TWI897846B - 可誘導之嵌合細胞激素受體 - Google Patents

可誘導之嵌合細胞激素受體

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Publication number
TWI897846B
TWI897846B TW108107136A TW108107136A TWI897846B TW I897846 B TWI897846 B TW I897846B TW 108107136 A TW108107136 A TW 108107136A TW 108107136 A TW108107136 A TW 108107136A TW I897846 B TWI897846 B TW I897846B
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Taiwan
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domain
cells
cell
receptor
immune cell
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TW108107136A
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English (en)
Chinese (zh)
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TW201945402A (zh
Inventor
安德魯 羅斯 納格
史賓瑟 帕克
瑞格斯 嘉維爾 費南多 恰佩羅
君慧 林
布拉康 湯瑪士 約翰 凡
Original Assignee
美商異基因治療有限公司
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Publication of TW201945402A publication Critical patent/TW201945402A/zh
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/4204—Epidermal growth factor receptors [EGFR]
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12Y502/00—Cis-trans-isomerases (5.2)
    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
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    • C12N2510/00—Genetically modified cells

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW108107136A 2018-03-02 2019-03-04 可誘導之嵌合細胞激素受體 TWI897846B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862637600P 2018-03-02 2018-03-02
US62/637,600 2018-03-02
PCT/US2019/020340 WO2019169290A1 (en) 2018-03-02 2019-03-01 Inducible chimeric cytokine receptors
WOPCT/US2019/020340 2019-03-01

Publications (2)

Publication Number Publication Date
TW201945402A TW201945402A (zh) 2019-12-01
TWI897846B true TWI897846B (zh) 2025-09-21

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TW108107136A TWI897846B (zh) 2018-03-02 2019-03-04 可誘導之嵌合細胞激素受體

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US (2) US12163169B2 (enExample)
EP (1) EP3759132A1 (enExample)
JP (2) JP7526101B2 (enExample)
KR (2) KR20250123938A (enExample)
CN (1) CN111819192A (enExample)
AR (1) AR114273A1 (enExample)
AU (2) AU2019227979B2 (enExample)
BR (1) BR112020017734A2 (enExample)
CA (1) CA3091681A1 (enExample)
IL (2) IL276831B2 (enExample)
MX (2) MX2020009051A (enExample)
SG (1) SG11202007771VA (enExample)
TW (1) TWI897846B (enExample)
WO (1) WO2019169290A1 (enExample)

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