JP2018536431A5 - - Google Patents
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- JP2018536431A5 JP2018536431A5 JP2018538064A JP2018538064A JP2018536431A5 JP 2018536431 A5 JP2018536431 A5 JP 2018536431A5 JP 2018538064 A JP2018538064 A JP 2018538064A JP 2018538064 A JP2018538064 A JP 2018538064A JP 2018536431 A5 JP2018536431 A5 JP 2018536431A5
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- Prior art keywords
- vector
- cell
- cancer
- nucleic acid
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013598 vector Substances 0.000 claims 12
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000002489 hematologic effect Effects 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000000244 kidney pelvis Anatomy 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims 1
- 206010010144 Completed suicide Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000004458 Myoma Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 241000520310 Rhabdomys Species 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000032383 Soft tissue cancer Diseases 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 230000005809 anti-tumor immunity Effects 0.000 claims 1
- 210000000436 anus Anatomy 0.000 claims 1
- 208000003373 basosquamous carcinoma Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 208000012191 childhood neoplasm Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000013601 cosmid vector Substances 0.000 claims 1
- 208000024558 digestive system cancer Diseases 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 201000010231 gastrointestinal system cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000003228 intrahepatic bile duct Anatomy 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000003899 penis Anatomy 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000004994 reproductive system Anatomy 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 210000000626 ureter Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239509P | 2015-10-09 | 2015-10-09 | |
| US62/239,509 | 2015-10-09 | ||
| PCT/US2016/056073 WO2017062820A1 (en) | 2015-10-09 | 2016-10-07 | Chimeric antigen receptors and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536431A JP2018536431A (ja) | 2018-12-13 |
| JP2018536431A5 true JP2018536431A5 (enExample) | 2019-11-07 |
| JP6821688B2 JP6821688B2 (ja) | 2021-01-27 |
Family
ID=57145073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538064A Active JP6821688B2 (ja) | 2015-10-09 | 2016-10-07 | キメラ抗原受容体および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10421810B2 (enExample) |
| EP (2) | EP3660044A1 (enExample) |
| JP (1) | JP6821688B2 (enExample) |
| CN (2) | CN114181960B (enExample) |
| AU (2) | AU2016335848B2 (enExample) |
| CA (1) | CA3001306C (enExample) |
| ES (1) | ES2778651T3 (enExample) |
| WO (2) | WO2017062820A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA123764C2 (uk) | 2014-09-15 | 2021-06-02 | МОЛМЕД СпА | Химерний рецептор антигену та його застосування при лікуванні пухлин, які експресують cd44 |
| EP4286511A3 (en) * | 2015-06-12 | 2024-03-06 | Lentigen Technology, Inc. | Method to treat cancer with engineered t-cells |
| CN114181960B (zh) | 2015-10-09 | 2024-08-23 | 美天施生物科技有限公司 | 嵌合抗原受体和使用方法 |
| EP3184548A1 (en) | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
| CN117298260A (zh) | 2016-09-02 | 2023-12-29 | 莱蒂恩技术公司 | 用DuoCAR治疗癌症的组合物和方法 |
| TW202402800A (zh) * | 2017-05-01 | 2024-01-16 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體類和使用彼等之方法 |
| CN107164410B (zh) * | 2017-05-27 | 2019-09-03 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的前列腺癌car-t治疗载体及其构建方法和应用 |
| CN107245500B (zh) * | 2017-05-27 | 2019-05-17 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的淋系白血病car-t治疗载体及其构建方法和应用 |
| CN107267555B (zh) * | 2017-05-27 | 2020-03-20 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用 |
| CN107177632B (zh) * | 2017-05-27 | 2020-02-07 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用 |
| CN107299110B (zh) | 2017-05-27 | 2019-11-22 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的胰腺癌、恶性间皮瘤car-t治疗载体及其构建方法和应用 |
| EP3703711A4 (en) * | 2017-11-03 | 2021-01-13 | Lentigen Technology, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER WITH ANTI-MMR1 IMMUNOTHERAPY |
| AU2019343184A1 (en) * | 2018-09-20 | 2021-04-15 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
| CN111454909B (zh) * | 2019-01-22 | 2024-12-10 | 北京大学深圳研究生院 | 天然配体介导的多靶点识别可调控基因工程化免疫细胞的制备方法 |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| JP7650809B2 (ja) * | 2019-03-06 | 2025-03-25 | レンティジェン・テクノロジー・インコーポレイテッド | 自己駆動型キメラ抗原受容体を用いてがんを処置するための組成物および方法 |
| EP3715368A1 (en) * | 2019-03-28 | 2020-09-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells |
| CN114450013A (zh) * | 2019-04-12 | 2022-05-06 | 爱莫里大学 | 用于促进造血细胞的细胞毒性的组合物和方法 |
| WO2020227447A1 (en) * | 2019-05-07 | 2020-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric antigen receptors targeting glypican-2 |
| US20220249565A1 (en) * | 2019-06-27 | 2022-08-11 | Eutilex Co., Ltd. | Chimeric antigen receptor with 4-ibb costimulatory domain |
| AU2020307673A1 (en) * | 2019-06-27 | 2022-01-20 | Eutilex Co., Ltd. | Chimeric antigen receptor with 4-1BB costimulatory domain |
| CN112812182B (zh) * | 2019-11-15 | 2023-01-06 | 深圳宾德生物技术有限公司 | 一种靶向fgfr4的单链抗体、嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用 |
| WO2021164959A1 (en) * | 2020-02-17 | 2021-08-26 | Miltenyi Biotec B.V. & Co. KG | Method for providing personalized cells with chimeric antigen receptors (car) against tumor microenvironment cells |
| WO2021168376A1 (en) * | 2020-02-20 | 2021-08-26 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| CN112159818B (zh) * | 2020-08-20 | 2023-02-21 | 山东兴瑞生物科技有限公司 | 用于治疗hcc的核酸、其制备方法、具有该核酸的car-t细胞及细胞的制备方法 |
| CA3193009A1 (en) * | 2020-08-26 | 2022-03-03 | The Regents Of The University Of California | Methods and compositions for treating glioblastoma |
| US20240115607A1 (en) | 2021-01-26 | 2024-04-11 | Cytocares (Shanghai) Inc. | Chimeric antigen receptor (car) constructs and nk cells expressing car constructs |
| CN112851794B (zh) * | 2021-02-04 | 2023-05-23 | 苏州铂维生物科技有限公司 | 一种基于cd271的抗原表位及其应用 |
| AR125753A1 (es) | 2021-05-04 | 2023-08-09 | Agenus Inc | Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos |
| WO2023076811A1 (en) * | 2021-10-26 | 2023-05-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Combination therapies with chimeric antigen receptors |
| KR20250005563A (ko) * | 2022-03-15 | 2025-01-09 | 뉴욕 지놈 센터 인코퍼레이티드 | 개선된 면역요법을 위한 방법 및 융합 단백질을 포함하는 조성물 |
| EP4562043A2 (en) | 2022-07-28 | 2025-06-04 | Lentigen Technology, Inc. | Chimeric antigen receptor therapies for treating solid tumors |
| WO2024196796A1 (en) * | 2023-03-17 | 2024-09-26 | Cartesian Therapeutics, Inc. | Intracellular signaling and costimulatory domains adapted for prolonged expression of chimeric antigen receptors |
| WO2025006499A2 (en) * | 2023-06-26 | 2025-01-02 | Atara Biotherapeutics, Inc. | Gpc3-targeted molecules and uses thereof |
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2016
- 2016-10-07 CN CN202111359062.8A patent/CN114181960B/zh active Active
- 2016-10-07 CN CN201680070221.3A patent/CN108779162B/zh active Active
- 2016-10-07 AU AU2016335848A patent/AU2016335848B2/en active Active
- 2016-10-07 EP EP19213308.0A patent/EP3660044A1/en active Pending
- 2016-10-07 EP EP16782384.8A patent/EP3359562B1/en active Active
- 2016-10-07 WO PCT/US2016/056073 patent/WO2017062820A1/en not_active Ceased
- 2016-10-07 JP JP2018538064A patent/JP6821688B2/ja active Active
- 2016-10-07 ES ES16782384T patent/ES2778651T3/es active Active
- 2016-10-07 US US15/767,076 patent/US10421810B2/en active Active
- 2016-10-07 CA CA3001306A patent/CA3001306C/en active Active
- 2016-10-10 WO PCT/US2016/056277 patent/WO2017062952A1/en not_active Ceased
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2019
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- 2024-01-10 US US18/408,907 patent/US20240150773A1/en active Pending
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