KR20160067513A - COMPOSITION FOR IMPROVING CONDITION OF HAIR AND SCALP CONTAINING (2S)-1-O-LINOLENOYL-2-O-LINOLENOYL-3-O-β-D-GALACTOPYRANOSYL-SN-GLYCEROL - Google Patents

Abstract

The present invention relates to a composition for improving a hair or scalp condition, wherein the composition contains (2S)-1-O-linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl-sn-glycerol. More specifically, the present invention relates to a skin external application composition or a pharmaceutical composition having an excellent scalp purifying and soothing effect. By containing the component, the growth of hair is promoted, and a loss of hair may be prevented and alleviated. Stimulation to the scalp is alleviated, and dandruff and scalp inflammation are controlled, so an overall hair condition is improved. According to the present invention, the proliferation of cells of the scalp is activated, so the hair root is reinforced. Thus, effects in reducing a loss of hair and promoting the growth of hair are exhibited. At the same time, scalp itchiness and dandruff may be effectively prevented.

Description

(2S) -1-O-linolenoyl-2-O-linolenoyl-3-O-? -D-galactopyranosyl-sn- glycerol {Compositions for improving hair or scalp 2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl-sn-glycerol}

The present invention relates to a hair or scalp condition improving composition containing (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol, (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol as an active ingredient to promote hair growth and prevent and improve hair loss, The present invention relates to a composition for external application for skin or a pharmaceutical composition which alleviates irritation to the scalp and suppresses dandruff and scalp inflammation to improve the overall hair condition and has excellent cleansing and soothing effect on the scalp.

The scalp is composed of the epidermis, dermis, and subcutaneous tissue, and the outermost tissue is the epidermis. The epidermis protects the body's sensitive tissues from damage. However, due to various physical and chemical external stimuli such as external temperature, humidity change, pollutants, stress, and lack of influence, the scalp function may be lost, and furthermore, it may affect hair loss.

In modern society, which emphasizes beauty, many people, both men and women, use hair dye, permanent hair, and the like in order to satisfy the need for expression of individuality. However, in the case of some sensitive scalp, chemical treatment such as dyeing and perming causes irritation such as itching or stinging of the scalp and inflammation, which leads to environmental hair loss.

In this way, it is possible to protect the scalp from stimulation, stress, and chemical treatment from the environment due to various causes, to promote hair growth while preventing hair loss, and to continue research on ecosystem-friendly and environmentally harmless components to humans .

(2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol of the present invention is known to have anticancer, anti- et al., Glycosyl glycerides from hydrophobic Panax ginseng inhibited NO production in LPS-stimulated RAW 264.7 cells, Journal of Ginseng Research (2014), doi: 10.1016 / j.jgr.2014.10.005), there is no known effect of preventing hair loss or enhancing scalp function.

The inventors of the present invention found that (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O-β -D-galactopyranosyl- sn -glycerol can enhance the proliferation of the dermal papilla cells and the proliferation of the dermal dermal cells, as well as alleviate the irritation to the scalp and suppress the dandruff, .

It is an object of the present invention to provide a composition showing excellent hair growth or scalp condition improving effect.

In order to achieve the above object, the present invention is (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol the hair loss or promoting hair growth containing, as an active ingredient Gt;

In addition, the present invention is (2S) service -1-O-linolenoyl-2- O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol or an anti-dandruff composition for scalp itch relief containing as an active ingredient do.

The composition of the present invention contains (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol as an active ingredient to activate scalp cell proliferation And thus, it is effective in reducing the hair loss phenomenon and promoting the hair growth, and also preventing the scalp itch and dandruff.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is well known and commonly used in the art.

The invention In one aspect, for containing the following formula (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol represented by the general formula (1) as an active ingredient To a composition for promoting hair growth or preventing hair loss.

[Chemical Formula 1]

The composition according to the present invention contains (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol as an active ingredient to enhance hair roots, promote blood circulation, Efficacy can be provided, and promoting effect of hair growth, hair growth, wool and prevention and improvement of hair loss can be shown.

In the present specification, the term " promoting hair growth "means not only promoting the generation of new hair but also allowing the existing hair to grow healthily, and the phenomenon in which the hair falls off the scalp and the hair becomes thin And suppression.

(2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol of the present invention can be prepared by a method described in a paper on glycosyl glyceride (Cha BJ et al., Glycosyl glycerides hydrophobic Panax ginseng inhibited NO production in LPS-stimulated RAW264.7 cells, Journal of Ginseng Research (2014), doi: 10.1016 / j.jgr.2014.10.005), but the present invention is not limited thereto. May be extracted from plants, synthesized according to methods known in the art, and commercially available ones may be used.

The composition for promoting hair growth or hair loss of the present invention can promote the hair growth by promoting the transition from the resting hair cycle to the growing hair cycle, thereby providing the effect of preventing hair loss.

The invention in another aspect, (2S) -1-O- linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol the anti-dandruff which contains as an active ingredient of the formula (1) Or scalp itching relief.

The anti-dandruff composition of the present invention can effectively remove toxins accumulated in hair and scalp to purify the scalp, inhibit proliferation and growth of dandruff, inhibit the scalp inflammation reaction, and inhibit the production and action of active oxygen It has excellent efficacy, so it can calm and strengthen the scalp and provide the effect of strengthening the original defense.

The composition for alleviating the itch of the present invention can stabilize the sensitive, stimulant or reactive scalp by reducing irritation such as itching and stinging of the scalp and alleviating and alleviating the scalp inflammation. In addition, hair condition can be improved healthily by providing a conditioning effect that makes rough and damaged hair soft and smooth.

In the present invention, the active ingredient may be contained in an amount of 0.001 to 50% by weight, based on the total weight of the hair growth promoting or hair loss preventing composition, or the composition for preventing dandruff or scalp itching, Preferably 0.01 to 30% by weight, more preferably 0.1 to 10% by weight. If the content of the active ingredient is less than 0.001% by weight, the effect or effect of the ingredient is insignificant, and if it exceeds 50% by weight, there is a problem of skin safety or shape.

In the present invention, the compositions for promoting hair growth or preventing hair loss, or compositions for alleviating dandruff or scalp itching can be used for hair tonic, hair nutrition lotion, scarf treatment, hair treatment, hair shampoo, hair rinse, hair lotion and scalp hair And a treatment agent.

The compositions of the present invention may be formulated in particular as a cosmetic composition and may be formulated containing a cosmetically or dermatologically acceptable medium or base. In addition, the composition of the present invention may be provided in any form suitable for topical application, for example, as a solution, an emulsion obtained by dispersing an oil phase in water phase, an emulsion obtained by dispersing water phase in water phase, a suspension, a solid, a gel, Pastes, foams, or aerosol compositions. Compositions of such formulations may be prepared according to conventional methods in the art.

In particular, the composition of the present invention is not particularly limited as a composition for a hair or scalp. For example, a hair tonic, a hair nutrition lotion, a scalp treatment, a hair treatment, a hair shampoo, a hair conditioner, Combination treatments, and the like.

In addition, the composition according to the present invention may contain, in addition to the above-mentioned substances, other ingredients which can give a synergistic effect to the main effect, to the extent that the main effect is not impaired. The composition according to the present invention may further comprise a humectant, an emollient, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a pH adjuster, an organic or inorganic pigment, a perfume, a cold agent or a limiting agent. The compounding amount of the above components can be easily selected by a person skilled in the art within the range not impairing the object and effect of the present invention, and the amount thereof may be from 0.01 to 5% by weight, specifically from 0.01 to 3% by weight based on the total weight of the composition .

In addition, the composition of the present invention can be formulated as a pharmaceutical composition. When the composition according to the present invention is applied to medicines, it may be formulated into oral, parenteral or parenteral dosage forms in solid, semi-solid or liquid form by adding an inorganic or organic carrier compatible with the active ingredient used in the present invention , The pharmaceutical composition according to the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously, and the like.

Examples of the formulations for oral administration include tablets, pills, granules, capsules, powders, fine granules, powders, emulsions, syrups and pellets. In addition, the formulations for parenteral administration include injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, and the like. The composition according to the present invention can be easily formulated into an active ingredient by carrying out the composition according to a conventional method. In this case, a surfactant, excipient, coloring agent, spice, preservative, stabilizer, buffer, suspending agent, have.

The dosage of the active ingredient of the pharmaceutical composition of the present invention will vary depending on the age, sex, body weight, pathological condition and severity of the subject to be treated, route of administration, or judgment of the prescriber. Determination of the appropriate dose based on these factors is well within the level of ordinary skill in the art and its daily dose is, for example, from 0.1 mg / kg / day to 100 mg / kg / day, more specifically from 5 mg / kg / day to 50 mg / / Day, but is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[ Reference example  One]

(2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol as an active ingredient for testing the efficacy of the composition of the present invention, al., Glycosyl glycerides from hydrophobic Panax ginseng inhibited NO production in LPS-stimulated RAW264.7 cells, Journal of Ginseng Research (2014), doi: 10.1016 / j.jgr.2014.10.005).

[ Reference example  2] Formulation Example  1 and Comparative Formulation Example  1

A shampoo was prepared with the composition shown in Table 1 below. Specifically, the surfactant and ethylene glycol distearate were added to purified water, heated to 80 DEG C to dissolve uniformly, and then gradually cooled to 40 DEG C with stirring. To the mixture were added the active ingredient according to the present invention and a preservative, A viscosity adjusting agent, a perfume, and a hair conditioning agent were mixed and stirred, followed by cooling to room temperature.

ingredient Formulation Example 1 Comparative Formulation Example 1 Ammonium lauryl sulfate 10 10 Polyoxyethylene lauryl ammonium sulfate 5 5 Cocoamidopropyl betaine 2 2 Ethylene glycol distearate 1.5 1.5 Cocoyl monoethanolamide 0.8 0.8 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 5.0 - Polyquaternium-10 0.2 0.2 Blue No. 1 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 Methyl paraben 0.1 0.1 Spices 0.8 0.8 Citric acid 0.1 0.1 Dimethicone 1.0 1.0 water to 100 to 100

[ Test Example  1] Dandruff reduction test

Twenty-four men aged 19 to 35 years with a relatively large number of dandruff were selected and divided into two groups of twelve persons. The shampoos of Formulation Example 1 and Comparative Formulation Example 1 were used for one month in the following manner for each group, Reduction rate was measured.

Before the start of the test, the dandruff was sampled with normal shampoo, and the dandruff accumulated for 2 days after shaking was collected. The dandruff weight was sampled every two days with each shampoo. Respectively. The accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated according to the following equation (1). The results are shown in Table 2 below.

Dandruff reduction rate (%) Formulation Example 1 37.34 Comparative Formulation Example 1 3.4

If you used as can be seen in Table 2, (2S) -1-O -linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl- Formulation Example 1 containing sn -glycerol is significantly And the dandruff prevention effect is excellent.

[ Test Example  2] Scalp itching prevention effect test

Twenty-four male and female twenty-four to twenty-five-year-olds who felt severe itchiness of the scalp were selected and divided into two groups of twelve, and the shampoo of Formulation Example 1 and Comparative Formulation Example 1 was used for each group once every three days for two weeks The posterior scalp itching prevention effect was evaluated through the following evaluation criteria, and the results are shown in Table 3 below.

[Evaluation standard]

Very good - 5 points

Excellent - 4 points

Usually - 3 points

Poor - 2 points

Very bad - 1 point

division Prevention of itching of scalp Formulation Example 1 3.2 Comparative Formulation Example 1 2.3

With like, (2S) -1-O- linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl- Comparative Formulation Example 1 which does not contain the sn -glycerol can be seen in the above Table 3 In case of Formulation Example 1 containing (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol, the effect of preventing scalp itching was poor It can be seen that it exhibits an effect of preventing scalp itching.

[ Test Example  3] hair follicles Dairy cattle  Cell proliferation effect

The keratin proteins that make up the hair are produced in hair follicle keratinocytes, which are differentiated from the dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the present composition, DP6 (rat immortalized dermal papilla cell) cell line was used in the present invention (Wendy Filsell, Journal of Cell Science 107, 1761-1772 (1994)). This dermal papilla cell line is a cell line isolated by microdissection method in the hair roots of male PVG rat beard and is a cell line which is cultured in DMEM (Dulbecco's modified Eagle's medium, Gibco BRL, Gaithersburg, MD, USA) containing 10% FBS (Fetal bovine serum) USA) for 24 hours in an incubator maintained at 37 ° C in 5% CO ₂ . After putting DP6 to 96 well plates were incubated at 37 ℃ incubator for 24 hours, the (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol respectively 5ppm , 10 ppm and 20 ppm, respectively. After 24 hours of drug treatment, cell proliferation was measured using WST-1 kit (Roche). The results are shown in Table 4 below.

division Cell proliferation (%) Untreated Control ( Control ) 100 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol (5 ppm ) 110.4 (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O - β-D-galactopyranosyl- sn -glycerol (10 ppm) 114.0 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol (20 ppm ) 129.8

When treated with (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol As can be seen in Table 4 increase the proliferation of dermal papilla cells, and, It can be confirmed that this is significantly increased depending on the concentration.

[ Test Example  4] Assessment of Potassium Ion Channel Activity Increase Effect

To investigate the effect of (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol on potassium ion channel activity used in the present invention, (SIGMA AlDRICH, T0891), which inhibits K _ATP channel, in fibroblasts to inhibit cell proliferation and restore cell proliferation by opening potassium ion channels again.

To evaluate the function of this composition as a K _ATP channel opener, the fibroblast cell line NIH3T3 (mouse embryonic fibroblast cell line) was used in the present invention. This cell line is a cell line obtained by natural immortalization of fibroblasts isolated from NIH Swiss mouse embryo by the 3T3 protocol. The cell line was cultured in DMEM (Dulbecco's modified Eagle's medium; Gibco BRL, Gaithersburg, MD, USA) containing 10% bovine serum (FBS) for 24 hours in an incubator maintained at 37 ° C in 5% CO ₂ . NIH3T3 was cultured in a 96-well plate for 24 hours in a 37 DEG C incubator, treated with 2.5 mM tolbutamide, and incubated with (2S) -1-O-linolenoyl-2-O-linolenoyl- -D-galactopyranosyl- sn -glycerol was treated at concentrations of 2.5 ppm, 5 ppm and 10 ppm. For comparison, minoxidil, which is known as a potential mitochondrial potassium ion channel opener (K _ATP channel opener) and used for the treatment of androgenetic alopecia, was used as a positive control and treated at a concentration of 10 μM. After 48 hours from the treatment of the samples, the cell survival rate was measured using a WST-1 kit (Roche). The results are shown in Table 5 below.

division Cell proliferation (%) Untreated Control (Control) 100 Minoxidil 132 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol (2.5 ppm ) 108.3 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol (5 ppm ) 112.2 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol (10 ppm ) 120.3

As it can be seen from Table 5 (2S) -1-O- linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol a proliferation of fibroblasts and the recovery treatment if the 2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol treated with the cell proliferative capacity of the cells.

[ Reference example  3] Formulation Example  2 and Comparative Formulation Example  Preparation of 2

A cream-based composition was prepared in a conventional manner according to the composition of Table 6 below (unit: wt%).

Compounding ingredient Formulation Example 2 Comparative Formulation Example 2 Labrafac 23 23 Tween 80 10.5 10.5 Glycerol monostearate 4.0 4.0 Stearic acid 7.0 7.0 Cetyl alcohol 2.0 2.0 Propylene glycol 9.0 9.0 Glycerol monooleate 3.5 3.5 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol One - water 40 41

[ Test Example  5] (2S) -1-O- linolenoyl -2-O- linolenoyl -3-O- [beta] -D-galactopyranosyl- sec wool effect of -glycerol

The hair of the back of the ICR mouse was depilated by a depilator, and hair was completely removed by using a depilatory cream (bit cream). (DNCB) was administered to a mouse deprived of hair and the like to induce skin irritation to set skin stress conditions to maximize hair growth and to evaluate the hair regeneration efficacy of the composition of the present invention , and scoring (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- the formulation example 2 and Comparative example 2 formulation of cream containing sn -glycerol to, The length of hair growth was measured and compared with the control group. The results are shown in Table 7 below.

Days to be treated (days) Fur Length (cm) Formulation Example 2 Treatment Comparative Formulation Example 2 Treatment 0 0.07 0.1 6 0.12 0.1 9 0.37 0.1 12 0.70 0.1

As shown in Table 7, the hair length of the group treated with the cream base of Formulation Example 2 showed a statistically significant difference (p < 0.01) compared with the group treated with the cream base of Comparative Formulation Example 2, (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol on the 12th day It can be confirmed that the length of hair of the group treated with the cream base material of Formulation Example 2 is longer than that of the group treated with the cream base material of Comparative Example 2 which is not Comparative Example 2. [

This suggests that (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol promoted hair regeneration even under conditions of restoration of hair formed under skin stress, This shows that there is a regenerating function for hair that has been lost under stress.

[ Reference example  4] Formulation Example  3 and Comparative Formulation Example  3 Preparation of

The scalp essences were prepared according to the composition shown in Table 8 below. More specifically, the (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol, polyoxyethylene hydrogenated castor oil (Polyoxyethylene Hydrogenated Castor Oils) / POE ( (Emalex HC-60, Nihon Emulsion Co., Ltd.), salicylic acid 0.2%, ethanol 10%, distilled water, ammonium acryloyldimethyltaurate / Vpicopolymer (manufactured by Aristoflex) and phenoxyethanol Phenoxyethanol, PE).

(Unit: wt%) ingredient Formulation Example 3 Comparative Formulation Example 3 Polyoxyethylene hydrogenated castor oil / POE (60) 0.5 0.5 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 0.2 - Salicylic acid 0.2 0.2 ethanol 10 10 Distilled water 88.3 88.5 Ammonium acryloyldimethyltaurate / Vpicopolymer 0.5 0.5 Phenoxyethanol 0.3 0.3

[ Test Example  6] Skin irritation test

In order to confirm whether or not skin irritation occurred when using the composition according to the present invention, 24 male and female 25- to 45-year-old male subjects who were relatively scarred with scalp itching were selected and divided into two groups of 12 persons. For each group, Formulation Example 3, Comparative Formulation Example 3 Of the scalp essence was used. Concretely, after washing the cheek piece, the water was wiped off and the sample was allowed to stand in a constant temperature and humidity room (temperature 24 ± 4 ° C., relative humidity 40 to 45%) for 15 minutes. The same amount of the scalp essence containing 0.2% of the efficacious substance was applied to the skin surface to the extent that did not allow the skin essence to flow therethrough. After 24 hours and 48 hours after the test substance was attached, the subject marked the degree of stimulation from 0 to 4 points (0 = no stimulation, 1 = very weak, 2 = weak, 3 = moderate, 4 = severe) (2 measurements in total), stinging, and burning sensation.

The number of subjects who complained of the above-mentioned stimulus for each time slot is shown in Table 9 below. In addition, the average value was calculated to derive the skin irritation as a mean score, and the results are shown in Table 9 below.

Test material name Test concentration 24hr 48hr Responses Judgment One 2 3 4 One 2 3 4 (n = 10) Formulation Example 3 0.20% One 0 0 0 0 0 0 0 One No stimulation Comparative Formulation Example 3 0.20% One 0 0 0 0 0 0 0 One No stimulation

From the results of Table 9, the composition of Formulation Example 3 (2S) -1-O-linolenoyl -2-O-linolenoyl-3-O-β-D-galactopyranosyl- Comparative Formulation Example 3 that does not include the sn -glycerol It was confirmed that there was no skin irritation. Therefore, the composition according to the present invention using (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol is safe for human body, It can be seen that there is no side effect even if it is used for a long time.

[ Reference example  5] Formulation Example  4 and Comparative Formulation Example  4

A scalp and hair combination treatment composition was prepared according to the composition of Table 10 below. The oil phase and water phase were separately prepared in a blender, the oil phase was slowly added to the water phase, emulsified at 3,000 rpm for 10 minutes using a homomixer, and then cooled to room temperature to prepare the scalp and hair combing treatments of Formulation Example 4 and Comparative Formulation Example 4 .

Component (% by weight) Formulation Example 4 Comparative Formulation Example 4 Purified water balance
(to 100) balance
(to 100) (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 0.5 - Cetyltrimethylammonium chloride 1.0 1.0 Cetyl alcohol 3.0 3.0 Stearyl alcohol 3.0 3.0 Preservatives, coloring and flavoring Suitable amount Suitable amount

[ Test Example  7] Sensory test

Sensory tests were carried out on the scalp and hair-combined treatment compositions of Formulation Example 4 and Comparative Formulation Example 4 by the following method. Twenty-four professional evaluation personnel were divided into two groups, and each group was allowed to use the scalp and hair-combing treatments of Formulation Example 4 and Comparative Formulation Example 4. The evaluation items shown in the following Table 11 were compared , And the test was conducted with the lowest score as 1 and the highest score as 5. The test results are shown in Table 11 below.

Item Scalp itching Scalp stimulus Hair softness / smoothness Formulation Example 4 2.6 2.5 1.4 Comparative Formulation Example 4 3.3 3.1 2.1

In the above Table 11, (2S) -1-O -linolenoyl-2-O-linolenoyl-3-O-β-D-galactopyranosyl- sn -glycerol Formulation Example 4 containing the (2S) -1-O- Compared to the case of Comparative Example 4 which did not contain linolenoyl-2-O-linolenoyl-3-O- beta -D-galactopyranosyl- sn -glycerol, the itching of the scalp was reduced and the irritation was reduced, It can be seen that it is better.

[ Formulation example  One] hair tonic

Hair tonics were prepared in a conventional manner according to the composition shown in Table 12 below.

ingredient Weight ratio (%) ethanol 50 menthol 0.02 glycerin 3 Salicylic acid 0.05 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 1.0 Spices and Pigments Proper amount Purified water Balance (to 100)

[ Formulation example  2] hair  Lotion

Hair lotions were prepared in a conventional manner according to the composition shown in Table 13 below.

ingredient Weight ratio (%) Cetostearyl alcohol 2.0 EDTA 2Na 0.2 Hydroxyethyl cellulose 0.5 Mineral oil 5.0 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 1.0 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[ Formulation example  3] Hair Nourishing Lotion

Hair nutritional lotion was prepared by a conventional method according to the composition shown in Table 14 below.

ingredient Weight ratio (%) Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Mineral oil 10.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 1.0 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[ Formulation example  4] Hair shampoo

Hair shampoos were prepared in a conventional manner according to the composition shown in Table 15 below.

ingredient weight% Purified water Balance (To 100) (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 1.0 Sodillauryl sulphite 36.0 Cocamidopropyl betaine 8.0 Palmitidine dimalate 2.0 Glycollosteralate 1.5 Polyquaternium 10 0.5 Saitric Acid 0.1 glycerin 2.0 Preservatives, coloring and flavoring Suitable amount

[ Formulation example  5] hair  Rinse

Hair rinses were prepared according to the compositions shown in Table 16 below by a conventional method.

ingredient weight% Purified water Balance (To 100) (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0- beta -D-galactopyranosyl- sn -glycerol 1.0 Propylene glycol 2.0 Cetyltrimethylammonium chloride 1.0 Cetyl alcohol 3.0 Stearyl alcohol 3.0 Mineral oil 0.5 Saitric Acid 0.2 Polydimethylsiloxane 1.0 Preservatives, coloring and flavoring Suitable amount

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (6)

A composition for promoting hair growth or preventing hair loss comprising (2S) -1-O-linolenoyl-2-O-linolenoyl-3-O-? -D-galactopyranosyl- sn -glycerol represented by the following formula 1 as an active ingredient.
[Chemical Formula 1]

[2] The composition for promoting hair growth or hair loss according to claim 1, wherein the active ingredient is contained in an amount of 0.001 to 50% by weight based on the total weight of the composition. The composition according to claim 1 or 2, wherein the composition is selected from the group consisting of hair tonic, hair nutritional lotion, scarf treatment, hair treatment, hair shampoo, hair rinse, hair lotion, and scalp hair- Of the composition for preventing hair growth stimulation or hair loss. A composition for alleviating dandruff or scalp itching comprising (2S) -1-O-linolenoyl-2-O-linolenoyl-3-0-? -D-galactopyranosyl- sn -glycerol as an active ingredient represented by the following formula
[Chemical Formula 1]

5. The composition for alleviating dandruff or scalp itching according to claim 4, wherein the active ingredient is contained in an amount of 0.001 to 50% by weight based on the total weight of the composition. [5] The composition according to claim 4 or 5, wherein the composition is selected from the group consisting of hair tonic, hair nourishing lotion, scarf treatment, hair treatment, hair shampoo, hair rinse, hair lotion and scalp hair- Wherein the composition has a formulation of dandruff or scalp itching.