JP2018537521A5 - - Google Patents
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- Publication number
- JP2018537521A5 JP2018537521A5 JP2018541088A JP2018541088A JP2018537521A5 JP 2018537521 A5 JP2018537521 A5 JP 2018537521A5 JP 2018541088 A JP2018541088 A JP 2018541088A JP 2018541088 A JP2018541088 A JP 2018541088A JP 2018537521 A5 JP2018537521 A5 JP 2018537521A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza vaccine
- vaccine according
- influenza
- thio
- pseudouridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960003971 influenza vaccine Drugs 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108700026244 Open Reading Frames Proteins 0.000 claims 5
- -1 cationic lipid Chemical class 0.000 claims 5
- 238000007385 chemical modification Methods 0.000 claims 5
- 230000000890 antigenic effect Effects 0.000 claims 4
- 101710146287 Hemagglutinin 1 Proteins 0.000 claims 3
- 101710146275 Hemagglutinin 2 Proteins 0.000 claims 3
- 229930182558 Sterol Natural products 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 150000003432 sterols Chemical class 0.000 claims 3
- 235000003702 sterols Nutrition 0.000 claims 3
- 241000712461 unidentified influenza virus Species 0.000 claims 3
- UVBYMVOUBXYSFV-XUTVFYLZSA-N 1-methylpseudouridine Chemical compound O=C1NC(=O)N(C)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UVBYMVOUBXYSFV-XUTVFYLZSA-N 0.000 claims 2
- 229940124873 Influenza virus vaccine Drugs 0.000 claims 2
- 101710128560 Initiator protein NS1 Proteins 0.000 claims 2
- 102000005348 Neuraminidase Human genes 0.000 claims 2
- 108010006232 Neuraminidase Proteins 0.000 claims 2
- 101710144127 Non-structural protein 1 Proteins 0.000 claims 2
- 101710144128 Non-structural protein 2 Proteins 0.000 claims 2
- 101710199667 Nuclear export protein Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108010061100 Nucleoproteins Proteins 0.000 claims 2
- 102000011931 Nucleoproteins Human genes 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- KYEKLQMDNZPEFU-KVTDHHQDSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazine-2,4-dione Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)N=C1 KYEKLQMDNZPEFU-KVTDHHQDSA-N 0.000 claims 1
- MUSPKJVFRAYWAR-XVFCMESISA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidine-2,4-dione Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)S[C@H]1N1C(=O)NC(=O)C=C1 MUSPKJVFRAYWAR-XVFCMESISA-N 0.000 claims 1
- JCNGYIGHEUKAHK-DWJKKKFUSA-N 2-Thio-1-methyl-1-deazapseudouridine Chemical compound CC1C=C(C(=O)NC1=S)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O JCNGYIGHEUKAHK-DWJKKKFUSA-N 0.000 claims 1
- BVLGKOVALHRKNM-XUTVFYLZSA-N 2-Thio-1-methylpseudouridine Chemical compound CN1C=C(C(=O)NC1=S)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O BVLGKOVALHRKNM-XUTVFYLZSA-N 0.000 claims 1
- CWXIOHYALLRNSZ-JWMKEVCDSA-N 2-Thiodihydropseudouridine Chemical compound C1C(C(=O)NC(=S)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O CWXIOHYALLRNSZ-JWMKEVCDSA-N 0.000 claims 1
- JUMHLCXWYQVTLL-KVTDHHQDSA-N 2-thio-5-aza-uridine Chemical compound [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C(=S)NC(=O)N=C1 JUMHLCXWYQVTLL-KVTDHHQDSA-N 0.000 claims 1
- VRVXMIJPUBNPGH-XVFCMESISA-N 2-thio-dihydrouridine Chemical compound OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=S VRVXMIJPUBNPGH-XVFCMESISA-N 0.000 claims 1
- GJTBSTBJLVYKAU-XVFCMESISA-N 2-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=S)NC(=O)C=C1 GJTBSTBJLVYKAU-XVFCMESISA-N 0.000 claims 1
- FGFVODMBKZRMMW-XUTVFYLZSA-N 4-Methoxy-2-thiopseudouridine Chemical compound COC1=C(C=NC(=S)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O FGFVODMBKZRMMW-XUTVFYLZSA-N 0.000 claims 1
- HOCJTJWYMOSXMU-XUTVFYLZSA-N 4-Methoxypseudouridine Chemical compound COC1=C(C=NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O HOCJTJWYMOSXMU-XUTVFYLZSA-N 0.000 claims 1
- VTGBLFNEDHVUQA-XUTVFYLZSA-N 4-Thio-1-methyl-pseudouridine Chemical compound S=C1NC(=O)N(C)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 VTGBLFNEDHVUQA-XUTVFYLZSA-N 0.000 claims 1
- AMMRPAYSYYGRKP-BGZDPUMWSA-N 5-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-ethylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)N(CC)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 AMMRPAYSYYGRKP-BGZDPUMWSA-N 0.000 claims 1
- DDHOXEOVAJVODV-GBNDHIKLSA-N 5-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=S)NC1=O DDHOXEOVAJVODV-GBNDHIKLSA-N 0.000 claims 1
- BNAWMJKJLNJZFU-GBNDHIKLSA-N 5-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidene-1h-pyrimidin-2-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=S BNAWMJKJLNJZFU-GBNDHIKLSA-N 0.000 claims 1
- ZXIATBNUWJBBGT-JXOAFFINSA-N 5-methoxyuridine Chemical compound O=C1NC(=O)C(OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZXIATBNUWJBBGT-JXOAFFINSA-N 0.000 claims 1
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- YKWUPFSEFXSGRT-JWMKEVCDSA-N Dihydropseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1C(=O)NC(=O)NC1 YKWUPFSEFXSGRT-JWMKEVCDSA-N 0.000 claims 1
- 101710199771 Matrix protein 1 Proteins 0.000 claims 1
- 101710199769 Matrix protein 2 Proteins 0.000 claims 1
- 229930185560 Pseudouridine Natural products 0.000 claims 1
- PTJWIQPHWPFNBW-UHFFFAOYSA-N Pseudouridine C Natural products OC1C(O)C(CO)OC1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-UHFFFAOYSA-N 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
- WGDUUQDYDIIBKT-UHFFFAOYSA-N beta-Pseudouridine Natural products OC1OC(CN2C=CC(=O)NC2=O)C(O)C1O WGDUUQDYDIIBKT-UHFFFAOYSA-N 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
- 229940045145 uridine Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021204270A JP7491639B2 (ja) | 2015-10-22 | 2021-12-16 | 広域インフルエンザウイルスワクチン |
| JP2024077558A JP2024105503A (ja) | 2015-10-22 | 2024-05-10 | 広域インフルエンザウイルスワクチン |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245225P | 2015-10-22 | 2015-10-22 | |
| US201562245031P | 2015-10-22 | 2015-10-22 | |
| US62/245,225 | 2015-10-22 | ||
| US62/245,031 | 2015-10-22 | ||
| US201562247501P | 2015-10-28 | 2015-10-28 | |
| US62/247,501 | 2015-10-28 | ||
| US201562248248P | 2015-10-29 | 2015-10-29 | |
| US62/248,248 | 2015-10-29 | ||
| PCT/US2016/058319 WO2017070620A2 (en) | 2015-10-22 | 2016-10-21 | Broad spectrum influenza virus vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204270A Division JP7491639B2 (ja) | 2015-10-22 | 2021-12-16 | 広域インフルエンザウイルスワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537521A JP2018537521A (ja) | 2018-12-20 |
| JP2018537521A5 true JP2018537521A5 (enExample) | 2020-08-13 |
| JP7384512B2 JP7384512B2 (ja) | 2023-11-21 |
Family
ID=58558155
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541088A Active JP7384512B2 (ja) | 2015-10-22 | 2016-10-21 | 広域インフルエンザウイルスワクチン |
| JP2021204270A Active JP7491639B2 (ja) | 2015-10-22 | 2021-12-16 | 広域インフルエンザウイルスワクチン |
| JP2024077558A Ceased JP2024105503A (ja) | 2015-10-22 | 2024-05-10 | 広域インフルエンザウイルスワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204270A Active JP7491639B2 (ja) | 2015-10-22 | 2021-12-16 | 広域インフルエンザウイルスワクチン |
| JP2024077558A Ceased JP2024105503A (ja) | 2015-10-22 | 2024-05-10 | 広域インフルエンザウイルスワクチン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180311336A1 (enExample) |
| EP (1) | EP3365007A4 (enExample) |
| JP (3) | JP7384512B2 (enExample) |
| KR (1) | KR20180096591A (enExample) |
| CN (2) | CN109310751A (enExample) |
| AU (2) | AU2016342048B2 (enExample) |
| BR (1) | BR112018008078A2 (enExample) |
| CA (1) | CA3003103A1 (enExample) |
| MA (1) | MA46023A (enExample) |
| MX (2) | MX2018004916A (enExample) |
| RU (1) | RU2018118337A (enExample) |
| WO (1) | WO2017070620A2 (enExample) |
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| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
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| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
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| US12150980B2 (en) | 2015-07-30 | 2024-11-26 | Modernatx, Inc. | Concatemeric peptide epitope RNAs |
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- 2016-10-21 CA CA3003103A patent/CA3003103A1/en active Pending
- 2016-10-21 KR KR1020187014338A patent/KR20180096591A/ko not_active Ceased
- 2016-10-21 BR BR112018008078A patent/BR112018008078A2/pt not_active Application Discontinuation
- 2016-10-21 MA MA046023A patent/MA46023A/fr unknown
- 2016-10-21 US US15/767,609 patent/US20180311336A1/en not_active Abandoned
- 2016-10-21 RU RU2018118337A patent/RU2018118337A/ru not_active Application Discontinuation
- 2016-10-21 CN CN201680074920.5A patent/CN109310751A/zh active Pending
- 2016-10-21 CN CN202410855926.2A patent/CN118846026A/zh active Pending
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2018
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2021
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2022
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2024
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