby
JP2008222697A (en) * 2007-03-15 2008-09-25 Newtree Industry Co Ltd Efficient method for producing ginseng extract with high content of saponin unique to red ginseng
JP2013017467A (en) * 2011-06-15 2013-01-31 Kaneka Corp Citral flavoring agent and method for manufacturing the same
US8883228B2 (en) 2003-07-31 2014-11-11 Tasly Pharmaceutical Group Co. Ltd. Composition for heart disease, its active ingredients, method to prepare same and uses thereof
JP2018148852A (en) * 2017-03-13 2018-09-27 国立大学法人 琉球大学 Production method of turmeric extract from which sugar or the like is removed
JP2019026634A (en) * 2017-07-27 2019-02-21 共栄化学工業株式会社 Composition for hair and external composition for skin
KR102066265B1 (en) * 2019-09-05 2020-01-14 이재성 Extraction method of cosmetic raw materials

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396543B2 (en) 2001-12-07 2008-07-08 Bizen Chemical Co., Ltd. Process for physicochemically producing glycogen and glycogen obtained thereby
US8883228B2 (en) 2003-07-31 2014-11-11 Tasly Pharmaceutical Group Co. Ltd. Composition for heart disease, its active ingredients, method to prepare same and uses thereof
JP2008222697A (en) * 2007-03-15 2008-09-25 Newtree Industry Co Ltd Efficient method for producing ginseng extract with high content of saponin unique to red ginseng
JP2013017467A (en) * 2011-06-15 2013-01-31 Kaneka Corp Citral flavoring agent and method for manufacturing the same
JP2018148852A (en) * 2017-03-13 2018-09-27 国立大学法人 琉球大学 Production method of turmeric extract from which sugar or the like is removed
JP2019026634A (en) * 2017-07-27 2019-02-21 共栄化学工業株式会社 Composition for hair and external composition for skin
KR102066265B1 (en) * 2019-09-05 2020-01-14 이재성 Extraction method of cosmetic raw materials

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