JP2018538253A5 - - Google Patents
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- Publication number
- JP2018538253A5 JP2018538253A5 JP2018522572A JP2018522572A JP2018538253A5 JP 2018538253 A5 JP2018538253 A5 JP 2018538253A5 JP 2018522572 A JP2018522572 A JP 2018522572A JP 2018522572 A JP2018522572 A JP 2018522572A JP 2018538253 A5 JP2018538253 A5 JP 2018538253A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl
- methylpyrimidin
- indoline
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(c(c(N1*(*)N*)c2)ccc2-c2cnc(C)nc2)C1=O Chemical compound CC(C)(c(c(N1*(*)N*)c2)ccc2-c2cnc(C)nc2)C1=O 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15193355.3 | 2015-11-06 | ||
| EP15193355 | 2015-11-06 | ||
| PCT/EP2016/076315 WO2017076842A1 (en) | 2015-11-06 | 2016-11-02 | Indolin-2-one derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538253A JP2018538253A (ja) | 2018-12-27 |
| JP2018538253A5 true JP2018538253A5 (enExample) | 2019-11-28 |
| JP6839184B2 JP6839184B2 (ja) | 2021-03-03 |
Family
ID=54476823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522572A Active JP6839184B2 (ja) | 2015-11-06 | 2016-11-02 | インドリン−２−オン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10519140B2 (enExample) |
| EP (1) | EP3371174B1 (enExample) |
| JP (1) | JP6839184B2 (enExample) |
| CN (1) | CN108137561B (enExample) |
| AR (1) | AR106589A1 (enExample) |
| TW (1) | TWI614244B (enExample) |
| WO (1) | WO2017076842A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6839184B2 (ja) | 2015-11-06 | 2021-03-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン誘導体 |
| UA122589C2 (uk) | 2015-11-06 | 2020-12-10 | Ф. Хоффманн-Ля Рош Аг | Похідні індолін-2-ону |
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| CN108137555B (zh) | 2015-11-06 | 2021-02-19 | 豪夫迈·罗氏有限公司 | 可用于治疗cns疾病的二氢吲哚-2-酮衍生物 |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| IL291839A (en) | 2019-10-01 | 2022-06-01 | Empyrean Neuroscience Inc | Genetic engineering of fungi to modulate tryptamine expression |
| WO2021231933A1 (en) * | 2020-05-15 | 2021-11-18 | Neucyte Pharmaceuticals | Anti-epileptic pharmaceutical compositions and use thereof |
| CN118984868A (zh) | 2021-12-31 | 2024-11-19 | 恩派瑞安神经科学公司 | 用于产生精神药物生物碱的遗传修饰的生物体 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3935514A1 (de) | 1989-10-25 | 1991-05-02 | Boehringer Mannheim Gmbh | Neue bicyclo-imidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW251284B (enExample) | 1992-11-02 | 1995-07-11 | Pfizer | |
| DE4427648A1 (de) | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung |
| FR2757157B1 (fr) | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
| WO2000040581A1 (en) | 1999-01-07 | 2000-07-13 | American Home Products Corporation | 3,4-dihydro-2h-benzo[1,4]oxazine derivatives |
| DK1303269T3 (da) | 2000-06-29 | 2006-03-20 | Neurosearch As | 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer |
| US7582616B2 (en) | 2002-12-31 | 2009-09-01 | Quesrema Enterprises Llc | Nucleoside transport inhibitors |
| HRP20060402A2 (hr) | 2004-05-11 | 2007-06-30 | Egis Gy�gyszergy�r Nyrt. | Derivati piridina alkilnih oksindola kao 5-ht7 receptorski aktivni agensi |
| US20060253263A1 (en) | 2005-04-11 | 2006-11-09 | Meshkin Brian J | Method to optimize drug selection, dosing and evaluation and to help predict therapeutic response and toxicity from immunosuppressant therapy |
| AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| AR056317A1 (es) | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| EP2032135A2 (en) | 2006-06-26 | 2009-03-11 | Helicon Therapeutics, Inc. | Method of modulating neurite outgrowth by the use of a galanin-3 receptor antagonist |
| WO2008046083A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of oxindole compounds as therapeutic agents |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| PT2114921E (pt) | 2006-12-30 | 2013-03-26 | Abbott Gmbh & Co Kg | Derivado de oxindol substituído e sua utilização como ligante do recetor de vasopressina |
| JO3126B1 (ar) * | 2007-11-14 | 2017-09-20 | Janssen Pharmaceutica Nv | مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1 |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| SG11201501923WA (en) | 2012-09-13 | 2015-04-29 | Hoffmann La Roche | 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders |
| WO2014202493A1 (en) * | 2013-06-19 | 2014-12-24 | F. Hoffmann-La Roche Ag | Indolin-2-one or pyrrolo-pyridin/pyrimidin-2-one derivatives |
| FR3017867A1 (fr) * | 2014-02-21 | 2015-08-28 | Inventiva | Nouveaux composes de type phenylazetidine carboxylate ou carboxamide |
| AU2015279377B2 (en) | 2014-06-26 | 2019-09-12 | F. Hoffmann-La Roche Ag | Indolin-2-one or pyrrolo-pyridin-2-one derivatives |
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| CN108137555B (zh) | 2015-11-06 | 2021-02-19 | 豪夫迈·罗氏有限公司 | 可用于治疗cns疾病的二氢吲哚-2-酮衍生物 |
| UA122589C2 (uk) | 2015-11-06 | 2020-12-10 | Ф. Хоффманн-Ля Рош Аг | Похідні індолін-2-ону |
| JP6839184B2 (ja) | 2015-11-06 | 2021-03-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン誘導体 |
-
2016
- 2016-11-02 JP JP2018522572A patent/JP6839184B2/ja active Active
- 2016-11-02 WO PCT/EP2016/076315 patent/WO2017076842A1/en not_active Ceased
- 2016-11-02 CN CN201680056575.2A patent/CN108137561B/zh active Active
- 2016-11-02 EP EP16790588.4A patent/EP3371174B1/en active Active
- 2016-11-04 AR ARP160103364A patent/AR106589A1/es unknown
- 2016-11-04 TW TW105135829A patent/TWI614244B/zh not_active IP Right Cessation
-
2018
- 2018-05-04 US US15/971,368 patent/US10519140B2/en active Active
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