JP2018530336A5 - - Google Patents
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- JP2018530336A5 JP2018530336A5 JP2018518438A JP2018518438A JP2018530336A5 JP 2018530336 A5 JP2018530336 A5 JP 2018530336A5 JP 2018518438 A JP2018518438 A JP 2018518438A JP 2018518438 A JP2018518438 A JP 2018518438A JP 2018530336 A5 JP2018530336 A5 JP 2018530336A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- nucleic acid
- perv
- porcine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021034493A JP7144122B2 (ja) | 2015-10-08 | 2021-03-04 | 多重ゲノム編集 |
| JP2021196238A JP7420439B2 (ja) | 2015-10-08 | 2021-12-02 | 多重ゲノム編集 |
| JP2022076779A JP7473136B2 (ja) | 2015-10-08 | 2022-05-06 | 多重ゲノム編集 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239239P | 2015-10-08 | 2015-10-08 | |
| US62/239,239 | 2015-10-08 | ||
| PCT/US2016/055916 WO2017062723A1 (en) | 2015-10-08 | 2016-10-07 | Multiplexed genome editing |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021034493A Division JP7144122B2 (ja) | 2015-10-08 | 2021-03-04 | 多重ゲノム編集 |
| JP2021196238A Division JP7420439B2 (ja) | 2015-10-08 | 2021-12-02 | 多重ゲノム編集 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530336A JP2018530336A (ja) | 2018-10-18 |
| JP2018530336A5 true JP2018530336A5 (enExample) | 2019-12-12 |
| JP7059468B2 JP7059468B2 (ja) | 2022-04-26 |
Family
ID=58488520
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518438A Active JP7059468B2 (ja) | 2015-10-08 | 2016-10-07 | 多重ゲノム編集 |
| JP2021034493A Active JP7144122B2 (ja) | 2015-10-08 | 2021-03-04 | 多重ゲノム編集 |
| JP2021196238A Active JP7420439B2 (ja) | 2015-10-08 | 2021-12-02 | 多重ゲノム編集 |
| JP2022076779A Active JP7473136B2 (ja) | 2015-10-08 | 2022-05-06 | 多重ゲノム編集 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021034493A Active JP7144122B2 (ja) | 2015-10-08 | 2021-03-04 | 多重ゲノム編集 |
| JP2021196238A Active JP7420439B2 (ja) | 2015-10-08 | 2021-12-02 | 多重ゲノム編集 |
| JP2022076779A Active JP7473136B2 (ja) | 2015-10-08 | 2022-05-06 | 多重ゲノム編集 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US10959413B2 (enExample) |
| EP (2) | EP4491732A3 (enExample) |
| JP (4) | JP7059468B2 (enExample) |
| KR (2) | KR102729669B1 (enExample) |
| CN (2) | CN108513580A (enExample) |
| AU (2) | AU2016335698B2 (enExample) |
| CA (1) | CA3001314A1 (enExample) |
| CL (1) | CL2018000902A1 (enExample) |
| CO (1) | CO2018004763A2 (enExample) |
| IL (2) | IL297017A (enExample) |
| MX (2) | MX2018004263A (enExample) |
| NZ (1) | NZ741778A (enExample) |
| SA (2) | SA518391294B1 (enExample) |
| WO (1) | WO2017062723A1 (enExample) |
| ZA (1) | ZA201802461B (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| IL308158A (en) * | 2012-12-17 | 2023-12-01 | Harvard College | Rna-guided human genome engineering |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3221457B1 (en) | 2014-11-21 | 2019-03-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| AU2016335698B2 (en) * | 2015-10-08 | 2022-12-01 | President And Fellows Of Harvard College | Multiplexed genome editing |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| AU2016365720B2 (en) | 2015-12-07 | 2020-11-26 | Arc Bio, Llc | Methods and compositions for the making and using of guide nucleic acids |
| WO2017109177A1 (en) | 2015-12-24 | 2017-06-29 | Selexis S.A. | Improved eukaryotic cells for protein manufacturing and methods of making them |
| SG10202102885UA (en) | 2016-05-20 | 2021-05-28 | Regeneron Pharma | Methods for breaking immunological tolerance using multiple guide rnas |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US11634721B2 (en) * | 2016-12-14 | 2023-04-25 | Dow Agrosciences Llc | Reconstruction of site specific nuclease binding sites |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| CN116732106A (zh) * | 2017-04-20 | 2023-09-12 | E开创生物技术股份有限公司 | 产生基因修改的动物的方法 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN107254551B (zh) * | 2017-06-06 | 2020-04-07 | 中国人民解放军军事科学院军事医学研究院 | 鉴定和选育PERV-pol基因缺陷型五指山小型猪新品系的方法 |
| EP3635114B1 (en) * | 2017-06-07 | 2024-11-06 | Arc Bio, LLC | Creation and use of guide nucleic acids |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| KR102158428B1 (ko) | 2018-08-16 | 2020-09-22 | (주)라트바이오 | 인위적 뉴클레아제를 생산하는 형질전환 배아 및 형질전환 동물의 제작 방법 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110358766A (zh) * | 2019-06-10 | 2019-10-22 | 云南农业大学 | 一种基于全基因组CRISPR/Cas9文库筛选异种移植抗原基因的方法 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN111549060A (zh) * | 2020-05-07 | 2020-08-18 | 西南大学 | 一种真核生物CRISPR/Cas9全基因组编辑细胞文库及构建方法 |
| CN111534541A (zh) * | 2020-05-07 | 2020-08-14 | 西南大学 | 一种真核生物CRISPR-Cas9双gRNA载体及构建方法 |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN112280802A (zh) * | 2020-05-21 | 2021-01-29 | 华中农业大学 | 基于piggyBac转座子系统制备稳定表达BE4蛋白的猪肾上皮细胞系的方法 |
| IL302830A (en) | 2020-11-13 | 2023-07-01 | Egenesis Inc | Cells, tissues, organs and animals with one or more genes that have been modified for improved survival and tolerance of a different-sex transplant |
| EP4426828A1 (en) | 2021-11-01 | 2024-09-11 | Tome Biosciences, Inc. | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
| US20250057980A1 (en) | 2021-12-22 | 2025-02-20 | Tome Biosciences, Inc. | Co-Delivery of a Gene Editor Construct and a Donor Template |
| CN114438083A (zh) * | 2022-01-29 | 2022-05-06 | 五邑大学 | 识别猪PERV基因的sgRNA及其编码DNA和应用 |
| WO2023205744A1 (en) | 2022-04-20 | 2023-10-26 | Tome Biosciences, Inc. | Programmable gene insertion compositions |
| KR102921507B1 (ko) * | 2022-05-06 | 2026-02-02 | 중앙대학교 산학협력단 | CRISPR-Cas9을 이용한 정교한 다중 유전체 편집 방법 및 이의 용도 |
| WO2023225670A2 (en) | 2022-05-20 | 2023-11-23 | Tome Biosciences, Inc. | Ex vivo programmable gene insertion |
| WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
| WO2024138194A1 (en) | 2022-12-22 | 2024-06-27 | Tome Biosciences, Inc. | Platforms, compositions, and methods for in vivo programmable gene insertion |
| WO2024234006A1 (en) | 2023-05-11 | 2024-11-14 | Tome Biosciences, Inc. | Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs) |
| WO2025050069A1 (en) | 2023-09-01 | 2025-03-06 | Tome Biosciences, Inc. | Programmable gene insertion using engineered integration enzymes |
| WO2025224107A1 (en) | 2024-04-22 | 2025-10-30 | Basecamp Research Ltd | Method and compositions for detecting off-target editing |
| WO2025224182A2 (en) | 2024-04-23 | 2025-10-30 | Basecamp Research Ltd | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1250594A4 (en) | 2000-01-19 | 2003-05-07 | Biotransplant Inc | PORC UNABLE TO TRANSMIT PORCINE ENDOGENEOUS RETROVIRUS, AND USES THEREOF |
| CN103397019A (zh) * | 2003-11-21 | 2013-11-20 | 雷维维科公司 | 干扰rna在生产转基因动物中的用途 |
| EP1582591A3 (en) * | 2004-02-27 | 2005-12-21 | Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut | Sirna and their use for knock down expression of porcine endogenous retrovirus |
| NZ539491A (en) * | 2005-04-15 | 2008-04-30 | Living Cell Products Pty Ltd | Swine population and uses thereof |
| EP2077329A1 (en) * | 2008-01-04 | 2009-07-08 | MWM Biomodels GmbH | Transgenic pig with altered incretin function |
| EP2931899A1 (en) * | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| IL308158A (en) * | 2012-12-17 | 2023-12-01 | Harvard College | Rna-guided human genome engineering |
| US10952843B2 (en) * | 2014-03-29 | 2021-03-23 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves |
| EP4176841A1 (en) * | 2013-05-03 | 2023-05-10 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves |
| US10188510B2 (en) * | 2013-05-03 | 2019-01-29 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves |
| US9907649B2 (en) * | 2013-05-03 | 2018-03-06 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valves and methods for anchoring same to cardiovascular structures |
| WO2014197748A2 (en) | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| AU2014312123A1 (en) * | 2013-08-29 | 2016-03-17 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| CN105899658B (zh) * | 2013-12-12 | 2020-02-18 | 布罗德研究所有限公司 | 针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用 |
| MA41382A (fr) | 2015-03-20 | 2017-11-28 | Univ Temple | Édition génique basée sur le système crispr/endonucléase à induction par tat |
| DE102015207944A1 (de) | 2015-04-29 | 2016-11-03 | Wacker Chemie Ag | Verfahren zur Herstellung organisch modifizierter Aerogele |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| CN105154471A (zh) * | 2015-08-11 | 2015-12-16 | 南方医科大学珠江医院 | 低表达或不表达perv的肝细胞的制备方法 |
| AU2016335698B2 (en) | 2015-10-08 | 2022-12-01 | President And Fellows Of Harvard College | Multiplexed genome editing |
| WO2017109177A1 (en) | 2015-12-24 | 2017-06-29 | Selexis S.A. | Improved eukaryotic cells for protein manufacturing and methods of making them |
| WO2018144546A1 (en) | 2017-02-01 | 2018-08-09 | President And Fellows Of Harvard College | Methods for increasing efficiency of gene editing in cells |
| CN116732106A (zh) | 2017-04-20 | 2023-09-12 | E开创生物技术股份有限公司 | 产生基因修改的动物的方法 |
-
2016
- 2016-10-07 AU AU2016335698A patent/AU2016335698B2/en active Active
- 2016-10-07 MX MX2018004263A patent/MX2018004263A/es unknown
- 2016-10-07 NZ NZ741778A patent/NZ741778A/en unknown
- 2016-10-07 US US15/766,551 patent/US10959413B2/en active Active
- 2016-10-07 IL IL297017A patent/IL297017A/en unknown
- 2016-10-07 EP EP24214109.1A patent/EP4491732A3/en active Pending
- 2016-10-07 WO PCT/US2016/055916 patent/WO2017062723A1/en not_active Ceased
- 2016-10-07 KR KR1020187012502A patent/KR102729669B1/ko active Active
- 2016-10-07 CA CA3001314A patent/CA3001314A1/en active Pending
- 2016-10-07 JP JP2018518438A patent/JP7059468B2/ja active Active
- 2016-10-07 CN CN201680071844.2A patent/CN108513580A/zh active Pending
- 2016-10-07 KR KR1020247037262A patent/KR102880582B1/ko active Active
- 2016-10-07 EP EP16854392.4A patent/EP3359661B1/en active Active
- 2016-10-07 CN CN202211152246.1A patent/CN116064664A/zh active Pending
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2018
- 2018-02-05 US US15/888,581 patent/US10375938B2/en active Active
- 2018-04-06 CL CL2018000902A patent/CL2018000902A1/es unknown
- 2018-04-06 MX MX2024007924A patent/MX2024007924A/es unknown
- 2018-04-07 SA SA518391294A patent/SA518391294B1/ar unknown
- 2018-04-07 SA SA523441205A patent/SA523441205B1/ar unknown
- 2018-04-08 IL IL258536A patent/IL258536A/en unknown
- 2018-04-13 ZA ZA2018/02461A patent/ZA201802461B/en unknown
- 2018-05-03 CO CONC2018/0004763A patent/CO2018004763A2/es unknown
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2019
- 2019-08-05 US US16/531,351 patent/US11064684B2/en active Active
- 2019-12-10 US US16/708,655 patent/US10925263B2/en active Active
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2020
- 2020-12-11 US US17/118,684 patent/US12133515B2/en active Active
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2021
- 2021-03-04 JP JP2021034493A patent/JP7144122B2/ja active Active
- 2021-12-02 JP JP2021196238A patent/JP7420439B2/ja active Active
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2022
- 2022-05-06 JP JP2022076779A patent/JP7473136B2/ja active Active
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2023
- 2023-02-28 AU AU2023201178A patent/AU2023201178B2/en active Active
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2024
- 2024-09-27 US US18/899,268 patent/US20250017181A1/en active Pending
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