KR20150030095A - Composition for improving condition of hair and scalp containing Panax ginseng extract and Green tea extract - Google Patents

Abstract

The present invention relates to a composition for alleviating condition of hair or scalp containing a Panax ginseng extract and a green tea extract, and more specifically, to a composition which prevents grey hair and hair loss, mitigates stimulation to scalp, inhibits dandruff and scalp inflammation, and improves overall hair condition and has excellent purification and soothing effect to scalp by mixing and using the Panax ginseng extract and the green tea extract.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for improving the condition of hair or scalp containing ginseng extract and green tea extract containing Panax ginseng extract and Green tea extract,

The present invention relates to a hair or scalp condition improving composition containing ginseng extract and green tea extract. More particularly, the present invention relates to a composition for preventing hair loss and hair loss by mixing ginseng extract and green tea extract, Dandruff, scalp inflammation and the like, thereby improving the overall hair condition, and having a cleansing and soothing effect on the scalp.

The scalp is composed of the epidermis, dermis, and subcutaneous tissue, and the outermost tissue is the epidermis. The epidermis protects the body's sensitive tissues from damage. However, due to various physical and chemical external stimuli such as external temperature, humidity change, pollutants, stress, and lack of influence, the scalp function may be lost, and furthermore, it may affect hair loss.

In modern society, which emphasizes beauty, many people, both men and women, use hair dye, permanent hair, and the like in order to satisfy the need for expression of individuality. However, in the case of some sensitive scalp, chemical treatment such as dyeing and perming causes irritation such as itching or stinging of the scalp and inflammation, which leads to environmental hair loss.

In this way, it is possible to protect the scalp from stimulation, stress, and chemical treatment from the environment due to various causes, to promote hair growth while preventing hair loss, and to continue research on ecosystem-friendly and environmentally harmless components to humans .

Accordingly, the inventors of the present invention found that, when the ginseng extract and the green tea extract are simultaneously used, the effect of preventing the white hair, hair loss, and dandruff is excellent, compared with the case of using each of these substances by synergistic effect.

Accordingly, it is an object of the present invention to provide a composition showing excellent hair or scalp condition improving effect by using ginseng extract and green tea extract simultaneously.

In order to achieve the above object, the present invention provides a composition for external application for skin or scalp, comprising a ginseng extract and a green tea extract as an active ingredient, or a pharmaceutical composition.

The composition of the present invention contains ginseng extract and green tea extract to prevent white hair and hair loss, alleviate scalp irritation, prevent scalp itching and dandruff, as well as make the hair softer and shiny.

The composition of the present invention contains ginseng extract and green tea extract as an active ingredient, thereby providing excellent hair or scalp condition improving effect.

The ginseng (Panax ginseng C.A. Meyer) used in the present invention is a plant belonging to the genus Omega and Ginseng. In the present invention, ginseng can be used regardless of its kind and year, and both dried and not dried ginseng can be used. In the present invention, ginseng can be used without limitation in the site, and specifically, roots of ginseng can be used.

The green tea used in the present invention is not limited to the type and number of days of cultivation, and both dried and non-dried green tea can be used. In the present invention, the green tea can be used without limitation in the area, and specifically, the leaves of green tea can be used.

The ginseng extract and green tea extract used in the present invention can be prepared by a method known in the art, and the method is not particularly limited. Specifically, ginseng extract or green tea extract can be prepared with water or an organic solvent. The organic solvent used in the present invention may be selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate, chloroform and a mixed solvent of these organic solvents and water, preferably 80% ethanol. At this time, the extraction temperature is preferably 10 to 80 ° C, and the extraction can be performed for 3 to 24 hours. If the extraction temperature and the extraction time are exceeded, the extraction efficiency may be deteriorated or the component may be changed.

The composition of the present invention may contain the ginseng extract and the green tea extract in an amount of 0.001 to 10 wt%, preferably 0.005 to 9.5 wt%, based on the total weight of the composition, 0.09 to 7.5 wt.%, 0.1 to 6.5 wt.%, 0.3 to 6 wt.%, 0.5 to 5.5 wt.%, Or 0.7 By weight to 5% by weight.

In the present invention, the ginseng extract and the green tea extract are mixed in a weight ratio of 0.1 to 10: 1. Preferably, ginseng extract and green tea extract are mixed in a weight ratio of 0.5 to 9.5: 1, 1 to 9: 1, or 1.5 to 8.5: 1, in order to maximize the synergistic effect of the two substances in combination .

The composition of the present invention can be used as a composition for preventing dandruff. It can purify the scalp by effectively discharging toxins accumulated in hair and scalp, inhibit proliferation and growth of dandruff and prevent scalp inflammation reaction, It has excellent antioxidant ability to inhibit the production and action, so it can calm and strengthen the scalp and provide the effect of strengthening the original defense.

The composition of the present invention can be used as a hair tonic composition, which promotes the transition of the resting hair cycle to the growing hair cycle, thereby promoting hair growth and preventing hair loss.

The composition of the present invention can be used as a composition for external application for skin preventing anti-whiplash, which can significantly increase the expression of MITF in melanocytes, thereby inhibiting white moth and promoting gray hair induction.

The composition of the present invention can stabilize a sensitive, irritating or reactive scalp by reducing irritation such as itching and stinging of the scalp and alleviating and alleviating the scalp inflammation. In addition, hair condition can be improved healthily by providing a conditioning effect that makes rough and damaged hair soft and smooth.

The composition of the present invention may be formulated as an external preparation for skin, in particular as a cosmetic composition, and may be formulated containing a cosmetically or dermatologically acceptable medium or base. In addition, the composition of the present invention may be provided in any form suitable for topical application, for example, as a solution, an emulsion obtained by dispersing an oil phase in water phase, an emulsion obtained by dispersing water phase in water phase, a suspension, a solid, a gel, Pastes, foams, or aerosol compositions. Compositions of such formulations may be prepared according to conventional methods in the art.

In particular, the composition for external application for skin of the present invention is not particularly limited as a composition for hair or scalp. For example, hair tonic, hair nutritional lotion, scalp treatment, hair treatment, hair shampoo, hair rinse, Scalp hair combined treatment, and the like.

In addition, the composition according to the present invention may contain, in addition to the above-mentioned substances, other ingredients which can give a synergistic effect to the main effect, to the extent that the main effect is not impaired. The composition according to the present invention may further comprise a humectant, an emollient, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a pH adjuster, an organic or inorganic pigment, a perfume, a cold agent or a limiting agent. The compounding amount of the above components can be easily selected by a person skilled in the art within the range not impairing the object and effect of the present invention, and the amount thereof may be from 0.01 to 5% by weight, specifically from 0.01 to 3% by weight based on the total weight of the composition .

In addition, the composition of the present invention can be formulated as a pharmaceutical composition. When the composition according to the present invention is applied to medicines, it may be formulated into oral, parenteral or parenteral dosage forms in solid, semi-solid or liquid form by adding an inorganic or organic carrier compatible with the active ingredient used in the present invention , The pharmaceutical composition according to the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously, and the like.

Examples of the formulations for oral administration include tablets, pills, granules, capsules, powders, fine granules, powders, emulsions, syrups and pellets. In addition, the formulations for parenteral administration include injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, and the like. The composition according to the present invention can be easily formulated into an active ingredient by carrying out the composition according to a conventional method. In this case, a surfactant, excipient, coloring agent, spice, preservative, stabilizer, buffer, suspending agent, have.

The dosage of the active ingredient of the pharmaceutical composition of the present invention will vary depending on the age, sex, body weight, pathological condition and severity of the subject to be treated, route of administration, or judgment of the prescriber. Determination of the appropriate dose based on these factors is well within the level of ordinary skill in the art and its daily dose is, for example, from 0.1 mg / kg / day to 100 mg / kg / day, more specifically from 5 mg / kg / day to 50 mg / / Day, but is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[Reference Example 1] Preparation of ginseng extract

1 kg of dried white ginseng was pulverized with a blender, and 5 liters of purified water was added thereto, followed by stirring at 38 to 42 ° C in hot water for 24 hours, followed by immersion for one day at 15 ° C. Thereafter, the residue and the filtrate were separated by filtration through a filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 270 g of the extract.

[Reference Example 2] Preparation of green tea extract

1 kg of first processed green tea leaves were pulverized with a blender, 5 liters of purified water was added thereto, and the mixture was stirred for 24 hours at 38 to 42 ° C in hot water, and then immersed at 15 ° C for 1 day. Thereafter, the residue and the filtrate were separated by filtration through a filter cloth and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 290 g of the extract.

[Example 1] Preparation of a mixture of ginseng extract and green tea extract

The ginseng extract prepared in Reference Example 1 and the green tea extract prepared in Reference Example 2 were mixed at a ratio of 1: 3.

[Example 2] Preparation of a mixture of ginseng extract and green tea extract

The ginseng extract prepared in Reference Example 1 and the green tea extract prepared in Reference Example 2 were mixed at a ratio of 1: 1.

[Example 3] Preparation of a mixture of ginseng extract and green tea extract

The ginseng extract prepared in Reference Example 1 and the green tea extract prepared in Reference Example 2 were mixed at a ratio of 3: 1.

[Referential Example 1] Preparation of Formulation Example and Comparative Formulation Example

A shampoo was prepared with the composition shown in Table 1 below. Specifically, the surfactant and ethylene glycol distearate were added to purified water, heated to 80 DEG C to dissolve uniformly, and then gradually cooled to 40 DEG C with stirring. To the mixture were added the active ingredient according to the present invention and a preservative, A viscosity adjusting agent, a perfume, and a hair conditioning agent were mixed and stirred, followed by cooling to room temperature.

ingredient Formulation Example Comparative Formulation Example One 2 3 One 2 3 Ammonium lauryl sulfate 10 10 10 10 10 10 Polyoxyethylene lauryl ammonium sulfate 5 5 5 5 5 5 Cocoamidopropyl betaine 2 2 2 2 2 2 Ethylene glycol distearate 1.5 1.5 1.5 1.5 1.5 1.5 Cocoyl monoethanolamide 0.8 0.8 0.8 0.8 0.8 0.8 Example 1 5.0 - - - - - Example 2 - 5.0 - - - - Example 3 - - 5.0 - - - Reference Example 1 - - - 5.0 - - Reference Example 2 - - - - 5.0 - Polyquaternium-10 0.2 0.2 0.2 0.2 0.2 0.2 Blue No. 1 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 Methyl paraben 0.1 0.1 0.1 0.1 0.1 0.1 Spices 0.8 0.8 0.8 0.8 0.8 0.8 Citric acid 0.1 0.1 0.1 0.1 0.1 0.1 Dimethicone 1.0 1.0 1.0 1.0 1.0 1.0 water to 100 to 100 to 100 to 100 to 100 to 100

[Test Example 1] Dandruff reduction effect test

Sixty men aged 19 to 35 years with a relatively large number of dandruff were selected and divided into six groups of 10 persons. The shampoos of Formulation Examples 1 to 3 and Comparative Formulation Examples 1 to 3 were used for one month in the following manner And the dysrhythmia reduction rate was measured.

Before the start of the test, the dandruff was sampled with normal shampoo, and the dandruff accumulated for 2 days after shaking was collected. The dandruff weight was sampled every two days with each shampoo. Respectively. The accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated according to the following equation (1). The results are shown in Table 2 below.

Dandruff reduction rate (%) Formulation Example 1 31.2 Formulation Example 2 32.0 Formulation Example 3 32.3 Comparative Formulation Example 1 27.5 Comparative Formulation Example 2 28.8 Comparative Formulation Example 3 2.5

As can be seen from the above Table 2, when Comparative Formulation Example 3 containing no ginseng extract or green tea extract was used, the effect of preventing dandruff hardly appeared. However, when Comparative Formulation Examples 1 or 2 and Formulation Examples 1 to 3 containing ginseng extract or green tea extract were used, it can be confirmed that dandruff was reduced. In particular, Formulation Examples 1 to 3 using ginseng extract and green tea extract , It can be seen that the dandruff prevention effect is remarkably excellent due to the synergistic effect of the mixed use of these extracts.

[Test Example 2] Test for preventing the itchiness of the scalp

Sixty men and women aged 25 to 45 years who were relatively scarred with scalp itching were selected and divided into 6 groups of 10 persons. The shampoos of Formulation Examples 1 to 3 and Comparative Formulation Examples 1 to 3 were applied to each group for 2 weeks After the use, the effect of preventing the itchiness of the scalp was evaluated through the following evaluation criteria, and the results are shown in Table 3 below.

[Evaluation standard]

Very good - 5 points

Excellent - 4 points

Usually - 3 points

Poor - 2 points

Very bad - 1 point

division Prevention of itching of scalp Formulation Example 1 3.0 Formulation Example 2 3.1 Formulation Example 3 3.0 Comparative Formulation Example 1 2.6 Comparative Formulation Example 2 2.7 Comparative Formulation Example 3 2.3

As can be seen from the above Table 3, Comparative Example 3 containing no ginseng extract or green tea extract was not effective in preventing scalp itching, and Comparative Example 1 containing only one kind of ginseng extract or green tea extract When 1 or 2 is used, the effect of preventing itchiness of the scalp appears, but it can be seen that the degree does not reach the normal level. On the other hand, in the case of Formulation Examples 1 to 3 in which ginseng extract and green tea extract were mixed, it can be seen that the effect of preventing the itchiness of scalp is superior due to the synergistic effect of mixing the extracts.

[Test Example 3] Effect of proliferation of dermal papilla cells

The keratin proteins that make up the hair are produced in hair follicle keratinocyte, which keratinocytes differentiate from the dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the present composition, DP6 (rat immortalized dermal papilla cell) cell line was used in the present invention (Wendy Filsell, Journal of Cell Science 107, 1761-1772 (1994)). This dermal papilla cell line was obtained by microdissection in the hair roots of male PVG rat beard and cultured in DMEM (Dulbecco's modified Eagle's medium, Gibco BRL, Gaithersburg, MD, USA) containing 10% FBS (Fetal bovine serum) USA) for 24 hours in an incubator maintained at 37 ° C in 5% CO ₂ . DP6 was added to a 96-well plate and cultured in a 37 ° C incubator for 24 hours. Then, the above Examples 1 to 3 and Reference Examples 1 and 2 were treated at concentrations of 5 ppm, 10 ppm and 20 ppm, respectively. After 24 hours of drug treatment, cell proliferation was measured using WST-1 kit (Roche). The results are shown in Table 4 below.

division Cell proliferation (%) Untreated Control (Control) 100 Example 1 5 ppm 109 10ppm 115 20 ppm 123 Example 2 5 ppm 109 10ppm 114 20 ppm 122 Example 3 5 ppm 108 10ppm 114 20 ppm 120 Reference Example 1 5 ppm 106 10ppm 112 20 ppm 117 Reference Example 2 5 ppm 105 10ppm 112 20 ppm 118

As can be seen from the above Table 4, in the case of Reference Examples 1 and 2 treated with ginseng extract or green tea extract, the effect of proliferation of the papilla cells is better than that of the control group not treated with the ginseng extract and green tea extract. In particular, in Examples 1 to 3 in which ginseng extract and green tea extract were mixed, the proliferation of the dermal papilla cells was more effectively increased due to the synergistic effect of the mixed use of the extracts, .

[Test Example 4] Evaluation of Potassium Ion Channel Activity Increase Effect

Minoxidil, a remedy for depilation, is known as a potential mitochondrial potassium ion channel opener (K _ATP channel opener) and is a representative drug used for the treatment of androgenetic alopecia. In order to evaluate the mechanism of minoxidil, cell proliferation was inhibited by treatment with tolbutamide (SIGMA AlDRICH, T0891) blocking K _ATP channel in fibroblasts constituting the dermis of the scalp, The restored test method was used.

To evaluate the function of this composition as a K _ATP channel opener, the fibroblast cell line NIH3T3 (mouse embryonic fibroblast cell line) cell line was used in the present invention. This cell line is a cell line obtained by natural immortalization of fibroblasts isolated from NIH Swiss mouse embryo by the 3T3 protocol. The cells were cultured in DMEM (Gibco BRL, Gaithersburg, MD, USA) containing 10% FBS for 24 hours in an incubator maintained at 37 ° C in 5% CO ₂ . NIH3T3 was added to a 96-well plate, cultured in a 37 ° C incubator for 24 hours, treated with 2.5 mM tolbutamide, and 10 minutes later, 10 μM of minoxidil, a positive control, and Examples 1 to 3 and Reference Examples 1 and 2, ppm, 5 ppm and 10 ppm, and cell proliferative activity was measured using WST-1 kit (Roche) after 48 hours of drug treatment. The results are shown in Table 5 below.

division Cell proliferation (%) Untreated Control (Control) 100 Minoxidil 132 Example 1 2.5 ppm 109 5 ppm 113 10ppm 121 Example 2 2.5 ppm 108 5 ppm 113 10ppm 120 Example 3 2.5 ppm 110 5 ppm 114 10ppm 122 Reference Example 1 2.5 ppm 106 5 ppm 111 10ppm 118 Reference Example 2 2.5 ppm 105 5 ppm 111 10ppm 117

As can be seen from Table 5, the proliferation effect of fibroblast cells was better in the case of Reference Examples 1 and 2 treated with ginseng extract or green tea extract than the control group not treated with ginseng extract and green tea extract . In particular, in Examples 1 to 3 in which ginseng extract and green tea extract were mixed, the proliferation of fibroblast cells was more effectively increased due to the synergistic effect of the use of these extracts, .

[Test Example 5] Test for promoting melanin production

Melanocytes (melan-a) were added to a 24-well microtiter plate at 50,000 cells / well in RPMI medium supplemented with 5% fetal bovine serum, 100 IU penicillin G and 0.2 μM TPA Respectively. In the next day, the cells were treated with the final concentration of 10 ppm or 50 ppm as the test substance, 0.1% DMSO as the negative control, 100 μM IBMX as the positive control, and 37 Lt; 0 > C for 3 days. After incubation, the wells were washed with PBS, and 100 μl of 1N NaOH was added thereto, and melanin in the cells was dissolved. The absorbance of dissolved melanin was measured at 405 nm using a microplate reader. The results of comparing melanin production promoting effect with the control group are shown in Table 6 below.

division Amount of melanin synthesis (%) DMSO (0.1%) 100 IBMX (100 [mu] M) 120 Example 1 10ppm 108 50 ppm 120 Example 2 10ppm 108 50 ppm 119 Example 3 10ppm 109 50 ppm 120 Reference Example 1 10ppm 105 50 ppm 116 Reference Example 2 10ppm 105 50 ppm 115

In Table 6, ginseng extract and green tea extract promoted the melanin synthesis of melanocytes. In particular, in Examples 1 to 3 in which ginseng extract and green tea extract were mixed, Indicating excellent melanin production promoting effect.

Test Example 6: Promotion of MITF and tyrosinase expression in melanocytes

The cells were divided into six wells (6-well microtiter plate) to a concentration of 500,000 cells / well using a 501mel cell line. DMSO 0.1% as a negative control, IBMX 100 μM as a positive control, 1 to 3, and Reference Examples 1 and 2 were respectively treated with 10 ppm, followed by culturing at 37 ° C for 24 hours, 48 hours, and 72 hours to obtain proteins. The proteins thus obtained were subjected to western blotting using MITF and tyrosinase antibodies. Protein extraction and Western blotting were routinely performed by standard methods used by those skilled in the art. After Western blotting, the result was compared with the negative control group of 100, and the results are shown in Tables 7 and 8 below.

Western blot using MITF antibody division 24 hours 48 hours 72 hours IBMX 120 99 210 Example 1 80 109 143 Example 2 80 110 145 Example 3 81 112 150 Reference Example 1 74 102 135 Reference Example 2 76 105 139

Western blot using tyrosinase antibody division 24 hours 48 hours 72 hours IBMX 153 142 279 Example 1 130 158 186 Example 2 131 160 187 Example 3 131 159 188 Reference Example 1 123 151 172 Reference Example 2 122 150 170

As shown in Tables 7 and 8, the ginseng extract and the green tea extract increase the MITF and tyrosinase protein expression in melanocytes. In particular, when the ginseng extract is mixed with the green tea extract, the effect of increasing the MITF and tyrosinase protein expression It can be confirmed that it is excellent.

[Referential Example 2] Preparation of Formulation Examples 4 to 6 and Comparative Formulation Examples 4 to 6

Using the above Examples 1 to 3 and Reference Examples 1 and 2, scalp essences were prepared according to the composition shown in Table 9 below. More specifically, polyoxyethylene hydrogenated castor oil / POE (60) (Emalex HC-60, manufactured by Nihon Emulsion Co., Ltd.), which is an effect substance of Examples 1 to 3 and Reference Examples 1 and 2, ), Salicylic acid 0.2%, ethanol 10%, distilled water, ammonium acryloyldimethyltaurate / Vpicopolymer (manufacturer: Aristoflex) and phenoxyethanol (PE) were used.

(Unit: wt%) ingredient Formulation Example Comparative Formulation Example 4 5 6 4 5 6 Polyoxyethylene hydrogenated castor oil / POE (60) 0.5 0.5 0.5 0.5 0.5 0.5 Example 1 0.2 - - - - - Example 2 - 0.2 - - - - Example 3 - - 0.2 - - - Reference Example 1 - - - 0.2 - - Reference Example 2 - - - - 0.2 - Salicylic acid 0.2 0.2 0.2 0.2 0.2 0.2 ethanol 10 10 10 10 10 10 Distilled water 88.3 88.3 88.3 88.3 88.3 88.3 Ammonium acryloyldimethyltaurate / Vpicopolymer 0.5 0.5 0.5 0.5 0.5 0.5 Phenoxyethanol 0.3 0.3 0.3 0.3 0.3 0.3

[Test Example 7] Skin irritation test

In order to confirm skin irritation during use of the composition according to the present invention, 60 men and women aged 25 to 45 years who felt severe scalp itching were selected and divided into six groups of 10 persons each. Formulations 4 to 6, The scalp essences of Examples 4-6 were used. Concretely, after washing the cheek piece, the water was wiped off and the sample was allowed to stand in a constant temperature and humidity room (temperature 24 ± 4 ° C., relative humidity 40 to 45%) for 15 minutes. The same amount of the scalp essence containing 0.2% of the efficacious substance was applied to the skin surface to the extent that did not allow the skin essence to flow therethrough. After 24 hours and 48 hours after the test substance was attached, the subject marked the degree of stimulation from 0 to 4 points (0 = no stimulation, 1 = very weak, 2 = weak, 3 = moderate, 4 = severe) (2 measurements in total), stinging, and burning sensation.

Table 10 shows the number of subjects who complained of the above-mentioned stimulation in each time slot. The mean value was calculated to derive the skin irritation as a mean score, and the results are shown in Table 10 below.

Test material name Test concentration 24hr 48hr Responses Judgment One 2 3 4 One 2 3 4 (n = 10) Formulation Example 4 0.20% One 0 0 0 0 0 0 0 One No stimulation Formulation Example 5 0.20% One 0 0 0 0 0 0 0 One No stimulation Formulation Example 6 0.20% One 0 0 0 0 0 0 0 One No stimulation Comparative Formulation Example 4 0.20% One 0 0 0 0 0 0 0 One No stimulation Comparative Formulation Example 5 0.20% One 0 0 0 0 0 0 0 One No stimulation Comparative Formulation Example 6 0.20% 0 0 0 0 One 0 0 0 One No stimulation

In the results shown in Table 10, the compositions containing the ginseng extract or the green tea extract, or the mixture of the extracts of Formulation Examples 4 to 6 and Comparative Formulation Examples 4 and 5 were prepared similarly to Comparative Formulation Example 6, . Therefore, it can be seen that the composition according to the present invention is safe for the human body and has no irritation to the skin by using an extract derived from ginseng and green tea as an active ingredient, and there is no side effect even if it is used for a long time.

[Reference Example 3] Preparation of Formulation Examples 7 to 9 and Comparative Formulation Examples 5 to 9

Using the above Examples 1 to 3 and Reference Examples 1 and 2, a scalp and hair combination treatment composition was prepared according to the composition shown in Table 11 below. The oil phase and the water phase were separately prepared in a blender and then the oil phase was gradually added to the water phase and emulsified at 3,000 rpm for 10 minutes using a homomixer and then cooled to room temperature to obtain the scalp and hair of Formulations 7 to 9 and Comparative Forms 7 to 9 A combined treatment was prepared.

Component (% by weight) Formulation Example Comparative Formulation Example 7 8 9 7 8 9 Purified water balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100) balance
(to 100) Example 1 0.5 - - - - - Example 2 - 0.5 - - - - Example 3 - - 0.5 - - - Reference Example 1 - - - 0.5 - - Reference Example 2 - - - - 0.5 - Cetyltrimethylammonium chloride 1.0 1.0 1.0 1.0 1.0 1.0 Cetyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 Stearyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 Preservatives, coloring and flavoring Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

[Test Example 8]

Sensory tests were conducted on the scalp and hair-combined treatment compositions of Formulation Examples 7 to 9 and Comparative Formulation Examples 7 to 9 in the following manner. Sixteen professional evaluation personnel were divided into six groups of ten each, and the scalp and hair combined treatments of Formulation Examples 7 to 9 and Comparative Formulation Examples 7 to 9 were used for each group. The evaluation items shown in the following Table 12 The test was conducted with the lowest score being 1 and the highest score being 5. The test results are shown in Table 12 below.

Item Scalp itching Scalp stimulus Hair softness / smoothness Formulation Example 7 2.6 2.5 2.6 Formulation Example 8 2.5 2.5 2.5 Formulation Example 9 2.5 2.4 2.6 Comparative Formulation Example 7 3.4 3.2 2.3 Comparative Formulation Example 8 3.3 3.3 2.2 Comparative Formulation Example 9 4.1 3.8 1.5

As shown in Table 12, in the case of Formulations 7 to 9 containing ginseng or green tea extract and Comparative Forms 7 to 9, the itching of the scalp is reduced and the irritation And the hair condition is also improved. Particularly, when Formulation Examples 7 to 9 containing a mixture of ginseng extract and green tea extract were used, it can be confirmed that the effect is particularly excellent.

[Formulation Example 1] Soft capsule

A soft capsule was prepared by mixing 150 mg of the ginseng extract of Reference Example 1, 150 mg of the green tea extract of Reference Example 2, 2 mg of palm oil, 8 mg of palm kernel oil, 4 mg of yellow radish and 6 mg of lecithin.

[Formulation Example 2] Tablets

150 mg of the ginseng extract of Reference Example 1, 150 mg of the green tea extract of Reference Example 2, 100 mg of glucose, 50 mg of red ginseng extract, 96 mg of starch and 4 mg of magnesium stearate were mixed and 40 mg of 30% ethanol was added to form granules. And the tablet was tableted using a tablet machine.

[Formulation Example 3] Granules

150 mg of the ginseng extract of Reference Example 1, 150 mg of the green tea extract of Reference Example 2, 100 mg of glucose, 50 mg of red ginseng extract and 600 mg of starch were mixed and 100 mg of 30% ethanol was added to form granules, followed by drying at 60 ° C to form granules And filled in the next bubble. The final weight of the contents was 1 g.

[Formulation Example 4] Hair tonic

Hair tonics were prepared according to the compositions shown in Table 13 below in a conventional manner.

ingredient Weight ratio (%) ethanol 50 menthol 0.02 glycerin 3 Salicylic acid 0.05 The ginseng extract of Reference Example 1 0.5 The green tea extract of Reference Example 2 0.5 Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 5] Hair lotion

Hair lotions were prepared in a conventional manner according to the composition shown in Table 14 below.

ingredient Weight ratio (%) Cetostearyl alcohol 2.0 EDTA 2Na 0.2 Hydroxyethyl cellulose 0.5 Mineral oil 5.0 The ginseng extract of Reference Example 1 0.5 The green tea extract of Reference Example 2 0.5 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 6] Hair nutrition lotion

The hair nutritional lotion was prepared according to the composition shown in Table 15 below by a conventional method.

ingredient Weight ratio (%) Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Mineral oil 10.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 The ginseng extract of Reference Example 1 0.5 The green tea extract of Reference Example 2 0.5 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[Formulation Example 7] Hair shampoo

Hair shampoos were prepared in a conventional manner according to the composition shown in Table 16 below.

ingredient weight% Purified water Balance (To 100) The ginseng extract of Reference Example 1 0.5 The green tea extract of Reference Example 2 0.5 Sodillauryl sulphite 36.0 Cocamidopropyl betaine 8.0 Palmitidine dimalate 2.0 Glycollosteralate 1.5 Polyquaternium 10 0.5 Saitric Acid 0.1 glycerin 2.0 Preservatives, coloring and flavoring Suitable amount

[Formulation Example 8] Hair rinse

Hair rinses were prepared according to the compositions shown in Table 17 below by a conventional method.

ingredient weight% Purified water Balance (To 100) The ginseng extract of Reference Example 1 0.5 The green tea extract of Reference Example 2 0.5 Propylene glycol 2.0 Cetyltrimethylammonium chloride 1.0 Cetyl alcohol 3.0 Stearyl alcohol 3.0 Mineral oil 0.5 Saitric Acid 0.2 Polydimethylsiloxane 1.0 Preservatives, coloring and flavoring Suitable amount

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (17)

A composition for external application for skin for improving hair or scalp comprising ginseng extract and green tea extract as an active ingredient. The composition for external application for skin according to claim 1, wherein the ginseng extract and the green tea extract are contained in an amount of 0.001 to 10 wt% based on the total weight of the composition. The composition for external application for skin according to claim 1, wherein the ginseng extract and green tea extract are mixed at a ratio of 0.1 to 10: 1 by weight. The method according to claim 1, wherein the ginseng extract and green tea extract are water; At least one organic solvent selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate and chloroform; And a mixed solvent of the organic solvent and water; At a temperature of 10 to 80 DEG C for 3 to 24 hours. The composition for external application for skin according to claim 1, wherein the composition is for preventing dandruff. The composition for external application for skin according to claim 1, wherein the composition is for hair growth. The composition for external application for skin according to claim 1, wherein the composition is for prevention of white hair. The composition for external application for skin according to claim 1, wherein the composition is for alleviating scalp irritation. The composition for external application for skin according to claim 1, wherein the composition is for improving hair softness. A pharmaceutical composition for improving the condition of hair or scalp comprising ginseng extract and green tea extract as active ingredients. [Claim 11] The pharmaceutical composition according to claim 10, wherein the ginseng extract and the green tea extract are contained as an active ingredient in an amount of 0.001 to 10 wt% based on the total weight of the composition. [Claim 11] The pharmaceutical composition according to claim 10, wherein the ginseng extract and green tea extract are mixed at a weight ratio of 0.1 to 10: 1. 11. The method of claim 10, wherein the ginseng extract and green tea extract are selected from the group consisting of water; At least one organic solvent selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate and chloroform; And a mixed solvent of the organic solvent and water; , At a temperature of 10 to 80 DEG C for 3 to 24 hours. 11. The pharmaceutical composition according to claim 10, wherein the composition is for preventing dandruff. 11. The pharmaceutical composition according to claim 10, wherein the composition is for hair growth. 11. The pharmaceutical composition according to claim 10, wherein the composition is for preventing white hair. 11. The pharmaceutical composition according to claim 10, wherein the composition is for alleviating scalp irritation.