JP2018537103A5 - - Google Patents
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- Publication number
- JP2018537103A5 JP2018537103A5 JP2018530502A JP2018530502A JP2018537103A5 JP 2018537103 A5 JP2018537103 A5 JP 2018537103A5 JP 2018530502 A JP2018530502 A JP 2018530502A JP 2018530502 A JP2018530502 A JP 2018530502A JP 2018537103 A5 JP2018537103 A5 JP 2018537103A5
- Authority
- JP
- Japan
- Prior art keywords
- rsv
- gene
- seq
- recombinant rsv
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 101
- 238000012986 modification Methods 0.000 claims description 24
- 230000004048 modification Effects 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 101150033828 NS1 gene Proteins 0.000 claims description 13
- 101150036080 at gene Proteins 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 12
- 125000003729 nucleotide group Chemical group 0.000 claims description 12
- 101150095629 NS2 gene Proteins 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 108700008625 Reporter Genes Proteins 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 4
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 4
- 102000014150 Interferons Human genes 0.000 claims description 4
- 108010050904 Interferons Proteins 0.000 claims description 4
- 208000036142 Viral infection Diseases 0.000 claims description 4
- 230000002238 attenuated effect Effects 0.000 claims description 4
- 238000004113 cell culture Methods 0.000 claims description 4
- 210000004748 cultured cell Anatomy 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 239000005090 green fluorescent protein Substances 0.000 claims description 4
- 229940079322 interferon Drugs 0.000 claims description 4
- 230000010076 replication Effects 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 230000009385 viral infection Effects 0.000 claims description 4
- 101150066838 12 gene Proteins 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 101150103632 M2-2 gene Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000002458 infectious effect Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 230000010468 interferon response Effects 0.000 claims description 2
- 239000007923 nasal drop Substances 0.000 claims description 2
- 229940100662 nasal drops Drugs 0.000 claims description 2
- 239000007922 nasal spray Substances 0.000 claims description 2
- 229940097496 nasal spray Drugs 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 241000724205 Rice stripe tenuivirus Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562266206P | 2015-12-11 | 2015-12-11 | |
| US62/266,206 | 2015-12-11 | ||
| PCT/US2016/066142 WO2017100756A1 (en) | 2015-12-11 | 2016-12-12 | Recombinant respiratory syncytial virus strains comprising ns1 and ns2 gene shifts |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018537103A JP2018537103A (ja) | 2018-12-20 |
| JP2018537103A5 true JP2018537103A5 (enExample) | 2020-01-23 |
| JP7063808B2 JP7063808B2 (ja) | 2022-05-09 |
| JP7063808B6 JP7063808B6 (ja) | 2022-06-07 |
Family
ID=58108722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530502A Active JP7063808B6 (ja) | 2015-12-11 | 2016-12-12 | Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10953083B2 (enExample) |
| EP (1) | EP3387120B1 (enExample) |
| JP (1) | JP7063808B6 (enExample) |
| KR (1) | KR20180085802A (enExample) |
| CN (1) | CN108699535B (enExample) |
| AU (1) | AU2016366768A1 (enExample) |
| CA (1) | CA3007474A1 (enExample) |
| WO (1) | WO2017100756A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3168100A1 (en) * | 2020-01-28 | 2021-08-05 | Codagenix Inc. | Deoptimized sars-cov-2 and methods and uses thereof |
| WO2022103671A1 (en) * | 2020-11-12 | 2022-05-19 | Merck Sharp & Dohme Corp. | Anti-respiratory syncytial virus (rsv) antibody cell-based potency assay |
| TW202535439A (zh) | 2023-11-17 | 2025-09-16 | 美商賽諾菲巴斯德公司 | 海藻糖疫苗調配物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3224404A1 (de) | 1982-06-30 | 1984-01-05 | LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl | Reibungskupplung sowie verfahren zu deren montage |
| CA2230033C (en) | 1995-09-27 | 2010-01-26 | Peter L. Collins | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| WO2001004271A2 (en) | 1999-07-13 | 2001-01-18 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Respiratory syncytial viruses expressing immune modulatory molecules |
| US6596529B1 (en) | 1997-05-02 | 2003-07-22 | Uab Research Foundation | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
| US7820182B2 (en) * | 1999-07-09 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions |
| EP1294858B1 (en) * | 2000-06-23 | 2008-12-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes |
| WO2017030997A1 (en) | 2015-08-14 | 2017-02-23 | Research Institute At Nationwide Children's Hospital | Respiratory syncytial virus having altered ns1 protein function and related materials and methods |
-
2016
- 2016-12-12 CA CA3007474A patent/CA3007474A1/en active Pending
- 2016-12-12 EP EP16838103.6A patent/EP3387120B1/en active Active
- 2016-12-12 CN CN201680081929.9A patent/CN108699535B/zh active Active
- 2016-12-12 KR KR1020187019755A patent/KR20180085802A/ko not_active Ceased
- 2016-12-12 WO PCT/US2016/066142 patent/WO2017100756A1/en not_active Ceased
- 2016-12-12 AU AU2016366768A patent/AU2016366768A1/en not_active Abandoned
- 2016-12-12 JP JP2018530502A patent/JP7063808B6/ja active Active
- 2016-12-12 US US16/061,316 patent/US10953083B2/en active Active
-
2021
- 2021-02-23 US US17/183,227 patent/US11918638B2/en active Active
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