JP2018528176A5 - - Google Patents
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- Publication number
- JP2018528176A5 JP2018528176A5 JP2018504675A JP2018504675A JP2018528176A5 JP 2018528176 A5 JP2018528176 A5 JP 2018528176A5 JP 2018504675 A JP2018504675 A JP 2018504675A JP 2018504675 A JP2018504675 A JP 2018504675A JP 2018528176 A5 JP2018528176 A5 JP 2018528176A5
- Authority
- JP
- Japan
- Prior art keywords
- acrylate
- drug
- hydrate
- patch
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 17
- 229940079593 drug Drugs 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 238000003860 storage Methods 0.000 claims 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 5
- 239000000178 monomer Substances 0.000 claims 5
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000003961 penetration enhancing agent Substances 0.000 claims 4
- 229920000193 polymethacrylate Polymers 0.000 claims 4
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 238000000151 deposition Methods 0.000 claims 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229940055577 oleyl alcohol Drugs 0.000 claims 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims 1
- WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 claims 1
- NQSLZEHVGKWKAY-UHFFFAOYSA-N 6-methylheptyl 2-methylprop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C(C)=C NQSLZEHVGKWKAY-UHFFFAOYSA-N 0.000 claims 1
- DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- -1 alkyl methacrylate Chemical compound 0.000 claims 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- GTBGXKPAKVYEKJ-UHFFFAOYSA-N decyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCOC(=O)C(C)=C GTBGXKPAKVYEKJ-UHFFFAOYSA-N 0.000 claims 1
- FWLDHHJLVGRRHD-UHFFFAOYSA-N decyl prop-2-enoate Chemical compound CCCCCCCCCCOC(=O)C=C FWLDHHJLVGRRHD-UHFFFAOYSA-N 0.000 claims 1
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000004907 flux Effects 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- LNCPIMCVTKXXOY-UHFFFAOYSA-N hexyl 2-methylprop-2-enoate Chemical compound CCCCCCOC(=O)C(C)=C LNCPIMCVTKXXOY-UHFFFAOYSA-N 0.000 claims 1
- LNMQRPPRQDGUDR-UHFFFAOYSA-N hexyl prop-2-enoate Chemical compound CCCCCCOC(=O)C=C LNMQRPPRQDGUDR-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 claims 1
- 229940040102 levulinic acid Drugs 0.000 claims 1
- 125000005641 methacryl group Chemical group 0.000 claims 1
- 238000000386 microscopy Methods 0.000 claims 1
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 claims 1
- 229940065472 octyl acrylate Drugs 0.000 claims 1
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 claims 1
- 229960002969 oleic acid Drugs 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- ULDDEWDFUNBUCM-UHFFFAOYSA-N pentyl prop-2-enoate Chemical compound CCCCCOC(=O)C=C ULDDEWDFUNBUCM-UHFFFAOYSA-N 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 claims 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1513442.2A GB201513442D0 (en) | 2015-07-30 | 2015-07-30 | Transdermal patch |
| GB1513442.2 | 2015-07-30 | ||
| PCT/GB2016/052308 WO2017017453A1 (en) | 2015-07-30 | 2016-07-28 | Transdermal delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528176A JP2018528176A (ja) | 2018-09-27 |
| JP2018528176A5 true JP2018528176A5 (https=) | 2019-09-12 |
| JP6793718B2 JP6793718B2 (ja) | 2020-12-02 |
Family
ID=54062903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504675A Expired - Fee Related JP6793718B2 (ja) | 2015-07-30 | 2016-07-28 | 経皮送達系 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20180221298A1 (https=) |
| EP (1) | EP3328432A1 (https=) |
| JP (1) | JP6793718B2 (https=) |
| KR (1) | KR20180031039A (https=) |
| CN (1) | CN108136028A (https=) |
| AR (1) | AR105534A1 (https=) |
| AU (1) | AU2016298762A1 (https=) |
| BR (1) | BR112018001564A2 (https=) |
| CA (1) | CA2994109A1 (https=) |
| GB (1) | GB201513442D0 (https=) |
| IL (1) | IL256994A (https=) |
| MA (1) | MA42522A (https=) |
| MX (1) | MX2018001320A (https=) |
| SG (1) | SG10201913253TA (https=) |
| TW (1) | TW201707693A (https=) |
| WO (1) | WO2017017453A1 (https=) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10231248A (ja) * | 1997-02-19 | 1998-09-02 | T T S Gijutsu Kenkyusho:Kk | ジヒドロエトルフィン含有経皮吸収型製剤 |
| US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| CN1780611B (zh) * | 2003-04-30 | 2013-01-30 | 珀杜医药公司 | 包括活性剂部分以及在活性剂层远侧的逆转剂的抗改造透皮剂型 |
| KR101159828B1 (ko) * | 2003-04-30 | 2012-07-04 | 퍼듀 퍼머 엘피 | 활성제 구성요소 및 활성제 층의 원위부에 억제제 구성요소를 포함하는 내변조성 경피제형 |
| DE102005011517A1 (de) * | 2005-03-10 | 2006-09-21 | Grünenthal GmbH | Transdermales therapeutisches System zur Verabreichung von Analgetika |
| TWI541246B (zh) * | 2008-12-08 | 2016-07-11 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| GB201309654D0 (en) * | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
-
2015
- 2015-07-30 GB GBGB1513442.2A patent/GB201513442D0/en not_active Ceased
-
2016
- 2016-07-28 US US15/748,545 patent/US20180221298A1/en not_active Abandoned
- 2016-07-28 JP JP2018504675A patent/JP6793718B2/ja not_active Expired - Fee Related
- 2016-07-28 BR BR112018001564A patent/BR112018001564A2/pt not_active IP Right Cessation
- 2016-07-28 MX MX2018001320A patent/MX2018001320A/es unknown
- 2016-07-28 AU AU2016298762A patent/AU2016298762A1/en not_active Abandoned
- 2016-07-28 CN CN201680055303.0A patent/CN108136028A/zh active Pending
- 2016-07-28 KR KR1020187005892A patent/KR20180031039A/ko not_active Withdrawn
- 2016-07-28 SG SG10201913253TA patent/SG10201913253TA/en unknown
- 2016-07-28 EP EP16747573.0A patent/EP3328432A1/en not_active Withdrawn
- 2016-07-28 CA CA2994109A patent/CA2994109A1/en not_active Abandoned
- 2016-07-28 WO PCT/GB2016/052308 patent/WO2017017453A1/en not_active Ceased
- 2016-07-28 MA MA042522A patent/MA42522A/fr unknown
- 2016-07-29 TW TW105124075A patent/TW201707693A/zh unknown
- 2016-07-29 AR ARP160102319A patent/AR105534A1/es unknown
-
2018
- 2018-01-18 IL IL256994A patent/IL256994A/en unknown
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