JP2018531578A5 - - Google Patents
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- Publication number
- JP2018531578A5 JP2018531578A5 JP2017560329A JP2017560329A JP2018531578A5 JP 2018531578 A5 JP2018531578 A5 JP 2018531578A5 JP 2017560329 A JP2017560329 A JP 2017560329A JP 2017560329 A JP2017560329 A JP 2017560329A JP 2018531578 A5 JP2018531578 A5 JP 2018531578A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- virus
- influenza
- influenza virus
- attenuated influenza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002238 attenuated effect Effects 0.000 claims 34
- 241000712461 unidentified influenza virus Species 0.000 claims 33
- 239000013598 vector Substances 0.000 claims 30
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 27
- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 229940024606 amino acid Drugs 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 17
- 235000018102 proteins Nutrition 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 241000712431 Influenza A virus Species 0.000 claims 11
- 101710128560 Initiator protein NS1 Proteins 0.000 claims 11
- 101710144127 Non-structural protein 1 Proteins 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 235000004252 protein component Nutrition 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 206010022000 influenza Diseases 0.000 claims 8
- 229920002472 Starch Polymers 0.000 claims 7
- 235000014633 carbohydrates Nutrition 0.000 claims 7
- 150000001720 carbohydrates Chemical class 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 235000019698 starch Nutrition 0.000 claims 7
- 239000008107 starch Substances 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 6
- 239000007853 buffer solution Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229960005486 vaccine Drugs 0.000 claims 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 241000713196 Influenza B virus Species 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 208000037797 influenza A Diseases 0.000 claims 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 3
- 108010087806 Carnosine Proteins 0.000 claims 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108010061100 Nucleoproteins Proteins 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000037798 influenza B Diseases 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 3
- 101150059368 nep gene Proteins 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 206010006500 Brucellosis Diseases 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- 241000606161 Chlamydia Species 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 241000197306 H1N1 subtype Species 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 101900222562 Influenza A virus Nucleoprotein Proteins 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- 102000004407 Lactalbumin Human genes 0.000 claims 2
- 108090000942 Lactalbumin Proteins 0.000 claims 2
- 241000222722 Leishmania <genus> Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 2
- 102000011931 Nucleoproteins Human genes 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 241000224526 Trichomonas Species 0.000 claims 2
- 241000223104 Trypanosoma Species 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 108010079058 casein hydrolysate Proteins 0.000 claims 2
- 239000000306 component Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 235000013923 monosodium glutamate Nutrition 0.000 claims 2
- MWORBFIKQWWKQH-UHFFFAOYSA-N n,n'-bis[2-(1h-imidazol-5-yl)ethyl]propanediamide Chemical compound C=1N=CNC=1CCNC(=O)CC(=O)NCCC1=CN=CN1 MWORBFIKQWWKQH-UHFFFAOYSA-N 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 229940073490 sodium glutamate Drugs 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 125000000185 sucrose group Chemical group 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 101710088335 Diacylglycerol acyltransferase/mycolyltransferase Ag85A Proteins 0.000 claims 1
- 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 241000197304 H2N2 subtype Species 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 101710085938 Matrix protein Proteins 0.000 claims 1
- 101710127721 Membrane protein Proteins 0.000 claims 1
- GNMWEUXPNNTXGS-UHFFFAOYSA-N N',N'-bis[2-(1H-imidazol-5-yl)ethyl]propanediamide Chemical compound C(CC(=O)N)(=O)N(CCC1=CN=CN1)CCC1=CN=CN1 GNMWEUXPNNTXGS-UHFFFAOYSA-N 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 101710102873 Polymerase basic protein 2 Proteins 0.000 claims 1
- 101710085035 RNA-directed RNA polymerase catalytic subunit Proteins 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 201000007180 bile duct carcinoma Diseases 0.000 claims 1
- 231100000676 disease causative agent Toxicity 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 108700010900 influenza virus proteins Proteins 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000000174 oncolytic effect Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015147703 | 2015-11-06 | ||
| RU2015147703A RU2628690C2 (ru) | 2015-11-06 | 2015-11-06 | Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний |
| PCT/RU2016/050066 WO2017078577A2 (ru) | 2015-11-06 | 2016-11-03 | Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531578A JP2018531578A (ja) | 2018-11-01 |
| JP2018531578A5 true JP2018531578A5 (enExample) | 2019-10-31 |
| JP6692835B2 JP6692835B2 (ja) | 2020-05-13 |
Family
ID=58662984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560329A Active JP6692835B2 (ja) | 2015-11-06 | 2016-11-03 | 感染性疾患の予防及び／又は処置並びに腫瘍性疾患の処置のための弱毒化インフルエンザベクター |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10392604B2 (enExample) |
| EP (1) | EP3382010A4 (enExample) |
| JP (1) | JP6692835B2 (enExample) |
| KR (1) | KR102604877B1 (enExample) |
| CN (1) | CN108026515B (enExample) |
| AU (1) | AU2016350939B9 (enExample) |
| CA (1) | CA2991023C (enExample) |
| CU (1) | CU24580B1 (enExample) |
| IL (1) | IL255259B (enExample) |
| MA (1) | MA43314A (enExample) |
| MX (1) | MX380393B (enExample) |
| RU (1) | RU2628690C2 (enExample) |
| SG (1) | SG11201709122VA (enExample) |
| UA (1) | UA125333C2 (enExample) |
| WO (1) | WO2017078577A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL267077B (en) * | 2017-05-26 | 2022-07-01 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | New glutaminyl cyclase inhibitors and their use in the treatment of various diseases |
| MX2020006530A (es) * | 2017-12-22 | 2020-10-15 | Codagenix Inc | Virus recombinante con region desoptimizada de par de codones y usos del mismo para el tratamiento de cancer. |
| CA3091508A1 (en) | 2018-03-08 | 2019-09-12 | Codagenix Inc. | Attenuated flaviviruses |
| US12239699B2 (en) | 2018-09-11 | 2025-03-04 | Shanghai Public Health Clinical Center | Immunogen for broad-spectrum influenza vaccine and application thereof |
| KR102370100B1 (ko) * | 2019-02-15 | 2022-03-07 | 아이디바이오 주식회사 | 이종 인플루엔자 a 바이러스에 대한 면역/치료반응을 형성하는 신규한 재조합 인플루엔자 바이러스 및 이를 포함하는 유전자 전달체 및 치료백신 |
| RU2726106C1 (ru) * | 2019-07-18 | 2020-07-09 | федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ гриппа им. А.А. Смородинцева" Минздрава России) | Рекомбинантный штамм вируса гриппа A/PR8-NS124-TB10.4-2A-HspX и способ специфической профилактики туберкулеза легких с использованием вакцины мукозального применения на его основе |
| BR112023004433A2 (pt) * | 2020-09-11 | 2023-04-11 | Univ Georgia | Ácido nucleico, vetor, segmento genômico viral, vírus, composição farmacêutica, método para induzir ou aumentar uma resposta imune contra o vírus influenza, vírus recombinante, método para induzir uma resposta imune em um sujeito em necessidade e polipeptídeo |
| JP2023549017A (ja) * | 2020-11-11 | 2023-11-22 | カリフォルニア インスティチュート オブ テクノロジー | 多価担体および関連するワクチン組成物 |
| CN113430178B (zh) * | 2021-06-21 | 2022-10-11 | 武汉大学 | 一种表达ii型单纯疱疹病毒蛋白的重组流感病毒株及其制备方法与应用 |
| WO2025041889A1 (ko) * | 2023-08-24 | 2025-02-27 | 성신여자대학교 연구산학협력단 | 외래 항원을 발현하는 재조합 인플루엔자 바이러스 벡터 및 이를 포함하는 백신 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999064570A1 (en) * | 1998-06-12 | 1999-12-16 | Mount Sinai School Of Medicine Of The City University Of New York | Novel methods and interferon deficient substrates for the propagation of viruses |
| CA2334857C (en) * | 1998-06-12 | 2012-03-20 | Mount Sinai School Of Medicine Of The City University Of New York | Interferon inducing genetically engineered attenuated viruses |
| AU2001250352B2 (en) * | 2000-03-02 | 2006-01-12 | Polymun Scientific Immunbiologische Forschung Gmbh | Recombinant influenza a viruses |
| US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| US7709190B2 (en) * | 2005-12-02 | 2010-05-04 | Board Of Regents, The University Of Texas System | Influenza A virus vaccines and inhibitors |
| EP2048237A1 (en) * | 2007-10-05 | 2009-04-15 | Avir Green Hills Biotechnology Research Development Trade Ag | Replication deficient Influenza virus for the expression of heterologous sequences |
| EP2072058A1 (en) * | 2007-12-21 | 2009-06-24 | Avir Green Hills Biotechnology Research Development Trade Ag | Modified influenza virus |
| WO2011014504A1 (en) * | 2009-07-27 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Recombinant influenza virus vectors and uses thereof |
| JP5845180B2 (ja) * | 2009-07-30 | 2016-01-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルス及びそれらの使用 |
| WO2011130652A2 (en) * | 2010-04-15 | 2011-10-20 | George Baer | Compositions and methods for vaccinating humans and animals against enveloped viruses |
| EP2576581A4 (en) * | 2010-06-06 | 2015-04-15 | Sinai School Medicine | RECOMBINANT RNA VIRUSES AND USES THEREOF |
| WO2012072088A1 (en) * | 2010-12-02 | 2012-06-07 | Bionor Immuno As | Peptide scaffold design |
| EP2708552A1 (en) * | 2012-09-12 | 2014-03-19 | Medizinische Universität Wien | Influenza virus |
-
2015
- 2015-11-06 RU RU2015147703A patent/RU2628690C2/ru active
-
2016
- 2016-11-03 US US15/566,202 patent/US10392604B2/en active Active
- 2016-11-03 AU AU2016350939A patent/AU2016350939B9/en active Active
- 2016-11-03 CA CA2991023A patent/CA2991023C/en active Active
- 2016-11-03 SG SG11201709122VA patent/SG11201709122VA/en unknown
- 2016-11-03 MX MX2017015462A patent/MX380393B/es unknown
- 2016-11-03 CN CN201680033797.2A patent/CN108026515B/zh active Active
- 2016-11-03 CU CU2018000035A patent/CU24580B1/es unknown
- 2016-11-03 UA UAA201709223A patent/UA125333C2/uk unknown
- 2016-11-03 WO PCT/RU2016/050066 patent/WO2017078577A2/ru not_active Ceased
- 2016-11-03 EP EP16862552.3A patent/EP3382010A4/en active Pending
- 2016-11-03 MA MA043314A patent/MA43314A/fr unknown
- 2016-11-03 KR KR1020177036573A patent/KR102604877B1/ko active Active
- 2016-11-03 JP JP2017560329A patent/JP6692835B2/ja active Active
-
2017
- 2017-10-25 IL IL255259A patent/IL255259B/en active IP Right Grant
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