JP2018535948A5 - - Google Patents
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- JP2018535948A5 JP2018535948A5 JP2018518592A JP2018518592A JP2018535948A5 JP 2018535948 A5 JP2018535948 A5 JP 2018535948A5 JP 2018518592 A JP2018518592 A JP 2018518592A JP 2018518592 A JP2018518592 A JP 2018518592A JP 2018535948 A5 JP2018535948 A5 JP 2018535948A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- lepr
- antigen
- binding fragment
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000005861 leptin receptors Human genes 0.000 claims description 41
- 108010019813 leptin receptors Proteins 0.000 claims description 41
- 239000000427 antigen Substances 0.000 claims description 40
- 102000036639 antigens Human genes 0.000 claims description 40
- 108091007433 antigens Proteins 0.000 claims description 40
- 239000012634 fragment Substances 0.000 claims description 38
- 150000001413 amino acids Chemical group 0.000 claims description 29
- 102000016267 Leptin Human genes 0.000 claims description 20
- 108010092277 Leptin Proteins 0.000 claims description 20
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 20
- 229940039781 leptin Drugs 0.000 claims description 20
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 19
- 101001129927 Homo sapiens Leptin receptor Proteins 0.000 claims description 19
- 102000007318 human leptin receptor Human genes 0.000 claims description 19
- 230000011664 signaling Effects 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 230000035772 mutation Effects 0.000 claims description 14
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 208000006132 lipodystrophy Diseases 0.000 claims description 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 8
- 230000007812 deficiency Effects 0.000 claims description 8
- 239000003112 inhibitor Substances 0.000 claims description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 8
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 8
- 230000019491 signal transduction Effects 0.000 claims description 7
- 101001063991 Homo sapiens Leptin Proteins 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 6
- 102000049953 human LEP Human genes 0.000 claims description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
- 102000006501 Angiopoietin-like Proteins Human genes 0.000 claims description 4
- 108010019425 Angiopoietin-like Proteins Proteins 0.000 claims description 4
- 102000051325 Glucagon Human genes 0.000 claims description 4
- 108060003199 Glucagon Proteins 0.000 claims description 4
- 108010063919 Glucagon Receptors Proteins 0.000 claims description 4
- 102100040890 Glucagon receptor Human genes 0.000 claims description 4
- 102000004877 Insulin Human genes 0.000 claims description 4
- 108090001061 Insulin Proteins 0.000 claims description 4
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 208000008589 Obesity Diseases 0.000 claims description 4
- 102100020888 Sodium/glucose cotransporter 2 Human genes 0.000 claims description 4
- 101710103228 Sodium/glucose cotransporter 2 Proteins 0.000 claims description 4
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 4
- 229960001058 bupropion Drugs 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 4
- 229960004666 glucagon Drugs 0.000 claims description 4
- 229940125396 insulin Drugs 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000002950 deficient Effects 0.000 claims description 3
- 230000006735 deficit Effects 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 201000000736 Amenorrhea Diseases 0.000 claims description 2
- 206010001928 Amenorrhoea Diseases 0.000 claims description 2
- 206010003694 Atrophy Diseases 0.000 claims description 2
- PWDLDBWXTVILPC-WGAVTJJLSA-N CC(C)(N)CC1=CC=CC=C1.C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 Chemical compound CC(C)(N)CC1=CC=CC=C1.C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 PWDLDBWXTVILPC-WGAVTJJLSA-N 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 2
- 201000005948 Donohue syndrome Diseases 0.000 claims description 2
- 208000003929 Familial Partial Lipodystrophy Diseases 0.000 claims description 2
- 206010056465 Food craving Diseases 0.000 claims description 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 108010001127 Insulin Receptor Proteins 0.000 claims description 2
- 102100036721 Insulin receptor Human genes 0.000 claims description 2
- 229940122199 Insulin secretagogue Drugs 0.000 claims description 2
- 208000013262 Localized lipodystrophy Diseases 0.000 claims description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 2
- 229940100389 Sulfonylurea Drugs 0.000 claims description 2
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 230000003187 abdominal effect Effects 0.000 claims description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 2
- 208000015228 acquired partial lipodystrophy Diseases 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 210000000577 adipose tissue Anatomy 0.000 claims description 2
- 231100000540 amenorrhea Toxicity 0.000 claims description 2
- 230000037444 atrophy Effects 0.000 claims description 2
- 229940012191 bupropion / naltrexone Drugs 0.000 claims description 2
- 102220429788 c.1226C>A Human genes 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 229910052805 deuterium Inorganic materials 0.000 claims description 2
- 230000037213 diet Effects 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims description 2
- 229960000815 ezetimibe Drugs 0.000 claims description 2
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 230000002267 hypothalamic effect Effects 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 229960005060 lorcaserin Drugs 0.000 claims description 2
- XTTZERNUQAFMOF-QMMMGPOBSA-N lorcaserin Chemical compound C[C@H]1CNCCC2=CC=C(Cl)C=C12 XTTZERNUQAFMOF-QMMMGPOBSA-N 0.000 claims description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 2
- 229960003105 metformin Drugs 0.000 claims description 2
- 108700008455 metreleptin Proteins 0.000 claims description 2
- 229960000668 metreleptin Drugs 0.000 claims description 2
- 229960003562 phentermine Drugs 0.000 claims description 2
- 229960003611 pramlintide Drugs 0.000 claims description 2
- 108010029667 pramlintide Proteins 0.000 claims description 2
- NRKVKVQDUCJPIZ-MKAGXXMWSA-N pramlintide acetate Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NRKVKVQDUCJPIZ-MKAGXXMWSA-N 0.000 claims description 2
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 229960004394 topiramate Drugs 0.000 claims description 2
- 229960002911 zonisamide Drugs 0.000 claims description 2
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 claims description 2
- 240000006409 Acacia auriculiformis Species 0.000 claims 1
- 229940127355 PCSK9 Inhibitors Drugs 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 8
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940122392 PCSK9 inhibitor Drugs 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000000249 far-infrared magnetic resonance spectroscopy Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 1
- 229960001243 orlistat Drugs 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562240021P | 2015-10-12 | 2015-10-12 | |
| US62/240,021 | 2015-10-12 | ||
| US201662359757P | 2016-07-08 | 2016-07-08 | |
| US62/359,757 | 2016-07-08 | ||
| US201662375495P | 2016-08-16 | 2016-08-16 | |
| US62/375,495 | 2016-08-16 | ||
| US201662393143P | 2016-09-12 | 2016-09-12 | |
| US62/393,143 | 2016-09-12 | ||
| PCT/US2016/056465 WO2017066204A1 (en) | 2015-10-12 | 2016-10-11 | Antigen-binding proteins that activate the leptin receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021039405A Division JP7165225B2 (ja) | 2015-10-12 | 2021-03-11 | レプチン受容体を活性化させる抗原結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535948A JP2018535948A (ja) | 2018-12-06 |
| JP2018535948A5 true JP2018535948A5 (OSRAM) | 2019-11-21 |
| JP7034068B2 JP7034068B2 (ja) | 2022-03-11 |
Family
ID=57184864
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518592A Active JP7034068B2 (ja) | 2015-10-12 | 2016-10-11 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2021039405A Active JP7165225B2 (ja) | 2015-10-12 | 2021-03-11 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2022169008A Active JP7436603B2 (ja) | 2015-10-12 | 2022-10-21 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2023202680A Active JP7699191B2 (ja) | 2015-10-12 | 2023-11-30 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2024018406A Active JP7759417B2 (ja) | 2015-10-12 | 2024-02-09 | レプチン受容体を活性化させる抗原結合タンパク質 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021039405A Active JP7165225B2 (ja) | 2015-10-12 | 2021-03-11 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2022169008A Active JP7436603B2 (ja) | 2015-10-12 | 2022-10-21 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2023202680A Active JP7699191B2 (ja) | 2015-10-12 | 2023-11-30 | レプチン受容体を活性化させる抗原結合タンパク質 |
| JP2024018406A Active JP7759417B2 (ja) | 2015-10-12 | 2024-02-09 | レプチン受容体を活性化させる抗原結合タンパク質 |
Country Status (32)
| Country | Link |
|---|---|
| US (6) | US10023644B2 (OSRAM) |
| EP (2) | EP4071173A1 (OSRAM) |
| JP (5) | JP7034068B2 (OSRAM) |
| KR (2) | KR20180070609A (OSRAM) |
| CN (1) | CN108368177B (OSRAM) |
| AU (2) | AU2016338851B2 (OSRAM) |
| BR (1) | BR112018007318A2 (OSRAM) |
| CA (1) | CA3000215A1 (OSRAM) |
| CL (2) | CL2018000946A1 (OSRAM) |
| CO (1) | CO2018003852A2 (OSRAM) |
| CY (1) | CY1125102T1 (OSRAM) |
| DK (1) | DK3362477T3 (OSRAM) |
| EA (1) | EA201890928A1 (OSRAM) |
| ES (1) | ES2908574T3 (OSRAM) |
| HR (1) | HRP20220426T8 (OSRAM) |
| HU (1) | HUE058280T2 (OSRAM) |
| IL (3) | IL316563A (OSRAM) |
| LT (1) | LT3362477T (OSRAM) |
| MX (2) | MX2018004531A (OSRAM) |
| MY (1) | MY187975A (OSRAM) |
| PH (1) | PH12018500663A1 (OSRAM) |
| PL (1) | PL3362477T3 (OSRAM) |
| PT (1) | PT3362477T (OSRAM) |
| RS (1) | RS63061B1 (OSRAM) |
| SG (1) | SG10201913432RA (OSRAM) |
| SI (1) | SI3362477T1 (OSRAM) |
| SM (1) | SMT202200125T1 (OSRAM) |
| TW (3) | TWI752920B (OSRAM) |
| UA (1) | UA124419C2 (OSRAM) |
| UY (1) | UY36942A (OSRAM) |
| WO (1) | WO2017066204A1 (OSRAM) |
| ZA (1) | ZA201801975B (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| EP3538554B1 (en) * | 2016-11-08 | 2025-08-13 | Regeneron Pharmaceuticals, Inc. | Antigen-binding proteins that antagonize leptin receptor |
| IL294491B2 (en) | 2017-05-05 | 2024-04-01 | Regeneron Pharma | Automatic injector |
| WO2019126071A1 (en) * | 2017-12-18 | 2019-06-27 | Regeneron Pharmaceuticals, Inc. | Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof |
| SI3773713T1 (sl) | 2018-04-06 | 2025-08-29 | Regeneron Pharmaceuticals, Inc. | Protitelo, agonist leptinskega receptorja, za uporabo pri povečanju kostne mase pri osebi, ki trpi zaradi presnovne disfunkcije ali hipoleptinemije |
| JP7328982B2 (ja) * | 2018-10-11 | 2023-08-17 | 住友化学株式会社 | プロピレンオキサイド精製装置、及び、プロピレンオキサイドの製造方法 |
| EP3918326A4 (en) * | 2019-01-31 | 2022-04-20 | Siemens Healthcare Diagnostics, Inc. | ANTI-NALOXONE AND ANTI-NALTREXONE MONOCLONAL ANTIBODIES AND METHODS OF PREPARATION AND USE THEREOF |
| US20220288169A1 (en) * | 2019-05-24 | 2022-09-15 | The Board of Supervisors of Louisiana State University and Agriculyural and Mechanical College | Compositions and methods for the treatment and prevention of hypoglycemic complications |
| GB2600273B (en) * | 2019-07-02 | 2024-06-05 | Univ Shanghai Technology | Antibody to leptin receptor |
| CN114746848B (zh) | 2019-12-03 | 2023-08-04 | 美光科技公司 | 用于存储装置的高速缓存架构 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| CN116670170A (zh) * | 2020-09-15 | 2023-08-29 | 瑞泽恩制药公司 | Lepr激动剂用于疼痛的用途 |
| EP4294257B1 (en) | 2021-02-22 | 2025-11-05 | Regeneron Pharmaceuticals, Inc. | Method for diagnosing and treating partial lipodystrophy |
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