KR20180085802A - Ns1 및 ns2 유전자 이동을 포함하는 재조합 rsv 균주 - Google Patents

Ns1 및 ns2 유전자 이동을 포함하는 재조합 rsv 균주 Download PDF

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KR20180085802A
KR20180085802A KR1020187019755A KR20187019755A KR20180085802A KR 20180085802 A KR20180085802 A KR 20180085802A KR 1020187019755 A KR1020187019755 A KR 1020187019755A KR 20187019755 A KR20187019755 A KR 20187019755A KR 20180085802 A KR20180085802 A KR 20180085802A
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rsv
gene
seq
recombinant
genome
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Korean (ko)
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피터 엘. 콜린스
토마스 찰스 맥카티
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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Publication of KR20180085802A publication Critical patent/KR20180085802A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18521Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18551Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
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  • Wood Science & Technology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187019755A 2015-12-11 2016-12-12 Ns1 및 ns2 유전자 이동을 포함하는 재조합 rsv 균주 Ceased KR20180085802A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562266206P 2015-12-11 2015-12-11
US62/266,206 2015-12-11
PCT/US2016/066142 WO2017100756A1 (en) 2015-12-11 2016-12-12 Recombinant respiratory syncytial virus strains comprising ns1 and ns2 gene shifts

Publications (1)

Publication Number Publication Date
KR20180085802A true KR20180085802A (ko) 2018-07-27

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KR1020187019755A Ceased KR20180085802A (ko) 2015-12-11 2016-12-12 Ns1 및 ns2 유전자 이동을 포함하는 재조합 rsv 균주

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US (2) US10953083B2 (enExample)
EP (1) EP3387120B1 (enExample)
JP (1) JP7063808B6 (enExample)
KR (1) KR20180085802A (enExample)
CN (1) CN108699535B (enExample)
AU (1) AU2016366768A1 (enExample)
CA (1) CA3007474A1 (enExample)
WO (1) WO2017100756A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CA3168100A1 (en) * 2020-01-28 2021-08-05 Codagenix Inc. Deoptimized sars-cov-2 and methods and uses thereof
WO2022103671A1 (en) * 2020-11-12 2022-05-19 Merck Sharp & Dohme Corp. Anti-respiratory syncytial virus (rsv) antibody cell-based potency assay
TW202535439A (zh) 2023-11-17 2025-09-16 美商賽諾菲巴斯德公司 海藻糖疫苗調配物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3224404A1 (de) 1982-06-30 1984-01-05 LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl Reibungskupplung sowie verfahren zu deren montage
CA2230033C (en) 1995-09-27 2010-01-26 Peter L. Collins Production of infectious respiratory syncytial virus from cloned nucleotide sequences
WO2001004271A2 (en) 1999-07-13 2001-01-18 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Respiratory syncytial viruses expressing immune modulatory molecules
US6596529B1 (en) 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
US7820182B2 (en) * 1999-07-09 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions
EP1294858B1 (en) * 2000-06-23 2008-12-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes
WO2017030997A1 (en) 2015-08-14 2017-02-23 Research Institute At Nationwide Children's Hospital Respiratory syncytial virus having altered ns1 protein function and related materials and methods

Also Published As

Publication number Publication date
EP3387120B1 (en) 2022-07-27
CN108699535A (zh) 2018-10-23
US20210177960A1 (en) 2021-06-17
JP2018537103A (ja) 2018-12-20
US10953083B2 (en) 2021-03-23
AU2016366768A1 (en) 2018-07-12
US20190184000A1 (en) 2019-06-20
JP7063808B6 (ja) 2022-06-07
EP3387120A1 (en) 2018-10-17
WO2017100756A1 (en) 2017-06-15
JP7063808B2 (ja) 2022-05-09
US11918638B2 (en) 2024-03-05
CN108699535B (zh) 2023-06-20
CA3007474A1 (en) 2017-06-15

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