JP2019006836A - クロイチゴ抽出物を使用して髪質を強化するための使用 - Google Patents
クロイチゴ抽出物を使用して髪質を強化するための使用 Download PDFInfo
- Publication number
- JP2019006836A JP2019006836A JP2018199117A JP2018199117A JP2019006836A JP 2019006836 A JP2019006836 A JP 2019006836A JP 2018199117 A JP2018199117 A JP 2018199117A JP 2018199117 A JP2018199117 A JP 2018199117A JP 2019006836 A JP2019006836 A JP 2019006836A
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- Japan
- Prior art keywords
- blackberry
- extract
- composition
- hair
- rubus fruticosus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
本発明で有用な局所適用組成物は、毛髪及び頭皮への局所適用に好適な製剤を含有する。一実施形態において、組成物はクロイチゴ抽出物及び化粧学的に許容できる局所キャリアを含有する。一実施形態において、化粧学的に許容できる局所キャリアは、組成物の約75重量%〜約95重量%、より好ましくは組成物の約75重量%〜約85重量%を構成する。
一実施形態において、本発明の組成物は1つ又は2つ以上の界面活性剤を含む。一実施形態において、組成物は発泡性界面活性剤を含む。「発泡性界面活性剤」は、水と混合して機械的に撹拌すると泡を発生する界面活性剤を意味する。一実施形態において、発泡性界面活性剤は、(1リットル当たり5グラムの濃度、温度49℃、及び水の硬度136mg/L(1ガロン当たり8グレイン)を使った)ASTM Standards 1001 15節15.04巻のASTM Annual Bookに記載されている界面活性剤D1173−53の発泡特性の標準試験方法における、少なくとも20mm(少なくとも50mmなど)の初期発泡高さ値を有する。発泡性界面活性剤の例には、アニオン性、非イオン性、カチオン性、及び両性の発泡性界面活性剤が挙げられるが、これらに限定されない。
一実施形態において、本発明による組成物は、1つ又は2つ以上の追加の化粧学的に活性の薬剤、並びに上述の構成成分を更に含有し得る。「化粧学的に活性の薬剤」は、合成化合物、又は天然源から分離、精製、若しくは濃縮された化合物、又は組織に対して化粧学的若しくは治療的に効果がある化合物の混合物を含有する天然抽出物であってよい化合物であり、これらの化合物には、抗酵母剤などの抗菌薬、抗真菌薬、及び抗菌剤、抗炎症薬、老化防止剤、駆虫薬、外用鎮痛薬、日焼け止め剤、光防護剤、酸化防止剤、角質溶解剤、洗剤/界面活性剤、加湿剤、栄養素、ビタミン、ミネラル、エネルギーエンハンサー、制汗剤、収斂剤、育毛促進剤、染毛剤、顔料、安定剤、皮膚保全剤、並びに矯臭剤又はPH変化剤などの賦香剤が挙げられるが、これらに限定されない。
種々の他の材料もまた、本発明に有用な組成物中に存在してもよい。これらの材料は、保湿剤、タンパク質及びポリペプチド、防腐剤及びアルカリ剤を含む。このような化学物質の例は、INCIハンドブックの1650〜1667頁に開示されている。本発明の組成物は、キレート剤(例えば、EDTA)及び防腐剤(例えば、パラベン)を更に含んでもよい。好適な防腐剤及びキレート剤の例は、INCIハンドブックの1626頁及び1654〜55頁に記載されている。更に、本明細書で有用な局所適用組成物は、染料、乳白剤(例えば、二酸化チタン)、顔料、及び芳香剤などの従来の美容補助剤を含むことができる。
一実施形態において、本発明の組成物は更に、メラニン若しくは合成メラニン誘導体、又はメラニン様分子、バニリン重合体、限定するものではないが、コレウスフォルスコリ(Coleus Forskoli)抽出物、ブグラン−P(Bugrane-P)抽出物、顔料(例えば、サンナ属又はクマコケモモ属の植物から取った褐色色素、又はカロチノイド若しくはカンタキサンチンを含有する植物から取った黄色色素、オレンジ色色素、赤色色素)を含有する天然源の抽出物などの天然抽出物、あるいは銅(例えば、CuCL2などの銅塩)を含有する化合物又は合成カロチノイド又はカンタキサンチンなどの合成化学物質などの黒化剤を含有する。合成メラニン誘導体の例は、米国特許第5,618,519号、同第5,384,116号及び同第5,227,459号に記載されている。可溶性メラニン誘導体の例は、第5,744,125号、第5,225,435号、第5,218,079号、及び第5,216,116号に記載されている。市販の可溶性メラニン誘導体の例には、San−mar laboratories,Inc.社(Elmsford,N.Y.)のMelasyn−100(商標)及びZylepsis社(Ashford,Kent,United Kingdom)のMelanze(商標)が挙げられる。
本発明の組成物は、ミネラルウォーター、例えば、Evian(登録商標)Mineral Water(Evian,France)などの自然に鉱水化されたミネラルウォーターを使って調製できる。一実施形態において、ミネラルウォーターは、少なくとも約200mg/L(例えば、約300mg/L〜約1000mg/L)の鉱化を有する。一実施形態において、ミネラルウォーターは、少なくとも約10mg/Lのカルシウム及び/又は少なくとも約5mg/Lのマグネシウムを含む。
本発明の組成物は、本組成物を身体の育毛所望部位に局所適用することによって、育毛を誘発するために利用することができる。本発明の組成物は、好ましくは身体の所望部位に少なくとも5日間にわたって少なくとも1日1回、より好ましくは少なくとも6週間にわたって毎日、最も好ましくは無期限に局所適用する。髪質を改善するためには、本組成物は少なくとも12週間にわたって少なくとも1日1回適用する必要がある。約2週間後、ユーザは育毛の増進に気づき始め、毛幹直径の増加、並びに/又はヘアーボリューム、髪つや、及び髪の毛の太さなどの髪の視覚属性の増強に気づくことができる。
ゲル基剤処方A1を下記表1に従って調製した。
次の成分を混合容器内で混合した。つまり、DI水、EDTA二ナトリウム、グリセリン、ジメチコーン、及びブチル化ヒドロキシトルエン(BHT)。続いて、プロップミキシング(prop mixing)を中速から高速(スイープブレード)で使用して40〜45℃まで加熱し、均質になるまで混ぜた。温度が40℃以下に達したら、次の成分をプロップミキシング(スイープブレード、中速)で1つずつ添加した。つまり、Sepigel 305、Phenonip XB。pHを水酸化ナトリウムで5.0に調整した。
クロイチゴ抽出物を含有する組成物(A2)、及びブチレングリコールと水のみを含有する組成物(A3)を、表2に記載の以下の処方を用いて、実施例1に記載されている手順に従って調製した。
組成物E1及びCを以下の表3の処方に従って調製した。発明に関する実施例E1は、濃度25%のクロイチゴ抽出物(A1とA2の比率が1:1)が得られるように、実施例1のゲル基剤A1と実施例2のクロイチゴ抽出組成物A2とを混合して、均質になるまで混ぜることにより調製した。更に、比較例C1は、実施例2のゲル基剤A1とA3とを混合することにより調製した。
クロイチゴ(ブラックベリー)抽出物を使ったC3Hマウスにおける育毛誘発
C3Hマウスにおける育毛誘発は、時間の関数(研究日数)に応じた、成長期に入るマウスの比率として測定した。
Williams E培地(マイナスグルタミン)、L−グルタミン、ファンギゾン、ペニシリン及びストレプトマイシン(Gibco社支給)から構成される培地を調整した。クロイチゴ抽出物と培地の原液を調製した。原液の1:10連続希釈を、適切な濃度を達成するまで調製した。
人間の毛包は、新しい美容整形サンプルから分離された。個々の毛包を、2.0mLの培地で満たした0.4μmインサートの6ウェルファルコンインサート細胞培養プレートに入れた。実施例5と同様に培地と原液を調製した。w/v計算を使用して、この培地に処置を加えた。培地は1日おきに交換した。0日目、1日目、3日目、5日目、7日目、及び9日目に画像を撮影した。毛幹の長さを測定して画像解析を行った。各群の平均値及び比率の増加を計算した。
以下の実施形態を表7に記載の処方を用いて実施した。
E2〜E5:
主容器の水を測定し、渦による撹拌を開始した。カルボマー−アクリル酸、シクロヘキサンを画面移動によりゆっくりと添加した。この混合物を、温度が55〜60℃に到達するまで加熱した。20%の水酸化ナトリウム溶液を作製した。20%の水酸化ナトリウム溶液でpHをpH 5.5〜6に調節してカルボマーを中和した。加熱を止め、混合物を45℃まで冷やした。マルトデキストリン(40%)ブラックベリー(クロイチゴ)葉抽出物(60%)を、グリセリルポリメタクリレート内で予め混合した。マルトデキストリン(40%)ブラックベリー(クロイチゴ)葉抽出物(60%)、グリセリルポリメタクリレートペーストを撹拌しながら容器に添加した。添加すると、粘土が低下し続けた。20%の水酸化ナトリウム溶液でpHをpH 5.5〜6.0に調節した。フェノキシエタノール(及び)カプリルグリコール(及び)ソルビン酸を撹拌しながらビーカー(製剤C12はフェノキシエタノール及び安息香酸ナトリウムを有した)に添加した。20%の水酸化ナトリウム溶液でpHをpH 5.5〜6に調節した。水で適量にした。ゲルが形成された。
(1) 濃度が少なくとも90mg/mL抽出物の溶液(90 mg extract/ml of solution)、ただし300mg/mL未満のブラックベリー抽出物を含む局所的に活性な組成物を、患者の頭皮、皮膚、まつ毛、眉、口ひげ領域、又はあごひげ領域に適用して育毛を強化する方法であって、少なくとも7日間毎日適用した後で頭皮に対する毛髪の範囲を増大させる、方法。
(2) 前記組成物が、濃度が少なくとも120mg/mL、ただし300mg/mL未満のブラックベリー抽出物を含む、実施態様1に記載の方法。
(3) 前記組成物が、濃度が少なくとも250mg/mL、ただし300mg/mL未満のブラックベリー抽出物を含む、実施態様1に記載の方法。
(4) 少なくとも90mg/mLで、300mg/mL未満のブラックベリー抽出物を含む、育毛強化用局所組成物。
(5) 少なくとも120mg/mLで、300mg/mL未満のブラックベリー抽出物を含む、育毛強化用局所組成物。
(7) 前記組成物が、ビタミン、ミネラル、タンパク質、ペプチド、脂肪酸、酸化防止剤、抗炎症剤、黒化剤、植物性抽出物、及びこれらの混合物からなるスキンケア剤を更に含む、実施態様4に記載の局所組成物。
(8) 患者の頭皮、皮膚、まつ毛、眉、口ひげ領域又はあごひげ領域の育毛を強化するための組成物であって、濃度が少なくとも90mg/mL抽出物の溶液、ただし300mg/mL未満のブラックベリー抽出物と、前記組成物の重量で少なくとも1重量パーセントのカルボマーとを含む、組成物。
Claims (5)
- 局所的な組成物であって、濃度が少なくとも90mg/mL抽出物の溶液、ただし300mg/mL未満のブラックベリー(Rubus fruticosus)の葉の抽出物を含み、及び、前記組成物あたり少なくとも1重量%のカルボマーをさらに含む、組成物の、ユーザの頭皮、皮膚、まつ毛、眉、口ひげ領域、又はあごひげ領域に前記組成物を適用することによる、育毛を強化するための使用であって、前記ブラックベリー(Rubus fruticosus)の葉の抽出物が、
(a) 2:8〜8:2の重量比率でエタノールと水とを含有する抽出剤をブラックベリー(Rubus fruticosus)の葉に加える工程、および
(b) 前記ブラックベリー(Rubus fruticosus)の葉を、前記抽出剤を用いて、80℃〜100℃の範囲の抽出温度で最大72時間にわたって抽出する工程、
によって生産される、使用。 - 局所的な組成物であって、濃度が少なくとも90mg/mL抽出物の溶液、ただし300mg/mL未満のブラックベリー(Rubus fruticosus)の葉の抽出物を含み、及び、前記組成物あたり少なくとも1重量%のカルボマーをさらに含む、組成物の、頭皮、皮膚、まつ毛、眉、口ひげ領域、又はあごひげ領域に前記組成物を適用することによる、育毛を強化するための使用であって、前記ブラックベリー(Rubus fruticosus)の葉の抽出物が、
(a) 2:8〜8:2の重量比率でエタノールと水とを含有する抽出剤をブラックベリー(Rubus fruticosus)の葉に加える工程、および
(b) 前記ブラックベリー(Rubus fruticosus)の葉を、前記抽出剤を用いて、80℃〜100℃の範囲の抽出温度で最大72時間にわたって抽出する工程、
によって生産される、使用(但し、ヒトに対する医療行為は除く)。 - 前記組成物が、濃度が少なくとも120mg/mL、ただし300mg/mL未満の前記ブラックベリー(Rubus fruticosus)の葉の抽出物を含む、請求項1又は2に記載の使用。
- 前記組成物が、濃度が少なくとも250mg/mL、ただし300mg/mL未満の前記ブラックベリー(Rubus fruticosus)の葉の抽出物を含む、請求項1〜3のいずれか一項に記載の使用。
- 前記組成物が、ビタミン、ミネラル、タンパク質、ペプチド、脂肪酸、酸化防止剤、抗炎症剤、黒化剤、植物性抽出物、及びこれらの混合物からなるスキンケア剤を更に含む、請求項1〜4のいずれか一項に記載の使用。
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Patent Citations (3)
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JPH0125895B2 (ja) * | 1980-03-06 | 1989-05-19 | Tsuaanraatofuaburiiku Furiidoritsuhisuhaafuen Ag | |
JPH03188014A (ja) * | 1989-12-15 | 1991-08-16 | Shiseido Co Ltd | 化粧料 |
JP2004091390A (ja) * | 2002-08-30 | 2004-03-25 | Hirofumi Tachibana | 育毛剤 |
Non-Patent Citations (1)
Title |
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J. AGRIC. FOOD CHEM., vol. 56, no. 3, JPN6017041516, 2008, pages 661 - 669, ISSN: 0004109768 * |
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