JP7063808B6 - Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株 - Google Patents

Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株 Download PDF

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JP7063808B6
JP7063808B6 JP2018530502A JP2018530502A JP7063808B6 JP 7063808 B6 JP7063808 B6 JP 7063808B6 JP 2018530502 A JP2018530502 A JP 2018530502A JP 2018530502 A JP2018530502 A JP 2018530502A JP 7063808 B6 JP7063808 B6 JP 7063808B6
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rsv
gene
recombinant
genome
seq
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JP2018537103A5 (enExample
JP2018537103A (ja
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ピーター エル． コリンズ
トーマス チャールズ マッカーティ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18521—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18551—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018530502A 2015-12-11 2016-12-12 Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株 Active JP7063808B6 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562266206P 2015-12-11 2015-12-11
US62/266,206 2015-12-11
PCT/US2016/066142 WO2017100756A1 (en) 2015-12-11 2016-12-12 Recombinant respiratory syncytial virus strains comprising ns1 and ns2 gene shifts

Publications (4)

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JP2018537103A JP2018537103A (ja) 2018-12-20
JP2018537103A5 JP2018537103A5 (enExample) 2020-01-23
JP7063808B2 JP7063808B2 (ja) 2022-05-09
JP7063808B6 true JP7063808B6 (ja) 2022-06-07

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US (2) US10953083B2 (enExample)
EP (1) EP3387120B1 (enExample)
JP (1) JP7063808B6 (enExample)
KR (1) KR20180085802A (enExample)
CN (1) CN108699535B (enExample)
AU (1) AU2016366768A1 (enExample)
CA (1) CA3007474A1 (enExample)
WO (1) WO2017100756A1 (enExample)

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CA3168100A1 (en) * 2020-01-28 2021-08-05 Codagenix Inc. Deoptimized sars-cov-2 and methods and uses thereof
WO2022103671A1 (en) * 2020-11-12 2022-05-19 Merck Sharp & Dohme Corp. Anti-respiratory syncytial virus (rsv) antibody cell-based potency assay
TW202535439A (zh) 2023-11-17 2025-09-16 美商賽諾菲巴斯德公司 海藻糖疫苗調配物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004501639A (ja) 2000-06-23 2004-01-22 ザ　ユーエイビー　リサーチ　ファンデイション 遺伝子再編成によるマイナス鎖ｒｎａウイルスの操作及び当該ウイルスの使用方法
JP2004515218A (ja) 2000-06-23 2004-05-27 アメリカ合衆国 プロモータへ隣接する遺伝子から保護抗原を発現する呼吸器系合胞体ウイルスワクチン

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
DE3224404A1 (de) 1982-06-30 1984-01-05 LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl Reibungskupplung sowie verfahren zu deren montage
CA2230033C (en) 1995-09-27 2010-01-26 Peter L. Collins Production of infectious respiratory syncytial virus from cloned nucleotide sequences
WO2001004271A2 (en) 1999-07-13 2001-01-18 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Respiratory syncytial viruses expressing immune modulatory molecules
US7820182B2 (en) * 1999-07-09 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions
WO2017030997A1 (en) 2015-08-14 2017-02-23 Research Institute At Nationwide Children's Hospital Respiratory syncytial virus having altered ns1 protein function and related materials and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004501639A (ja) 2000-06-23 2004-01-22 ザ　ユーエイビー　リサーチ　ファンデイション 遺伝子再編成によるマイナス鎖ｒｎａウイルスの操作及び当該ウイルスの使用方法
JP2004515218A (ja) 2000-06-23 2004-05-27 アメリカ合衆国 プロモータへ隣接する遺伝子から保護抗原を発現する呼吸器系合胞体ウイルスワクチン

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUKREYEV, A. et al.，Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells，Journal of Virology，2001年，Vol.75, No.24，P.12128-12140
MUNIR, S. et al.，Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells，Journal of Virology，2008年，Vol.82, No.17，P.8780-8796

Also Published As

Publication number Publication date
EP3387120B1 (en) 2022-07-27
CN108699535A (zh) 2018-10-23
US20210177960A1 (en) 2021-06-17
JP2018537103A (ja) 2018-12-20
US10953083B2 (en) 2021-03-23
AU2016366768A1 (en) 2018-07-12
US20190184000A1 (en) 2019-06-20
EP3387120A1 (en) 2018-10-17
WO2017100756A1 (en) 2017-06-15
JP7063808B2 (ja) 2022-05-09
US11918638B2 (en) 2024-03-05
KR20180085802A (ko) 2018-07-27
CN108699535B (zh) 2023-06-20
CA3007474A1 (en) 2017-06-15

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