JP2018534256A5 - - Google Patents
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- JP2018534256A5 JP2018534256A5 JP2018515823A JP2018515823A JP2018534256A5 JP 2018534256 A5 JP2018534256 A5 JP 2018534256A5 JP 2018515823 A JP2018515823 A JP 2018515823A JP 2018515823 A JP2018515823 A JP 2018515823A JP 2018534256 A5 JP2018534256 A5 JP 2018534256A5
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- Japan
- Prior art keywords
- human
- compound
- medicament
- neoplastic
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 42
- 239000003814 drug Substances 0.000 claims description 38
- 210000005170 neoplastic cell Anatomy 0.000 claims description 37
- 206010028980 Neoplasm Diseases 0.000 claims description 35
- 150000002148 esters Chemical class 0.000 claims description 25
- -1 heterocyclic amine Chemical class 0.000 claims description 21
- 230000012010 growth Effects 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 210000005260 human cell Anatomy 0.000 claims description 14
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 12
- 231100000433 cytotoxic Toxicity 0.000 claims description 12
- 230000001472 cytotoxic effect Effects 0.000 claims description 12
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 230000001613 neoplastic effect Effects 0.000 claims description 10
- 235000015097 nutrients Nutrition 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 claims description 8
- 230000004083 survival effect Effects 0.000 claims description 8
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims description 5
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims description 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 125000001931 aliphatic group Chemical group 0.000 claims description 5
- 150000001336 alkenes Chemical class 0.000 claims description 5
- 150000001345 alkine derivatives Chemical class 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 150000001540 azides Chemical class 0.000 claims description 5
- 230000029918 bioluminescence Effects 0.000 claims description 5
- 238000005415 bioluminescence Methods 0.000 claims description 5
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 125000000524 functional group Chemical group 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
- 208000032839 leukemia Diseases 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 230000003211 malignant effect Effects 0.000 claims description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
- 230000001394 metastastic effect Effects 0.000 claims description 5
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 5
- 230000009826 neoplastic cell growth Effects 0.000 claims description 5
- 201000002528 pancreatic cancer Diseases 0.000 claims description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 230000030833 cell death Effects 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 150000002632 lipids Chemical class 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 3
- 208000008589 Obesity Diseases 0.000 claims description 3
- 229930012538 Paclitaxel Natural products 0.000 claims description 3
- 208000006218 bradycardia Diseases 0.000 claims description 3
- 230000036471 bradycardia Effects 0.000 claims description 3
- 229960003668 docetaxel Drugs 0.000 claims description 3
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 claims description 3
- 229960004671 enzalutamide Drugs 0.000 claims description 3
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 3
- 229960005277 gemcitabine Drugs 0.000 claims description 3
- 229960000485 methotrexate Drugs 0.000 claims description 3
- 235000020824 obesity Nutrition 0.000 claims description 3
- 229960001592 paclitaxel Drugs 0.000 claims description 3
- 229960001603 tamoxifen Drugs 0.000 claims description 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000011301 standard therapy Methods 0.000 claims description 2
- 230000004614 tumor growth Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 13
- 0 CCCCCCCCc1ccc(C2C(CO)[N+]*CC2)cc1 Chemical compound CCCCCCCCc1ccc(C2C(CO)[N+]*CC2)cc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232377P | 2015-09-24 | 2015-09-24 | |
| US62/232,377 | 2015-09-24 | ||
| PCT/US2016/053815 WO2017053990A1 (en) | 2015-09-24 | 2016-09-26 | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534256A JP2018534256A (ja) | 2018-11-22 |
| JP2018534256A5 true JP2018534256A5 (enExample) | 2019-11-07 |
| JP6853539B2 JP6853539B2 (ja) | 2021-03-31 |
Family
ID=58387539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515823A Active JP6853539B2 (ja) | 2015-09-24 | 2016-09-26 | 合成スフィンゴ脂質様分子、薬物、これらの合成方法、および処置方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10995068B2 (enExample) |
| EP (1) | EP3352753A4 (enExample) |
| JP (1) | JP6853539B2 (enExample) |
| CN (1) | CN108366990B (enExample) |
| CA (1) | CA2999177A1 (enExample) |
| MX (1) | MX394367B (enExample) |
| WO (1) | WO2017053990A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6617702B2 (ja) | 2013-07-15 | 2019-12-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｆｔｙ７２０のアザサイクリック拘束アナログ |
| EP3352753A4 (en) | 2015-09-24 | 2019-03-13 | The Regents of The University of California | SYNTHETIC SPHINGOLIPIDE-SIMILAR MOLECULES, MEDICAMENTS, METHODS FOR THEIR SYNTHESIS AND TREATMENT PROCEDURES |
| MA50532A (fr) * | 2017-11-03 | 2020-09-09 | Univ Virginia Patent Foundation | Compositions et méthodes pour le traitement de cancers |
| US20210261583A1 (en) * | 2018-06-14 | 2021-08-26 | The Regents Of The University Of California | Synthetic Cytotoxic Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment |
| WO2021062168A1 (en) * | 2019-09-25 | 2021-04-01 | The Regents Of The University Of California | Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment |
| JP2023501578A (ja) * | 2019-11-13 | 2023-01-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 代謝障害のための薬物製剤および処置方法 |
| MX2022008627A (es) | 2020-01-13 | 2022-11-08 | Verge Analytics Inc | Pirazolo-pirimidinas sustituidas y usos de las mismas. |
| CN116617221B (zh) * | 2022-02-11 | 2025-06-17 | 复旦大学 | Trpml1特异性小分子激动剂ml-sa1在制药中的用途 |
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| US20210261583A1 (en) | 2018-06-14 | 2021-08-26 | The Regents Of The University Of California | Synthetic Cytotoxic Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment |
| WO2021062168A1 (en) | 2019-09-25 | 2021-04-01 | The Regents Of The University Of California | Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment |
| JP2023501578A (ja) | 2019-11-13 | 2023-01-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 代謝障害のための薬物製剤および処置方法 |
| US20240277740A1 (en) | 2020-05-16 | 2024-08-22 | Viratides, Llc | Treatment of known and unknown viral infection with lipid agents |
| WO2022094615A1 (en) | 2020-10-29 | 2022-05-05 | The Regents Of The University Of California | Compounds and methods for increased antisense activity |
| US20240066006A1 (en) | 2020-12-17 | 2024-02-29 | The Regents Of The University Of California | Antiviral Compounds and Applications Thereof |
-
2016
- 2016-09-26 EP EP16849886.3A patent/EP3352753A4/en not_active Withdrawn
- 2016-09-26 CN CN201680068271.8A patent/CN108366990B/zh not_active Expired - Fee Related
- 2016-09-26 JP JP2018515823A patent/JP6853539B2/ja active Active
- 2016-09-26 MX MX2018003685A patent/MX394367B/es unknown
- 2016-09-26 CA CA2999177A patent/CA2999177A1/en active Pending
- 2016-09-26 WO PCT/US2016/053815 patent/WO2017053990A1/en not_active Ceased
- 2016-09-26 US US15/760,199 patent/US10995068B2/en not_active Expired - Fee Related
-
2021
- 2021-03-08 US US17/195,556 patent/US11479530B2/en active Active
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2022
- 2022-10-13 US US18/046,471 patent/US11999693B2/en active Active
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