JP2018532428A5 - - Google Patents
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- JP2018532428A5 JP2018532428A5 JP2018534513A JP2018534513A JP2018532428A5 JP 2018532428 A5 JP2018532428 A5 JP 2018532428A5 JP 2018534513 A JP2018534513 A JP 2018534513A JP 2018534513 A JP2018534513 A JP 2018534513A JP 2018532428 A5 JP2018532428 A5 JP 2018532428A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- zinc finger
- domain
- item
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000040430 polynucleotide Human genes 0.000 claims description 12
- 108091033319 polynucleotide Proteins 0.000 claims description 12
- 239000002157 polynucleotide Substances 0.000 claims description 12
- 239000013607 AAV vector Substances 0.000 claims description 10
- 101710185494 Zinc finger protein Proteins 0.000 claims description 10
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims description 10
- 101150043003 Htt gene Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 108020001507 fusion proteins Proteins 0.000 claims description 8
- 102000037865 fusion proteins Human genes 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 210000002569 neuron Anatomy 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 210000004556 brain Anatomy 0.000 claims description 4
- 238000013518 transcription Methods 0.000 claims description 4
- 230000035897 transcription Effects 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 108700028369 Alleles Proteins 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 210000001577 neostriatum Anatomy 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 11
- 238000000034 method Methods 0.000 description 9
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222588P | 2015-09-23 | 2015-09-23 | |
| US62/222,588 | 2015-09-23 | ||
| PCT/US2016/053374 WO2017053753A1 (en) | 2015-09-23 | 2016-09-23 | Htt repressors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173022A Division JP2021007405A (ja) | 2015-09-23 | 2020-10-14 | Ｈｔｔリプレッサー及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532428A JP2018532428A (ja) | 2018-11-08 |
| JP2018532428A5 true JP2018532428A5 (enExample) | 2019-09-26 |
| JP6853257B2 JP6853257B2 (ja) | 2021-03-31 |
Family
ID=58387548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534513A Active JP6853257B2 (ja) | 2015-09-23 | 2016-09-23 | Ｈｔｔリプレッサー及びその使用 |
| JP2020173022A Pending JP2021007405A (ja) | 2015-09-23 | 2020-10-14 | Ｈｔｔリプレッサー及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173022A Pending JP2021007405A (ja) | 2015-09-23 | 2020-10-14 | Ｈｔｔリプレッサー及びその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10435441B2 (enExample) |
| EP (1) | EP3352776B1 (enExample) |
| JP (2) | JP6853257B2 (enExample) |
| KR (1) | KR102803519B1 (enExample) |
| CN (1) | CN108348576B (enExample) |
| AU (2) | AU2016325613B2 (enExample) |
| CL (1) | CL2018000749A1 (enExample) |
| DK (1) | DK3352776T3 (enExample) |
| EA (1) | EA037993B1 (enExample) |
| ES (1) | ES3032775T3 (enExample) |
| FI (1) | FI3352776T3 (enExample) |
| HR (1) | HRP20250728T1 (enExample) |
| HU (1) | HUE071655T2 (enExample) |
| IL (1) | IL258030B (enExample) |
| LT (1) | LT3352776T (enExample) |
| MX (1) | MX391052B (enExample) |
| PL (1) | PL3352776T3 (enExample) |
| PT (1) | PT3352776T (enExample) |
| RS (1) | RS66924B1 (enExample) |
| SI (1) | SI3352776T1 (enExample) |
| WO (1) | WO2017053753A1 (enExample) |
| ZA (2) | ZA201801679B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN112410338A (zh) | 2014-11-14 | 2021-02-26 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| LT3352776T (lt) * | 2015-09-23 | 2025-07-10 | Sangamo Therapeutics, Inc. | Htt represoriai ir jų panaudojimas |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| SG11201809699XA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| KR20220108216A (ko) | 2016-05-18 | 2022-08-02 | 보이저 테라퓨틱스, 인크. | 헌팅톤 질환을 치료하기 위한 조성물 및 방법 |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3716767A4 (en) * | 2017-10-24 | 2021-11-24 | Sangamo Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF RARE DISEASES |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US11421007B2 (en) | 2018-04-18 | 2022-08-23 | Sangamo Therapeutics, Inc. | Zinc finger protein compositions for modulation of huntingtin (Htt) |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020150338A1 (en) * | 2019-01-15 | 2020-07-23 | Sangamo Therapeutics, Inc. | Htt repressors and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| AU2020228028A1 (en) | 2019-02-25 | 2021-09-30 | University Of Massachusetts | DNA-binding domain transactivators and uses thereof |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021016453A1 (en) * | 2019-07-23 | 2021-01-28 | University Of Rochester | Targeted rna cleavage with crispr-cas |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| TW202515898A (zh) | 2023-06-30 | 2025-04-16 | 日商武田藥品工業股份有限公司 | Ｈｔｔ抑制物及其用途 |
| KR102868476B1 (ko) | 2025-02-20 | 2025-10-13 | 본아이에프 주식회사 | 냄비용 모듈형 교반기 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| EP0770129B1 (en) | 1994-01-18 | 2005-11-23 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| CA2186118C (en) | 1994-03-23 | 2010-10-19 | Richard W. Hanson | Compacted nucleic acids and their delivery to cells |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| CA2196419C (en) | 1994-08-20 | 2007-08-21 | Yen Choo | Improvements in or relating to binding proteins for recognition of dna |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5928638A (en) | 1996-06-17 | 1999-07-27 | Systemix, Inc. | Methods for gene transfer |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| WO1999061066A2 (en) | 1998-05-27 | 1999-12-02 | Avigen, Inc. | Convection-enhanced delivery of aav vectors |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US20100293669A2 (en) * | 1999-05-06 | 2010-11-18 | Jingdong Liu | Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| HK1049515B (en) | 1999-12-06 | 2006-01-13 | Sangamo Biosciences Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| DE60143192D1 (de) | 2000-02-08 | 2010-11-18 | Sangamo Biosciences Inc | Zellen zur entdeckung von medikamenten |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| US7182944B2 (en) | 2001-04-25 | 2007-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of increasing distribution of nucleic acids |
| WO2003016496A2 (en) | 2001-08-20 | 2003-02-27 | The Scripps Research Institute | Zinc finger binding domains for cnn |
| US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| AU2003251286B2 (en) | 2002-01-23 | 2007-08-16 | The University Of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| US20030232410A1 (en) | 2002-03-21 | 2003-12-18 | Monika Liljedahl | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| US7074596B2 (en) | 2002-03-25 | 2006-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse mRNA cap analogues |
| JP2006502748A (ja) | 2002-09-05 | 2006-01-26 | カリフォルニア インスティテュート オブ テクノロジー | 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法 |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US20060239966A1 (en) | 2003-10-20 | 2006-10-26 | Tornoee Jens | In vivo gene therapy of parkinson's disease |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| EP2292274A1 (en) | 2004-09-16 | 2011-03-09 | Sangamo BioSciences, Inc. | Compositions and methods for protein production |
| EP1807009B1 (en) | 2004-10-05 | 2014-11-26 | Genzyme Corporation | Stepped cannula |
| MX2007013757A (es) | 2005-05-05 | 2008-01-24 | Univ Arizona | Reagrupacion permitida de secuencia (seer)-met odo de novedad para visualizar secuencias de adn especificas. |
| EP1928557B1 (en) | 2005-08-23 | 2018-06-06 | The Regents of The University of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
| PL2019683T5 (pl) | 2006-04-25 | 2022-12-05 | The Regents Of The University Of California | Podawanie czynników wzrostu do leczenia zaburzeń OUN |
| ES2465996T3 (es) | 2006-05-25 | 2014-06-09 | Sangamo Biosciences, Inc. | Métodos y composiciones para la inactivación genética |
| JP5266210B2 (ja) | 2006-05-25 | 2013-08-21 | サンガモ バイオサイエンシズ インコーポレイテッド | 改変開裂ハーフドメイン |
| US7837668B2 (en) | 2006-10-10 | 2010-11-23 | Ceregene, Inc. | Needle assembly for use in delivering precise dosages of proteinaceous pharmaceutical compositions and methods for use of same |
| CA2684378C (en) | 2007-04-26 | 2016-11-29 | Sangamo Biosciences, Inc. | Targeted integration into the ppp1r12c locus |
| AR066660A1 (es) * | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
| EP2167523B1 (en) | 2007-06-19 | 2014-07-23 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| EP2188384B1 (en) | 2007-09-27 | 2015-07-15 | Sangamo BioSciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| JP2011518555A (ja) | 2008-04-14 | 2011-06-30 | サンガモ バイオサイエンシーズ， インコーポレイテッド | 標的組込みのための線形ドナーコンストラクト |
| EP2294191B1 (en) | 2008-06-10 | 2016-09-28 | Sangamo BioSciences, Inc. | Methods and compositions for generation of bax- and bak-deficient cell lines |
| AU2009283194B2 (en) | 2008-08-22 | 2014-10-16 | Sangamo Therapeutics, Inc. | Methods and compositions for targeted single-stranded cleavage and targeted integration |
| AU2009322964B2 (en) | 2008-12-04 | 2014-10-09 | Sangamo Therapeutics, Inc. | Genome editing in rats using zinc-finger nucleases |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| CA2769262C (en) | 2009-07-28 | 2019-04-30 | Sangamo Biosciences, Inc. | Methods and compositions for treating trinucleotide repeat disorders |
| EP3165234B1 (de) | 2009-07-31 | 2019-04-03 | ethris GmbH | Rna mit einer kombination aus unmodifizierten und modifizierten nucleotiden zur proteinexpression |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| WO2011097036A1 (en) | 2010-02-08 | 2011-08-11 | Sangamo Biosciences, Inc. | Engineered cleavage half-domains |
| JP2013518602A (ja) | 2010-02-09 | 2013-05-23 | サンガモ バイオサイエンシーズ， インコーポレイテッド | 部分的に一本鎖のドナー分子による標的化ゲノム改変 |
| US9567573B2 (en) | 2010-04-26 | 2017-02-14 | Sangamo Biosciences, Inc. | Genome editing of a Rosa locus using nucleases |
| EP3156062A1 (en) | 2010-05-17 | 2017-04-19 | Sangamo BioSciences, Inc. | Novel dna-binding proteins and uses thereof |
| CA3157027A1 (en) | 2010-07-21 | 2012-01-26 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a t-cell receptor gene |
| ES2713560T3 (es) | 2010-10-15 | 2019-05-22 | Fund Centre De Regulacio Genòmica | Péptidos que tienen dominios de dedos de zinc y usos de estos |
| US9150847B2 (en) | 2011-09-21 | 2015-10-06 | Sangamo Biosciences, Inc. | Methods and compositions for regulation of transgene expression |
| US8895264B2 (en) | 2011-10-27 | 2014-11-25 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the HPRT locus |
| HK1200871A1 (en) | 2011-11-16 | 2015-08-14 | Sangamo Therapeutics, Inc. | Modified dna-binding proteins and uses thereof |
| NZ629427A (en) * | 2012-02-29 | 2016-04-29 | Sangamo Biosciences Inc | Methods and compositions for treating huntington’s disease |
| DK2890780T3 (da) * | 2012-08-29 | 2020-09-21 | Sangamo Therapeutics Inc | Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand |
| EP3730615A3 (en) | 2013-05-15 | 2020-12-09 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a genetic condition |
| JP6594891B2 (ja) | 2014-03-18 | 2019-10-23 | サンガモ セラピューティクス， インコーポレイテッド | ジンクフィンガータンパク質発現を調節するための方法および組成物 |
| CN106413760B (zh) | 2014-05-08 | 2020-01-14 | 桑格摩生物科学股份有限公司 | 用于治疗亨廷顿病的方法和组合物 |
| JP6873917B2 (ja) | 2015-05-12 | 2021-05-19 | サンガモ セラピューティクス， インコーポレイテッド | ヌクレアーゼ介在性遺伝子発現調節 |
| LT3352776T (lt) * | 2015-09-23 | 2025-07-10 | Sangamo Therapeutics, Inc. | Htt represoriai ir jų panaudojimas |
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2016
- 2016-09-23 LT LTEPPCT/US2016/053374T patent/LT3352776T/lt unknown
- 2016-09-23 KR KR1020187009994A patent/KR102803519B1/ko active Active
- 2016-09-23 PT PT168497212T patent/PT3352776T/pt unknown
- 2016-09-23 RS RS20250597A patent/RS66924B1/sr unknown
- 2016-09-23 HU HUE16849721A patent/HUE071655T2/hu unknown
- 2016-09-23 AU AU2016325613A patent/AU2016325613B2/en active Active
- 2016-09-23 ES ES16849721T patent/ES3032775T3/es active Active
- 2016-09-23 JP JP2018534513A patent/JP6853257B2/ja active Active
- 2016-09-23 FI FIEP16849721.2T patent/FI3352776T3/fi active
- 2016-09-23 EP EP16849721.2A patent/EP3352776B1/en active Active
- 2016-09-23 SI SI201631908T patent/SI3352776T1/sl unknown
- 2016-09-23 DK DK16849721.2T patent/DK3352776T3/da active
- 2016-09-23 MX MX2018003491A patent/MX391052B/es unknown
- 2016-09-23 IL IL258030A patent/IL258030B/en unknown
- 2016-09-23 EA EA201890493A patent/EA037993B1/ru unknown
- 2016-09-23 PL PL16849721.2T patent/PL3352776T3/pl unknown
- 2016-09-23 CN CN201680061809.2A patent/CN108348576B/zh active Active
- 2016-09-23 HR HRP20250728TT patent/HRP20250728T1/hr unknown
- 2016-09-23 WO PCT/US2016/053374 patent/WO2017053753A1/en not_active Ceased
- 2016-09-23 US US15/274,357 patent/US10435441B2/en active Active
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2018
- 2018-03-12 ZA ZA201801679A patent/ZA201801679B/en unknown
- 2018-03-21 CL CL2018000749A patent/CL2018000749A1/es unknown
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2019
- 2019-05-27 ZA ZA2019/03325A patent/ZA201903325B/en unknown
- 2019-08-26 US US16/550,949 patent/US11123443B2/en active Active
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2020
- 2020-06-17 AU AU2020204035A patent/AU2020204035B2/en active Active
- 2020-10-14 JP JP2020173022A patent/JP2021007405A/ja active Pending
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2021
- 2021-08-13 US US17/402,233 patent/US12551575B2/en active Active
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