JP7265237B2 - Hair composition and external skin composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to a composition containing a novel active ingredient derived from a natural product and excellent in biosafety, and particularly having a hair growth effect, an anti-aging effect and a whitening effect.

In recent years, the scalp is damaged by various factors such as aging, stress, and ultraviolet rays, and the number of people suffering from hair troubles is increasing, not only in men but also in women. Proposed. Conventionally, research on androgenetic alopecia (alopecia in the prime of life) and female pattern alopecia (androgenetic alopecia occurring in women) has been conducted as a hair trouble, and male hormones are involved in these alopecia. As a result, various antiandrogen agents, female hormone mimetic agents, etc. have been proposed as ameliorating agents for hair troubles.

Furthermore, recent research has shown that not only the number of hairs is reduced, but also the hair growth period is shortened in the hair growth cycle (hair cycle). It has also been clarified that the condition and "decrease in firmness and stiffness" of hair occur. Hair grows according to a periodic hair cycle (hair cycle) consisting of telogen, anagen, and catagen phases, and the cycle is regulated by various factors. Therefore, the hair can be grown thick and long by promoting the production of factors that cause the transition from the telogen phase to the anagen phase and factors involved in the maintenance of the anagen phase. As a result, it is possible to prevent/improve hair loss and thinning hair, and to improve the loss of luster and elasticity of hair.

In order to prevent the scalp from aging and becoming unhealthy as described above and to keep it in a youthful state, furthermore, based on the above-mentioned research on the mechanism of scalp damage and hair loss, various hair growth / hair growth agents and hair loss suppression agents (referred to as hair restorers, etc.) have been proposed. For example, minoxidil and adenosine are known as active ingredients that exhibit hair-restoring and hair-nourishing effects, and hair restorers and the like containing these ingredients have been proposed. However, active ingredients contained in conventional hair restorers and the like may cause side effects such as irritation of the scalp, and there is a demand for sufficiently effective and highly safe hair-restoring ingredients and hair loss-suppressing ingredients.

JP 2016-523957

As a result of intensive studies on the above problems of the prior art, the present inventors found that a carrot extract containing a high concentration of saponin suppresses the proliferation of highly active androgen (DHT)-dependent SC-3 cells. I found In addition, the present inventors have newly found that a combination of a carrot extract and a tea extract containing methylated catechin can provide a hair composition having a hair-growing effect and an effect of restoring the health of the hair cycle. Patent Document 1 discloses a skin protection composition containing epigallocatechin and ginseng-derived ginsenoside F1. It has not been known that the substance has a hair-growth effect, and furthermore, has an effect of adjusting the environment in dermal papilla cells and restoring the hair cycle.

SUMMARY OF THE INVENTION The present invention is a carrot extract of the Araliaceae genus Panax containing high concentrations of saponins.
The present invention is a hair composition containing a carrot extract containing a high concentration of saponin as an active ingredient.
The present invention is a hair composition comprising a carrot extract containing a high concentration of saponins and an extract of Camellia sinensis, a plant belonging to the genus Camellia of the family Theaceae.
The present invention provides a carrot extract of the genus Panax of the Araliaceae family (Araliaceae) containing high concentrations of saponins, and an extract of Camellia sinensis, a plant of the genus Camellia (Theaceae family), It is an external skin composition containing, as an active ingredient, an extract of a plant belonging to the genus Callicarpa of the Labiatae family.

INDUSTRIAL APPLICABILITY The present invention is a carrot extract containing a high concentration of saponin, and the androgen receptor binding inhibitory effect exhibited by this extract can provide a hair composition having an excellent hair growth effect. Furthermore, by using a carrot extract and a tea extract containing methylated catechins in combination, a composition for hair exhibiting a hair growth effect, an effect of adjusting the environment in dermal papilla cells, and an effect of restoring the hair cycle. can provide.

In addition, the present invention provides anti-aging and whitening effects by combining a carrot extract containing a high concentration of saponin, a tea extract containing methylated catechins, and a plant extract of the genus Callicarpa. An excellent composition for external use on the skin can be provided.

Plants belonging to the genus Araliaceae used in the present invention include Panax ginseng (C.A. Meyer), Panax japonicus, Panax pseudoginseng and the like.

There are no particular limitations on the parts of the extract of a plant belonging to the genus Araliaceae of the genus Araliaceae, and suitable parts such as whole plants, leaves, flowers, stamens, pistils, stems, roots, seeds (grains), and fruits can be used. , it is preferable to use roots and fruits. Red ginseng and white ginseng obtained by processing the root of a plant belonging to the genus Panax can also be used.

The “tea” used in the present invention is “Camellia sinensis” which is a plant of the genus Camellia in the family Theaceae. Any tea variety can be used, and examples include Yutakamidori, Okumidori, Saemimidori, Sayamakaori, Kanayamidori, Asatsuyu, Samidori, Gokou, Benifuuki, and Tadanishiki. .

The tea material used in the present invention may be the whole plant, leaves, flowers, stems, seeds, fruits, roots, etc., but the use of the whole plant or leaves is preferred. When using leaves, oolong tea leaves or black tea leaves may be used.

Examples of plants belonging to the genus Callicarpa used in the present invention include Callicarpa japonica, Callicarpa japonica var. luxurians, Callicarpa dichotoma, Callicarpa formosana, and Callicarpa mollis. is mentioned.

For the preparation of the extract, the plant to be extracted is washed with water in advance to remove foreign matter, if necessary, and then dried as it is or dried, and if necessary, finely chopped or pulverized, and then immersed or countercurrently applied. It can be carried out by contacting with an extraction solvent according to a conventional method such as an extraction method or a steam distillation method. Moreover, in the present invention, a supercritical extraction method may be employed.

Extraction solvents used for extract treatment include water; lower alcohols such as methanol, ethanol and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin; ethyl acetate and butyl acetate. , esters such as methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; Two or more kinds are mixed and used. In the present invention, it is preferable to use solvents having different polarities (water and ethanol, etc.) from the viewpoint of obtaining a high concentration of saponin.

In preparation of the extract, there is no particular limitation on the pH of the extract, but it is generally preferred to be in the range of pH 3-9. The pH is adjusted by adding an alkalinity adjuster such as sodium hydroxide, sodium carbonate, or potassium hydroxide, or an acidity adjuster such as citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid to the extraction solvent. be able to.

Extraction conditions such as extraction temperature and time vary depending on the type and pH of the solvent used, or the size of the plant material. In the case of the immersion method, the extraction temperature is in the range of 0 to 80°C. The extraction time is preferably in the range of 1 to 7 days in the case of cold extraction at 4°C, and in the range of 1 hour to 3 days in the case of medium temperature extraction around 40°C. In the case of high temperature extraction at 80° C., the time should be in the range of 1 hour to 24 hours. In the case of the immersion method, the bath ratio is generally 1 to 200 times, preferably 1 to 100 times the weight of the plant material.

Among the extracts prepared as described above, the carrot extract may be subjected to an operation called aging in order to increase the saponin concentration. For example, the extract is aged by allowing it to stand at 20 to 25° C. or room temperature for 5 to 10 days. Alternatively, the saponin concentration may be increased using an enzymatic decomposition method or a fermentation method.

The extract prepared as described above is further subjected to one or more of activated carbon treatment, ion exchange resin treatment, synthetic adsorbent, silica gel, and recrystallization treatment in combination to obtain a high concentration of saponin. It may be prepared into an extract containing. Activated charcoal can be made from plant materials such as pine, bamboo, coconut shells, walnut shells, etc., as well as coal, petroleum, etc., and high-temperature carbonization using gases such as steam, carbon dioxide, and air for these raw materials. Activated carbon can be obtained by a physical method such as a chemical method such as a method using a chemical such as zinc chloride, and then heated to make it porous. Examples of synthetic adsorbents include nonionic resins such as styrene/divinylbenzene copolymers and methacrylic acid ester polymers.

When the extract according to the present invention is incorporated into a hair composition or external skin composition (including cosmetics, quasi-drugs, and external pharmaceuticals), for example, if it is a skin external preparation for hair growth and hair growth, it is generally Typically, it is 0.00001 to 5.0% by weight (% by weight of solids, the same shall apply hereinafter), preferably 0.001 to 3.0% by weight. In the case of a skin external preparation for washing hair such as shampoo, the content is generally 0.00001 to 5.0% by weight (% by weight of solid content, the same shall apply hereinafter), preferably 0.0001 to 1.0% by weight. %. In the case of rinses and conditioners, the content is generally 0.00001 to 5.0% by weight (% by weight of solids, the same shall apply hereinafter), preferably 0.001 to 1.0% by weight. In the case of basic cosmetics for skin care, it is generally in the range of 0.002 to 1.0% by weight, preferably in the range of 0.02 to 0.2% by weight. .0% by weight, preferably in the range of 0.02-0.2% by weight.

When the extract according to the present invention is blended into skin external preparations for hair, other active ingredients (hair matrix cell activator, antiandrogenic agent, blood circulation promoter, sebum secretion inhibitor, Anti-inflammatory agent, hair protectant, hair cycle growth maintenance agent, etc.) may be combined to provide synergistic hair growth/hair nourishing effects, hair quality improvement effects, and scalp inflammation prevention: Improvement effects can also be expected.

For example, ingredients that can be expected to have a synergistic effect on hair growth/hair growth and prevention/improvement of scalp inflammation include minoxidil, cyproterone acetate, pentadecanoic acid glyceride, 6-aminobenzylpurine (cytopurine), adenosine, trans-3, 4'-dimethyl 3-hydroxy flavanone (t-flavanone), assembly extract, hinokitiol, photosensitizer, pantothenic acid and its derivatives, vitamin E and its derivatives, nicotinic acid derivatives (nicotinamide etc.), carpronium chloride, female hormones (ethinyl estradiol, estrone, etc.), salicylic acid, dipotassium glycyrrhizinate, hinokitiol, benzalkonium chloride, isopropylmethylphenol, l-menthol, pyridoxine hydrochloride (vitamin B6), thioxolone, camphor, resorcinol, perilla leaf extract, tea extract, tamasaki Tsuzurafuji root extract, bis-type alkaloid obtained from Tamasakitsutsurafuji, licorice extract, assembly extract, gypsy flower extract, chamomile extract, royal jelly fermented product, lotus seed fermented product, ginkgo biloba extract, Paldarco bark extract, gentian extract, panax ginseng extract, fermented soy milk, hydrolyzed black soybean extract, Salicornia extract, bamboo shoot extract, kudzu root extract, honeycomb extract, clove extract, collagen, amino acids, vitamins, etc., any one or more thereof may be blended.

In particular, "dipotassium glycyrrhizinate, licorice extract, Paldarco bark extract or gentian extract" that suppresses inflammation of the scalp, cytokine (TGF-β1) involved in hair growth (inducing factor for transition from hair growth phase to regression phase), etc. "Perilla leaf extract" that suppresses the synthesis of, "Isopropylmethylphenol" that has the effect of suppressing inflammation of the scalp and has a bactericidal effect, "Tamasaki Tsutsujifuji root extract or a bis-type alkaloid obtained therefrom" that has a blood flow promoting effect, blood ``Panax ginseng extract'' with blood flow promoting effect and sebum secretion suppressing effect, ``Senburi extract'' with blood circulation promoting effect, ``Soymilk fermented liquid'' with sebum oxidation inhibitory effect, ``Salicornia extract'' that restores the barrier function of the scalp, It is preferable to use in combination with at least one of "bamboo shoot extract or kudzu root extract" which promotes the transition to the growth phase of hair, "mitsui kelp extract" which suppresses hair loss, and "collagen" which suppresses dryness of the scalp.

In addition, hair cosmetics (including quasi-drugs) containing the extract according to the present invention may contain, in addition to the above-mentioned components, components normally used in hair compositions, such as oily components, surfactants ( (synthetic, natural), moisturizing agents, thickeners, antiseptic/bactericidal agents, powder ingredients, UV absorbers, antioxidants, chelating agents, pH adjusters, pigments, fragrances, etc. can do. In addition, as long as the effectiveness and features of the active ingredient according to the present invention are not impaired, other physiologically active ingredients may be used in combination.

Examples of oily components include olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cacao oil, meadowfoam oil, shea butter, tea tree oil, avocado oil, Plant-derived oils and fats such as macadamia nut oil, carrot oil, panax ginseng oil, bergamot oil, plant-derived squalane; animal-derived oils and fats such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax and lanolin; Hydrocarbons such as paraffin, petrolatum, paraffin wax, and squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, and eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, and stearyl alcohol; myristic Synthetic esters and synthetic triglycerides such as isopropyl acid, isopropyl palmitate, butyl oleate, 2-ethylhexylglyceride, higher fatty acid octyldodecyl (octyldodecyl stearate, etc.) and the like can be mentioned.

Examples of surfactants include polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, poly Nonionic surfactants such as oxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkylphenyl ether sulfates, Anionic surfactants such as polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkylphenyl ether phosphates; quaternary ammonium salts, primary to tertiary fatty amine salts, tri cationic surfactants such as alkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylenepolyamine fatty acid amide salts; N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N,N,N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N',N'-dimethyl-N'- Amphoteric surfactants such as β-hydroxypropylammoniosulfobetaine and the like can be used.

Examples of emulsifiers or emulsifying aids include stevia derivatives such as enzyme-treated stevia, saponin or its derivatives, casein or its salts (sodium, etc.), complexes of sugar and protein, sucrose or its esters, lactose, soybean-derived water-soluble Polysaccharides, complexes of soybean-derived protein and polysaccharides, lanolin or its derivatives, cholesterol, stevia derivatives (stevia enzyme-treated products, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins and their Derivatives, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented grains (barley, beans, cereals, etc.) and the like can also be blended.

Moisturizing agents include, for example, glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and sugars such as trehalose, and mucopolysaccharides (eg, hyaluronic acid). acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen hydrolyzate, NMF-related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, silane root (white and white) extracts, various amino acids and derivatives thereof.

Examples of thickening agents include alginic acid, agar, carrageenan, fucoidan, and other brown algae, green algae, or red algae-derived components; Polysaccharides; gums such as xanthan gum, tragacanth gum, guar gum; cellulose derivatives such as carboxymethyl cellulose and hydroxyethyl cellulose; synthetic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, acrylic acid/methacrylic acid copolymer; and derivatives thereof; polyglutamic acid and derivatives thereof;

Antiseptic/bactericidal agents include, for example, urea; paraoxybenzoic acid esters such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate; phenoxyethanol, dichlorophen, hexachlorophene, chlorhexidine hydrochloride, benz chloride Ruconium, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodenyl urea), propanediol, 1,2-pentanediol, various essential oils, dry distillation of bark, fermented radish, plant-derived ethanol such as sugarcane or 1,3-butylene glycol and the like.

Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, cellulose. cereals (rice, wheat, corn, millet, etc.) powders, beans (soybeans, azuki beans, etc.) powders, etc.

UV absorbers include, for example, ethyl para-aminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .

Examples of antioxidants include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and derivatives thereof (eg, vitamin E nicotinate, vitamin E linoleate, etc.).

Examples of chelating agents include trisodium ethylenediaminehydroxyethyltriacetate, edetic acid or salts thereof, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate, tetrasodium hydroxyethanediphosphonate, and the like.

Examples of pH adjusters include citric acid or salts thereof, lactic acid or salts thereof, glycolic acid, succinic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, sodium hydroxide and potassium hydroxide.

Examples of physiologically active ingredients include placenta extract, saxifrage extract, saxifrage extract, perilla extract, rice bran extract or its hydrolyzate, white mustard extract or its hydrolyzate, fermented white mustard, peony extract or hydrolyzate thereof, lotus seed extract or hydrolyzate thereof, ginseng extract or hydrolyzate thereof, adlay hydrolyzate, fermented adlay seed, sake lees extract or ceramide contained therein, fermented sake lees, Pandanus amaryllifolius Roxb. extract, Arcangelicia flava Merrilli extract, rice leaf extract or its hydrolyzate, eggplant (bergamot, long eggplant, Kamo eggplant, rice) eggplant, etc.) extract or its hydrolyzate, apricot fruit extract, seaweed extract such as katamen eucheuma, jellyfish water, rice extract or its hydrolyzate, fermented rice extract, germinated rice extract or its hydrolyzate fermented germinated rice, damask rose flower extract, linoleic acid and its derivatives or extracts (e.g., liposomal linoleic acid), animal- or fish-derived collagen and its derivatives, elastin and its derivatives, glycyrrhetinic acid and Its derivatives, t-cycloamino acid derivatives, vitamin A and its derivatives, allantoin, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, carrot extract, red ginseng extract, loofah extract, sea lettuce extract, peach extract peach kernel extract, kiwi extract, sunflower seed or bud extract, Zizyphus joazeiro extract, daily lily extract or ferment, hibiscus flower extract or ferment, wormwood extract, cherimoya extract, mango extract, mangosteen extract, funori extract, oolong tea extract, purple orchid extract, sansho pericarp or seed coat extract or hydrolyzate, safflower flower extract, casablanca extract, sweet potato extract or Its fermented product, guava leaf extract, Houttuynia cordata extract, Banpeiyu extract, aloe extract, fig flower extract, apple extract and the like.

Next, the present invention will be described in more detail with production examples, formulation examples and test examples, but the present invention is not limited thereto. In the following, all parts mean parts by weight, and all percentages mean weight %.

Production example 1. Preparation of Carrot Extract To 100 g of dried Asian ginseng, 500 g of purified water and 500 g of ethanol were added and immersed at 4° C. for 12 hours. This was filtered and allowed to stand at room temperature for 1 week. The extract solution after standing was filtered to obtain 680 g of a transparent brown carrot extract solution (solid concentration: 2.78%).

Production example 2. Preparation of Carrot Extract 713 g of a carrot extract solution was obtained in the same manner as in Production Example 1, except that 100 g of dried Asian ginseng was used instead of Panax ginseng (solid concentration: 2.26%).

Production example 3. Preparation of Carrot Extract 675 g of a carrot extract solution was obtained in the same manner as in Production Example 1, except that 100 g of dried ginseng was used instead of Panax ginseng (solid concentration: 2.47%).

Production example 4. Preparation of Carrot Extract 691 g of a carrot extract solution was obtained (solid concentration: 2.83%) in the same manner as in Production Example 1, except that 100 g of dried red ginseng was used.

Comparative production example 1. Preparation of Carrot Extract 420 g of purified water and 180 g of 1,3-butylene glycol were added to 100 g of dried Asian ginseng, and extracted at 40° C. for 24 hours. This was filtered to obtain 452 g of a transparent brown carrot extract solution (solid concentration: 3.26%).

Test example 1. Saponin concentration measurement test [Test method]
2.0 mL of acetic anhydride was added to 0.2 g of the carrot extract solution obtained in Production Examples 1 to 4 and Test Example 1, heated in a water bath for 2 minutes, and then filtered. 0.5 mL of sulfuric acid was gently added to 1.0 mL of the obtained filtrate, and it was confirmed whether the interface between the two liquids turned reddish brown.
Next, the state of the test tube in which the interface was observed to be red was photographed with a digital camera, and the strength of the redness was quantified by image analysis. First, the obtained image file was loaded into image analysis software (CS Analyzer, manufactured by ATTO), converted to a grayscale image with only R (reddish) among the RGB elements, and then black and white were reversed. Only the portion of the interface that was red in the original image was selected, and the intensity of whiteness (intensity of redness in the original image) was analyzed. The obtained values were compared with the carrot extract of Comparative Production Example 1, and the relative values of the analytical values of Production Examples 1 to 4 were shown when the analytical value of Comparative Production Example 1 was set to 1.0.

The measurement results of Test Example 1 are shown below.
[Table 1]

As shown in Table 1, it was confirmed that the extracts according to Production Examples 1 to 4 of the present invention contained saponin at a higher concentration than the extract of Comparative Production Example 1.

Test example 2. Evaluation test of highly active androgen (DHT) receptor binding inhibitory effect SC-3 cells exhibiting DHT-dependent proliferation were seeded in a 96-well microplate, and after 24 hours, both DHT and sample solution were added to each well. was added. Here, the extracts of Production Examples 1 to 4 and the extracts of Comparative Production Examples 1 to 2 were used as sample solutions, respectively, to final concentrations of 1.0% and 2.0%. After addition of both DHT and sample solution, SC-3 cells were cultured for an additional 3 days and cell proliferation was measured using the MTT reduction method. In addition, a control section was set to which no sample solution was added, and cell proliferation was measured by the MTT reduction method. The measurement results were shown as relative values when the value in the control section was taken as 100.

Table 2 shows the results of Test Example 2 of the present invention.
[Table 2]

As shown in Table 2, it was confirmed that the extracts according to Production Examples 1 to 4 of the present invention have remarkably superior SC-3 cell growth inhibitory effects compared to the extract of Comparative Production Example 1. rice field. Therefore, by blending the extract according to the present invention, it is possible to provide a hair composition exhibiting a hair growth effect based on the androgen receptor binding inhibitory action.

The composition for hair according to the present invention may contain a tea extract in addition to the carrot extract. In particular, Benifuuki extract contains methylated catechins and has intracellular oxidative damage inhibitory and anti-inflammatory effects (see Japanese Patent Laid-Open Publication No. 2015-134737 by the present applicant). By blending it into a hair composition, it has the effect of adjusting the environment in dermal papilla cells and restoring the hair cycle.

Further, in the present invention, in addition to the above-mentioned carrot extract having an antioxidant effect, Benifuuki extract having an anti-inflammatory effect, and Murasakikibu fruit extract having melanin synthesis inhibitory effect and melanin decomposition promoting effect are used as active ingredients, Due to these effects, it is also possible to provide an external skin composition (skin care cosmetic) having excellent anti-aging and whitening effects.

Formulation example 1. Hair restorer [ingredient] part 1,3-butylene glycol 10.0
Ethanol 20.0
Dipotassium glycyrrhizinate 0.1
Panax ginseng extract 0.3
Tamasakitsutsurafuji extract 0.01
Extract of Production Example 1 5.0
Perfume Appropriate amount Purified water Amount to make the total amount 100 parts The above ingredients were sufficiently stirred and mixed to obtain a hair restorer.

Formulation example 2. Hair Restorer A hair restorer was obtained in the same manner as in Formulation Example 1, except that the extract 5.0 of Production Example 1 was replaced with the extract 5.0 of Production Example 1 in the ingredients of Formulation Example 1.

Formulation example 3. Hair restorer A hair restorer was obtained in the same manner as in Formulation Example 1, except that the extract 5.0 of Production Example 3 was used in place of the extract 5.0 of Production Example 1 among the ingredients of Formulation Example 1.

Formulation example 4. Hair restorer A hair restorer was obtained in the same manner as in Formulation Example 1, except that the extract 5.0 of Production Example 4 was used in place of the extract 5.0 of Production Example 1.

Formulation example 5. Hair Restorer A hair restorer was obtained in the same manner as in Formulation Example 1, except that 0.3 parts of the Panax ginseng extract was replaced with 0.3 parts of the Japonica japonica extract.

Formulation example 6. Hair restorer A hair restorer was obtained in the same manner as in Formulation Example 1, except that 0.3 of the Japonica japonicum extract was used in place of 0.01 of the extract of Rhododendron japonicum.

Formulation example 7. Hair restorer [ingredient] part 1,3-butylene glycol 10.0
Ethanol 20.0
Dipotassium glycyrrhizinate 0.1
Panax ginseng extract 0.3
Tamasakitsutsurafuji extract 0.01
Extract of Production Example 1 3.0
Benifuki tea leaf extract 2.0
Perfume Appropriate amount Purified water Amount to make the total amount 100 parts The above ingredients were sufficiently stirred and mixed to obtain a hair restorer.

Formulation example 8. Hair restorer [Ingredients] part l-menthol 0.8
Adenosine 1.0
Extract of Production Example 1 2.0
assembly extract 0.3
1,3-butylene glycol 10.0
Phenoxyethanol 0.2
Ethanol 20.0
Purified water Amount to make the total amount 100 parts The above ingredients were sufficiently stirred and mixed to obtain a hair restorer.

Formulation example 9. Hair Restorer A hair restorer was obtained in the same manner as in Formulation Example 8, except that minoxidil was used in place of adenosine among the ingredients of Formulation Example 8.

Formulation example 10. Hair Restorer A hair restorer was obtained in the same manner as in Formulation Example 8, except that 6-benzylaminopurine was used in place of adenosine among the ingredients of Formulation Example 8.

Formulation example 11. Hair restorer [Ingredients] Part dipotassium glycyrrhizinate 0.1
l-menthol 0.1
Extract of Production Example 1 1.0
Soy lecithin 0.2
1,3-butylene glycol 10.0
Ethanol 20.0
Bamboo shoot skin extract 3.0
Brown algae extract 3.0
Salicornia extract 3.0
Gentian Extract 3.0
Eelgrass extract 3.0
Perilla leaf extract 3.0
Purified water Amount that makes the total amount 100 parts

Formulation example 12. Hair Cream [Ingredients] Part Liquid Paraffin 15.0
Vaseline 15.0
Bleached Beeswax 2.0
Extract of Production Example 1 3.0
Benifuki tea leaf extract 2.0
Brown algae extract 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Glycerin 5.0
1,3-butylene glycol 2.0
Polyoxyethylene hydrogenated castor oil 3.0
Chelating agent 0.1
Preservative 0.1
Perfume 0.1
Pigment 0.01
Purified water Amount that makes the total amount 100 parts

Formulation example 13. Hair Shampoo [Ingredient] Part Sodium N-coconut oil fatty acid methyl taurate 10.0
Sodium polyoxyethylene (3) alkyl ether sulfate 20.0
Lauryldimethylaminoacetate betaine 10.0
Coconut fatty acid diethanolamide 4.0
Methylparaben 0.1
Citric acid 0.1
Extract of Production Example 1 3.0
Collagen 5.0
Eelgrass extract 5.0
Salicornia extract 5.0
Pau d'Arco bark extract 5.0
Perilla leaf extract 5.0
1,3-butylene glycol 2.0
Purified water Amount that makes the total amount 100 parts

Formulation example 14. Hair Shampoo A hair shampoo was obtained in the same manner as in Formulation Example 13, except that the extract 3.0 of Production Example 1 was replaced with the extract 3.0 of Production Example 1.

Example 15. Hair rinse [Ingredients] Part polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
Extract of Production Example 1 3.0
Benifuki tea leaf extract 2.0
1,3-butylene glycol 5.0
Purified water Amount that makes the total amount 100 parts

Example 16. Hair Rinse A hair rinse was obtained in the same manner as in Formulation Example 15, except that the extract 3.0 of Production Example 1 was replaced with the extract 3.0 of Production Example 1 among the ingredients of Formulation Example 15.

Formulation example 17. Hair rinse A hair rinse was obtained in the same manner as in Formulation Example 15, except that the extract 3.0 of Production Example 3 was used in place of the extract 3.0 of Production Example 1 among the ingredients of Formulation Example 15.

Formulation example 18. Hair rinse A hair rinse was obtained in the same manner as in Formulation Example 15, except that the extract 3.0 of Production Example 1 was replaced with the extract 3.0 of Production Example 1 in the ingredients of Formulation Example 15.

Formulation example 19. Lotion [Ingredients] Part Jojoba oil 1.0
Polyoxyethylene (5.5) cetyl alcohol 5.0
Butylparaben 0.1
Extract of Production Example 1 5.0
Benifuki tea leaf extract 2.0
Murasakishibu fruit extract 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts

Formulation example 20. Emulsion [Ingredients] Part Liquid paraffin 6.0
Hexalane 4.0
Jojoba oil 1.0
Lotus essential oil 0.025
Polyoxyethylene (20) sorbitan monostearate 1.0
Lipophilic glyceryl stearate 1.0
Hydrogenated soybean lecithin 1.5
Extract of Production Example 1 3.0
L-ascorbic acid-2-glucoside 2.0
Benifuki tea leaf extract 2.0
Murasakishibu fruit extract 2.0
Potassium hydroxide 0.5
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethyl cellulose 0.3
Sodium hyaluronate 0.01
Water-soluble collagen 0.1
Fragrance Appropriate amount Purified water Amount to make the total amount 100 parts

Formulation example 21. Milky lotion A milky lotion is obtained in the same manner as in Formulation Example 20, except that 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide contained in Formulation Example 20 are replaced with 2.0 parts of tranexamic acid. rice field.

Formulation example 22. A milky lotion was obtained in the same manner as in Formulation Example 20 except that 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide contained in Formulation Example 20 were replaced with 3.0 parts of arbutin. .

Formulation example 23. Milky lotion A milky lotion was prepared in the same manner as in Formulation Example 20, except that 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide contained in Formulation Example 20 were replaced with 5.0 parts of nicotinamide. Obtained.

Formulation example 24. Lotion [ingredient] Part Extract of Production Example 2 10.0
Benifuki tea leaf extract 2.0
Murasakishibu fruit extract 2.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Guar gum 0.1
Fragrance Appropriate amount Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts

Example 25. Liquid foundation [ingredients] part stearic acid 2.4
Propylene glycol monostearate 2.0
Cetostearyl alcohol 0.2
Liquid Lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
Extract of Production Example 3 5.0
Benifuki tea leaf extract 2.0
Murasakishibu fruit extract 2.0
Carboxymethylcellulose sodium 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Titanium oxide 8.0
Talc 4.0
Color pigment Appropriate amount Purified water Amount to make the total amount 100 parts

Formulation example 17. Body Shampoo [Ingredients] Part N-lauroylmethylalanine sodium 25.0
Coconut fatty acid potassium liquid (40%) 26.0
Coconut fatty acid diethanolamide 3.0
Methylparaben 0.1
Extract of Production Example 1 5.0
Benifuki tea leaf extract 2.0
Murasakishibu fruit extract 2.0
1,3-butylene glycol 2.0
Purified water Amount that makes the total amount 100 parts

Claims (2)

A hair restorer containing an extract of carrot belonging to the genus Tochibanin of the family Araliaceae and a tea extract of Camellia genus Camellia belonging to the family Theaceae. 2. The hair restorer according to claim 1, further comprising an extract of a plant belonging to the genus Murasaki.