JP2018535648A5 - - Google Patents
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- JP2018535648A5 JP2018535648A5 JP2018513797A JP2018513797A JP2018535648A5 JP 2018535648 A5 JP2018535648 A5 JP 2018535648A5 JP 2018513797 A JP2018513797 A JP 2018513797A JP 2018513797 A JP2018513797 A JP 2018513797A JP 2018535648 A5 JP2018535648 A5 JP 2018535648A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- antibody
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 description 26
- 241000829111 Human polyomavirus 1 Species 0.000 description 17
- 239000000427 antigen Substances 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
- 108091007433 antigens Proteins 0.000 description 14
- 239000008194 pharmaceutical composition Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 239000003814 drug Substances 0.000 description 7
- 239000003018 immunosuppressive agent Substances 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 6
- 206010011793 Cystitis haemorrhagic Diseases 0.000 description 4
- 201000002802 hemorrhagic cystitis Diseases 0.000 description 4
- 229940125721 immunosuppressive agent Drugs 0.000 description 4
- 208000017169 kidney disease Diseases 0.000 description 4
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical group COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 description 4
- 229960004866 mycophenolate mofetil Drugs 0.000 description 4
- 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 description 4
- 206010065042 Immune reconstitution inflammatory syndrome Diseases 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 206010055181 BK virus infection Diseases 0.000 description 2
- 229940122739 Calcineurin inhibitor Drugs 0.000 description 2
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 description 2
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 2
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 206010023163 JC virus infection Diseases 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 2
- 206010047115 Vasculitis Diseases 0.000 description 2
- 206010058874 Viraemia Diseases 0.000 description 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 2
- 229960002170 azathioprine Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- 206010009887 colitis Diseases 0.000 description 2
- 229930182912 cyclosporin Natural products 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 210000004565 granule cell Anatomy 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 230000001861 immunosuppressant effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229940124302 mTOR inhibitor Drugs 0.000 description 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 150000004712 monophosphates Chemical group 0.000 description 2
- 229960000951 mycophenolic acid Drugs 0.000 description 2
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 2
- 201000001119 neuropathy Diseases 0.000 description 2
- 230000007823 neuropathy Effects 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 208000033808 peripheral neuropathy Diseases 0.000 description 2
- 230000006825 purine synthesis Effects 0.000 description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
- 229960002930 sirolimus Drugs 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 229960001967 tacrolimus Drugs 0.000 description 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000701460 JC polyomavirus Species 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 206010038910 Retinitis Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021153503A JP7284790B2 (ja) | 2015-09-16 | 2021-09-21 | ポリオーマウイルス中和抗体 |
| JP2023032616A JP7706489B2 (ja) | 2015-09-16 | 2023-03-03 | ポリオーマウイルス中和抗体 |
| JP2025110154A JP2025143348A (ja) | 2015-09-16 | 2025-06-30 | ポリオーマウイルス中和抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/089764 | 2015-09-16 | ||
| CN2015089764 | 2015-09-16 | ||
| PCT/IB2016/055339 WO2017046676A1 (en) | 2015-09-16 | 2016-09-08 | Polyomavirus neutralizing antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153503A Division JP7284790B2 (ja) | 2015-09-16 | 2021-09-21 | ポリオーマウイルス中和抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535648A JP2018535648A (ja) | 2018-12-06 |
| JP2018535648A5 true JP2018535648A5 (enExample) | 2019-10-17 |
| JP7053455B2 JP7053455B2 (ja) | 2022-04-12 |
Family
ID=56936456
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513797A Active JP7053455B2 (ja) | 2015-09-16 | 2016-09-08 | ポリオーマウイルス中和抗体 |
| JP2021153503A Active JP7284790B2 (ja) | 2015-09-16 | 2021-09-21 | ポリオーマウイルス中和抗体 |
| JP2023032616A Active JP7706489B2 (ja) | 2015-09-16 | 2023-03-03 | ポリオーマウイルス中和抗体 |
| JP2025110154A Pending JP2025143348A (ja) | 2015-09-16 | 2025-06-30 | ポリオーマウイルス中和抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153503A Active JP7284790B2 (ja) | 2015-09-16 | 2021-09-21 | ポリオーマウイルス中和抗体 |
| JP2023032616A Active JP7706489B2 (ja) | 2015-09-16 | 2023-03-03 | ポリオーマウイルス中和抗体 |
| JP2025110154A Pending JP2025143348A (ja) | 2015-09-16 | 2025-06-30 | ポリオーマウイルス中和抗体 |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US9862760B2 (enExample) |
| EP (2) | EP3350218B1 (enExample) |
| JP (4) | JP7053455B2 (enExample) |
| CN (2) | CN113929771B (enExample) |
| AR (1) | AR106043A1 (enExample) |
| AU (1) | AU2016322814B2 (enExample) |
| CA (1) | CA2995795A1 (enExample) |
| DK (1) | DK3350218T5 (enExample) |
| ES (1) | ES2973856T3 (enExample) |
| FI (1) | FI3350218T3 (enExample) |
| HR (1) | HRP20240413T1 (enExample) |
| HU (1) | HUE065935T2 (enExample) |
| IL (2) | IL296800A (enExample) |
| LT (1) | LT3350218T (enExample) |
| MX (2) | MX392098B (enExample) |
| PL (1) | PL3350218T3 (enExample) |
| PT (1) | PT3350218T (enExample) |
| RS (1) | RS65441B1 (enExample) |
| SI (1) | SI3350218T1 (enExample) |
| SM (1) | SMT202400124T1 (enExample) |
| TW (2) | TWI726911B (enExample) |
| UY (1) | UY36905A (enExample) |
| WO (1) | WO2017046676A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| KR102019033B1 (ko) | 2016-11-11 | 2019-09-06 | 다이노나(주) | Cd40에 특이적으로 결합하는 항체 및 그의 용도 |
| CA3083363A1 (en) * | 2017-12-01 | 2019-06-06 | Novartis Ag | Polyomavirus neutralizing antibodies |
| US10946238B1 (en) | 2018-07-23 | 2021-03-16 | Life Fitness, Llc | Exercise machines having adjustable elliptical striding motion |
| CR20210435A (es) | 2019-02-18 | 2021-09-20 | Lilly Co Eli | Formulación de anticuerpos terapéuticos |
| US12410238B2 (en) | 2019-06-19 | 2025-09-09 | Icahn School Of Medicine At Mount Sinai | Monoclonal antibodies against JC virus |
| WO2021236724A2 (en) * | 2020-05-20 | 2021-11-25 | Remd Biotherapeutics, Inc. | Human endothelin receptor a (etar) antagonist antibodies |
| LT4126932T (lt) * | 2020-06-09 | 2024-02-12 | Memo Therapeutics Ag | Antikūno molekulės prieš bk virusą |
| TW202207986A (zh) * | 2020-06-12 | 2022-03-01 | 美商艾普利克斯製藥公司 | 多瘤病毒中和抗體之給藥 |
| CA3199750A1 (en) * | 2020-10-29 | 2022-05-05 | Flagship Pioneering Innovations V, Inc. | Chicken anemia virus (cav)-based vectors |
| JP2024510976A (ja) * | 2021-03-12 | 2024-03-12 | アイカーン スクール オブ メディシン アット マウント サイナイ | Ｂｋウイルスに対する中和モノクローナル抗体 |
| WO2023175171A1 (en) | 2022-03-18 | 2023-09-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Bk polyomavirus antibodies and uses thereof |
| CA3254085A1 (en) * | 2022-05-18 | 2023-11-23 | The Brigham And Women's Hospital, Inc. | KLRB1 LIAISON AGENTS AND THEIR METHODS OF USE |
| CN118725124B (zh) * | 2023-03-29 | 2025-09-16 | 东莞市朋志生物科技有限公司 | 抗胃蛋白酶原ⅱ抗体、检测胃蛋白酶原ⅱ的试剂和试剂盒 |
| WO2025111317A1 (en) * | 2023-11-21 | 2025-05-30 | The Brigham And Women's Hospital, Inc. | Klrb1 binding agents and methods of use thereof |
| EP4659810A1 (en) | 2024-06-07 | 2025-12-10 | Université de Strasbourg | Bkv neutralizing antibodies |
| EP4659811A1 (en) * | 2024-06-07 | 2025-12-10 | Université de Strasbourg | Bk virus neutralizing antibodies |
| WO2025252939A1 (en) * | 2024-06-07 | 2025-12-11 | Universite De Strasbourg | Bk virus neutralizing antibodies |
| WO2025252935A1 (en) | 2024-06-07 | 2025-12-11 | Universite De Strasbourg | Bkv neutralizing antibodies |
| CN119320446A (zh) * | 2024-12-02 | 2025-01-17 | 上海云泽生物科技有限公司 | 一种抗bkv抗体及其应用 |
| CN120623324B (zh) * | 2025-08-13 | 2025-10-31 | 北京溯本源和生物科技有限公司 | 一种用于bk病毒vp1蛋白检测的单克隆抗体3c7及应用 |
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