JP2024074801A5 - - Google Patents
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- JP2024074801A5 JP2024074801A5 JP2024029998A JP2024029998A JP2024074801A5 JP 2024074801 A5 JP2024074801 A5 JP 2024074801A5 JP 2024029998 A JP2024029998 A JP 2024029998A JP 2024029998 A JP2024029998 A JP 2024029998A JP 2024074801 A5 JP2024074801 A5 JP 2024074801A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- cancer
- cytokine receptor
- chimeric cytokine
- inducible chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862637600P | 2018-03-02 | 2018-03-02 | |
| US62/637,600 | 2018-03-02 | ||
| PCT/US2019/020340 WO2019169290A1 (en) | 2018-03-02 | 2019-03-01 | Inducible chimeric cytokine receptors |
| JP2020568943A JP7526101B2 (ja) | 2018-03-02 | 2019-03-01 | 誘導性キメラサイトカイン受容体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568943A Division JP7526101B2 (ja) | 2018-03-02 | 2019-03-01 | 誘導性キメラサイトカイン受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024074801A JP2024074801A (ja) | 2024-05-31 |
| JP2024074801A5 true JP2024074801A5 (enExample) | 2024-10-11 |
Family
ID=65952060
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568943A Active JP7526101B2 (ja) | 2018-03-02 | 2019-03-01 | 誘導性キメラサイトカイン受容体 |
| JP2024029998A Pending JP2024074801A (ja) | 2018-03-02 | 2024-02-29 | 誘導性キメラサイトカイン受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568943A Active JP7526101B2 (ja) | 2018-03-02 | 2019-03-01 | 誘導性キメラサイトカイン受容体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12163169B2 (enExample) |
| EP (1) | EP3759132A1 (enExample) |
| JP (2) | JP7526101B2 (enExample) |
| KR (2) | KR20250123938A (enExample) |
| CN (1) | CN111819192A (enExample) |
| AR (1) | AR114273A1 (enExample) |
| AU (2) | AU2019227979B2 (enExample) |
| BR (1) | BR112020017734A2 (enExample) |
| CA (1) | CA3091681A1 (enExample) |
| IL (2) | IL276831B2 (enExample) |
| MX (2) | MX2020009051A (enExample) |
| SG (1) | SG11202007771VA (enExample) |
| TW (1) | TWI897846B (enExample) |
| WO (1) | WO2019169290A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| EP4286522A3 (en) * | 2016-03-23 | 2024-02-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| SG11201908492PA (en) | 2017-03-27 | 2019-10-30 | Nat Univ Singapore | Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy |
| CN111801348A (zh) | 2018-02-09 | 2020-10-20 | 新加坡国立大学 | 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| WO2019169290A1 (en) | 2018-03-02 | 2019-09-06 | Allogene Therapeutics, Inc. | Inducible chimeric cytokine receptors |
| KR20200138741A (ko) | 2018-04-02 | 2020-12-10 | 내셔널 유니버시티 오브 싱가포르 | 면역 세포에서 발현되는 막-결합 항-사이토카인 비-신호전달 결합제를 이용한 인간 사이토카인의 중화 |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| US11786553B2 (en) | 2019-03-01 | 2023-10-17 | Allogene Therapeuctics, Inc. | Chimeric cytokine receptors bearing a PD-1 ectodomain |
| PH12021551861A1 (en) * | 2019-03-01 | 2022-05-30 | Allogene Therapeutics Inc | Constitutively active chimeric cytokine receptors |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| CA3151472A1 (en) * | 2019-10-08 | 2021-04-15 | Brad Nelson | Chimeric cytokine receptors |
| CN115315273A (zh) * | 2020-01-14 | 2022-11-08 | 辛德凯因股份有限公司 | Il-2直向同源物及其使用方法 |
| AU2021227191A1 (en) * | 2020-02-24 | 2022-08-25 | Allogene Therapeutics, Inc. | BCMA car-T cells with enhanced activities |
| IL295888A (en) * | 2020-02-24 | 2022-10-01 | Us Health | Nk cells or t cells expressing hematopoietic growth factor receptors and use for treating cancer |
| EP4110801A1 (en) | 2020-02-25 | 2023-01-04 | Quell Therapeutics Limited | Chimeric receptors for use in engineered cells |
| CN115812077A (zh) | 2020-05-08 | 2023-03-17 | 高山免疫科学股份有限公司 | April和baff抑制性免疫调节蛋白及其使用方法 |
| US20230310606A1 (en) * | 2020-07-17 | 2023-10-05 | Simurx, Inc. | Chimeric myd88 receptors for redirecting immunosuppressive signaling and related compositions and methods |
| EP4267601A1 (en) * | 2020-12-23 | 2023-11-01 | Quell Therapeutics Limited | Inducible signalling protein |
| TW202246492A (zh) * | 2021-02-24 | 2022-12-01 | 中國大陸商杭州啟函生物科技有限公司 | 用於增強的免疫療法的系統和方法 |
| KR102829018B1 (ko) | 2021-03-03 | 2025-07-04 | 서울대학교산학협력단 | 키메릭 항원 수용체-대식 세포의 제조 방법 및 그 세포의 용도 |
| JP2024515577A (ja) * | 2021-04-07 | 2024-04-10 | プロヴィンシャル ヘルス サービシーズ オーソリティ | 修飾された顆粒球コロニー刺激因子(g-csf)及びこれに結合するキメラサイトカイン受容体 |
| CN113512125B (zh) * | 2021-04-26 | 2024-01-19 | 北京双赢科创生物科技有限公司 | 一种携带stat结合基序的嵌合抗原受体分子及表达该嵌合抗原受体分子的nk细胞 |
| CA3219976A1 (en) * | 2021-05-14 | 2022-11-17 | Board Of Regents, The University Of Texas System | Chimeric polypeptides and methods of use |
| EP4365295A1 (en) * | 2021-06-28 | 2024-05-08 | Aichi Prefecture | Chimeric cytokine receptor |
| CA3232668A1 (en) | 2021-09-17 | 2023-03-23 | Parker Institute For Cancer Immunotherapy | Switch receptors using il-9 signaling domains |
| GB202117298D0 (en) | 2021-11-30 | 2022-01-12 | Quell Therapeutics Ltd | Signalling protein |
| TW202334398A (zh) | 2021-12-22 | 2023-09-01 | 英商圭爾醫療有限公司 | 組成型細胞激素受體 |
| EP4499680A1 (en) | 2022-03-29 | 2025-02-05 | Allogene Therapeutics, Inc. | Chimeric switch receptors for the conversion of immunesuppressive signals to costimulatory signals |
| JP2025525421A (ja) * | 2022-06-28 | 2025-08-05 | カリスマ セラピューティクス インコーポレイテッド | スイッチ受容体及び修飾免疫細胞 |
| CA3260970A1 (en) * | 2022-07-11 | 2024-01-18 | Univ Leland Stanford Junior | Tunable Cytokine Receptor Signaling Domains |
| CN114949000B (zh) * | 2022-08-02 | 2022-10-04 | 卡瑞济(北京)生命科技有限公司 | 麝香提取物及其增强car-t细胞疗效的应用 |
| CN117683139A (zh) * | 2022-09-09 | 2024-03-12 | 信达细胞制药(苏州)有限公司 | 组成型嵌合细胞因子受体及表达其的免疫细胞及应用 |
| GB202217541D0 (en) | 2022-11-24 | 2023-01-11 | Quell Therapeutics Ltd | Recombinant receptor |
| WO2024133472A1 (en) | 2022-12-22 | 2024-06-27 | Quell Therapeutics Limited | Constitutive cytokine receptors |
| AU2024212695A1 (en) | 2023-01-23 | 2025-08-14 | Medizinische Hochschule Hannover | Anti-entpd3 chimeric antigen receptor |
| EP4403580A1 (en) | 2023-01-23 | 2024-07-24 | Medizinische Hochschule Hannover | Anti-entpd3 chimeric antigen receptor |
| KR20250165594A (ko) | 2023-02-07 | 2025-11-26 | 퀠 테라퓨틱스 리미티드 | Treg 세포의 배양 방법 |
| WO2024175805A1 (en) | 2023-02-24 | 2024-08-29 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4420676A1 (en) | 2023-02-24 | 2024-08-28 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| TW202442689A (zh) | 2023-03-03 | 2024-11-01 | 美商亞森諾生物科學公司 | 靶向psma及ca9之系統 |
| WO2024194605A1 (en) | 2023-03-17 | 2024-09-26 | Quell Therapeutics Limited | Treg therapy |
| WO2024194355A1 (en) | 2023-03-20 | 2024-09-26 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4434539A1 (en) | 2023-03-20 | 2024-09-25 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| WO2024263710A1 (en) | 2023-06-20 | 2024-12-26 | Allogene Therapeutics, Inc. | Methods of detection for engineered cells |
| WO2024261480A1 (en) | 2023-06-21 | 2024-12-26 | Quell Therapeutics Limited | Constitutive cytokine receptors |
| WO2025007073A2 (en) * | 2023-06-29 | 2025-01-02 | Dispatch Biotherapeutics, Inc. | Synthetic cytokine receptors |
| WO2025026347A1 (en) * | 2023-07-31 | 2025-02-06 | Nanjing Legend Biotech Co., Ltd. | Chimeric cytokine receptors and methods of use thereof |
| WO2025064779A1 (en) * | 2023-09-20 | 2025-03-27 | University Of Southern California | Synthetic tgf-beta redirectors and uses thereof in chimeric antigen receptor-mediated cell therapy and others |
| WO2025076134A1 (en) * | 2023-10-03 | 2025-04-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nk cells or t cells expressing chimeric hematopoietic growth factor receptors and methods of use |
| WO2025096560A1 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Engineered cells |
| WO2025096643A1 (en) * | 2023-11-01 | 2025-05-08 | Baylor College Of Medicine | Reverse fate receptors to enhance the efficacy of engineered t cells |
| WO2025111277A2 (en) * | 2023-11-20 | 2025-05-30 | Carisma Therapeutics Inc. | Compositions and methods relating to redirected soluble modulators |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| IL114825A0 (en) | 1994-08-04 | 1995-12-08 | Regeneron Pharma | Rtk/cytokine receptor chimeras |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| AU3668897A (en) * | 1996-07-17 | 1998-02-09 | University Of Medicine And Dentistry Of New Jersey | Chimeric receptors for jak-stat signal transduction |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| DK1257632T3 (da) | 2000-02-24 | 2008-01-28 | Xcyte Therapies Inc | Samtidig stimulering og opkoncentrering af celler |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| WO2007075899A2 (en) | 2005-12-21 | 2007-07-05 | Maxygen, Inc. | Dual agonist compounds and uses thereof |
| PT2856876T (pt) | 2007-03-30 | 2018-03-28 | Memorial Sloan Kettering Cancer Center | Expressão constitutiva de ligantes co-estimulatórios em linfócitos t adotivamente transferidos |
| DK2331680T3 (en) | 2008-09-22 | 2017-08-21 | Baylor College Medicine | Methods and Compositions for Generating an Immune Response by Induction of CD-40 as well as Pattern Recognition Receptor Adapters |
| WO2011069004A1 (en) | 2009-12-04 | 2011-06-09 | Quest Diagnostics Investments Incorporated | Mpl mutations in jak2 v617f negative patients with myeloproliferative disease |
| NZ723731A (en) * | 2011-04-08 | 2020-05-29 | Baylor College Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| PE20141520A1 (es) | 2011-07-29 | 2014-11-17 | Univ Pennsylvania | Receptores coestimuladores de cambio |
| GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| KR20150131218A (ko) | 2013-03-14 | 2015-11-24 | 벨리쿰 파마슈티컬스, 인크. | T 세포 증식의 제어 방법 |
| CA2912172A1 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| EP3087101B1 (en) * | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| AU2015330017A1 (en) * | 2014-10-07 | 2017-04-27 | Cellectis | Method for modulating car-induced immune cells activity |
| EP3608408A1 (en) | 2014-12-15 | 2020-02-12 | Bellicum Pharmaceuticals, Inc. | Methods for controlled activation or elimination of therapeutic cells |
| CA2973529A1 (en) | 2015-01-26 | 2016-08-04 | Cellectis | Cll1-specific multi-chain chimeric antigen receptor |
| US10336810B2 (en) * | 2015-02-12 | 2019-07-02 | University Health Network | Chimeric antigen receptors, encoding nucleic acids and methods of use thereof |
| JP6921001B2 (ja) | 2015-04-13 | 2021-08-18 | ファイザー・インク | B細胞成熟抗原を標的にするキメラ抗原受容体 |
| AU2016248317A1 (en) | 2015-04-15 | 2017-11-09 | Promedior, Inc. | Methods for treating myeloproliferative disorders |
| GB201514875D0 (en) * | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| GB201518816D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| WO2019055946A1 (en) * | 2017-09-18 | 2019-03-21 | F1 Oncology, Inc. | METHODS AND COMPOSITIONS FOR THE GENETIC MODIFICATION AND EXPANSION OF LYMPHOCYTES AND THE REGULATION OF THE ACTIVITY THEREOF |
| CN116970630A (zh) * | 2016-08-26 | 2023-10-31 | 贝勒医学院 | 用于细胞治疗的组成型活性细胞因子受体 |
| EP3541833B1 (en) | 2016-11-17 | 2024-01-24 | 2seventy bio, Inc. | Tgf beta signal convertor |
| WO2018104473A1 (en) | 2016-12-07 | 2018-06-14 | Oslo Universitetssykehus Hf | Compositions and methods for cell therapy |
| GB201702617D0 (en) | 2017-02-17 | 2017-04-05 | Autolus Ltd | Receptor |
| EP3589733A1 (en) | 2017-03-03 | 2020-01-08 | F1 Oncology, Inc. | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof |
| GB201719557D0 (en) | 2017-11-24 | 2018-01-10 | Autolus Ltd | Polypeptide |
| WO2019118508A1 (en) | 2017-12-12 | 2019-06-20 | The Trustees Of The University Of Pennsylvania | Genetically modified immune cells targeting ny-eso-1 and methods of use thereof |
| WO2019169290A1 (en) * | 2018-03-02 | 2019-09-06 | Allogene Therapeutics, Inc. | Inducible chimeric cytokine receptors |
| KR20210025525A (ko) | 2018-06-22 | 2021-03-09 | 카이트 파마 인코포레이티드 | 키메라 막횡단 단백질 및 그의 용도 |
| GB201814203D0 (en) | 2018-08-31 | 2018-10-17 | King S College London | Engineered regulatory t cell |
| PH12021551861A1 (en) | 2019-03-01 | 2022-05-30 | Allogene Therapeutics Inc | Constitutively active chimeric cytokine receptors |
| US11786553B2 (en) | 2019-03-01 | 2023-10-17 | Allogene Therapeuctics, Inc. | Chimeric cytokine receptors bearing a PD-1 ectodomain |
-
2019
- 2019-03-01 WO PCT/US2019/020340 patent/WO2019169290A1/en not_active Ceased
- 2019-03-01 IL IL276831A patent/IL276831B2/en unknown
- 2019-03-01 JP JP2020568943A patent/JP7526101B2/ja active Active
- 2019-03-01 CA CA3091681A patent/CA3091681A1/en active Pending
- 2019-03-01 KR KR1020257025809A patent/KR20250123938A/ko active Pending
- 2019-03-01 AR ARP190100529A patent/AR114273A1/es unknown
- 2019-03-01 KR KR1020207027009A patent/KR102842692B1/ko active Active
- 2019-03-01 AU AU2019227979A patent/AU2019227979B2/en active Active
- 2019-03-01 US US16/290,388 patent/US12163169B2/en active Active
- 2019-03-01 EP EP19713907.4A patent/EP3759132A1/en active Pending
- 2019-03-01 MX MX2020009051A patent/MX2020009051A/es unknown
- 2019-03-01 SG SG11202007771VA patent/SG11202007771VA/en unknown
- 2019-03-01 IL IL317065A patent/IL317065A/en unknown
- 2019-03-01 BR BR112020017734-2A patent/BR112020017734A2/pt unknown
- 2019-03-01 CN CN201980016890.6A patent/CN111819192A/zh active Pending
- 2019-03-04 TW TW108107136A patent/TWI897846B/zh active
-
2020
- 2020-08-31 MX MX2025009955A patent/MX2025009955A/es unknown
-
2024
- 2024-02-29 JP JP2024029998A patent/JP2024074801A/ja active Pending
- 2024-10-16 US US18/917,035 patent/US20250333719A1/en active Pending
- 2024-12-04 AU AU2024278090A patent/AU2024278090A1/en active Pending
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