CN108136028A - 经皮递送系统 - Google Patents

经皮递送系统 Download PDF

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Publication number
CN108136028A
CN108136028A CN201680055303.0A CN201680055303A CN108136028A CN 108136028 A CN108136028 A CN 108136028A CN 201680055303 A CN201680055303 A CN 201680055303A CN 108136028 A CN108136028 A CN 108136028A
Authority
CN
China
Prior art keywords
patch
dihydroetorphine
hydrate
salt
acrylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680055303.0A
Other languages
English (en)
Chinese (zh)
Inventor
史蒂夫·怀特洛克
德博拉·菲莉丝·哈丁
海伦·约翰逊
凯文·史密斯
吉尔·蒙蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of CN108136028A publication Critical patent/CN108136028A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680055303.0A 2015-07-30 2016-07-28 经皮递送系统 Pending CN108136028A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1513442.2A GB201513442D0 (en) 2015-07-30 2015-07-30 Transdermal patch
GB1513442.2 2015-07-30
PCT/GB2016/052308 WO2017017453A1 (en) 2015-07-30 2016-07-28 Transdermal delivery system

Publications (1)

Publication Number Publication Date
CN108136028A true CN108136028A (zh) 2018-06-08

Family

ID=54062903

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680055303.0A Pending CN108136028A (zh) 2015-07-30 2016-07-28 经皮递送系统

Country Status (16)

Country Link
US (1) US20180221298A1 (https=)
EP (1) EP3328432A1 (https=)
JP (1) JP6793718B2 (https=)
KR (1) KR20180031039A (https=)
CN (1) CN108136028A (https=)
AR (1) AR105534A1 (https=)
AU (1) AU2016298762A1 (https=)
BR (1) BR112018001564A2 (https=)
CA (1) CA2994109A1 (https=)
GB (1) GB201513442D0 (https=)
IL (1) IL256994A (https=)
MA (1) MA42522A (https=)
MX (1) MX2018001320A (https=)
SG (1) SG10201913253TA (https=)
TW (1) TW201707693A (https=)
WO (1) WO2017017453A1 (https=)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10231248A (ja) * 1997-02-19 1998-09-02 T T S Gijutsu Kenkyusho:Kk ジヒドロエトルフィン含有経皮吸収型製剤
US20020010127A1 (en) * 2000-02-08 2002-01-24 Benjamin Oshlack Controlled-release compositions containing opioid agonist and antagonist
CN1780611A (zh) * 2003-04-30 2006-05-31 珀杜医药公司 包括活性剂部分以及在活性剂层远侧的逆转剂的抗改造透皮剂型
US20070298091A1 (en) * 2005-03-10 2007-12-27 Gruenenthal Gmbh Transdermal Therapeutic System For Administering Analgesics
CN102307877A (zh) * 2008-12-08 2012-01-04 欧洲凯尔特公司 二氢埃托啡及其制备
CN105555274A (zh) * 2013-05-30 2016-05-04 欧洲凯尔特公司 用于提供疼痛减轻和麻醉的二氢埃托啡

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101159828B1 (ko) * 2003-04-30 2012-07-04 퍼듀 퍼머 엘피 활성제 구성요소 및 활성제 층의 원위부에 억제제 구성요소를 포함하는 내변조성 경피제형

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10231248A (ja) * 1997-02-19 1998-09-02 T T S Gijutsu Kenkyusho:Kk ジヒドロエトルフィン含有経皮吸収型製剤
US20020010127A1 (en) * 2000-02-08 2002-01-24 Benjamin Oshlack Controlled-release compositions containing opioid agonist and antagonist
CN1780611A (zh) * 2003-04-30 2006-05-31 珀杜医药公司 包括活性剂部分以及在活性剂层远侧的逆转剂的抗改造透皮剂型
US20070298091A1 (en) * 2005-03-10 2007-12-27 Gruenenthal Gmbh Transdermal Therapeutic System For Administering Analgesics
CN102307877A (zh) * 2008-12-08 2012-01-04 欧洲凯尔特公司 二氢埃托啡及其制备
CN105555274A (zh) * 2013-05-30 2016-05-04 欧洲凯尔特公司 用于提供疼痛减轻和麻醉的二氢埃托啡

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
SATOSHI OHMORI ET AL: ""Transdermal Delivery of the Potent Analgesic Dihydroetorphine: Kinetic Analysis of Skin Permeation and Analgesic Effect in the Hairless Rat"", 《J. PHARM. PHARMACOL.》 *
SATOSHI OHMORI ET AL: "A Protective Effect against Undesirable Increase of Dihydroetorphine Permeation through Damaged Skin by Using Pressure-Sensitive Adhesive Tape with an Ethylene-Vinyl Acetate Co-Polymer Membrane", 《BIOL. PHARM. BULL.》 *
SATOSHI OHMORI ET AL: "Dihydroetorphine: A Potent Analgesic: Pharmacology, Toxicology, Pharmacokinetics, and Clinical Effects", 《CNS DRUG REVIEWS》 *
XIAO PING CHEN: "Transdemal permeation of dihydro etorphine hydrochloride influence of pH, concentration and surfactants on in vitro permeation", 《JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES》 *
郭庆东，等: "介质pH, 药物浓度, 月桂氮酮对二氢埃托啡透皮(蛇皮)作用的影响", 《中国药学杂志》 *
陈小平，等: "二氢埃托啡透皮给药系统的研究", 《药学学报》 *

Also Published As

Publication number Publication date
JP2018528176A (ja) 2018-09-27
MA42522A (fr) 2018-06-06
MX2018001320A (es) 2018-08-15
SG10201913253TA (en) 2020-03-30
JP6793718B2 (ja) 2020-12-02
KR20180031039A (ko) 2018-03-27
TW201707693A (zh) 2017-03-01
BR112018001564A2 (pt) 2018-09-18
EP3328432A1 (en) 2018-06-06
WO2017017453A1 (en) 2017-02-02
US20180221298A1 (en) 2018-08-09
AR105534A1 (es) 2017-10-11
GB201513442D0 (en) 2015-09-16
AU2016298762A1 (en) 2018-02-15
CA2994109A1 (en) 2017-02-02
IL256994A (en) 2018-03-29

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Application publication date: 20180608