JP2018526033A5 - - Google Patents

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Publication number
JP2018526033A5
JP2018526033A5 JP2018532485A JP2018532485A JP2018526033A5 JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5 JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5
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JP
Japan
Prior art keywords
receptor
cancer
cell
dysfunctional
chimeric antigen
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JP2018532485A
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English (en)
Japanese (ja)
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JP6957471B2 (ja
JP2018526033A (ja
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Priority claimed from PCT/AU2016/050851 external-priority patent/WO2017041143A1/en
Publication of JP2018526033A publication Critical patent/JP2018526033A/ja
Publication of JP2018526033A5 publication Critical patent/JP2018526033A5/ja
Priority to JP2021164222A priority Critical patent/JP7253020B2/ja
Application granted granted Critical
Publication of JP6957471B2 publication Critical patent/JP6957471B2/ja
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JP2018532485A 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用 Active JP6957471B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021164222A JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903719A AU2015903719A0 (en) 2015-09-11 Chimeric antigen receptor and uses thereof
AU2015903719 2015-09-11
PCT/AU2016/050851 WO2017041143A1 (en) 2015-09-11 2016-09-10 Chimeric antigen receptors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021164222A Division JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Publications (3)

Publication Number Publication Date
JP2018526033A JP2018526033A (ja) 2018-09-13
JP2018526033A5 true JP2018526033A5 (OSRAM) 2020-09-10
JP6957471B2 JP6957471B2 (ja) 2021-11-02

Family

ID=58240468

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018532485A Active JP6957471B2 (ja) 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Pending JP2023082052A (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Pending JP2023082052A (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Country Status (8)

Country Link
US (3) US12121539B2 (OSRAM)
EP (2) EP3347474B1 (OSRAM)
JP (4) JP6957471B2 (OSRAM)
KR (2) KR20180043841A (OSRAM)
CN (2) CN108350462B (OSRAM)
AU (4) AU2016318230B2 (OSRAM)
ES (1) ES2848478T3 (OSRAM)
WO (1) WO2017041143A1 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3226897T3 (pl) 2014-12-05 2021-08-30 Memorial Sloan Kettering Cancer Center Przeciwciała do celowania w antygen dojrzewania limfocytów b i sposoby ich zastosowania
KR20180043841A (ko) 2015-09-11 2018-04-30 카리나 바이오테크 피티와이 엘티디 키메라 항원 수용체 및 이의 용도
PL233352B1 (pl) * 2016-09-15 2019-10-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe białko fuzyjne
PL3703750T3 (pl) 2017-11-01 2025-04-07 Juno Therapeutics, Inc. Chimeryczne receptory antygenowe specyficzne dla antygenu dojrzewania komórek b i kodujące polinukleotydy
CA3080395A1 (en) 2017-11-06 2019-05-09 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
WO2019134036A1 (en) 2018-01-03 2019-07-11 Qu Biologics Inc. Innate targeting of adoptive cellular therapies
JP2021514648A (ja) * 2018-03-01 2021-06-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 新規の標的抗原結合部分のための特異性アッセイ
KR20250151559A (ko) * 2018-03-15 2025-10-21 펀다멘탈 솔류션스 코포레이션 프로그램 가능한 면역세포 수용체 복합체 시스템
AU2019275479B2 (en) * 2018-05-21 2022-12-08 Biosceptre (Aust) Pty Ltd Chimeric antigen receptors with modified linker domains and uses thereof
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
CA3117419A1 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
BR112022000142A2 (pt) * 2019-07-26 2022-04-12 Biosceptre Aust Pty Ltd Métodos de tratamento
US20250281611A1 (en) * 2021-03-11 2025-09-11 Biosceptre ( Aust ) Pty Ltd Novel cell therapy system
MX2023015028A (es) * 2021-09-01 2024-02-16 Biosceptre Aust Pty Ltd Nuevos aglutinantes del p2x7 disfuncional.
JP2025531021A (ja) * 2022-09-14 2025-09-19 バイオセプター (オースト) プロプライエタリー・リミテッド 免疫細胞を検出する方法
EP4587067A1 (en) * 2022-09-14 2025-07-23 Biosceptre (Aust) Pty Ltd In vivo detection of immune cells
AU2023343788A1 (en) * 2022-09-14 2025-02-20 Biosceptre (Aust) Pty Ltd Enrichment of engineered immune cells
TW202525839A (zh) * 2023-09-06 2025-07-01 美國加利福尼亞大學董事會 治療癌症之方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4940661A (en) 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
US5512483A (en) 1993-05-21 1996-04-30 Mcgill University Expression vectors responsive to steroid hormones
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
RU97121687A (ru) 1995-05-26 2005-01-20 Синджента Лимитед (Gb) Ген-переключатель, представляющий ген рецептора экдизона
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
AUPP991199A0 (en) 1999-04-21 1999-05-13 University Of Sydney, The Methods for diagnosing pre-cancerous and cancerous conditions
WO2001020155A1 (fr) 1999-09-16 2001-03-22 Liangqi Zhang Membrane de reduction de pression pour carburateur
AUPQ968700A0 (en) 2000-08-28 2000-09-21 Intreat Pty Limited Treatment of urinary incontinence
AUPR201500A0 (en) 2000-12-11 2001-01-11 Biosceptre Pty Ltd Methods for identifying pre-neoplastic and neoplastic states in mammals
EP1961767B1 (en) 2001-01-17 2012-03-07 Biosceptre International Limited Diagnosis and treatment of cancers and other conditions
US20030203411A1 (en) * 2001-06-05 2003-10-30 Sabbadini Roger A. Methods of minicell-based delivery
NZ565994A (en) 2001-09-03 2010-02-26 Intreat Pty Ltd Antibodies to non-functional P2X7 receptor, diagnosis and treatment of cancers and other conditions
CA2402930A1 (en) * 2002-09-19 2004-03-19 William Herman Targeted ligands
DK2330121T3 (en) 2004-06-02 2014-12-15 Adalta Pty Ltd Binding moieties based on shark IgNar domains
US8067550B2 (en) * 2006-10-10 2011-11-29 Biosceptre International Limited Hybridomas producing antibodies against non functional P2X7 receptor
US20100036101A1 (en) 2006-10-10 2010-02-11 Angus Gidley-Baird Antibodies against non functional p2x7 receptor
BRPI0815416A2 (pt) * 2007-08-15 2014-10-21 Amunix Inc Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
EP2201377B1 (en) 2007-09-14 2012-01-18 Biosceptre International Limited Purinergic (p2x) receptors in extra-cellular body fluid
ES2619681T3 (es) * 2007-09-14 2017-06-26 Biosceptre (Aust) Pty Ltd Novedosos epítopos P2X7
US8840186B2 (en) 2007-11-07 2014-09-23 L&P Swiss Holding Ag Support assembly and corresponding seat structure
BRPI0915367B8 (pt) 2008-07-04 2021-05-25 Biosceptre International Ltd peptídeo anti-p2x7
JP5164806B2 (ja) 2008-11-12 2013-03-21 サンデン株式会社 車両用通信制御装置
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法
ES2557456T3 (es) * 2009-08-20 2016-01-26 Biosceptre (Aust) Pty Ltd Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
JP5992831B2 (ja) * 2009-12-24 2016-09-14 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 非機能性オリゴマーp2x7受容体に対する抗体
US9562094B2 (en) 2010-09-10 2017-02-07 Biosceptre (Aust) Pty Ltd Companion animal treatments
EP2646461A2 (en) 2010-12-03 2013-10-09 Cyclogenix Ltd VARIANTS OF igNAR
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP3693017A1 (en) * 2010-12-14 2020-08-12 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
CA2840251C (en) 2011-07-01 2023-09-12 Biosceptre International Limited Combination therapy of diseases that are associated with non-functional p2x7 receptor expression
US10117896B2 (en) * 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
PT3105317T (pt) * 2014-02-14 2019-02-27 Cellectis Células para imunoterapia manipuladas para atuar sobre antigénios presentes tanto em células imunitárias como em células patológicas
RU2727451C2 (ru) 2014-12-05 2020-07-21 Сити Оф Хоуп Т-клетки, модифицированные химерным рецептором антигена, нацеленным на cs1
JP6912386B2 (ja) 2015-01-26 2021-08-04 ザ ユニバーシティー オブ シカゴ 癌特異的なIL13Rα2を認識するCAR T細胞
AU2016240410B2 (en) 2015-04-02 2021-09-16 Biosceptre (Aust) Pty Ltd Pain treatment
KR20180043841A (ko) 2015-09-11 2018-04-30 카리나 바이오테크 피티와이 엘티디 키메라 항원 수용체 및 이의 용도
WO2017181001A1 (en) 2016-04-15 2017-10-19 Trustees Of Dartmouth College High affinity b7-h6 antibodies and antibody fragments
EP3487877A4 (en) 2016-07-19 2020-01-01 Unum Therapeutics Inc. USE OF THE ANTIBODY COUPLED T CELL RECEPTOR (ACTR) WITH MULTIPLE CANCER ANTIBODIES IN THE TREATMENT OF CANCER
US20190263928A1 (en) 2016-09-30 2019-08-29 Baylor College Of Medicine Adaptive chimeric antigen receptor t-cell design
WO2018071959A1 (en) 2016-10-21 2018-04-26 Biosceptre (Uk) Limited Cytotoxic particles
AU2019275479B2 (en) 2018-05-21 2022-12-08 Biosceptre (Aust) Pty Ltd Chimeric antigen receptors with modified linker domains and uses thereof
BR112022000142A2 (pt) 2019-07-26 2022-04-12 Biosceptre Aust Pty Ltd Métodos de tratamento

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