|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
USRE28819E
(en)
|
1972-12-08 |
1976-05-18 |
Syntex (U.S.A.) Inc. |
Dialkylated glycol compositions and medicament preparations containing same
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
DE2352702A1
(de)
*
|
1973-10-20 |
1975-06-26 |
Hoechst Ag |
Basisch substituierte 1,4-dihydro-2hisochinolinderivate und verfahren zu ihrer herstellung
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4358603A
(en)
|
1981-04-16 |
1982-11-09 |
Syntex (U.S.A.) Inc. |
Acetal stabilized prostaglandin compositions
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
HU196714B
(en)
|
1984-10-04 |
1989-01-30 |
Monsanto Co |
Process for producing non-aqueous composition comprising somatotropin
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US6010715A
(en)
|
1992-04-01 |
2000-01-04 |
Bertek, Inc. |
Transdermal patch incorporating a polymer film incorporated with an active agent
|
|
US6024975A
(en)
|
1992-04-08 |
2000-02-15 |
Americare International Diagnostics, Inc. |
Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
|
WO1995017182A1
(en)
*
|
1993-12-23 |
1995-06-29 |
Eli Lilly And Company |
Protein kinase c inhibitors
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
|
US5983134A
(en)
|
1995-04-23 |
1999-11-09 |
Electromagnetic Bracing Systems Inc. |
Electrophoretic cuff apparatus drug delivery system
|
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
|
ATE268591T1
(de)
|
1995-06-27 |
2004-06-15 |
Takeda Chemical Industries Ltd |
Verfahren zur herstellung von zubereitungen mit verzögerter freisetzung
|
|
US6167301A
(en)
|
1995-08-29 |
2000-12-26 |
Flower; Ronald J. |
Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
US5985317A
(en)
|
1996-09-06 |
1999-11-16 |
Theratech, Inc. |
Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
|
|
HUP0000116A3
(en)
|
1996-10-01 |
2000-08-28 |
Stanford Res Inst Int |
Taste-masked microcapsule compositions and methods of manufacture
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
ES2221019T3
(es)
|
1996-10-31 |
2004-12-16 |
Takeda Chemical Industries, Ltd. |
Preparacion de liberacion mantenida.
|
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
|
DE69719367T2
(de)
|
1996-12-20 |
2003-10-16 |
Takeda Chemical Industries, Ltd. |
Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
CA2226058C
(en)
*
|
1997-01-30 |
2008-01-29 |
F. Hoffmann-La Roche Ag |
8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives
|
|
US5860957A
(en)
|
1997-02-07 |
1999-01-19 |
Sarcos, Inc. |
Multipathway electronically-controlled drug delivery system
|
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
|
US5948433A
(en)
|
1997-08-21 |
1999-09-07 |
Bertek, Inc. |
Transdermal patch
|
|
JP4395200B2
(ja)
|
1997-10-28 |
2010-01-06 |
バンドー化学株式会社 |
皮膚貼付薬シート及びそのための基材シートの製造方法
|
|
SK10272000A3
(sk)
|
1998-01-16 |
2001-01-18 |
Takeda Chemical Industries, Ltd. |
Prostriedok s trvalým uvoľňovaním, spôsob jeho výroby a jeho použitia
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
WO2000017203A1
(en)
|
1998-09-18 |
2000-03-30 |
Basf Aktiengesellschaft |
Pyrrolopyrimidines as protein kinase inhibitors
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
|
US6256533B1
(en)
|
1999-06-09 |
2001-07-03 |
The Procter & Gamble Company |
Apparatus and method for using an intracutaneous microneedle array
|
|
JP3966693B2
(ja)
|
2000-01-20 |
2007-08-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
含窒素環化合物およびそれらを含んでなる医薬組成物
|
|
CN1205185C
(zh)
*
|
2000-01-20 |
2005-06-08 |
卫材株式会社 |
含氮的环状化合物及含有该化合物的药物组合物
|
|
US6261595B1
(en)
|
2000-02-29 |
2001-07-17 |
Zars, Inc. |
Transdermal drug patch with attached pocket for controlled heating device
|
|
WO2001072751A1
(en)
|
2000-03-29 |
2001-10-04 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
|
ATE556048T1
(de)
|
2000-08-10 |
2012-05-15 |
Mitsubishi Tanabe Pharma Corp |
Prolinderivate und ihre verwendung als heilmittel
|
|
NZ540233A
(en)
|
2001-04-18 |
2007-02-23 |
Euro Celtique Sa |
Nociceptin analogs for the treatment of pain
|
|
WO2003064425A1
(en)
*
|
2002-01-28 |
2003-08-07 |
Pfizer Japan Inc. |
N-substituted spiropiperidine compounds as ligands for orl-1 receptor
|
|
JPWO2003095427A1
(ja)
|
2002-05-10 |
2005-09-15 |
大正製薬株式会社 |
スピロ環化合物
|
|
WO2004022558A2
(en)
*
|
2002-09-09 |
2004-03-18 |
Janssen Pharmaceutica, N.V. |
Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
|
|
US7045527B2
(en)
*
|
2002-09-24 |
2006-05-16 |
Amgen Inc. |
Piperidine derivatives
|
|
UA80171C2
(en)
*
|
2002-12-19 |
2007-08-27 |
Pfizer Prod Inc |
Pyrrolopyrimidine derivatives
|
|
WO2005016913A1
(en)
|
2003-08-19 |
2005-02-24 |
Pfizer Japan, Inc. |
Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
|
|
US20080118442A1
(en)
|
2003-09-10 |
2008-05-22 |
Map Pharmaceuticals, Inc. |
Aerosol Formulations for Delivery of Dihydroergotamine to the Systemic Circulations Via Pulmonary Inhalation
|
|
AR046756A1
(es)
|
2003-12-12 |
2005-12-21 |
Solvay Pharm Gmbh |
Derivados de hidronopol como agonistas de receptores orl-1 humanos.
|
|
US20050228023A1
(en)
|
2003-12-19 |
2005-10-13 |
Sri International |
Agonist and antagonist ligands of the nociceptin receptor
|
|
WO2005092858A2
(en)
|
2004-03-29 |
2005-10-06 |
Pfizer Japan Inc. |
Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist
|
|
AU2006252781A1
(en)
|
2005-06-02 |
2006-12-07 |
Janssen Pharmaceutica, N.V. |
Novel 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators
|
|
CN101534824A
(zh)
|
2006-11-17 |
2009-09-16 |
艾博特公司 |
作为化学活素受体拮抗剂的氨基吡咯烷
|
|
CN101679430B
(zh)
|
2007-04-09 |
2013-12-25 |
詹森药业有限公司 |
用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
|
|
EP2141163A1
(de)
*
|
2008-07-02 |
2010-01-06 |
Bayer Schering Pharma AG |
Substituierte Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
|
|
EA201200471A1
(ru)
*
|
2009-09-10 |
2012-10-30 |
Новартис Аг |
Простые эфирные производные бициклических гетероарилов
|
|
UY33227A
(es)
*
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
WO2012020813A1
(ja)
*
|
2010-08-10 |
2012-02-16 |
大日本住友製薬株式会社 |
縮環ピロリジン誘導体
|
|
TW201348231A
(zh)
|
2012-02-29 |
2013-12-01 |
Amgen Inc |
雜雙環化合物
|
|
WO2014017659A1
(ja)
*
|
2012-07-27 |
2014-01-30 |
独立行政法人理化学研究所 |
急性骨髄性白血病の治療又は再発抑制剤
|
|
WO2014102588A2
(en)
|
2012-12-27 |
2014-07-03 |
Purdue Pharma L.P. |
Indole and indoline-type piperidine compounds and uses thereof
|
|
US9884844B2
(en)
|
2012-12-31 |
2018-02-06 |
Sunovion Pharmaceuticals, Inc. |
Heterocyclic compounds and methods of use thereof
|
|
JP2016113366A
(ja)
*
|
2013-03-29 |
2016-06-23 |
大鵬薬品工業株式会社 |
アセトアミド基を有する１，２，４−トリアジン−６−カルボキサミド誘導体
|
|
TWI663166B
(zh)
*
|
2013-04-24 |
2019-06-21 |
健生藥品公司 |
新化合物
|
|
ES2646019T3
(es)
*
|
2013-05-14 |
2017-12-11 |
Nerviano Medical Sciences S.R.L. |
Derivados de 6-amino-7-deaza-purina, proceso para su preparación y su uso como inhibidores de cinasa
|
|
TWI627173B
(zh)
*
|
2013-09-26 |
2018-06-21 |
比利時商健生藥品公司 |
作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
|
|
EP3209670B1
(en)
*
|
2014-10-23 |
2018-10-03 |
Janssen Pharmaceutica NV |
New thienopyrimidine derivatives as nik inhibitors
|
|
US9981962B2
(en)
*
|
2014-10-23 |
2018-05-29 |
Janssen Pharmaceutica Nv |
Pyrazole derivatives as NIK inhibitors
|
|
CN108883103A
(zh)
*
|
2015-12-02 |
2018-11-23 |
阿斯特来亚治疗有限责任公司 |
哌啶基痛敏肽受体化合物
|