KR20160066254A - Composition for improving condition of hair and scalp containing Picrionoside A - Google Patents

Abstract

The present invention relates to a composition for improving the condition of hair and scalp, containing picrionoside A and, more specifically, to a composition for an external skin or a pharmaceutical composition which promotes hair growth by containing the component, can prevent and improve hair loss, improves overall hair condition by alleviating the stimulation with respect to the scalp and inhibiting dandruff and scalp inflammation, and has excellent purifying and soothing effects with respect to the scalp. In addition, the present invention enhances hair root by activating cell proliferation of the scalp. thereby hair loss reduction and hair growth promoting effects are provided, the prevention of scalp itch and the dandruff is effective.

Description

TECHNICAL FIELD The present invention relates to a hair or scalp condition improving composition containing picronoside A,

The present invention relates to a hair or scalp condition improving composition containing Picrionoside A, and more particularly to a hair or scalp condition improving composition containing Picrionoside A as an active ingredient to promote hair growth The present invention relates to a composition for external application for skin or a pharmaceutical composition which can alleviate irritation to the scalp and inhibit dandruff, scalp inflammation and the like, thereby improving the overall hair condition and having excellent cleansing and soothing effect on the scalp.

The scalp is composed of the epidermis, dermis, and subcutaneous tissue, and the outermost tissue is the epidermis. The epidermis protects the body's sensitive tissues from damage. However, due to various physical and chemical external stimuli such as external temperature, humidity change, pollutants, stress, and lack of influence, the scalp function may be lost, and furthermore, it may affect hair loss.

In modern society, which emphasizes beauty, many people, both men and women, use hair dye, permanent hair, and the like in order to satisfy the need for expression of individuality. However, in the case of some sensitive scalp, chemical treatment such as dyeing and perming causes irritation such as itching or stinging of the scalp and inflammation, which leads to environmental hair loss.

In this way, it is possible to protect the scalp from stimulation, stress, and chemical treatment from the environment due to various causes, to promote hair growth while preventing hair loss, and to continue research on ecosystem-friendly and environmentally harmless components to humans .

Picrionoside A (Picrionoside A) can be isolated or chemically synthesized from a terpenoid component extracted from a part of the perennial plant Asplenium scolopendrium belonging to the fern tail gosarit (Natural Product Sciences, 14 (4): 265-268 (2008)). For icaricide II compound icariside II, whitening activity is already known (International Patent Publication No. WO 2008/035918, published on Mar. 27, 2008). On the other hand, remarkable research results of picronoside A, an icaricide-based compound, have not been reported yet.

As a result, the present inventors have found that when treating picrionoside A on the skin, the proliferation of the dermal papilla cells and the growth of the scalp, The inventors of the present invention have found that it is possible not only to enhance the proliferation of dermal cells but also to alleviate the stimulation to the scalp and suppress the dandruff.

It is an object of the present invention to provide a composition showing excellent hair growth or scalp condition improving effect.

In order to achieve the above object, the present invention provides a composition for promoting hair growth or preventing alopecia including Picorionoside A as an active ingredient.

The present invention also provides a composition for preventing dandruff or scalp itching comprising Picrionoside A as an active ingredient.

The composition of the present invention contains picrionoside A as an active ingredient, thereby activating the cell proliferation of the scalp to strengthen the hair follicle, thereby providing a hair loss phenomenon and a hair growth promoting effect, .

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is well known and commonly used in the art.

In one aspect, the present invention relates to a composition for promoting hair growth or preventing hair loss comprising, as an active ingredient, picronoside A (Picrionoside A) represented by the following formula:

[Chemical Formula 1]

The composition according to the present invention provides an effect such as hair root strengthening, blood circulation promotion and antioxidation by containing Picrionoside A as an active ingredient, and it is effective to promote hair growth, hair growth, wool, Lt; / RTI >

In the present specification, the term " promoting hair growth "means not only promoting the generation of new hair but also allowing the existing hair to grow healthily, and the phenomenon in which the hair falls off the scalp and the hair becomes thin And suppression.

The composition for promoting hair growth or hair loss of the present invention can promote the hair growth by promoting the transition from the resting hair cycle to the growing hair cycle, thereby providing the effect of preventing hair loss.

In another aspect, the present invention relates to a composition for preventing dandruff or scalp itching comprising, as an active ingredient, Picorionoside A represented by the above formula (1).

The anti-dandruff composition of the present invention can effectively remove toxins accumulated in hair and scalp to purify the scalp, inhibit proliferation and growth of dandruff, inhibit the scalp inflammation reaction, and inhibit the production and action of active oxygen It has excellent efficacy, so it can calm and strengthen the scalp and provide the effect of strengthening the original defense.

The composition for alleviating the itch of the present invention can stabilize the sensitive, stimulant or reactive scalp by reducing irritation such as itching and stinging of the scalp and alleviating and alleviating the scalp inflammation. In addition, hair condition can be improved healthily by providing a conditioning effect that makes rough and damaged hair soft and smooth.

In the present invention, the active ingredient may be contained in an amount of 0.001 to 50% by weight, based on the total weight of the hair growth promoting or hair loss preventing composition, or the composition for preventing dandruff or scalp itching, Preferably 0.01 to 30% by weight, more preferably 0.1 to 10% by weight. If the content of the active ingredient is less than 0.001% by weight, the effect or effect of the ingredient is insignificant, and if it exceeds 50% by weight, there is a problem of skin safety or shape.

In the present invention, the compositions for promoting hair growth or preventing hair loss, or compositions for alleviating dandruff or scalp itching can be used for hair tonic, hair nutrition lotion, scarf treatment, hair treatment, hair shampoo, hair rinse, hair lotion and scalp hair And a treatment agent.

The compositions of the present invention may be formulated in particular as a cosmetic composition and may be formulated containing a cosmetically or dermatologically acceptable medium or base. In addition, the composition of the present invention may be provided in any form suitable for topical application, for example, as a solution, an emulsion obtained by dispersing an oil phase in water phase, an emulsion obtained by dispersing water phase in water phase, a suspension, a solid, a gel, Pastes, foams, or aerosol compositions. Compositions of such formulations may be prepared according to conventional methods in the art.

In particular, the composition of the present invention is not particularly limited as a composition for a hair or scalp. For example, a hair tonic, a hair nutrition lotion, a scalp treatment, a hair treatment, a hair shampoo, a hair conditioner, Combination treatments, and the like.

In addition, the composition according to the present invention may contain, in addition to the above-mentioned substances, other ingredients which can give a synergistic effect to the main effect, to the extent that the main effect is not impaired. The composition according to the present invention may further comprise a humectant, an emollient, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a pH adjuster, an organic or inorganic pigment, a perfume, a cold agent or a limiting agent. The compounding amount of the above components can be easily selected by a person skilled in the art within the range not impairing the object and effect of the present invention, and the amount thereof may be from 0.01 to 5% by weight, specifically from 0.01 to 3% by weight based on the total weight of the composition .

In addition, the composition of the present invention can be formulated as a pharmaceutical composition. When the composition according to the present invention is applied to medicines, it may be formulated into oral, parenteral or parenteral dosage forms in solid, semi-solid or liquid form by adding an inorganic or organic carrier compatible with the active ingredient used in the present invention , The pharmaceutical composition according to the present invention may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously, and the like.

Examples of the formulations for oral administration include tablets, pills, granules, capsules, powders, fine granules, powders, emulsions, syrups and pellets. In addition, the formulations for parenteral administration include injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, and the like. The composition according to the present invention can be easily formulated into an active ingredient by carrying out the composition according to a conventional method. In this case, a surfactant, excipient, coloring agent, spice, preservative, stabilizer, buffer, suspending agent, have.

The dosage of the active ingredient of the pharmaceutical composition of the present invention will vary depending on the age, sex, body weight, pathological condition and severity of the subject to be treated, route of administration, or judgment of the prescriber. Determination of the appropriate dose based on these factors is well within the level of ordinary skill in the art and its daily dose is, for example, from 0.1 mg / kg / day to 100 mg / kg / day, more specifically from 5 mg / kg / day to 50 mg / / Day, but is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[ Reference example  One]

In order to obtain Picrionoside A as an active ingredient for the test of the efficacy of the composition of the present invention, MeOH extract was obtained by ultrasonically extracting the ground part of dried nadobacospora leaves and then using MeOH. The fraction was further fractionated into n-hexane, CH2Cl2, n-BuOH and H2O layers. One compound was separated from the CH2Cl2 layer in the fraction through silica gel column chromatography with Sephadex LH-20. The fraction was separated from the n-BuOH layer by MCI-gel column chromatography (MCI-gel column chromatography, 100 % H2O- > 100% MeOH). 3.0 mg of picronoside A was obtained using HPLC (High-performance liquid chromatography, AcCN-H2O = 19: 81, 2 ml / min, YMC J'sphere ODS-H80).

[ Reference example  2] Formulation Example  1 and Comparative Formulation Example  1

A shampoo was prepared with the composition shown in Table 1 below. Specifically, the surfactant and ethylene glycol distearate were added to purified water, heated to 80 DEG C to dissolve uniformly, and then gradually cooled to 40 DEG C with stirring. To the mixture were added the active ingredient according to the present invention and a preservative, A viscosity adjusting agent, a perfume, and a hair conditioning agent were mixed and stirred, followed by cooling to room temperature.

ingredient Formulation Example 1 Comparative Formulation Example 1 Ammonium lauryl sulfate 10 10 Polyoxyethylene lauryl ammonium sulfate 5 5 Cocoamidopropyl betaine 2 2 Ethylene glycol distearate 1.5 1.5 Cocoyl monoethanolamide 0.8 0.8 Picrionoside A (Picrionoside A) 5.0 - Polyquaternium-10 0.2 0.2 Blue No. 1 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 Methyl paraben 0.1 0.1 Spices 0.8 0.8 Citric acid 0.1 0.1 Dimethicone 1.0 1.0 water to 100 to 100

[ Test Example  1] Dandruff reduction test

Twenty-four men aged 19 to 35 years with a relatively large number of dandruff were selected and divided into two groups of twelve persons. The shampoos of Formulation Example 1 and Comparative Formulation Example 1 were used for one month in the following manner for each group, Reduction rate was measured.

Before the start of the test, the dandruff was sampled with normal shampoo, and the dandruff accumulated for 2 days after shaking was collected. The dandruff weight was sampled every two days with each shampoo. Respectively. The accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated according to the following equation (1). The results are shown in Table 2 below.

Dandruff reduction rate (%) Formulation Example 1 37.34 Comparative Formulation Example 1 3.4

As can be seen from the above Table 2, when Formulation Example 1 containing Picrionoside A was used, it was found that the dandruff prevention effect was remarkably excellent.

[ Test Example  2] Scalp itching prevention effect test

Twenty-four male and female twenty-four to twenty-five-year-olds who felt severe itchiness of the scalp were selected and divided into two groups of twelve, and the shampoo of Formulation Example 1 and Comparative Formulation Example 1 was used for each group once every three days for two weeks The posterior scalp itching prevention effect was evaluated through the following evaluation criteria, and the results are shown in Table 3 below.

[Evaluation standard]

Very good - 5 points

Excellent - 4 points

Usually - 3 points

Poor - 2 points

Very bad - 1 point

division Prevention of itching of scalp Formulation Example 1 3.0 Comparative Formulation Example 1 2.3

As can be seen from the above Table 3, when Comparative Formulation Example 1 containing no Picrionoside A was used, the effect of preventing the itchiness of the scalp was not good, and when Picrionoside A was used, In the case of Formulation Example 1, which shows excellent effect of preventing scalp itching.

[ Test Example  3] hair follicles Dairy cattle  Cell proliferation effect

The keratin proteins that make up the hair are produced in hair follicle keratinocytes, which are differentiated from the dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the present composition, DP6 (rat immortalized dermal papilla cell) cell line was used in the present invention (Wendy Filsell, Journal of Cell Science 107, 1761-1772 (1994)). This dermal papilla cell line is a cell line isolated by microdissection method in the hair roots of male PVG rat beard and is a cell line which is cultured in DMEM (Dulbecco's modified Eagle's medium, Gibco BRL, Gaithersburg, MD, USA) containing 10% FBS (Fetal bovine serum) USA) for 24 hours in an incubator maintained at 37 ° C in 5% CO ₂ . DP6 was added to a 96-well plate and cultured in a 37 ° C incubator for 24 hours. Then, the above-mentioned Picrionoside A was treated at a concentration of 5 ppm, 10 ppm and 20 ppm, respectively. After 24 hours of drug treatment, cell proliferation was measured using WST-1 kit (Roche). The results are shown in Table 4 below.

division Cell proliferation (%) Untreated Control ( Control ) 100 Picrionoside A (5 ppm ) 110.4 Picrionoside A (10 ppm ) 114.0 Picrionoside A (20 ppm ) 129.8

As shown in Table 4, when picronoside A was treated, proliferation of dermal papilla cells was increased, which was significantly increased in a concentration-dependent manner.

[ Test Example  4] Assessment of Potassium Ion Channel Activity Increase Effect

In order to investigate the effect of Picrionoside A on potassium ion channel activity used in the present invention, tolbutamide (SIGMA AlDRICH, T0891) blocking the K _ATP channel in fibroblasts constituting the dermis of the scalp was used To inhibit cell proliferation, and to regain cell proliferation by opening the potassium ion channel again.

To evaluate the function of this composition as a K _ATP channel opener, the fibroblast cell line NIH3T3 (mouse embryonic fibroblast cell line) was used in the present invention. This cell line is a cell line obtained by natural immortalization of fibroblasts isolated from NIH Swiss mouse embryo by the 3T3 protocol. The cell line was cultured in DMEM (Dulbecco's modified Eagle's medium; Gibco BRL, Gaithersburg, MD, USA) containing 10% bovine serum (FBS) for 24 hours in an incubator maintained at 37 ° C in 5% CO ₂ . NIH3T3 was cultured in a 96-well plate for 24 hours in a 37 ° C incubator, treated with 2.5 mM tolbutamide, and after 10 minutes, Picrionoside A was added at concentrations of 2.5 ppm, 5 ppm and 10 ppm Respectively. For comparison, minoxidil, which is known as a potential mitochondrial potassium ion channel opener (K _ATP channel opener) and used for the treatment of androgenetic alopecia, was used as a positive control and treated at a concentration of 10 μM. After 48 hours from the treatment of the sample, the cell survival rate was measured using a WST-1 kit (Roche). The results are shown in Table 5 below.

division Cell proliferation (%) Untreated Control (Control) 100 Minoxidil 132 Picrionoside A (2.5 ppm ) 108.3 Picrionoside A (5 ppm ) 112.2 Picrionoside A (10 ppm ) 120.3

As can be seen in Table 5, the proliferation of fibroblasts was restored when Picrionoside A was treated, and the cell proliferation was increased in a concentration-dependent manner in the treated Picronoside A (Picrionoside A) .

[ Reference example  3] Formulation Example  2 and Comparative Formulation Example  Preparation of 2

A cream-based composition was prepared in a conventional manner according to the composition of Table 6 below (unit: wt%).

Compounding ingredient Formulation Example 2 Comparative Formulation Example 2 Labrafac 23 23 Tween 80 10.5 10.5 Glycerol monostearate 4.0 4.0 Stearic acid 7.0 7.0 Cetyl alcohol 2.0 2.0 Propylene glycol 9.0 9.0 Glycerol monooleate 3.5 3.5 Picrionoside A (Picrionoside A) One - water 40 41

[ Test Example  5] Picronoside  A ( Picrionoside  A) wool effect

The hair of the back of the ICR mouse was depilated by a depilator, and hair was completely removed by using a depilatory cream (bit cream). (DNCB) was administered to a mouse deprived of hair and the like to induce skin irritation to set skin stress conditions to maximize hair growth and to evaluate the hair regeneration efficacy of the composition of the present invention , The creams of Formulation Example 2 and Comparative Formulation Example 2 containing Picrionoside A were treated and the length of the hair growth hair was measured according to the days of treatment and compared with the control group. The results are shown in Table 7 below.

Days to be treated (days) Fur Length (cm) Formulation Example 2 Treatment Comparative Formulation Example 2 Treatment 0 0.07 0.1 6 0.12 0.1 9 0.37 0.1 12 0.70 0.1

As shown in Table 7, the hair length of the group treated with the cream base of Formulation Example 2 showed a statistically significant difference (p < 0.01) compared with the group treated with the cream base of Comparative Formulation Example 2, And the length was increased to about 0.66 cm in the day of the 12th day, compared to the group treated with the cream base material of Comparative Formulation Example 2 which did not contain Picrionoside A, And the length of the hair of the treated group was longer.

This suggests that Picrionoside A promotes hair regeneration even under conditions of restoration of hair formed under skin stress, thereby showing regeneration function for hair removed under stress.

[ Reference example  4] Formulation Example  3 and Comparative Formulation Example  3 Preparation of

The scalp essences were prepared according to the composition shown in Table 8 below. More specifically, it is possible to use Picrionoside A, Polyoxyethylene Hydrogenated Castor Oils / POE 60 (Emalex HC-60, Nihon Emulsion Co., Ltd.), salicylic acid The composition was prepared using 0.2%, 10% ethanol, distilled water, ammonium acryloyldimethyltaurate / Vpicopolymer (manufacturer: Aristoflex) and phenoxyethanol (PE).

(Unit: wt%) ingredient Formulation Example 3 Comparative Formulation Example 3 4 4 Polyoxyethylene hydrogenated castor oil / POE (60) 0.5 0.5 Picrionoside A (Picrionoside A) 0.2 - Salicylic acid 0.2 0.2 ethanol 10 10 Distilled water 88.3 88.3 Ammonium acryloyldimethyltaurate / Vpicopolymer 0.5 0.5 Phenoxyethanol 0.3 0.3

[ Test Example  6] Skin irritation test

In order to confirm whether or not skin irritation occurred when using the composition according to the present invention, 24 male and female 25- to 45-year-old male subjects who were relatively scarred with scalp itching were selected and divided into two groups of 12 persons. For each group, Formulation Example 3, Comparative Formulation Example 3 Of the scalp essence was used. Concretely, after washing the cheek piece, the water was wiped off and the sample was allowed to stand in a constant temperature and humidity room (temperature 24 ± 4 ° C., relative humidity 40 to 45%) for 15 minutes. The same amount of the scalp essence containing 0.2% of the efficacious substance was applied to the skin surface to the extent that did not allow the skin essence to flow therethrough. After 24 hours and 48 hours after the test substance was attached, the subject marked the degree of stimulation from 0 to 4 points (0 = no stimulation, 1 = very weak, 2 = weak, 3 = moderate, 4 = severe) (2 measurements in total), stinging, and burning sensation.

The number of subjects who complained of the above-mentioned stimulus for each time slot is shown in Table 9 below. In addition, the average value was calculated to derive the skin irritation as a mean score, and the results are shown in Table 9 below.

Test material name Test concentration 24hr 48hr Responses Judgment One 2 3 4 One 2 3 4 (n = 10) Formulation Example 3 0.20% One 0 0 0 0 0 0 0 One No stimulation Comparative Formulation Example 3 0.20% One 0 0 0 0 0 0 0 One No stimulation

From the results of Table 9, it can be confirmed that the composition of Formulation Example 3 was free from skin irritation as in Comparative Formulation Example 3 which does not contain Picrionoside A. Therefore, it can be seen that the composition according to the present invention using Picrionoside A is safe for human body, has no irritation to the skin, and has no side effects even when used for a long period of time.

[ Reference example  5] Formulation Example  4 and Comparative Formulation Example  4

A scalp and hair combination treatment composition was prepared according to the composition of Table 10 below. The oil phase and water phase were separately prepared in a blender, the oil phase was slowly added to the water phase, emulsified at 3,000 rpm for 10 minutes using a homomixer, and then cooled to room temperature to prepare the scalp and hair combing treatments of Formulation Example 4 and Comparative Formulation Example 4 .

Component (% by weight) Formulation Example 4 Comparative Formulation Example 4 7 7 Purified water balance
(to 100) balance
(to 100) Picrionoside A (Picrionoside A) 0.5 - Cetyltrimethylammonium chloride 1.0 1.0 Cetyl alcohol 3.0 3.0 Stearyl alcohol 3.0 3.0 Preservatives, coloring and flavoring Suitable amount Suitable amount

[ Test Example  7] Sensory test

Sensory tests were carried out on the scalp and hair-combined treatment compositions of Formulation Example 4 and Comparative Formulation Example 4 by the following method. Twenty-four professional evaluation personnel were divided into two groups, and each group was allowed to use the scalp and hair-combing treatments of Formulation Example 4 and Comparative Formulation Example 4. The evaluation items shown in the following Table 11 were compared , And the test was conducted with the lowest score as 1 and the highest score as 5. The test results are shown in Table 11 below.

Item Scalp itching Scalp stimulus Hair softness / smoothness Formulation Example 4 2.6 2.5 1.4 Comparative Formulation Example 4 3.3 3.1 2.1

As shown in Table 11, Formulation Example 4 including Picrionoside A showed a decrease in the itchiness of the scalp as compared with Comparative Formulation Example 4 which did not contain Picrionoside A And the feeling of stimulation was alleviated, and the state of hair was also improved.

[ Formulation example  One] hair tonic

Hair tonics were prepared in a conventional manner according to the composition shown in Table 12 below.

ingredient Weight ratio (%) ethanol 50 menthol 0.02 glycerin 3 Salicylic acid 0.05 Picrionoside A (Picrionoside A) 1.0 Spices and Pigments Proper amount Purified water Balance (to 100)

[ Formulation example  2] hair  Lotion

Hair lotions were prepared in a conventional manner according to the composition shown in Table 13 below.

ingredient Weight ratio (%) Cetostearyl alcohol 2.0 EDTA 2Na 0.2 Hydroxyethyl cellulose 0.5 Mineral oil 5.0 Picrionoside A (Picrionoside A) 1.0 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[ Formulation example  3] Hair Nourishing Lotion

Hair nutritional lotion was prepared by a conventional method according to the composition shown in Table 14 below.

ingredient Weight ratio (%) Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.7 Mineral oil 10.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Picrionoside A (Picrionoside A) 1.0 antiseptic Proper amount Spices and Pigments Proper amount Purified water Balance (to 100)

[ Formulation example  4] Hair shampoo

Hair shampoos were prepared in a conventional manner according to the composition shown in Table 15 below.

ingredient weight% Purified water Balance (To 100) Picrionoside A (Picrionoside A) 1.0 Sodillauryl sulphite 36.0 Cocamidopropyl betaine 8.0 Palmitidine dimalate 2.0 Glycollosteralate 1.5 Polyquaternium 10 0.5 Saitric Acid 0.1 glycerin 2.0 Preservatives, coloring and flavoring Suitable amount

[ Formulation example  5] hair  Rinse

Hair rinses were prepared according to the compositions shown in Table 16 below by a conventional method.

ingredient weight% Purified water Balance (To 100) Picrionoside A (Picrionoside A) 1.0 Propylene glycol 2.0 Cetyltrimethylammonium chloride 1.0 Cetyl alcohol 3.0 Stearyl alcohol 3.0 Mineral oil 0.5 Saitric Acid 0.2 Polydimethylsiloxane 1.0 Preservatives, coloring and flavoring Suitable amount

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (6)

A composition for promoting hair growth or preventing hair loss comprising an effective ingredient of Picrionoside A represented by the following formula (1).
[Chemical Formula 1]

[2] The composition for promoting hair growth or hair loss according to claim 1, wherein the active ingredient is contained in an amount of 0.001 to 50% by weight based on the total weight of the composition. The composition according to claim 1 or 2, wherein the composition is selected from the group consisting of hair tonic, hair nutritional lotion, scarf treatment, hair treatment, hair shampoo, hair rinse, hair lotion, and scalp hair- Of the composition for preventing hair growth stimulation or hair loss. A composition for alleviating dandruff or scalp itching comprising, as an active ingredient, picrionoside A represented by the following formula (1).
[Chemical Formula 1]

5. The composition for alleviating dandruff or scalp itching according to claim 4, wherein the active ingredient is contained in an amount of 0.001 to 50% by weight based on the total weight of the composition. [5] The composition according to claim 4 or 5, wherein the composition is selected from the group consisting of hair tonic, hair nourishing lotion, scarf treatment, hair treatment, hair shampoo, hair rinse, hair lotion and scalp hair- Wherein the composition has a formulation of dandruff or scalp itching.