CN108699535B - 包含ns1和ns2基因迁移的重组呼吸道合胞病毒株 - Google Patents

包含ns1和ns2基因迁移的重组呼吸道合胞病毒株 Download PDF

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CN108699535B
CN108699535B CN201680081929.9A CN201680081929A CN108699535B CN 108699535 B CN108699535 B CN 108699535B CN 201680081929 A CN201680081929 A CN 201680081929A CN 108699535 B CN108699535 B CN 108699535B
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rsv
gene
recombinant
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genome
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CN108699535A (zh
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P·L·柯林斯
T·C·麦卡蒂
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18551—Methods of production or purification of viral material

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CN201680081929.9A 2015-12-11 2016-12-12 包含ns1和ns2基因迁移的重组呼吸道合胞病毒株 Active CN108699535B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562266206P 2015-12-11 2015-12-11
US62/266,206 2015-12-11
PCT/US2016/066142 WO2017100756A1 (en) 2015-12-11 2016-12-12 Recombinant respiratory syncytial virus strains comprising ns1 and ns2 gene shifts

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CN108699535A CN108699535A (zh) 2018-10-23
CN108699535B true CN108699535B (zh) 2023-06-20

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US (2) US10953083B2 (enExample)
EP (1) EP3387120B1 (enExample)
JP (1) JP7063808B6 (enExample)
KR (1) KR20180085802A (enExample)
CN (1) CN108699535B (enExample)
AU (1) AU2016366768A1 (enExample)
CA (1) CA3007474A1 (enExample)
WO (1) WO2017100756A1 (enExample)

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CA3168100A1 (en) * 2020-01-28 2021-08-05 Codagenix Inc. Deoptimized sars-cov-2 and methods and uses thereof
WO2022103671A1 (en) * 2020-11-12 2022-05-19 Merck Sharp & Dohme Corp. Anti-respiratory syncytial virus (rsv) antibody cell-based potency assay
TW202535439A (zh) 2023-11-17 2025-09-16 美商賽諾菲巴斯德公司 海藻糖疫苗調配物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000693A2 (en) * 2000-06-23 2002-01-03 The Government Of The United States Of America Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes
CN1384883A (zh) * 1999-07-13 2002-12-11 美国政府健康及人类服务部 表达免疫调节分子的重组呼吸道合胞病毒的制备

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
DE3224404A1 (de) 1982-06-30 1984-01-05 LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl Reibungskupplung sowie verfahren zu deren montage
CA2230033C (en) 1995-09-27 2010-01-26 Peter L. Collins Production of infectious respiratory syncytial virus from cloned nucleotide sequences
US6596529B1 (en) 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
US7820182B2 (en) * 1999-07-09 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions
WO2017030997A1 (en) 2015-08-14 2017-02-23 Research Institute At Nationwide Children's Hospital Respiratory syncytial virus having altered ns1 protein function and related materials and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1384883A (zh) * 1999-07-13 2002-12-11 美国政府健康及人类服务部 表达免疫调节分子的重组呼吸道合胞病毒的制备
WO2002000693A2 (en) * 2000-06-23 2002-01-03 The Government Of The United States Of America Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Evaluation of recombinant respiratory syncytial virus gene deletion mutants in African green monkeys for their potential as live attenuated vaccine candidates;JIN H等;《VACCINE》;20030908;摘要 *
Repiratory syncytial Virus Infection of Human Airway Epithelial Cells Is Polarized, Specific to Ciliated Cells, and without Obvious Cytopathology;L. ZHANG等;《JOURNAL OF VIROLOGY》;20020601;"Materials and methods" *

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Publication number Publication date
EP3387120B1 (en) 2022-07-27
CN108699535A (zh) 2018-10-23
US20210177960A1 (en) 2021-06-17
JP2018537103A (ja) 2018-12-20
US10953083B2 (en) 2021-03-23
AU2016366768A1 (en) 2018-07-12
US20190184000A1 (en) 2019-06-20
JP7063808B6 (ja) 2022-06-07
EP3387120A1 (en) 2018-10-17
WO2017100756A1 (en) 2017-06-15
JP7063808B2 (ja) 2022-05-09
US11918638B2 (en) 2024-03-05
KR20180085802A (ko) 2018-07-27
CA3007474A1 (en) 2017-06-15

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