|
DE286509C
(cg-RX-API-DMAC7.html)
|
|
|
|
|
|
DE257197C
(cg-RX-API-DMAC7.html)
|
|
|
|
|
|
US3914252A
(en)
|
1971-03-15 |
1975-10-21 |
Continental Oil Co |
Preparation of N-iodocompounds
|
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
EP0851925B1
(en)
|
1995-09-21 |
2005-08-03 |
Genentech, Inc. |
Human growth hormone variants
|
|
WO1998022577A1
(en)
|
1996-11-15 |
1998-05-28 |
Maria Grazia Masucci |
Fusion proteins having increased half-lives
|
|
CA2296770A1
(en)
|
1997-07-14 |
1999-01-28 |
Bolder Biotechnology, Inc. |
Derivatives of growth hormone and related proteins
|
|
EP1200124B1
(en)
|
1999-07-13 |
2008-09-10 |
Bolder Biotechnology, Inc. |
Erythropoietin-immunoglobulin fusion proteins
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
EP1240337B1
(en)
|
1999-12-24 |
2006-08-23 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
WO2002055532A2
(en)
|
2001-01-11 |
2002-07-18 |
Maxygen Aps |
Variant growth hormone molecules conjugated with macromolecular compounds
|
|
US20060183197A1
(en)
|
2001-01-11 |
2006-08-17 |
Andersen Kim V |
Variant growth hormone molecules conjugated with macromolecules compounds
|
|
US20020169125A1
(en)
|
2001-03-21 |
2002-11-14 |
Cell Therapeutics, Inc. |
Recombinant production of polyanionic polymers and uses thereof
|
|
WO2003042245A2
(en)
|
2001-11-12 |
2003-05-22 |
University Of Wales College Of Medicine |
Growth hormone variations in humans and their uses
|
|
GB2384001B
(en)
|
2001-12-14 |
2004-02-04 |
Asterion Ltd |
Chimeric growth hormone-growth hormone receptor proteins
|
|
EP2298805A3
(en)
|
2002-09-27 |
2011-04-13 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US20040180054A1
(en)
|
2003-03-13 |
2004-09-16 |
Hanmi Pharm. Co., Ltd. |
Physiologically active polypeptide conjugate having prolonged in vivo half-life
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
EP1682584B1
(en)
|
2003-11-13 |
2013-04-17 |
Hanmi Science Co., Ltd. |
A pharmaceutical composition comprising an immunoglobulin fc region as a carrier
|
|
CA2552043A1
(en)
|
2004-01-21 |
2005-08-04 |
Novo Nordisk A/S |
Transglutaminase mediated conjugation of peptides
|
|
KR100594607B1
(ko)
|
2004-11-03 |
2006-06-30 |
재단법인서울대학교산학협력재단 |
신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법
|
|
US7998930B2
(en)
|
2004-11-04 |
2011-08-16 |
Hanall Biopharma Co., Ltd. |
Modified growth hormones
|
|
WO2006081249A2
(en)
|
2005-01-25 |
2006-08-03 |
Cell Therapeutics, Inc. |
Conjugates of biologically active proteins having a modified in vivo half-life
|
|
WO2006079641A2
(en)
*
|
2005-01-27 |
2006-08-03 |
Novo Nordisk A/S |
Insulin derivatives conjugated with structurally well defined branched polymers
|
|
CN101123992A
(zh)
*
|
2005-02-16 |
2008-02-13 |
诺和诺德公司 |
缀合有结构完全确定的支化聚合物的促胰岛素剂的衍生物
|
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
|
|
EP1874816A4
(en)
|
2005-04-26 |
2010-08-25 |
Medimmune Inc |
MODULATION OF THE ANTIBODY EFFECTOR FUNCTION BY "HINGE" DOMENGINE ENGINEERING
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
EP1968641B1
(en)
|
2005-12-12 |
2014-06-11 |
Innova Biosciences Limited |
Production of conjugates
|
|
US8334257B2
(en)
|
2005-12-20 |
2012-12-18 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
AU2007223888A1
(en)
|
2006-03-06 |
2007-09-13 |
Amunix, Inc. |
Genetic packages and uses thereof
|
|
WO2008019368A2
(en)
|
2006-08-07 |
2008-02-14 |
Teva Biopharmaceuticals Usa, Inc. |
Albumin-insulin fusion proteins
|
|
JP5323710B2
(ja)
|
2006-10-26 |
2013-10-23 |
ヤンセン バイオテツク,インコーポレーテツド |
ヒトに適合するモノクローナル抗体に使用するための方法
|
|
WO2008049711A1
(en)
|
2006-10-27 |
2008-05-02 |
Novo Nordisk A/S |
Peptide extended insulins
|
|
WO2008147456A2
(en)
|
2006-11-20 |
2008-12-04 |
Massachusetts Institute Of Technology |
Drug delivery systems using fc fragments
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
KR20080095141A
(ko)
|
2007-04-23 |
2008-10-28 |
포항공과대학교 산학협력단 |
인간 알부민 링커를 통하여 면역글로불린의 Fc에 결합된생리학적 활성 폴리펩티드의 융합 폴리펩티드, 및 이의제조방법
|
|
CA2687377C
(en)
|
2007-05-30 |
2013-05-14 |
Genexine Co., Ltd. |
Immunoglobulin fusion proteins
|
|
EP4119579A1
(en)
|
2007-05-31 |
2023-01-18 |
Genmab A/S |
Stable igg4 antibodies
|
|
WO2009015345A1
(en)
|
2007-07-25 |
2009-01-29 |
Amgen Inc. |
Pharmaceutical compositions comprising fc fusion proteins
|
|
EP2185701A4
(en)
|
2007-08-15 |
2011-03-02 |
Amunix Operating Inc |
COMPOSITIONS AND METHODS FOR ENHANCING THE PRODUCTION OF RECOMBINANT POLYPEPTIDES
|
|
US8586532B2
(en)
|
2007-08-24 |
2013-11-19 |
Novo Nordisk Healthcare A/G |
Method for selectively modifying a protein via transglutaminase catalyzed reaction
|
|
WO2009053368A1
(en)
|
2007-10-22 |
2009-04-30 |
Merck Serono S.A. |
Single ifn-beta fused to a mutated igg fc fragment
|
|
JP6146949B2
(ja)
|
2008-06-20 |
2017-06-21 |
ノバルティス アーゲー |
凝集が低減された免疫グロブリン
|
|
US20110119848A1
(en)
|
2008-07-02 |
2011-05-26 |
Koninklijke Philips Electronics N.V. |
V-spring configuration and end attachment assemblies therefor for use in a personal care appliance
|
|
US9636420B2
(en)
*
|
2008-07-23 |
2017-05-02 |
Hanmi Science Co., Ltd. |
Polypeptide complex comprising non-peptidyl polymer having three functional ends
|
|
EP2356142B1
(en)
|
2008-11-10 |
2016-08-10 |
Novo Nordisk A/S |
E. coli bl21 strain lacking a functional group ii capsular gene cluster.
|
|
DK3178835T3
(da)
|
2009-02-03 |
2019-06-24 |
Amunix Pharmaceuticals Inc |
Forlængede rekombinante polypeptider og sammensætninger omfattende samme
|
|
GB0914110D0
(en)
|
2009-08-12 |
2009-09-16 |
Medical Res Council |
Peptide libraries
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
CN104147611A
(zh)
|
2009-09-30 |
2014-11-19 |
葛兰素集团有限公司 |
具有延长的半衰期的药物融合体和缀合物
|
|
BR112012010252A2
(pt)
|
2009-10-29 |
2016-12-06 |
Janssen Biotech Inc |
variantes de glicosilação de anticorpo
|
|
US8637637B2
(en)
|
2010-01-12 |
2014-01-28 |
Bill Nai-Chau Sun |
Fc fusion proteins of human growth hormone
|
|
RS59459B1
(sr)
|
2010-01-22 |
2019-11-29 |
Novo Nordisk Healthcare Ag |
Hormoni rasta sa produženom in-vivo efikasnošću
|
|
JP5980689B2
(ja)
|
2010-01-22 |
2016-08-31 |
ノヴォ・ノルディスク・ヘルス・ケア・アーゲー |
安定な成長ホルモン化合物
|
|
AR081066A1
(es)
|
2010-04-02 |
2012-06-06 |
Hanmi Holdings Co Ltd |
Conjugado de insulina donde se usa un fragmento de inmunoglobulina
|
|
MX357674B
(es)
|
2010-05-21 |
2018-07-18 |
Xl Protein Gmbh |
Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.
|
|
KR101337797B1
(ko)
|
2010-07-14 |
2013-12-06 |
한미사이언스 주식회사 |
지속형 인간 성장 호르몬 결합체 액상 제제
|
|
WO2012010516A1
(en)
|
2010-07-22 |
2012-01-26 |
Novo Nordisk Health Care Ag |
Growth hormone conjugates
|
|
US9783571B2
(en)
*
|
2011-04-05 |
2017-10-10 |
Warham Lance Martin |
Isolation of cysteine containing peptides
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
MX366864B
(es)
*
|
2012-02-27 |
2019-07-26 |
Amunix Operating Inc |
Composiciones de conjugados de xten y métodos para realizarlas.
|
|
CA2873112A1
(en)
|
2012-05-11 |
2013-11-14 |
Alexander Krantz |
Site-specific labeling and targeted delivery of proteins for the treatment of cancer
|
|
KR101993393B1
(ko)
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
EP3004156A1
(en)
|
2013-06-07 |
2016-04-13 |
Novo Nordisk A/S |
Method for making mature insulin polypeptides
|
|
JP6822839B2
(ja)
|
2013-09-13 |
2021-01-27 |
ザ・スクリップス・リサーチ・インスティテュート |
修飾された治療剤、及びその組成物
|
|
EP3663763B1
(en)
|
2013-11-26 |
2022-02-16 |
The Brigham and Women's Hospital, Inc. |
Compositions and methods for modulating an immune response
|
|
KR20160088429A
(ko)
|
2013-11-26 |
2016-07-25 |
노파르티스 아게 |
케톤-변형된 폴리펩티드에 대한 옥심 접합을 위한 방법
|
|
TW201619188A
(zh)
|
2014-03-05 |
2016-06-01 |
優稀美生物醫藥公司 |
多聚體Fc蛋白質
|
|
WO2016042093A1
(en)
|
2014-09-17 |
2016-03-24 |
Novo Nordisk A/S |
Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)
|
|
EP3260139A4
(en)
|
2015-02-17 |
2018-09-05 |
Hanmi Pharm. Co., Ltd. |
Long-acting insulin or insulin analogue complex
|
|
AR105616A1
(es)
|
2015-05-07 |
2017-10-25 |
Lilly Co Eli |
Proteínas de fusión
|
|
JP6983075B2
(ja)
|
2015-06-02 |
2021-12-17 |
ノヴォ ノルディスク アー/エス |
極性の組換え延長部を有するインスリン
|
|
RU2698727C9
(ru)
|
2015-08-14 |
2022-03-30 |
Рс Биотекнолоджиз, Инк. |
Ковалентные линкеры в конъюгатах антитело-лекарственное средство, способы их получения и применение
|
|
MA43348A
(fr)
|
2015-10-01 |
2018-08-08 |
Novo Nordisk As |
Conjugués de protéines
|
|
MA49339A
(fr)
|
2017-04-05 |
2020-02-12 |
Novo Nordisk As |
Conjugués insuline-fc à extension oligomère
|
|
CN112839681A
(zh)
|
2018-10-10 |
2021-05-25 |
诺和诺德股份有限公司 |
寡聚体延伸的胰岛素-Fc缀合物及其医学用途
|