JP2018534236A5 - - Google Patents
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- JP2018534236A5 JP2018534236A5 JP2018507018A JP2018507018A JP2018534236A5 JP 2018534236 A5 JP2018534236 A5 JP 2018534236A5 JP 2018507018 A JP2018507018 A JP 2018507018A JP 2018507018 A JP2018507018 A JP 2018507018A JP 2018534236 A5 JP2018534236 A5 JP 2018534236A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- cdr2
- cdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004965 antibodies Human genes 0.000 claims description 58
- 108090001123 antibodies Proteins 0.000 claims description 58
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 35
- 206010012289 Dementia Diseases 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 102000013498 tau Proteins Human genes 0.000 claims description 11
- 108010026424 tau Proteins Proteins 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 10
- 201000011240 frontotemporal dementia Diseases 0.000 claims description 9
- 206010001897 Alzheimer's disease Diseases 0.000 claims description 8
- 210000004556 Brain Anatomy 0.000 claims description 8
- 208000003715 Parkinsonian Disorders Diseases 0.000 claims description 6
- 206010034010 Parkinsonism Diseases 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 5
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims description 3
- 210000004227 Basal Ganglia Anatomy 0.000 claims description 3
- 210000004369 Blood Anatomy 0.000 claims description 3
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims description 3
- 210000000349 Chromosomes Anatomy 0.000 claims description 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims description 3
- 206010070976 Craniocerebral injury Diseases 0.000 claims description 3
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 3
- 201000010450 Creutzfeldt-Jakob disease Diseases 0.000 claims description 3
- 208000009093 Diffuse Neurofibrillary Tangles with Calcification Diseases 0.000 claims description 3
- 201000010374 Down syndrome Diseases 0.000 claims description 3
- 206010018341 Gliosis Diseases 0.000 claims description 3
- 208000005264 Motor Neuron Disease Diseases 0.000 claims description 3
- 206010028003 Motor neurone disease Diseases 0.000 claims description 3
- 208000001089 Multiple System Atrophy Diseases 0.000 claims description 3
- 206010068871 Myotonic dystrophy Diseases 0.000 claims description 3
- 210000002682 Neurofibrillary Tangles Anatomy 0.000 claims description 3
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 3
- 201000011585 Pick's disease Diseases 0.000 claims description 3
- 210000002381 Plasma Anatomy 0.000 claims description 3
- 102000030002 Prion Proteins Human genes 0.000 claims description 3
- 108091000054 Prion Proteins Proteins 0.000 claims description 3
- 210000002966 Serum Anatomy 0.000 claims description 3
- 208000005765 Traumatic Brain Injury Diseases 0.000 claims description 3
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims description 3
- 230000001154 acute Effects 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 230000001054 cortical Effects 0.000 claims description 3
- 230000001809 detectable Effects 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 201000008319 inclusion body myositis Diseases 0.000 claims description 3
- 230000000750 progressive Effects 0.000 claims description 3
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 3
- 230000002739 subcortical Effects 0.000 claims description 3
- 208000006141 Amyloid angiopathy Diseases 0.000 claims description 2
- 206010014599 Encephalitis Diseases 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 206010022114 Injury Diseases 0.000 claims description 2
- 208000000170 Postencephalitic Parkinson Disease Diseases 0.000 claims description 2
- 210000001779 Taste Buds Anatomy 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 230000005298 paramagnetic Effects 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000001575 pathological Effects 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 101700011746 vs Proteins 0.000 claims 1
- 206010059245 Angiopathy Diseases 0.000 description 1
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 1
- 206010044688 Trisomy 21 Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204699P | 2015-08-13 | 2015-08-13 | |
| US62/204,699 | 2015-08-13 | ||
| US201562211123P | 2015-08-28 | 2015-08-28 | |
| US62/211,123 | 2015-08-28 | ||
| PCT/US2016/046513 WO2017027685A2 (en) | 2015-08-13 | 2016-08-11 | Antibody-based molecules specific for the truncated asp421 epitope of tau and their uses in the diagnosis and treatment of tauopathy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534236A JP2018534236A (ja) | 2018-11-22 |
| JP2018534236A5 true JP2018534236A5 (hr) | 2019-09-19 |
| JP6913078B2 JP6913078B2 (ja) | 2021-08-04 |
Family
ID=57984099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507018A Active JP6913078B2 (ja) | 2015-08-13 | 2016-08-11 | タウの短縮型Ａｓｐ４２１エピトープに特異的な、抗体を基にした分子、ならびにタウ異常症の診断および治療におけるそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10988528B2 (hr) |
| EP (1) | EP3334453A4 (hr) |
| JP (1) | JP6913078B2 (hr) |
| CN (1) | CN108135986B (hr) |
| WO (1) | WO2017027685A2 (hr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018152359A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| CN109912715A (zh) * | 2017-12-13 | 2019-06-21 | 凯惠科技发展(上海)有限公司 | 一种EGFRvIII抗体及其偶联物、制备方法和应用 |
| EP3947464A4 (en) * | 2019-04-05 | 2023-01-11 | B-Portal Biologics, Inc. | FUSION CONSTRUCTIONS AND THEIR USES |
| CN113874078A (zh) | 2019-04-05 | 2021-12-31 | Tauc3生物制品有限公司 | 抗tauc3抗体及其应用 |
| CN110679549B (zh) * | 2019-11-05 | 2021-08-20 | 南通大学 | 一种阿尔茨海默病小鼠模型的构建方法 |
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| JP3070763B2 (ja) | 1989-08-09 | 2000-07-31 | ロメッド インコーポレイティド | テクネチウムまたはレニウムでの抗体または他のタンパク質の直接放射能標識 |
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-
2016
- 2016-08-11 EP EP16835896.8A patent/EP3334453A4/en active Pending
- 2016-08-11 JP JP2018507018A patent/JP6913078B2/ja active Active
- 2016-08-11 US US15/750,975 patent/US10988528B2/en active Active
- 2016-08-11 WO PCT/US2016/046513 patent/WO2017027685A2/en active Application Filing
- 2016-08-11 CN CN201680057687.XA patent/CN108135986B/zh active Active
-
2021
- 2021-02-16 US US17/176,374 patent/US11958898B2/en active Active
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