JP2015517484A5 - - Google Patents
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- Publication number
- JP2015517484A5 JP2015517484A5 JP2015510875A JP2015510875A JP2015517484A5 JP 2015517484 A5 JP2015517484 A5 JP 2015517484A5 JP 2015510875 A JP2015510875 A JP 2015510875A JP 2015510875 A JP2015510875 A JP 2015510875A JP 2015517484 A5 JP2015517484 A5 JP 2015517484A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pharmaceutical composition
- sequence
- peptide
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- QDYOZKNUWCMVJZ-UWTATZPHSA-N (1R)-1-amino-2-sulfanylethanesulfinic acid Chemical group SC[C@H](N)S(O)=O QDYOZKNUWCMVJZ-UWTATZPHSA-N 0.000 claims 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N 3-Mercaptopropane-1,2-diol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000005794 allergic hypersensitivity disease Diseases 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000003840 hydrochlorides Chemical class 0.000 claims 2
- 239000012535 impurity Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 229940035024 thioglycerol Drugs 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 150000001242 acetic acid derivatives Chemical class 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N methylsulfanylbenzene Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003449 preventive Effects 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Claims (13)
- CPAVKRDVDLFLT (SEQ ID NO: 1)の配列から成るペプチドの塩酸塩。
- ５質量％未満の(a)SEQ ID NO: 1の配列から成るペプチドからの末端システイン-プロリン残基の開裂により生じる不純物を含む請求項１記載の塩。
- ５質量％未満の(b)SEQ ID NO: 1の配列から成るペプチドのシステインスルフィン酸形態及び／又は(c)SEQ ID NO: 1の配列から成るペプチドのダイマーを含む請求項１又は２記載の塩。
- 請求項１から３のいずれか１項に記載の塩酸塩及び医薬的に許容可能な担体又は希釈剤を含有する医薬組成物。
- 更に追加のペプチド１種以上又はそれらの医薬的に許容可能な塩を含有する請求項４記載の医薬組成物。
- 該追加のペプチド１種以上又はそれらの医薬的に許容可能な塩が、SEQ ID NO: 2から7の配列から成るペプチド又はそれらの医薬的に許容可能な塩から選択される請求項５記載の医薬組成物。
- 該追加のペプチド１種以上又はそれらの医薬的に許容可能な塩が、SEQ ID NO: 2から7の配列から成る６種のペプチド又はそれらの医薬的に許容可能な塩である請求項６記載の医薬組成物。
- ・チオグリセロール、チオアニソール又はメチオニンの少なくとも１種；及び／又は
・トレハロース又はショ糖の少なくとも１種
を更に含む請求項７記載の医薬組成物。 - ・SEQ ID NO: 1の配列から成るペプチドの塩酸塩；
・SEQ ID NO: 2から7の配列から成る6種のペプチドの酢酸塩；
・トレハロース；
・チオグリセロール；
・メチオニン及び任意成分として、
・リン酸
を含む請求項７又は８記載の医薬組成物。 - ５質量％未満の(a)SEQ ID NO: 1の配列から成るペプチドからの末端システイン-プロリン残基の開裂により生じる不純物を含む請求項４から９のいずれか１項に記載の医薬組成物。
- ５質量％未満の(b)SEQ ID NO: 1の配列から成るペプチドのシステインスルフィン酸形態及び／又は(c)SEQ ID NO: 1の配列から成るペプチドのダイマーを含む請求項４から１０のいずれか１項に記載の医薬組成物。
- 請求項１から３のいずれか１項に記載の塩酸塩を活性成分として含む、ネコに対するアレルギーの予防又は治療剤。
- 請求項４から１１のいずれか１項に記載の医薬組成物を活性成分として含む、ネコに対するアレルギーの予防又は治療剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201208293A GB201208293D0 (en) | 2012-05-11 | 2012-05-11 | Hydrochlorice salt of peptide |
| GB1208293.9 | 2012-05-11 | ||
| PCT/GB2013/051201 WO2013167897A1 (en) | 2012-05-11 | 2013-05-09 | Hydrochloride salt of peptide and its use in combination with other peptides for immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517484A JP2015517484A (ja) | 2015-06-22 |
| JP2015517484A5 true JP2015517484A5 (ja) | 2016-06-30 |
| JP5982562B2 JP5982562B2 (ja) | 2016-08-31 |
Family
ID=46396890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510875A Expired - Fee Related JP5982562B2 (ja) | 2012-05-11 | 2013-05-09 | ペプチドの塩酸塩及び他のペプチドとの併用によるその免疫治療用途 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9657061B2 (ja) |
| EP (1) | EP2847209B8 (ja) |
| JP (1) | JP5982562B2 (ja) |
| KR (1) | KR20150014955A (ja) |
| CN (1) | CN104428311B (ja) |
| AU (1) | AU2013257784A1 (ja) |
| BR (1) | BR112014028130A2 (ja) |
| CA (1) | CA2873120A1 (ja) |
| EA (1) | EA201492068A1 (ja) |
| GB (2) | GB201208293D0 (ja) |
| HK (1) | HK1201850A1 (ja) |
| IL (1) | IL235388A (ja) |
| IN (1) | IN2014DN09367A (ja) |
| MX (1) | MX2014013394A (ja) |
| SG (1) | SG11201407446TA (ja) |
| WO (1) | WO2013167897A1 (ja) |
| ZA (1) | ZA201408290B (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| GB201501017D0 (en) * | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| PT3626729T (pt) | 2014-12-23 | 2021-11-03 | Immatics Biotechnologies Gmbh | Novos péptidos e combinações de péptidos para uso na imunoterapia contra o carcinoma hepatocelular (chc) e outros cancros |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| IL260877B2 (en) | 2015-03-27 | 2023-10-01 | Immatics Biotechnologies Gmbh | New peptides and a combination of peptides for use in immunotherapy against different types of tumors |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| TWI792442B (zh) * | 2021-07-23 | 2023-02-11 | 建誼生技股份有限公司 | 依特卡肽鹽酸鹽之製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002347369A1 (en) * | 2001-12-05 | 2003-06-17 | Circassia Limited | Immunotherapeutic methods and systems |
| WO2007084460A2 (en) | 2006-01-18 | 2007-07-26 | Qps, Llc | Pharmaceutical compositions with enhanced stability |
| GB0710529D0 (en) * | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| DK2190473T3 (da) * | 2007-08-15 | 2013-03-25 | Circassia Ltd | Peptid med reduceret dimerdannelse |
| GB2455108A (en) * | 2007-11-28 | 2009-06-03 | Circassia Ltd | T-Cell dependent method for detecting non-allergic or intrinsic disorders |
| GB0821806D0 (en) * | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| GB2490644A (en) * | 2010-03-31 | 2012-11-07 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
-
2012
- 2012-05-11 GB GB201208293A patent/GB201208293D0/en not_active Ceased
-
2013
- 2013-05-09 CA CA 2873120 patent/CA2873120A1/en not_active Abandoned
- 2013-05-09 WO PCT/GB2013/051201 patent/WO2013167897A1/en active Application Filing
- 2013-05-09 AU AU2013257784A patent/AU2013257784A1/en not_active Abandoned
- 2013-05-09 GB GB201421491A patent/GB2517354A/en not_active Withdrawn
- 2013-05-09 JP JP2015510875A patent/JP5982562B2/ja not_active Expired - Fee Related
- 2013-05-09 KR KR20147034734A patent/KR20150014955A/ko not_active Application Discontinuation
- 2013-05-09 BR BR112014028130A patent/BR112014028130A2/pt not_active IP Right Cessation
- 2013-05-09 SG SG11201407446TA patent/SG11201407446TA/en unknown
- 2013-05-09 CN CN201380036507.6A patent/CN104428311B/zh not_active Expired - Fee Related
- 2013-05-09 MX MX2014013394A patent/MX2014013394A/es unknown
- 2013-05-09 US US14/400,052 patent/US9657061B2/en active Active - Reinstated
- 2013-05-09 EA EA201492068A patent/EA201492068A1/ru unknown
- 2013-05-09 EP EP13722023.2A patent/EP2847209B8/en active Active
- 2013-05-09 IN IN9367DEN2014 patent/IN2014DN09367A/en unknown
-
2014
- 2014-10-29 IL IL235388A patent/IL235388A/en not_active IP Right Cessation
- 2014-11-12 ZA ZA2014/08290A patent/ZA201408290B/en unknown
-
2015
- 2015-03-05 HK HK15102275.5A patent/HK1201850A1/xx unknown
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