JP2018531369A5 - - Google Patents

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JP2018531369A5
JP2018531369A5 JP2018502804A JP2018502804A JP2018531369A5 JP 2018531369 A5 JP2018531369 A5 JP 2018531369A5 JP 2018502804 A JP2018502804 A JP 2018502804A JP 2018502804 A JP2018502804 A JP 2018502804A JP 2018531369 A5 JP2018531369 A5 JP 2018531369A5
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Japan
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bead
segment
signal detection
reaction
well
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JP2018502804A
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Japanese (ja)
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JP2018531369A6 (ja
JP6949816B2 (ja
JP2018531369A (ja
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Priority claimed from PCT/US2016/042913 external-priority patent/WO2017065854A2/en
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Publication of JP2018531369A5 publication Critical patent/JP2018531369A5/ja
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JP2018502804A 2015-07-22 2016-07-19 空間的に分離してビーズを保持するビーズウェル形状及びシグナル検出セグメントを有する流体デバイス並びに関連する方法 Active JP6949816B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562195381P 2015-07-22 2015-07-22
US62/195,381 2015-07-22
PCT/US2016/042913 WO2017065854A2 (en) 2015-07-22 2016-07-19 Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods

Publications (4)

Publication Number Publication Date
JP2018531369A JP2018531369A (ja) 2018-10-25
JP2018531369A6 JP2018531369A6 (ja) 2018-12-13
JP2018531369A5 true JP2018531369A5 (enExample) 2019-08-29
JP6949816B2 JP6949816B2 (ja) 2021-10-13

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JP2018502804A Active JP6949816B2 (ja) 2015-07-22 2016-07-19 空間的に分離してビーズを保持するビーズウェル形状及びシグナル検出セグメントを有する流体デバイス並びに関連する方法

Country Status (5)

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US (3) US10870111B2 (enExample)
EP (1) EP3313573A2 (enExample)
JP (1) JP6949816B2 (enExample)
CN (2) CN114272966B (enExample)
WO (1) WO2017065854A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9617589B2 (en) 2012-05-25 2017-04-11 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
JP6847934B2 (ja) 2015-10-05 2021-03-24 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill アッセイを多重化する為のデコード方法並びに関連する流体デバイス、キット、及び固体支持体
JP6966266B2 (ja) * 2017-09-05 2021-11-10 日本電波工業株式会社 感知センサの製造方法
US12234377B2 (en) 2018-05-18 2025-02-25 The University Of North Carolina At Chapel Hill Compositions, devices, and methods for improving a surface property of a substrate
CN109126913A (zh) * 2018-08-06 2019-01-04 陈思 一种多孔微流体芯片
WO2020162996A2 (en) 2018-11-13 2020-08-13 The University Of North Carolina At Chapel Hill Analysis systems with microfluidic devices, microfluidic devices and related methods
DE102019100256A1 (de) * 2019-01-07 2020-07-09 Als Automated Lab Solutions Gmbh Probengefäß mit einer Kavität zur Aufnahme einer Probe
WO2021097250A2 (en) 2019-11-14 2021-05-20 The Trustees Of Columbia University In The City Of New York Systems, methods, and compositions for generating multi-omic information from single cells
WO2022178253A1 (en) * 2021-02-19 2022-08-25 IsoPlexis Corporation Methods and devices for spatially resolved analysis of proteomic and genetic information

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4978540A (en) 1988-01-20 1990-12-18 Lee Tung Ching Production of frozen foods and other products
WO1991011533A1 (en) 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Method for isolating primer extension products from template-directed dna polymerase reactions
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6547942B1 (en) 1996-06-28 2003-04-15 Caliper Technologies Corp. Electropipettor and compensation means for electrophoretic bias
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
WO1999039829A1 (en) 1998-02-04 1999-08-12 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
US20040014168A1 (en) 1998-06-11 2004-01-22 Howard Hughes Medical Institute Reagents and methods for library synthesis and screening
JP2002521690A (ja) * 1998-07-28 2002-07-16 バイオメトリック イメージング インコーポレイテッド 細胞運動性アッセイのための装置および方法
US7079241B2 (en) * 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
US6602702B1 (en) * 1999-07-16 2003-08-05 The University Of Texas System Detection system based on an analyte reactive particle
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
AU2001257454A1 (en) 2000-04-28 2001-11-12 Quantum Dot Corporation Methods and compositions for polynucleotide analysis using generic capture sequences
US7326563B2 (en) * 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
WO2002061392A2 (en) * 2001-01-31 2002-08-08 Board Of Regents, The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
AT410444B (de) 2001-03-02 2003-04-25 Oesterr Forsch Seibersdorf Verfahren zur detektion von nukleinsäuremolekülen
US6913732B2 (en) * 2001-03-19 2005-07-05 Corning Incorporated Microplate for performing crystallography studies and methods for making and using such microplates
EP1256632A3 (en) 2001-05-07 2004-01-02 Smithkline Beecham Corporation High throughput polymorphism screening
CN1464071A (zh) 2002-06-27 2003-12-31 赵翀 镶嵌式高通量基因芯片检测技术及试剂盒
EP1566639A4 (en) * 2002-11-08 2006-10-11 Hiroshi Takahashi METHOD FOR EXAMINING CANCER CELLS AND REAGENT THEREOF
JP2007525963A (ja) 2003-06-20 2007-09-13 イルミナ インコーポレイテッド 全ゲノム増幅および遺伝型決定のための方法および組成物
US20060088857A1 (en) * 2003-12-01 2006-04-27 Said Attiya Method for isolation of independent, parallel chemical micro-reactions using a porous filter
WO2005071056A1 (ja) 2004-01-23 2005-08-04 Kitakyushu Foundation For The Advancement Of Industry, Science And Technology バイオチップ及びそれを用いた試料溶液の機能性検査方法
US20060228734A1 (en) * 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
WO2007021864A2 (en) 2005-08-11 2007-02-22 Eksigent Technologies, Llc Methods and apparatuses for generating a seal between a conduit and a reservoir well
WO2007092713A2 (en) 2006-02-02 2007-08-16 Trustees Of The University Of Pennsylvania Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease
JP4540070B2 (ja) * 2006-06-09 2010-09-08 株式会社スギノマシン 微小検体回収装置および微小検体回収方法
CN105925696A (zh) 2006-11-06 2016-09-07 科隆迪亚戈有限公司 使用结合元件用于分析的装置和方法
GB0703997D0 (en) 2007-03-01 2007-04-11 Oxitec Ltd Methods for detecting nucleic sequences
BRPI0813718A2 (pt) 2007-07-13 2014-12-30 Univ Leland Stanford Junior Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados
US7969331B2 (en) 2007-07-19 2011-06-28 Nidec Motor Corporation System and method for verifying entry of keystrokes received from a capacitive keypad
CN101848765B (zh) 2007-07-23 2016-03-09 科隆迪亚戈有限公司 分析方法
CN101896275A (zh) 2007-12-17 2010-11-24 龚海庆 微流控器件
JP5283924B2 (ja) * 2008-02-21 2013-09-04 株式会社日立製作所 核酸増幅用デバイス
KR101563687B1 (ko) * 2008-09-02 2015-11-09 삼성전자주식회사 표적 분자 분리를 위한 미세유동 카트리지, 분리장치, 및 이를 이용한 표적 분자 분리 방법
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
JP5271672B2 (ja) * 2008-11-06 2013-08-21 日立マクセル株式会社 プレート状容器、その成形に用いる鋳型およびそれを用いた処理法
CN101458251B (zh) * 2009-01-04 2013-02-27 东南大学 高通量检测生物大分子的磁性颗粒微阵列装置及其使用方法
JP2012515533A (ja) 2009-01-20 2012-07-12 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 診断、予後診断、および創薬ターゲットの同定のための単細胞遺伝子発現の方法
US9347092B2 (en) 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
SG174429A1 (en) * 2009-03-16 2011-10-28 Toray Industries Analysis chip, analysis method and method for stirring solution
CA2791655C (en) 2010-03-01 2014-11-04 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
JP2011196849A (ja) 2010-03-19 2011-10-06 Rohm Co Ltd 回転式分析チップおよびそれを用いた測定システム
CN101838702A (zh) * 2010-06-02 2010-09-22 何农跃 高通量单核苷酸多态性检测方法
WO2012026541A1 (ja) * 2010-08-27 2012-03-01 国立大学法人東京大学 タンパク質又はペプチドのプリンティング方法、及び、タンパク質アレイ又はペプチドアレイ、並びに、機能性タンパク質又は機能性ペプチドの同定方法
JP5872569B2 (ja) 2010-10-27 2016-03-01 キャピタルバイオ コーポレーションCapitalBio Corporation マイクロアレイに基づくアッセイのための粒子と結合させた発光団で標識された分子
WO2012109460A1 (en) 2011-02-09 2012-08-16 Adeptrix Corp. Devices and methods for producing and analyzing microarrays
US9329174B2 (en) * 2011-03-08 2016-05-03 Japan Science And Technology Agency Bead trapping method and method for detecting target molecule
WO2012129242A2 (en) 2011-03-23 2012-09-27 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US9709469B2 (en) * 2011-11-11 2017-07-18 The Regents Of The University Of California Valveless microfluidic device
US9617589B2 (en) 2012-05-25 2017-04-11 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
CN104619862B (zh) 2012-06-15 2017-10-31 得克萨斯系统大学董事会 单细胞的多转录物的高通量测序
GB201212775D0 (en) * 2012-07-18 2012-08-29 Dna Electronics Ltd Sensing apparatus and method
US9914968B2 (en) * 2012-09-26 2018-03-13 Cepheid Honeycomb tube
WO2014176435A2 (en) 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
KR102221894B1 (ko) * 2013-10-22 2021-03-03 버클리 라잇츠, 인크. 격리 펜을 갖는 미세유체 소자 및 이를 사용한 생물학적 미세 물체를 시험하는 방법
CN105689028B (zh) * 2016-01-20 2018-06-19 中国科学院上海微系统与信息技术研究所 用于免疫微球单一分布的微流体芯片、方法及其应用

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