CN108366990B - 合成的鞘脂类分子、药物、它们的合成方法及治疗方法 - Google Patents

合成的鞘脂类分子、药物、它们的合成方法及治疗方法 Download PDF

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CN108366990B
CN108366990B CN201680068271.8A CN201680068271A CN108366990B CN 108366990 B CN108366990 B CN 108366990B CN 201680068271 A CN201680068271 A CN 201680068271A CN 108366990 B CN108366990 B CN 108366990B
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compound
tumor
cells
cancer
human
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CN108366990A (zh
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艾梅·埃丁格
斯蒂芬·哈内斯伊恩
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University of Montreal
University of California, San Diego
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680068271.8A 2015-09-24 2016-09-26 合成的鞘脂类分子、药物、它们的合成方法及治疗方法 Expired - Fee Related CN108366990B (zh)

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US201562232377P 2015-09-24 2015-09-24
US62/232,377 2015-09-24
PCT/US2016/053815 WO2017053990A1 (en) 2015-09-24 2016-09-26 Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

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CN108366990B true CN108366990B (zh) 2021-09-03

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US (3) US10995068B2 (enExample)
EP (1) EP3352753A4 (enExample)
JP (1) JP6853539B2 (enExample)
CN (1) CN108366990B (enExample)
CA (1) CA2999177A1 (enExample)
MX (1) MX394367B (enExample)
WO (1) WO2017053990A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11999693B2 (en) 2015-09-24 2024-06-04 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015009731A2 (en) 2013-07-15 2015-01-22 The Regents Of The University Of California Azacyclic constrained analogs of fty720
MA50532A (fr) 2017-11-03 2020-09-09 Univ Virginia Patent Foundation Compositions et méthodes pour le traitement de cancers
US20210261583A1 (en) * 2018-06-14 2021-08-26 The Regents Of The University Of California Synthetic Cytotoxic Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment
WO2021062168A1 (en) * 2019-09-25 2021-04-01 The Regents Of The University Of California Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
CA3158256A1 (en) * 2019-11-13 2021-05-20 Aimee EDINGER Drug formulations and methods of treatment for metabolic disorders
US12486274B2 (en) 2020-01-13 2025-12-02 Verge Analytics, Inc. Substituted pyrazolo-pyrimidines and uses thereof
CN116617221B (zh) * 2022-02-11 2025-06-17 复旦大学 Trpml1特异性小分子激动剂ml-sa1在制药中的用途

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US8309768B2 (en) * 2010-11-29 2012-11-13 The Ohio State University Research Foundation FTY720-derived anticancer agents
WO2015009731A2 (en) * 2013-07-15 2015-01-22 The Regents Of The University Of California Azacyclic constrained analogs of fty720
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Publication number Priority date Publication date Assignee Title
US11999693B2 (en) 2015-09-24 2024-06-04 The Regents Of The University Of California Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment

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HK1259078A1 (zh) 2019-11-22
MX394367B (es) 2025-03-24
US20230122855A1 (en) 2023-04-20
CA2999177A1 (en) 2017-03-30
US20180265464A1 (en) 2018-09-20
EP3352753A1 (en) 2018-08-01
CN108366990A (zh) 2018-08-03
MX2018003685A (es) 2018-08-15
JP6853539B2 (ja) 2021-03-31
US10995068B2 (en) 2021-05-04
WO2017053990A1 (en) 2017-03-30
US11479530B2 (en) 2022-10-25
US20210261504A1 (en) 2021-08-26
JP2018534256A (ja) 2018-11-22
EP3352753A4 (en) 2019-03-13
US11999693B2 (en) 2024-06-04

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