JP2018525000A5 - - Google Patents
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- JP2018525000A5 JP2018525000A5 JP2018506178A JP2018506178A JP2018525000A5 JP 2018525000 A5 JP2018525000 A5 JP 2018525000A5 JP 2018506178 A JP2018506178 A JP 2018506178A JP 2018506178 A JP2018506178 A JP 2018506178A JP 2018525000 A5 JP2018525000 A5 JP 2018525000A5
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- 239000002773 nucleotide Substances 0.000 claims 97
- 125000003729 nucleotide group Chemical group 0.000 claims 97
- 238000012217 deletion Methods 0.000 claims 50
- 230000037430 deletion Effects 0.000 claims 50
- 210000004027 cell Anatomy 0.000 claims 38
- 108010009992 CD163 antigen Proteins 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 33
- 241001465754 Metazoa Species 0.000 claims 30
- 238000003780 insertion Methods 0.000 claims 24
- 230000037431 insertion Effects 0.000 claims 24
- 108700028369 Alleles Proteins 0.000 claims 22
- 230000002759 chromosomal effect Effects 0.000 claims 13
- 241000282898 Sus scrofa Species 0.000 claims 10
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 claims 7
- 235000013601 eggs Nutrition 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 108010042407 Endonucleases Proteins 0.000 claims 3
- 102000004533 Endonucleases Human genes 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 210000000287 oocyte Anatomy 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000000366 juvenile effect Effects 0.000 claims 2
- 244000144972 livestock Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 238000009395 breeding Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 230000004952 protein activity Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021184502A JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2024025140A JP2024059790A (ja) | 2015-08-06 | 2024-02-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202145P | 2015-08-06 | 2015-08-06 | |
| US62/202,145 | 2015-08-06 | ||
| PCT/US2016/043467 WO2017023570A1 (en) | 2015-08-06 | 2016-07-22 | Pathogen-resistant animals having modified cd163 genes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021184502A Division JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018525000A JP2018525000A (ja) | 2018-09-06 |
| JP2018525000A5 true JP2018525000A5 (cg-RX-API-DMAC7.html) | 2019-08-29 |
Family
ID=57943474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506178A Withdrawn JP2018525000A (ja) | 2015-08-06 | 2016-07-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2021184502A Withdrawn JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2024025140A Pending JP2024059790A (ja) | 2015-08-06 | 2024-02-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021184502A Withdrawn JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2024025140A Pending JP2024059790A (ja) | 2015-08-06 | 2024-02-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Country Status (20)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2709445T3 (en) | 2011-05-16 | 2018-11-19 | Univ Missouri | ANIMALS RESISTANT TO PORCIN REPRODUCTION AND RESPIRATION DISEASE |
| CN109475107A (zh) * | 2015-08-06 | 2019-03-15 | 密苏里大学管理者 | 具有修饰的cd163基因的抗病原体动物 |
| GB201617559D0 (en) * | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| US20200377881A1 (en) * | 2017-03-24 | 2020-12-03 | President And Fellows Of Harvard College | Methods of Genome Engineering by Nuclease-Transposase Fusion Proteins |
| CN107354170A (zh) * | 2017-08-24 | 2017-11-17 | 中国农业科学院北京畜牧兽医研究所 | 一种基因敲除载体以及制备cd163基因敲除猪成纤维细胞的方法 |
| US12060403B2 (en) | 2017-10-16 | 2024-08-13 | Kansas State University Research Foundation | Methods and compositions for treating and protecting against porcine reproductive and respiratory syndrome virus |
| CN107937345B (zh) * | 2017-11-16 | 2019-01-29 | 山东蓝思种业股份有限公司 | 一种制备同时敲除cd163基因和cd13基因的猪成纤维细胞的方法 |
| US11160260B2 (en) | 2018-04-17 | 2021-11-02 | The Curators Of The University Of Missouri | Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) |
| BR112020021066A2 (pt) * | 2018-04-17 | 2021-02-17 | The Curators Of The University Of Missouri | método para proteger um feto suíno da infecção com o vírus da síndrome respiratória e reprodutiva suína (prrsv) |
| CN108753832A (zh) * | 2018-04-20 | 2018-11-06 | 中山大学 | 一种利用CRISPR/Cas9编辑大白猪CD163基因的方法 |
| KR102059503B1 (ko) | 2018-07-31 | 2019-12-26 | 충북대학교 산학협력단 | 돼지생식기호흡기증후군 바이러스 저항성 개체 판별을 위한 단일염기다형성 마커 조성물 |
| CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
| WO2020198541A1 (en) * | 2019-03-27 | 2020-10-01 | Recombinetics, Inc. | Porcine reproductive and respiratory syndrome virus (prrsv) resistant swine |
| CN110438155A (zh) * | 2019-08-15 | 2019-11-12 | 中国农业科学院北京畜牧兽医研究所 | 修饰cd163基因第561位氨基酸的组合物、应用、细胞及基因编辑猪的制备方法 |
| CN110684723B (zh) * | 2019-11-21 | 2021-03-12 | 东北农业大学 | 一种猪卵母细胞体外成熟培养液及其制备方法与应用 |
| GB201919294D0 (en) * | 2019-12-24 | 2020-02-05 | Eco Animal Health Ltd | Antibodies or binding proteins |
| BR112022020072A2 (pt) * | 2020-05-05 | 2022-11-29 | Genus Plc | Genes cd163, células, linhagens de células, par de grnas, complexo crispr, métodos para editar um gene cd163, preparar uma célula, produzir animais e determinar a presença ou ausência de uma sequência editada, embrião, leitão ou porco adulto, iniciador de pcr, sonda de pcr, usos e método de criação de um porco resistente ao prrsv |
| CN113512534B (zh) * | 2020-09-23 | 2024-04-23 | 杭州启函生物科技有限公司 | 用于遗传修饰和靶向的组合物和方法 |
| CN116348063A (zh) * | 2020-10-15 | 2023-06-27 | Abs全球公司 | 猪的选性精液和其使用方法 |
| CN112094866B (zh) * | 2020-11-10 | 2021-05-11 | 北京首农未来生物科技有限公司 | 一种利用SpRY-Cas9系统制备CD163基因编辑猪的方法 |
| CN118660963A (zh) * | 2021-11-01 | 2024-09-17 | 西格马-奥尔德里奇有限责任公司 | 用于crispr-cas系统的电穿孔增强剂 |
| JP2023129028A (ja) | 2022-03-04 | 2023-09-14 | 三井化学株式会社 | 無電解めっき用プライマー組成物、積層体及びその製造方法 |
| CN114774468B (zh) * | 2022-04-20 | 2022-12-20 | 温氏食品集团股份有限公司 | 一种等位基因分子标记及抗蓝耳病猪群体组建方法 |
| US20240358007A1 (en) * | 2023-04-30 | 2024-10-31 | Vincenzo Michael Biella | High Efficiency Beef Cattle Having Modified ACTN3 Genes |
| CN116671491B (zh) * | 2023-07-04 | 2024-01-23 | 四川省畜牧科学研究院 | 一种南江黄羊的种羊选育方法 |
| CN119979720B (zh) * | 2025-02-26 | 2025-09-23 | 中国农业科学院北京畜牧兽医研究所 | 猪精液品质相关的分子标记鉴定及其应用 |
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| KR102760488B1 (ko) | 2015-08-06 | 2025-02-03 | 더 큐레이터스 오브 더 유니버시티 오브 미주리 | 변형된 cd163 유전자를 갖는 병원균-내성 동물 |
| CN109475107A (zh) * | 2015-08-06 | 2019-03-15 | 密苏里大学管理者 | 具有修饰的cd163基因的抗病原体动物 |
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-
2016
- 2016-07-22 CN CN201680058107.9A patent/CN109475107A/zh active Pending
- 2016-07-22 US US15/216,865 patent/US10091975B2/en active Active
- 2016-07-22 PT PT168335149T patent/PT3331355T/pt unknown
- 2016-07-22 PL PL16833514.9T patent/PL3331355T3/pl unknown
- 2016-07-22 RS RS20240750A patent/RS65691B1/sr unknown
- 2016-07-22 SM SM20240272T patent/SMT202400272T1/it unknown
- 2016-07-22 BR BR112018002417A patent/BR112018002417A2/pt not_active Application Discontinuation
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- 2016-07-22 ES ES16833514T patent/ES2981381T3/es active Active
- 2016-07-22 HU HUE16833514A patent/HUE066989T2/hu unknown
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- 2016-07-22 WO PCT/US2016/043467 patent/WO2017023570A1/en not_active Ceased
- 2016-07-22 RU RU2018107842A patent/RU2018107842A/ru not_active Application Discontinuation
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2018
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2023
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2024
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