JP2018529626A5 - - Google Patents
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- JP2018529626A5 JP2018529626A5 JP2017554073A JP2017554073A JP2018529626A5 JP 2018529626 A5 JP2018529626 A5 JP 2018529626A5 JP 2017554073 A JP2017554073 A JP 2017554073A JP 2017554073 A JP2017554073 A JP 2017554073A JP 2018529626 A5 JP2018529626 A5 JP 2018529626A5
- Authority
- JP
- Japan
- Prior art keywords
- glu
- ala
- pro
- amino acid
- synthetic peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 231100000614 Poison Toxicity 0.000 description 2
- 241000239226 Scorpiones Species 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
Description
本発明に係るサソリ毒耐熱合成ペプチド（ＳＶＨＲＳＰ）のアミノ酸配列は以下のとおりである：ＳＥＱ ＩＤ Ｎｏ．１：（Ｎ端）Ｌｙｓ−Ｖａｌ−Ｌｅｕ−Ａｓｎ−Ｇｌｙ−Ｐｒｏ−Ｇｌｕ−Ｇｌｕ−Ｇｌｕ−Ａｌａ−Ａｌａ−Ａｌａ−Ｐｒｏ−Ａｌａ−Ｇｌｕ（Ｃ端）。サソリ毒耐熱合成ペプチドは人工合成された活性ポリペプチドであり、１５個のアミノ酸残基を含み、分子量が１５２４Ｄａである。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610645111.7 | 2016-08-08 | ||
| CN201610645111.7A CN106220713B (zh) | 2016-08-08 | 2016-08-08 | 一种蝎毒耐热合成肽及其用途 |
| PCT/CN2016/112078 WO2018028117A1 (zh) | 2016-08-08 | 2016-12-26 | 一种蝎毒耐热合成肽及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529626A JP2018529626A (ja) | 2018-10-11 |
| JP2018529626A5 true JP2018529626A5 (ja) | 2018-12-27 |
| JP6483858B2 JP6483858B2 (ja) | 2019-03-13 |
Family
ID=57547837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554073A Active JP6483858B2 (ja) | 2016-08-08 | 2016-12-26 | サソリ毒耐熱合成ペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10442837B2 (ja) |
| EP (1) | EP3505530B1 (ja) |
| JP (1) | JP6483858B2 (ja) |
| CN (1) | CN106220713B (ja) |
| CA (1) | CA2984569C (ja) |
| ES (1) | ES2945407T3 (ja) |
| WO (1) | WO2018028117A1 (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106220713B (zh) * | 2016-08-08 | 2017-09-01 | 大连医科大学 | 一种蝎毒耐热合成肽及其用途 |
| CN109232718B (zh) * | 2018-11-09 | 2020-04-14 | 泰安市启航生物科技有限公司 | 一种合成肽sp2及其应用 |
| CN111647051B (zh) * | 2019-03-04 | 2022-02-01 | 中国医科大学 | 一种基于钠通道结构的短肽及其应用 |
| CN111896651B (zh) * | 2020-07-30 | 2021-04-23 | 山东大学 | 一种白眉蝮蛇蛇毒类凝血酶特征多肽及其应用 |
| CN114028537B (zh) * | 2021-11-27 | 2024-03-29 | 上海万锦医药科技有限公司 | 一种含有svhrsp蝎毒肽的药物组合物及其制备方法 |
| CN117224655B (zh) * | 2023-09-14 | 2024-05-14 | 大连医科大学 | 蝎毒耐热合成肽(svhrsp)在制备治疗肠道炎症的药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171595C (zh) * | 2001-02-19 | 2004-10-20 | 大连高新园区全国高技术产业化微生态中试基地 | 获取无毒有效蝎毒的生产工艺及由该工艺制备的治疗癫痫的药物 |
| US20030235902A1 (en) * | 2001-12-13 | 2003-12-25 | Kazuhiko Ishikawa | Heat-resistant thioredoxin and related enzymes |
| CN100465272C (zh) * | 2002-01-18 | 2009-03-04 | 中国科学院上海有机化学研究所 | 重组东亚马氏钳蝎毒rBmKaIT1的基因工程 |
| CN100516217C (zh) * | 2004-09-22 | 2009-07-22 | 山西大学 | 一种人工合成的蝎氯离子通道神经毒素基因-rBmK CTa |
| US20070191272A1 (en) * | 2005-09-27 | 2007-08-16 | Stemmer Willem P | Proteinaceous pharmaceuticals and uses thereof |
| CN1817902A (zh) * | 2006-03-07 | 2006-08-16 | 山西大学 | 一种重组蝎昆虫毒素及其可溶性表达和纯化方法 |
| CN101450966B (zh) * | 2007-11-29 | 2012-06-27 | 武汉摩尔生物科技有限公司 | 一种抗耐药菌的多肽及用途 |
| CN101284870B (zh) * | 2008-06-03 | 2011-09-14 | 武汉大学 | 一种抗麻疹病毒和人免疫缺陷病毒的多肽及用途 |
| CN103304630B (zh) * | 2012-03-07 | 2014-09-17 | 中国科学院大连化学物理研究所 | 东亚钳蝎蝎毒中的gpcr活性多肽及其提取分离和应用 |
| CN104341495A (zh) | 2013-07-31 | 2015-02-11 | 张万琴 | 一种蝎毒耐热多肽和制备方法及其应用 |
| CN106220713B (zh) * | 2016-08-08 | 2017-09-01 | 大连医科大学 | 一种蝎毒耐热合成肽及其用途 |
-
2016
- 2016-08-08 CN CN201610645111.7A patent/CN106220713B/zh active Active
- 2016-12-26 EP EP16905684.3A patent/EP3505530B1/en active Active
- 2016-12-26 JP JP2017554073A patent/JP6483858B2/ja active Active
- 2016-12-26 CA CA2984569A patent/CA2984569C/en active Active
- 2016-12-26 WO PCT/CN2016/112078 patent/WO2018028117A1/zh active Application Filing
- 2016-12-26 ES ES16905684T patent/ES2945407T3/es active Active
-
2017
- 2017-11-01 US US15/800,802 patent/US10442837B2/en active Active
-
2019
- 2019-09-17 US US16/573,495 patent/US10870680B2/en active Active
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